FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Volume 325:1261-1266 October 31, 1991 Number 18 Next

	Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

Abstract

BACKGROUND. Aspirin is known to improve the outcome of patients who have had a cerebral transient ischemic attack, but the optimal dose of aspirin remains uncertain. Experimental evidence indicates that 30 mg of aspirin daily alters platelet aggregation more favorably than the 300-mg dose currently used in patients after transient ischemic attack or minor ischemic stroke. METHODS. We assessed the effects of two doses of a water-soluble preparation of acetylsalicylic acid, or aspirin (30 mg vs. 283 mg a day), on the occurrence of death from all vascular causes, nonfatal stroke, or nonfatal myocardial infarction in a double-blind, randomized, controlled clinical trial in patients who had had a transient ischemic attack or minor stroke. A total of 3131 patients participated in the study. The mean follow-up was 2.6 years. RESULTS. In the group assigned to receive 30 mg of aspirin, the frequency of death from vascular causes, nonfatal stroke, or nonfatal myocardial infarction was 228 of 1555 (14.7 percent), as compared with 240 of 1576 (15.2 percent) in the group assigned to receive 283 mg. The age- and sex-adjusted hazard ratio for the group receiving the lower dose was 0.91 (95 percent confidence interval, 0.76 to 1.09). There were slightly fewer major bleeding complications in the 30-mg group than in the 283-mg group (40 vs. 53), and significantly fewer reports of minor bleeding (49 vs. 84). Fewer patients receiving 30 mg of aspirin reported gastrointestinal symptoms (164 vs. 179) and other adverse effects (73 vs. 90). CONCLUSIONS. Our data indicate that 30 mg of aspirin daily is no less effective in the prevention of vascular events than a 283-mg dose in patients with a transient ischemic attack or minor stroke, and has fewer adverse effects.

This article has been cited by other articles:

• Wermer, M J H, Greebe, P, Algra, A, Rinkel, G J E (2009). Long-term mortality and vascular event risk after aneurysmal subarachnoid haemorrhage. J. Neurol. Neurosurg. Psychiatry 80: 1399-1401 [Abstract] [Full Text]  
• Easton, J. D., Saver, J. L., Albers, G. W., Alberts, M. J., Chaturvedi, S., Feldmann, E., Hatsukami, T. S., Higashida, R. T., Johnston, S. C., Kidwell, C. S., Lutsep, H. L., Miller, E., Sacco, R. L. (2009). Definition and Evaluation of Transient Ischemic Attack: A Scientific Statement for Healthcare Professionals From the American Heart Association/American Stroke Association Stroke Council; Council on Cardiovascular Surgery and Anesthesia; Council on Cardiovascular Radiology and Intervention; Council on Cardiovascular Nursing; and the Interdisciplinary Council on Peripheral Vascular Disease: The American Academy of Neurology affirms the value of this statement as an educational tool for neurologists.. Stroke 40: 2276-2293 [Abstract] [Full Text]  
• Berger, J. S., Brown, D. L., Burke, G. L., Oberman, A., Kostis, J. B., Langer, R. D., Wong, N. D., Wassertheil-Smoller, S. (2009). Aspirin Use, Dose, and Clinical Outcomes in Postmenopausal Women With Stable Cardiovascular Disease: The Women's Health Initiative Observational Study. Circ Cardiovasc Qual Outcomes 2: 78-87 [Abstract] [Full Text]  
• Barnett, H. J.M. (2009). Personal Reflections From a Front-Row Seat at the Greatest Show on Earth (Life): Part II (Stroke Research Commentary). Stroke 40: e53-e65 [Full Text]  
• Adams, H. P. Jr (2009). Secondary Prevention of Atherothrombotic Events After Ischemic Stroke. Mayo Clin Proc. 84: 43-51 [Abstract] [Full Text]  
• Halkes, P H A, Gray, L J, Bath, P M W, Diener, H-C, Guiraud-Chaumeil, B, Yatsu, F M, Algra, A (2008). Dipyridamole plus aspirin versus aspirin alone in secondary prevention after TIA or stroke: a meta-analysis by risk. J. Neurol. Neurosurg. Psychiatry 79: 1218-1223 [Abstract] [Full Text]  
• van Wijk, I, Koudstaal, P J, Kappelle, L J, van Gijn, J, Gorter, J W, Algra, A, for the LiLAC Study Group, (2008). Long-term occurrence of death and cardiovascular events in patients with transient ischaemic attack or minor ischaemic stroke: comparison between arterial and cardiac source of the index event. J. Neurol. Neurosurg. Psychiatry 79: 895-899 [Abstract] [Full Text]  
• Patrono, C., Baigent, C., Hirsh, J., Roth, G. (2008). Antiplatelet Drugs: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest 133: 199S-233S [Abstract] [Full Text]  
• Albers, G. W., Amarenco, P., Easton, J. D., Sacco, R. L., Teal, P. (2008). Antithrombotic and Thrombolytic Therapy for Ischemic Stroke: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest 133: 630S-669S [Abstract] [Full Text]  
• Johnson, S. G., Rogers, K., Delate, T., Witt, D. M. (2008). Outcomes Associated With Combined Antiplatelet and Anticoagulant Therapy. Chest 133: 948-954 [Abstract] [Full Text]  
• Levy, E. I., Mocco, J., Samuelson, R. M., Ecker, R. D., Jahromi, B. S., Hopkins, L. N. (2008). Optimal treatment of carotid artery disease.. J Am Coll Cardiol 51: 979-985 [Abstract] [Full Text]  
• Kim, H.-H., Liao, J. K. (2008). Translational Therapeutics of Dipyridamole. Arterioscler. Thromb. Vasc. Bio. 28: s39-s42 [Abstract] [Full Text]  
• Patrono, C., Rocca, B. (2008). Aspirin: Promise and Resistance in the New Millennium. Arterioscler. Thromb. Vasc. Bio. 28: s25-s32 [Abstract] [Full Text]  
• Berger, J. S., Stebbins, A., Granger, C. B., Ohman, E. M., Armstrong, P. W., Van de Werf, F., White, H. D., Simes, R. J., Harrington, R. A., Califf, R. M., Peterson, E. D. (2008). Initial Aspirin Dose and Outcome Among ST-Elevation Myocardial Infarction Patients Treated With Fibrinolytic Therapy. Circulation 117: 192-199 [Abstract] [Full Text]  
• Air, E. L., Kissela, B. M. (2007). Diabetes, the Metabolic Syndrome, and Ischemic Stroke: Epidemiology and possible mechanisms. Diabetes Care 30: 3131-3140 [Full Text]  
• Samuelson, R. M., Yamamoto, J., Levy, E. I., Siddiqui, A. H., Hopkins, L. N. (2007). The Argument to Support Broader Application of Extracranial Carotid Artery Stent Technology. Circulation 116: 1602-1610 [Full Text]  
• Campbell, C. L., Smyth, S., Montalescot, G., Steinhubl, S. R. (2007). Aspirin Dose for the Prevention of Cardiovascular Disease: A Systematic Review. JAMA 297: 2018-2024 [Abstract] [Full Text]  
• Liao, J. K. (2007). Secondary Prevention of Stroke and Transient Ischemic Attack: Is More Platelet Inhibition the Answer?. Circulation 115: 1615-1621 [Abstract] [Full Text]  
• Bates, E. R., Babb, C. J. D., Casey, D. E., Cates, C. U., Duckwiler, G. R., Feldman, T. E., Gray, W. A., Ouriel, K., Peterson, E. D., Rosenfield, K., Rundback, J. H., Safian, R. D., Sloan, M. A., White, C. J. (2007). ACCF/SCAI/SVMB/SIR/ASITN 2007 Clinical Expert Consensus Document on Carotid Stenting: A Report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents (ACCF/SCAI/SVMB/SIR/ASITN Clinical Expert Consensus Document Committee on Carotid Stenting). Vasc Med 12: 35-83  
• American Society of Interventional & Therapeutic N, , Society for Cardiovascular Angiography and Interve, , Society for Vascular Medicine and Biology, , Society of Interventional Radiology, , Bates, E. R., Babb, J. D., Casey, D. E. Jr, Cates, C. U., Duckwiler, G. R., Feldman, T. E., Gray, W. A., Ouriel, K., Peterson, E. D., Rosenfield, K., Rundback, J. H., Safian, R. D., Sloan, M. A., White, C. J., Harrington, R. A., Abrams, J., Anderson, J. L., Bates, E. R., Eisenberg, M. J., Grines, C. L., Hlatky, M. A., Lichtenberg, R. C., Lindner, J. R., Pohost, G. M., Schofield, R. S., Shubrooks, S. J. JR, Stein, J. H., Tracy, C. M., Vogel, R. A., Wesley, D. J. (2007). ACCF/SCAI/SVMB/SIR/ASITN 2007 Clinical Expert Consensus Document on Carotid Stenting: A Report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents (ACCF/SCAI/SVMB/SIR/ASITN Clinical Expert Consensus Document Committee on Carotid Stenting). J Am Coll Cardiol 49: 126-170 [Full Text]  
• van Wijk, I, Lindeman, E, Kappelle, L J, van Gijn, J, Koudstaal, P J, Gorter, J W, Algra, A, for the LiLAC Study Group*, (2006). Functional status and use of healthcare facilities in long-term survivors of transient ischaemic attack or minor ischaemic stroke. J. Neurol. Neurosurg. Psychiatry 77: 1238-1243 [Abstract] [Full Text]  
• Cuffe, R. L., Howard, S. C., Algra, A., Warlow, C. P., Rothwell, P. M. (2006). Medium-Term Variability of Blood Pressure and Potential Underdiagnosis of Hypertension in Patients With Previous Transient Ischemic Attack or Minor Stroke. Stroke 37: 2776-2783 [Abstract] [Full Text]  
• Halkes, P. H.A., Kappelle, L. J., van Gijn, J., van Wijk, I., Koudstaal, P. J., Algra, A. (2006). Large Subcortical Infarcts: Clinical Features, Risk Factors, and Long-Term Prognosis Compared With Cortical and Small Deep Infarcts. Stroke 37: 1828-1832 [Abstract] [Full Text]  
• De Schryver, E L L M, Algra, A, Donders, R C J M, van Gijn, J, Kappelle, L J (2006). Type of stroke after transient monocular blindness or retinal infarction of presumed arterial origin. J. Neurol. Neurosurg. Psychiatry 77: 734-738 [Abstract] [Full Text]  
• Vermeer, S. E., Sandee, W., Algra, A., Koudstaal, P. J., Kappelle, L. J., Dippel, D. W.J., on behalf of the Dutch TIA Trial Study Group, (2006). Impaired Glucose Tolerance Increases Stroke Risk in Nondiabetic Patients With Transient Ischemic Attack or Minor Ischemic Stroke. Stroke 37: 1413-1417 [Abstract] [Full Text]  
• Halkes, P. H.A., van Gijn, J., Kappelle, L. J., Koudstaal, P. J., Algra, A. (2006). Classification of Cause of Death After Stroke in Clinical Research. Stroke 37: 1521-1524 [Abstract] [Full Text]  
• Dhamoon, M. S., Sciacca, R. R., Rundek, T., Sacco, R. L., Elkind, M.S.V. (2006). Recurrent stroke and cardiac risks after first ischemic stroke: The Northern Manhattan Study. Neurology 66: 641-646 [Abstract] [Full Text]  
• Ariesen, M J, Algra, A, Warlow, C P, Rothwell, P M, on behalf of the Cerebrovascular Cohort Studies Co, (2006). Predictors of risk of intracerebral haemorrhage in patients with a history of TIA or minor ischaemic stroke. J. Neurol. Neurosurg. Psychiatry 77: 92-94 [Abstract] [Full Text]  
• Howard, S. C., Algra, A., Warlow, C. P., Rothwell, P. M. (2006). Potential Consequences for Recruitment, Power, and External Validity of Requirements for Additional Risk Factors for Eligibility in Randomized Controlled Trials in Secondary Prevention of Stroke. Stroke 37: 209-215 [Abstract] [Full Text]  
• Patrono, C., Garcia Rodriguez, L. A., Landolfi, R., Baigent, C. (2005). Low-dose aspirin for the prevention of atherothrombosis.. NEJM 353: 2373-2383 [Full Text]  
• Chan, A. T., Giovannucci, E. L., Meyerhardt, J. A., Schernhammer, E. S., Curhan, G. C., Fuchs, C. S. (2005). Long-term Use of Aspirin and Nonsteroidal Anti-inflammatory Drugs and Risk of Colorectal Cancer. JAMA 294: 914-923 [Abstract] [Full Text]  
• Cannon, C. P., Mehta, S. R., Aranki, S. F. (2005). Balancing the Benefit and Risk of Oral Antiplatelet Agents in Coronary Artery Bypass Surgery. Ann. Thorac. Surg. 80: 768-779 [Abstract] [Full Text]  
• Jamieson, D. G., Parekh, A., Ezekowitz, M. D. (2005). Review of Antiplatelet Therapy in Secondary Prevention of Cerebrovascular Events: A Need for Direct Comparisons Between Antiplatelet Agents. J CARDIOVASC PHARMACOL THER 10: 153-161 [Abstract]  
• Rothwell, P. M., Howard, S. C., Power, D. A., Gutnikov, S. A., Algra, A., van Gijn, J., Clark, T. G., Murphy, M. F.G., Warlow, C. P., for the Cerebrovascular Cohort Studies Collaborati, (2004). Fibrinogen Concentration and Risk of Ischemic Stroke and Acute Coronary Events in 5113 Patients With Transient Ischemic Attack and Minor Ischemic Stroke. Stroke 35: 2300-2305 [Abstract] [Full Text]  
• Patrono, C., Coller, B., FitzGerald, G. A., Hirsh, J., Roth, G. (2004). Platelet-Active Drugs: The Relationships Among Dose, Effectiveness, and Side Effects: The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest 126: 234S-264S [Abstract] [Full Text]  
• Albers, G. W., Amarenco, P., Easton, J. D., Sacco, R. L., Teal, P. (2004). Antithrombotic and Thrombolytic Therapy for Ischemic Stroke: The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest 126: 483S-512S [Abstract] [Full Text]  
• Monagle, P., Chan, A., Massicotte, P., Chalmers, E., Michelson, A. D. (2004). Antithrombotic Therapy in Children*: The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest 126: 645S-687S [Abstract] [Full Text]  
• Varanasi, J. S., Steinhubl, S. R. (2004). Antiplatelet Effect of Aspirin in Patients With Cerebrovascular Disease. Stroke 35: e144-e145 [Full Text]  
• Albers, G. W. (2004). A review of published TIA treatment recommendations. Neurology 62: S26-S28 [Full Text]  
• Culebras, A., Rotta-Escalante, R., Vila, J., Dominguez, R., Abiusi, G., Famulari, A., Rey, R., Bauso-Tosselli, L., Gori, H., Ferrari, J., Reich, E. (2004). Triflusal vs aspirin for prevention of cerebral infarction: A randomized stroke study. Neurology 62: 1073-1080 [Abstract] [Full Text]  
• Eliasziw, M., Kennedy, J., Hill, M. D., Buchan, A. M., Barnett, H. J.M. (2004). Early risk of stroke after a transient ischemic attack in patients with internal carotid artery disease. CMAJ 170: 1105-1109 [Abstract] [Full Text]  
• Quinn, M. J., Aronow, H. D., Califf, R. M., Bhatt, D. L., Sapp, S., Kleiman, N. S., Harrington, R. A., Kong, D. F., Kandzari, D. E., Topol, E. J. (2004). Aspirin dose and six-month outcome after an acute coronary syndrome. J Am Coll Cardiol 43: 972-978 [Abstract] [Full Text]  
• Ariesen, M.J., Algra, A., Koudstaal, P.J., Rothwell, P.M., van Walraven, C., for the AFASAK, DTT, EAFT, PATAF, SPAF, SPIRIT, an, (2004). Risk of Intracerebral Hemorrhage in Patients With Arterial Versus Cardiac Origin of Cerebral Ischemia on Aspirin or Placebo: Analysis of Individual Patient Data From 9 Trials. Stroke 35: 710-714 [Abstract] [Full Text]  
• Algra, A., Gates, P. C., Fox, A. J., Hachinski, V., Barnett, H. J.M. (2003). Side of Brain Infarction and Long-Term Risk of Sudden Death in Patients With Symptomatic Carotid Disease. Stroke 34: 2871-2875 [Abstract] [Full Text]  
• Howard, J. J, Souchek, J., Collins, T. C (2003). Ischaemic outcomes assessment survey: A pilot study in patients with peripheral arterial disease. British Journal of Diabetes & Vascular Disease 3: 424-430 [Abstract]  
• Peters, R. J.G., Mehta, S. R., Fox, K. A.A., Zhao, F., Lewis, B. S., Kopecky, S. L., Diaz, R., Commerford, P. J., Valentin, V., Yusuf, S., for the Clopidogrel in Unstable angina to prevent, (2003). Effects of Aspirin Dose When Used Alone or in Combination With Clopidogrel in Patients With Acute Coronary Syndromes: Observations From the Clopidogrel in Unstable angina to prevent Recurrent Events (CURE) Study. Circulation 108: 1682-1687 [Abstract] [Full Text]  
• De Schryver, E.L.L.M. (2003). Dipyridamole in Stroke Prevention: Effect of Dipyridamole on Blood Pressure. Stroke 34: 2339-2342 [Abstract] [Full Text]  
• Flossmann, E., Rothwell, P. M. (2003). Prognosis of vertebrobasilar transient ischaemic attack and minor stroke. Brain 126: 1940-1954 [Abstract] [Full Text]  
• De Schryver, E.L.L.M., Algra, A., van Gijn, J. (2003). Cochrane Review: Dipyridamole for Preventing Major Vascular Events in Patients With Vascular Disease. Stroke 34: 2072-2080 [Abstract] [Full Text]  
• Topol, E. J., Easton, D., Harrington, R. A., Amarenco, P., Califf, R. M., Graffagnino, C., Davis, S., Diener, H.-C., Ferguson, J., Fitzgerald, D., Granett, J., Shuaib, A., Koudstaal, P. J., Theroux, P., Van de Werf, F., Sigmon, K., Pieper, K., Vallee, M., Willerson, J. T. (2003). Randomized, Double-Blind, Placebo-Controlled, International Trial of the Oral IIb/IIIa Antagonist Lotrafiban in Coronary and Cerebrovascular Disease. Circulation 108: 399-406 [Abstract] [Full Text]  
• Matias-Guiu, J., Ferro, J. M., Alvarez-Sabin, J., Torres, F., Jimenez, M. D., Lago, A., Melo, T., Tong, D. C. (2003). Comparison of Triflusal and Aspirin for Prevention of Vascular Events in Patients After Cerebral Infarction: The TACIP Study: A Randomized, Double-Blind, Multicenter Trial * Can Aspirin Ever Be Surpassed for Stroke Prevention?. Stroke 34: 840-848 [Abstract] [Full Text]  
• Johnston, S. C. (2002). Transient Ischemic Attack. NEJM 347: 1687-1692 [Full Text]  
• Weisman, S. M., Graham, D. Y. (2002). Evaluation of the Benefits and Risks of Low-Dose Aspirin in the Secondary Prevention of Cardiovascular and Cerebrovascular Events. Arch Intern Med 162: 2197-2202 [Abstract] [Full Text]  
• Elkins, J. S., Sidney, S., Gress, D. R., Go, A. S., Bernstein, A. L., Johnston, S. C. (2002). Electrocardiographic Findings Predict Short-term Cardiac Morbidity After Transient Ischemic Attack. Arch Neurol 59: 1437-1441 [Abstract] [Full Text]  
• Vermeer, S. E., Algra, A., Franke, C. L., Koudstaal, P. J., Rinkel, G. J.E. (2002). Long-term prognosis after recovery from primary intracerebral hemorrhage. Neurology 59: 205-209 [Abstract] [Full Text]  
• Mouradian, M. S., Majumdar, S. R., Senthilselvan, A., Khan, K., Shuaib, A. (2002). How Well Are Hypertension, Hyperlipidemia, Diabetes, and Smoking Managed After a Stroke or Transient Ischemic Attack?. Stroke 33: 1656-1659 [Abstract] [Full Text]  
• Collaboration, A. T. (2002). Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. BMJ 324: 71-86 [Abstract] [Full Text]  
• CAPLAN, L R (2001). Evidence based medicine: concerns of a clinical neurologist. J. Neurol. Neurosurg. Psychiatry 71: 569-574 [Full Text]  
• Catella-Lawson, F. (2001). Vascular biology of thrombosis: Platelet-vessel wall interactions and aspirin effects. Neurology 57: S5-7 [Abstract] [Full Text]  
• Syrbe, G., Redlich, H., Weidlich, B., Ludwig, J., Kopitzsch, S., Gockeritz, A., Herzog, K. (2001). Individual Dosing of ASA Prophylaxis by Controlling Platelet Aggregation. CLIN APPL THROMB HEMOST 7: 209-213 [Abstract]  
• Agnelli, G. (2001). Rationale for the use of platelet aggregation inhibitors in PAD patients. Vasc Med 6: 13-15 [Abstract]  
• Saloheimo, P., Juvela, S., Hillbom, M. (2001). Use of Aspirin, Epistaxis, and Untreated Hypertension as Risk Factors for Primary Intracerebral Hemorrhage in Middle-Aged and Elderly People. Stroke 32: 399-404 [Abstract] [Full Text]  
• Patrono, C., Coller, B., Dalen, J. E., FitzGerald, G. A., Fuster, V., Gent, M., Hirsh, J., Roth, G. (2001). Platelet-Active Drugs : The Relationships Among Dose, Effectiveness, and Side Effects. Chest 119 : 39S-63S [Full Text]  
• Albers, G. W., Amarenco, P., Easton, J. D., Sacco, R. L., Teal, P. (2001). Antithrombotic and Thrombolytic Therapy for Ischemic Stroke. Chest 119 : 300S-320S [Full Text]  
• Johnston, S. C., Gress, D. R., Browner, W. S., Sidney, S. (2000). Short-term Prognosis After Emergency Department Diagnosis of TIA. JAMA 284: 2901-2906 [Abstract] [Full Text]  
• Derry, S., Loke, Y. K. (2000). Risk of gastrointestinal haemorrhage with long term use of aspirin: meta-analysis. BMJ 321: 1183-1187 [Abstract] [Full Text]  
• Burgess, M I, Densem, C G, Brooks, N H, Levy, R D, Lee, H S (2000). The real cost of aspirin. Postgrad. Med. J. 76: 734-735 [Abstract] [Full Text]  
• Altman, R., Rouvier, J., Scazziota, A. (2000). State-of-the-Art Review : Secondary Prevention of Myocardial Infarction: Beneficial Effect of Combining Oral Anticoagulant Plus Aspirin: Therapy Based on Evidence. CLIN APPL THROMB HEMOST 6: 126-134  
• Sacco, R. L., Elkind, M. S. (2000). Update on Antiplatelet Therapy for Stroke Prevention. Arch Intern Med 160: 1579-1582 [Full Text]  
• Awtry, E. H., Loscalzo, J. (2000). Aspirin. Circulation 101: 1206-1218 [Full Text]  
• Hart, R. G., Halperin, J. L., McBride, R., Benavente, O., Man-Son-Hing, M., Kronmal, R. A. (2000). Aspirin for the Primary Prevention of Stroke and Other Major Vascular Events: Meta-analysis and Hypotheses. Arch Neurol 57: 326-332 [Abstract] [Full Text]  
• Kernan, W. N., Viscoli, C. M., Brass, L. M., Makuch, R. W., Sarrel, P. M., Horwitz, R. I. (2000). Blood Pressure Exceeding National Guidelines Among Women After Stroke. Stroke 31: 415-419 [Abstract] [Full Text]  
• Albers, G. W., Hart, R. G., Lutsep, H. L., Newell, D. W., Sacco, R. L. (1999). Supplement to the Guidelines for the Management of Transient Ischemic Attacks : A Statement From the Ad Hoc Committee on Guidelines for the Management of Transient Ischemic Attacks, Stroke Council, American Heart Association. Stroke 30: 2502-2511 [Full Text]  
• Wilterdink, J. L., Easton, J. D. (1999). Dipyridamole Plus Aspirin in Cerebrovascular Disease. Arch Neurol 56: 1087-1092 [Abstract] [Full Text]  
• ALGRA, A, VAN GIJN, J, ALGRA, A, KOUDSTAAL, P J (1999). Secondary prevention after cerebral ischaemia of presumed arterial origin: is aspirin still the touchstone?. J. Neurol. Neurosurg. Psychiatry 66: 557-559 [Full Text]  
• Randi, M. L., Rossi, C., Fabris, F., Menapace, L., Girolami, A. (1999). State-of-the-Art Review : Aspirin Seems as Effective as Myelosuppressive Agents in the Prevention of Rethrombosis in Essential Thrombocythemia. CLIN APPL THROMB HEMOST 5: 131-135 [Abstract]  
• Thrift, A. G, McNeil, J. J, Forbes, A., Donnan, G. A (1999). Risk of primary intracerebral haemorrhage associated with aspirin and non-steroidal anti-inflammatory drugs: case-control study. BMJ 318: 759-764 [Abstract] [Full Text]  
• He, J., Whelton, P. K., Vu, B., Klag, M. J. (1998). Aspirin and Risk of Hemorrhagic Stroke: A Meta-analysis of Randomized Controlled Trials. JAMA 280: 1930-1935 [Abstract] [Full Text]  
• Forbes, C.D. (1998). Secondary prevention of stroke -- an update. The Journal of the Royal Society for the Promotion of Health 118: 15-17 [Abstract]  
• Masuhr, F., Busch, M., Einhaupl, K. M. (1998). Differences in Medical and Surgical Therapy for Stroke Prevention Between Leading Experts in North America and Western Europe. Stroke 29: 339-345 [Abstract] [Full Text]  
• Altman, R. (1998). Controversies in Antithrombotic Therapy in Cardiovascular Diseases. CLIN APPL THROMB HEMOST 4: 11-24 [Abstract]  
• Dippel, D. W.J., Koudstaal, P. J. (1997). We Need Stronger Predictors of Major Vascular Events in Patients With a Recent Transient Ischemic Attack or Nondisabling Stroke. Stroke 28: 774-776 [Abstract] [Full Text]  
• Nishimura, H., Naritomi, H., Iwamoto, Y., Tachibana, H., Sugita, M. (1996). In Vivo Evaluation of Antiplatelet Agents in Gerbil Model of Carotid Artery Thrombosis. Stroke 27: 1099-1104 [Abstract] [Full Text]  
• Hart, R. G., Harrison, M. J.G. (1996). Aspirin Wars : The Optimal Dose of Aspirin to Prevent Stroke. Stroke 27: 585-587 [Full Text]  
• Barnett, H.J.M., Kaste, M., Meldrum, H., Eliasziw, M. (1996). Aspirin Dose in Stroke Prevention : Beautiful Hypotheses Slain by Ugly Facts. Stroke 27: 588-592 [Full Text]  
• Sempere, A. P., Duarte, J., Cabezas, C., Claveria, L. E. (1996). Incidence of Transient Ischemic Attacks and Minor Ischemic Strokes in Segovia, Spain. Stroke 27: 667-671 [Abstract] [Full Text]  
• Patrono, C., Roth, G. J. (1996). Aspirin in Ischemic Cerebrovascular Disease : How Strong Is the Case for a Different Dosing Regimen?. Stroke 27: 756-760 [Abstract] [Full Text]  
• Maruyama, S., Uchiyama, S., Tohgi, H., Hirai, S., Ikeda, Y., Shinohara, Y., Matsuda, T., Fujishima, M., Kameyama, M. (1995). A Randomized Trial of E5510 versus Aspirin in Patients with Transient Ischemic Attacks: The Japanese E5510 TIA Study-1 (JETS-1) Group. ANGIOLOGY 46: 999-1008 [Abstract]  
• Garcia-Dorado, D., Theroux, P., Tornos, P., Sambola, A., Oliveras, J., Santos, M., Soler, J. S. (1995). Previous Aspirin Use May Attenuate the Severity of the Manifestation of Acute Ischemic Syndromes. Circulation 92: 1743-1748 [Abstract] [Full Text]  
• Pouleur, H., Buyse, M. (1995). EFFECTS OF DIPYRIDAMOLE IN COMBINATION WITH ANTICOAGULANT THERAPY ON SURVIVAL AND THROMBOEMBOLIC EVENTS IN PATIENTS WITH PROSTHETIC HEART VALVESA meta-analysis of the randomized trials. J. Thorac. Cardiovasc. Surg. 110: 463-472 [Abstract] [Full Text]  
• Minar, E., Ahmadi, A., Koppensteiner, R., Maca, Th., Stumpflen, A., Ugurluoglu, A., Ehringer, H. (1995). Comparison of Effects of High-Dose and Low-Dose Aspirin on Restenosis After Femoropopliteal Percutaneous Transluminal Angioplasty. Circulation 91: 2167-2173 [Abstract] [Full Text]  
• Weil, J., Colin-Jones, D., Langman, M., Lawson, D., Logan, R., Murphy, M., Rawlins, M., Vessey, M., Wainwright, P. (1995). Prophylactic aspirin and risk of peptic ulcer bleeding. BMJ 310: 827-830 [Abstract] [Full Text]  
• Gorelick, P. B. (1995). Stroke Prevention. Arch Neurol 52: 347-355 [Abstract]  
• Moore, W. S., Barnett, H.J.M., Beebe, H. G., Bernstein, E. F., Brener, B. J., Brott, T., Caplan, L. R., Day, A., Goldstone, J., Hobson, R. W. II, Kempczinski, R. F., Matchar, D. B., Mayberg, M. R., Nicolaides, A. N., Norris, J. W., Ricotta, J. J., Robertson, J. T., Rutherford, R. B., Thomas, D., Toole, J. F., Trout, H. H. III, Wiebers, D. O. (1995). Guidelines for Carotid Endarterectomy : A Multidisciplinary Consensus Statement From the Ad Hoc Committee, American Heart Association. Circulation 91: 566-579 [Abstract] [Full Text]  
• Moore, W. S., Barnett, H.J.M., Beebe, H. G., Bernstein, E. F., Brener, B. J., Brott, T., Caplan, L. R., Day, A., Goldstone, J., Hobson, R. W. II, Kempczinski, R. F., Matchar, D. B., Mayberg, M. R., Nicolaides, A. N., Norris, J. W., Ricotta, J. J., Robertson, J. T., Rutherford, R. B., Thomas, D., Toole, J. F., Trout, H. H. III, Wiebers, D. O. (1995). Guidelines for Carotid Endarterectomy : A Multidisciplinary Consensus Statement From the Ad Hoc Committee, American Heart Association. Stroke 26: 188-201 [Abstract] [Full Text]  
• Patrono, C. (1994). Aspirin as an Antiplatelet Drug. NEJM 330: 1287-1294 [Full Text]  
• Pop, G. A. M., Koudstaal, P. J., Meeder, H. J., Algra, A., van Latum, J. C., van Gijn, J., Dutch TIA Trial Study Group, (1994). Predictive Value of Clinical History and Electrocardiogram in Patients With Transient Ischemic Attack or Minor Ischemic Stroke for Subsequent Cardiac and Cerebral Ischemic Events. Arch Neurol 51: 333-341 [Abstract]  
• Antiplatelet Trialists, (1994). Collaborative overview of randomised trials of antiplatelet therapy Prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients. BMJ 308: 81-106 [Abstract] [Full Text]  
• (1994). Aspirin to prevent heart attack or stroke. DTB 32: 1-3 [Abstract] [Full Text]