BACKGROUND. The presence of airway inflammation even in mild asthma points to the potential value of antiinflammatory therapy. We compared the effect of an inhaled corticosteroid, budesonide, with that of an inhaled beta 2-agonist, terbutaline, in the long-term treatment of newly detected asthma. METHODS. We studied 103 patients (29 male and 74 female patients 15 to 64 years old) in whom asthma had appeared within the previous year. The patients were randomly assigned in blinded fashion to two treatment groups: one to receive 600 micrograms of inhaled budesonide twice a day, and the other to receive 375 micrograms of inhaled terbutaline twice a day. The study period was two years. RESULTS. After six weeks of treatment, the patients treated with budesonide tolerated inhaled histamine better than the patients treated with terbutaline (a difference of one doubling dose step, P less than 0.001), and the difference was sustained. Patients' diaries kept during the first three months of the study and during the last month of the first and second years showed budesonide to be more effective than terbutaline in improving peak expiratory flow in the morning (average increase from the pretreatment value, 32.8 liters per minute for budesonide vs. 4.8 liters per minute for terbutaline; P less than 0.001) and in the evening (P less than 0.01). Budesonide was also more effective in reducing the symptoms of asthma (P less than 0.01) and the use of supplemental beta 2-agonist medication (P less than 0.01). Ten patients were withdrawn from the terbutaline group because treatment was insufficiently effective, whereas only one dropped out of the budesonide group. The adverse reactions to both treatments were few and mild. CONCLUSIONS. Antiinflammatory therapy with inhaled budesonide is an effective first-line treatment for patients with newly detected, mild asthma, and it is superior to the use of terbutaline in such patients.
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[Abstract][Full Text]
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[Abstract][Full Text]
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[Full Text]
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[Abstract][Full Text]
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[Abstract][Full Text]
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[Abstract][Full Text]
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121: 151-157
[Abstract][Full Text]
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(2001). The Cost Effectiveness of Early Treatment with Fluticasone Propionate 250 {micro}g Twice a Day in Subjects with Obstructive Airway Disease . Results of the DIMCA Program. Am. J. Respir. Crit. Care Med.
164: 2057-2066
[Abstract][Full Text]
Matsumoto, H., Ishihara, K., Hasegawa, T., Umeda, B.-i., Niimi, A., Hino, M.
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[Abstract][Full Text]
Cates, C.
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323: 976-979
[Full Text]
Naureckas, E. T., Solway, J.
(2001). Mild Asthma. NEJM
345: 1257-1262
[Full Text]
PARTRIDGE, M R
(2001). The profile of respiratory conditions: why government action is necessary. Thorax
56: 744-745
[Full Text]
Haahtela, T, Klaukka, T, Koskela, K, Erhola, M, Laitinen, L A
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[Full Text]
KIPS, J. C., PAUWELS, R. A.
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[Full Text]
BIJL-HOFLAND, I. D., CLOOSTERMAN, S. G. M., FOLGERING, H. Th. M., van den ELSHOUT, F. J. J., van WEEL, C., van SCHAYCK, C. P.
(2001). Inhaled Corticosteroids, Combined with Long-acting beta 2-Agonists, Improve the Perception of Bronchoconstriction in Asthma. Am. J. Respir. Crit. Care Med.
164: 764-769
[Abstract][Full Text]
Kips, J C, Pauwels, R A
(2001). Low dose inhaled corticosteroids and the prevention of death from asthma. Thorax
56: ii74-78
[Full Text]
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285: 2583-2593
[Abstract][Full Text]
Chanez, P., Karlstrom, R., Godard, P.
(2001). High or standard initial dose of budesonide to control mild-to-moderate asthma?. Eur Respir J
17: 856-862
[Abstract][Full Text]
Tattersfield, A E, Town, G I, Johnell, O, Picado, C, Aubier, M, Braillon, P, Karlström, R
(2001). Bone mineral density in subjects with mild asthma randomised to treatment with inhaled corticosteroids or non-corticosteroid treatment for two years. Thorax
56: 272-278
[Abstract][Full Text]
Sin, D.D., Tu, J.V.
(2001). Inhaled corticosteroid therapy reduces the risk of rehospitalization and all-cause mortality in elderly asthmatics. Eur Respir J
17: 380-385
[Abstract][Full Text]
Busse, W. W., Lemanske, R. F.
(2001). Asthma. NEJM
344: 350-362
[Full Text]
Mapp, C. E.
(2000). Inhaled Glucocorticoids in Chronic Obstructive Pulmonary Disease. NEJM
343: 1960-1961
[Full Text]
Kolbe, J, Fergusson, W, Vamos, M, Garrett, J
(2000). Case-control study of severe life threatening asthma (SLTA) in adults: demographics, health care, and management of the acute attack. Thorax
55: 1007-1015
[Abstract][Full Text]
Busse, W. W.
(2000). A 47-Year-Old Woman With Severe Asthma. JAMA
284: 2225-2233
[Full Text]
BOULET, L.-P., TURCOTTE, H., LAVIOLETTE, M., NAUD, F., BERNIER, M.-C., MARTEL, S., CHAKIR, J.
(2000). Airway Hyperresponsiveness, Inflammation, and Subepithelial Collagen Deposition in Recently Diagnosed versus Long-standing Mild Asthma . Influence of Inhaled Corticosteroids. Am. J. Respir. Crit. Care Med.
162: 1308-1313
[Abstract][Full Text]
CASTRO-RODRIGUEZ, J. A., HOLBERG, C. J., WRIGHT, A. L., MARTINEZ, F. D.
(2000). A Clinical Index to Define Risk of Asthma in Young Children with Recurrent Wheezing. Am. J. Respir. Crit. Care Med.
162: 1403-1406
[Abstract][Full Text]
CHRISTIAN VIRCHOW, J. Jr., PRASSE, A., NAYA, I., SUMMERTON, L., HARRIS, A., The Zafirlukast Study Group,
(2000). Zafirlukast Improves Asthma Control in Patients Receiving High-Dose Inhaled Corticosteroids. Am. J. Respir. Crit. Care Med.
162: 578-585
[Abstract][Full Text]
ISRAEL, E., DRAZEN, J. M., LIGGETT, S. B., BOUSHEY, H. A., CHERNIACK, R. M., CHINCHILLI, V. M., COOPER, D. M., FAHY, J. V., FISH, J. E., FORD, J. G., KRAFT, M., KUNSELMAN, S., LAZARUS, S. C., LEMANSKE, R. F. Jr., MARTIN, R. J., MCLEAN, D. E., PETERS, S. P., SILVERMAN, E. K., SORKNESS, C. A., SZEFLER, S. J., WEISS, S. T., YANDAVA, C. N.
(2000). The Effect of Polymorphisms of the beta 2-Adrenergic Receptor on the Response to Regular Use of Albuterol in Asthma. Am. J. Respir. Crit. Care Med.
162: 75-80
[Abstract][Full Text]
Sharek, P. J., Bergman, D. A.
(2000). The Effect of Inhaled Steroids on the Linear Growth of Children With Asthma: A Meta-analysis. Pediatrics
106: 8e-8
[Abstract][Full Text]
Barnes, N. C, Miller, C. J
(2000). Effect of leukotriene receptor antagonist therapy on the risk of asthma exacerbations in patients with mild to moderate asthma: an integrated analysis of zafirlukast trials. Thorax
55: 478-483
[Abstract][Full Text]
Diaz, T., Sturm, T., Matte, T., Bindra, M., Lawler, K., Findley, S., Maylahn, C.
(2000). Medication Use Among Children With Asthma in East Harlem. Pediatrics
105: 1188-1193
[Abstract][Full Text]
BOUSQUET, J., JEFFERY, P. K., BUSSE, W. W., JOHNSON, M., VIGNOLA, A. M.
(2000). Asthma . From Bronchoconstriction to Airways Inflammation and Remodeling. Am. J. Respir. Crit. Care Med.
161: 1720-1745
[Full Text]
PEDERSEN, S.
(2000). Why Does Airway Inflammation Persist? Is It Failure to Treat Early?. Am. J. Respir. Crit. Care Med.
161: S182-185
[Full Text]
(2000). The use of inhaled corticosteroids in adults with asthma. DTB
38: 5-8
[Abstract][Full Text]
GROL, M. H., GERRITSEN, J., VONK, J. M., SCHOUTEN, J. P., KOËTER, G. H., RIJCKEN, B., POSTMA, D. S.
(1999). Risk Factors for Growth and Decline of Lung Function in Asthmatic Individuals up to Age 42 years . A 30-year Follow-up Study. Am. J. Respir. Crit. Care Med.
160: 1830-1837
[Abstract][Full Text]
Welch, M., Bernstein, D., Gross, G., Kane, R. E., Banerji, D.
(1999). A Controlled Trial of Chlorofluorocarbon-Free Triamcinolone Acetonide Inhalation Aerosol in the Treatment of Adult Patients With Persistent Asthma. Chest
116: 1304-1312
[Abstract][Full Text]
(1999). Inhaled glucocorticosteroids in adults and children. CMAJ
161: s24-28
[Full Text]
GRÜNBERG, K., TIMMERS, M. C., de KLERK, E. P. A., DICK, E. C., STERK, P. J.
(1999). Experimental Rhinovirus 16 Infection Causes Variable Airway Obstruction in Subjects with Atopic Asthma. Am. J. Respir. Crit. Care Med.
160: 1375-1380
[Abstract][Full Text]
Goodman, D. C., Lozano, P., Stukel, T. A., Chang, C.-h., Hecht, J.
(1999). Has Asthma Medication Use in Children Become More Frequent, More Appropriate, or Both?. Pediatrics
104: 187-194
[Abstract][Full Text]
CROCKETT, A.
(1999). Screening older patients for obstructive airways disease. Thorax
54: 472-473
[Full Text]
LAATIKAINEN, A. K., KROGER, H. P. J., TUKIAINEN, H. O., HONKANEN, R. J., SAARIKOSKI, S. V.
(1999). Bone Mineral Density in Perimenopausal Women with Asthma . A Population-based Cross-sectional Study. Am. J. Respir. Crit. Care Med.
159: 1179-1185
[Abstract][Full Text]
van Grunsven, P M, van Schayck, C P, Molema, J, Akkermans, R P, van Weel, C
(1999). Effect of inhaled corticosteroids on bronchial responsiveness in patients with "corticosteroid naive" mild asthma: a meta-analysis. Thorax
54: 316-322
[Abstract][Full Text]
van Noord, J A, Schreurs, A J M, Mol, S J M, Mulder, P G H
(1999). Addition of salmeterol versus doubling the dose of fluticasone propionate in patients with mild to moderate asthma. Thorax
54: 207-212
[Abstract][Full Text]
van den BOOM, G., van SCHAYCK, C. P., RUTTEN-van MOLKEN, M. P. M. H., TIRIMANNA, P. R. S., den OTTER, J. J., van GRUNSVEN, P. M., BUITENDIJK, M. J., van HERWAARDEN, C. L. A., van WEEL, C.
(1998). Active Detection of Chronic Obstructive Pulmonary Disease and Asthma in the General Population . Results and Economic Consequences of the DIMCA Program. Am. J. Respir. Crit. Care Med.
158: 1730-1738
[Abstract][Full Text]
HAAHTELA, T., KLAUKKA, T.
(1998). Societal and health care benefits of early use of inhaled steroids. Thorax
53: 1005-1006
[Full Text]
Blais, L., Suissa, S., Boivin, J.-F., Ernst, P.
(1998). First treatment with inhaled corticosteroids and the prevention of admissions to hospital for asthma. Thorax
53: 1025-1029
[Abstract][Full Text]
Lange, P., Parner, J., Vestbo, J., Schnohr, P., Jensen, G.
(1998). A 15-Year Follow-Up Study of Ventilatory Function in Adults with Asthma. NEJM
339: 1194-1200
[Abstract][Full Text]
Faul, J. L, Leonard, C. T, Burke, C. M, Tormey, V. J, Poulter, L. W
(1998). Fluticasone propionate induced alterations to lung function and the immunopathology of asthma over time. Thorax
53: 753-761
[Abstract][Full Text]
BLAIS, L., ERNST, P., BOIVIN, J.-F., SUISSA, S.
(1998). Inhaled Corticosteroids and the Prevention of Readmission to Hospital for Asthma. Am. J. Respir. Crit. Care Med.
158: 126-132
[Abstract][Full Text]
BARNES, P. J., PEDERSEN, S., BUSSE, W. W.
(1998). Efficacy and Safety of Inhaled Corticosteroids . New Developments. Am. J. Respir. Crit. Care Med.
157: S1-53
[Full Text]
Pauwels, R. A., Lofdahl, C.-G., Postma, D. S., Tattersfield, A. E., O'Byrne, P., Barnes, P. J., Ullman, A., The Formoterol and Corticosteroids Establishing Th,
(1997). Effect of Inhaled Formoterol and Budesonide on Exacerbations of Asthma. NEJM
337: 1405-1411
[Abstract][Full Text]
LI, X., WILSON, J. W.
(1997). Increased Vascularity of the Bronchial Mucosa in Mild Asthma. Am. J. Respir. Crit. Care Med.
156: 229-233
[Abstract][Full Text]
HORWITZ, R. J., MCGILL, K. A., BUSSE, W. W.
(1997). The Role of Leukotriene Modifiers in the Treatment of Asthma. Am. J. Respir. Crit. Care Med.
157: 1363-1371
[Full Text]
FABBRI, L. M., CARAMORI, G., BEGHÉ, B., PAPI, A., CIACCIA, A.
(1997). Physiologic Consequences of Long-term Inflammation. Am. J. Respir. Crit. Care Med.
157: 195-198
[Full Text]
TURNER, M. O., TAYLOR, D., BENNETT, R., MARK FITZGERALD, J.
(1997). A Randomized Trial Comparing Peak Expiratory Flow and Symptom Self-management Plans for Patients with Asthma Attending a Primary Care Clinic. Am. J. Respir. Crit. Care Med.
157: 540-546
[Abstract][Full Text]
Steigman, D. M., Mark, E. J.
(1997). Case 4-1997- A 37-Year-Old Man with AIDS and Wheezing Refractory to Bronchodilator Medication. NEJM
336: 357-364
[Full Text]
Lahdensuo, A., Haahtela, T., Herrala, J., Kava, T., Kiviranta, K., Kuusisto, P., Peramaki, E., Poussa, T., Saarelainen, S., Svahn, T.
(1996). Randomised comparison of guided self management and traditional treatment of asthma over one year. BMJ
312: 748-752
[Abstract][Full Text]
,
(1996). North of England evidence based guidelines development project: summary version of evidence based guideline for the primary care management of asthma in adults. BMJ
312: 762-766
[Full Text]
Barnes, P. J.
(1995). Inhaled Glucocorticoids for Asthma. NEJM
332: 868-875
[Full Text]
Haahtela, T., Jarvinen, M., Kava, T., Kiviranta, K., Koskinen, S., Lehtonen, K., Nikander, K., Persson, T., Selroos, O., Sovijarvi, A., Stenius-Aarniala, B., Svahn, T., Tammivaara, R., Laitinen, L. A.
(1994). Effects of Reducing or Discontinuing Inhaled Budesonide in Patients with Mild Asthma. NEJM
331: 700-705
[Abstract][Full Text]
Drazen, J. M., Israel, E.
(1994). Treating Mild Asthma -- When Are Inhaled Steroids Indicated?. NEJM
331: 737-739
[Full Text]
Weinberger, S. E.
(1993). Recent Advances in Pulmonary Medicine- First of Two Parts. NEJM
328: 1389-1397
[Full Text]
Kelly, H. W.
(1992). Long-Term Management of Asthma. Journal of Pharmacy Practice
5: 167-176
(1991). EARLY USE OF INHALED STEROIDS IS SUPERIOR TO BETA- AGONISTS IN ASTHMA. JWatch General
1991: 2-2
[Full Text]
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