BACKGROUND AND METHODS. Surveillance by repeated colonoscopy is currently recommended for patients with colorectal adenomas. We assessed the long-term risk of colorectal cancer after rigid-instrument sigmoidoscopy and polypectomy in 1618 patients with rectosigmoid adenomas (tumor of the rectum or distal sigmoid colon) who did not undergo surveillance. A total of 22,462 person-years of observation were accrued (mean, 14 years per patient). RESULTS. The incidence of subsequent rectal cancer in these patients was similar to that in the general population (standardized incidence ratio, 1.2; 95 percent confidence interval, 0.7 to 2.1). Most rectal cancers developed in patients whose adenomas had been inadequately removed; the risk was very low after complete removal. The risk of subsequent colon cancer depended on the histologic type, size, and number of adenomas in the rectosigmoid. Among 842 patients with a rectosigmoid adenoma that was tubulovillous, villous, or large (greater than or equal to 1 cm), colon cancer developed in 31 patients. The standardized incidence ratio was 3.6 (95 percent confidence interval, 2.4 to 5.0) overall and 6.6 (95 percent confidence interval, 3.3 to 11.8) if there were multiple rectosigmoid adenomas. Among the remaining 776 patients with only small, tubular adenomas (whether single or multiple), colon cancer developed in only 4 patients. The standardized incidence ratio in this group was 0.5 (95 percent confidence interval, 0.1 to 1.3). CONCLUSIONS. Follow-up colonoscopic examinations may be warranted in patients with tubulovillous, villous, or large adenomas in the rectosigmoid, particularly if the adenomas are also multiple. In patients with only a single, small tubular adenoma that is only mildly or moderately dysplastic (43 percent of our series), however, surveillance may not be of value because the risk of cancer is so low.
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Department of Mathematics, Imperial Cancer Research Fund, London, United Kingdom.
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331: 1047-
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(2005). Quality in the technical performance of screening flexible sigmoidoscopy: recommendations of an international multi-society task group. Gut
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[Abstract][Full Text]
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235: 13-16
[Full Text]
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[Abstract][Full Text]
Hawk, E. T., Levin, B.
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23: 378-391
[Abstract][Full Text]
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[Abstract][Full Text]
Mysliwiec, P. A., Brown, M. L., Klabunde, C. N., Ransohoff, D. F.
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[Abstract][Full Text]
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[Abstract][Full Text]
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(2004). Colorectal Adenomas: A Prototype for the Use of Surrogate End Points in the Development of Cancer Prevention Drugs. Clin. Cancer Res.
10: 3908-3918
[Full Text]
Rockey, D. C., Zarchy, T. M., Pais, S., Uribe, J. R., Bongiorno, C., Katz, P. O., Thomas, G. S., Pickhardt, P. J.
(2004). Virtual Colonoscopy to Screen for Colorectal Cancer. NEJM
350: 1148-1150
[Full Text]
Hurlstone, D P, Cross, S S, Slater, R, Sanders, D S, Brown, S
(2004). Detecting diminutive colorectal lesions at colonoscopy: a randomised controlled trial of pan-colonic versus targeted chromoscopy. Gut
53: 376-380
[Abstract][Full Text]
Colao, A., Ferone, D., Marzullo, P., Lombardi, G.
(2004). Systemic Complications of Acromegaly: Epidemiology, Pathogenesis, and Management. Endocr. Rev.
25: 102-152
[Abstract][Full Text]
Murray, M A, Zimmerman, M J, Ee, H C
(2004). Sporadic duodenal adenoma is associated with colorectal neoplasia. Gut
53: 261-265
[Abstract][Full Text]
Hurlstone, D P, Cross, S S, Adam, I, Shorthouse, A J, Brown, S, Sanders, D S, Lobo, A J
(2004). Efficacy of high magnification chromoscopic colonoscopy for the diagnosis of neoplasia in flat and depressed lesions of the colorectum: a prospective analysis. Gut
53: 284-290
[Abstract][Full Text]
Wiesner, G. L., Daley, D., Lewis, S., Ticknor, C., Platzer, P., Lutterbaugh, J., MacMillen, M., Baliner, B., Willis, J., Elston, R. C., Markowitz, S. D.
(2003). A subset of familial colorectal neoplasia kindreds linked to chromosome 9q22.2-31.2. Proc. Natl. Acad. Sci. USA
100: 12961-12965
[Abstract][Full Text]
Reid, M. E., Marshall, J. R., Roe, D., Lebowitz, M., Alberts, D., Battacharyya, A. K., Martinez, M. E.
(2003). Smoking Exposure as a Risk Factor for Prevalent and Recurrent Colorectal Adenomas. Cancer Epidemiol. Biomarkers Prev.
12: 1006-1011
[Abstract][Full Text]
Ferrucci, J. T.
(2003). Virtual Colonoscopy for Colon Cancer Screening: Further Reflections on Polyps and Politics. Am. J. Roentgenol.
181: 795-797
[Full Text]
Mahmood, U., Weissleder, R.
(2003). Near-Infrared Optical Imaging of Proteases in Cancer. Molecular Cancer Therapeutics
2: 489-496
[Abstract][Full Text]
Watson, A J M
(2003). Are proximal colorectal cancers always associated with distal adenomas?. Gut
52: 317-318
[Full Text]
Atkin, W S, Northover, J M A
(2003). Population based endoscopic screening for colorectal cancer. Gut
52: 321-322
[Full Text]
Gondal, G, Grotmol, T, Hofstad, B, Bretthauer, M, Eide, T J, Hoff, G
(2003). Grading of distal colorectal adenomas as predictors for proximal colonic neoplasia and choice of endoscope in population screening: experience from the Norwegian Colorectal Cancer Prevention study (NORCCAP). Gut
52: 398-403
[Abstract][Full Text]
Yood, M. U., Oliveria, S., Boyer, J. G., Wells, K., Stang, P., Johnson, C. C.
(2003). Colon Polyp Recurrence in a Managed Care Population. Arch Intern Med
163: 422-426
[Abstract][Full Text]
NICOLLIER-FAHRNI, A., VADER, J.-P., FROEHLICH, F., GONVERS, J.-J., BURNAND, B.
(2003). Development of appropriateness criteria for colonoscopy: comparison between a standardized expert panel and an evidence-based medicine approach. Int J Qual Health Care
15: 15-22
[Abstract][Full Text]
(2003). POEM: Single, small adenoma low risk for recurrent colon polyps. BMJ
326: 0-0
[Full Text]
Segnan, N., Senore, C., Andreoni, B., Aste, H., Bonelli, L., Crosta, C., Ferraris, R., Gasperoni, S., Penna, A., Risio, M., Rossini, F. P., Sciallero, S., Zappa, M., Atkin, W. S.
(2002). Baseline Findings of the Italian Multicenter Randomized Controlled Trial of "Once-Only Sigmoidoscopy"--SCORE. JNCI J Natl Cancer Inst
94: 1763-1772
[Abstract][Full Text]
Boyle, P., Leon, M. E.
(2002). Epidemiology of colorectal cancer. Br Med Bull
64: 1-25
[Abstract][Full Text]
Atkin, W S, Saunders, B P
(2002). Surveillance guidelines after removal of colorectal adenomatous polyps. Gut
51: v6-9
[Full Text]
Nusko, G, Mansmann, U, Kirchner, T., Hahn, E G
(2002). Risk related surveillance following colorectal polypectomy. Gut
51: 424-428
[Abstract][Full Text]
Anderson, W. F., Guyton, K. Z., Hiatt, R. A., Vernon, S. W., Levin, B., Hawk, E.
(2002). Colorectal Cancer Screening for Persons at Average Risk. JNCI J Natl Cancer Inst
94: 1126-1133
[Full Text]
Maule, W. F., Bruzzi, J. F., Brennan, D. D., Fenlon, H. M., Sood, A., Sood, R., Ransohoff, D. F., Sandler, R. S.
(2002). Screening for Colorectal Cancer. NEJM
346: 1672-1674
[Full Text]
O'Shaughnessy, J. A., Kelloff, G. J., Gordon, G. B., Dannenberg, A. J., Hong, W. K., Fabian, C. J., Sigman, C. C., Bertagnolli, M. M., Stratton, S. P., Lam, S., Nelson, W. G., Meyskens, F. L., Alberts, D. S., Follen, M., Rustgi, A. K., Papadimitrakopoulou, V., Scardino, P. T., Gazdar, A. F., Wattenberg, L. W., Sporn, M. B., Sakr, W. A., Lippman, S. M., Von Hoff, D. D.
(2002). Treatment and Prevention of Intraepithelial Neoplasia: An Important Target for Accelerated New Agent Development : Recommendations of the American Association for Cancer Research Task Force on the Treatment and Prevention of Intraepithelial Neoplasia. Clin. Cancer Res.
8: 314-346
[Abstract][Full Text]
Bleiberg, H.
(2002). Hemoccult should no longer be used for the screening of colorectal cancer. Ann Oncol
13: 44-46
[Full Text]
Lund, J N, Scholefield, J H, Grainge, M J, Smith, S J, Mangham, C, Armitage, N C, Robinson, M H, Logan, R F A
(2001). Risks, costs, and compliance limit colorectal adenoma surveillance: lessons from a randomised trial. Gut
49: 91-96
[Abstract][Full Text]
Jenkins, P. J., Besser, M.
(2001). CLINICAL PERSPECTIVE: Acromegaly and Cancer: A Problem. J. Clin. Endocrinol. Metab.
86: 2935-2941
[Full Text]
Citarda, F, Tomaselli, G, Capocaccia, R, Barcherini, S, Crespi, M, Group, T. I. M. S.
(2001). Efficacy in standard clinical practice of colonoscopic polypectomy in reducing colorectal cancer incidence. Gut
48: 812-815
[Abstract][Full Text]
Yashiro, M., Carethers, J. M., Laghi, L., Saito, K., Slezak, P., Jaramillo, E., Rubio, C., Koizumi, K., Hirakawa, K., Boland, C. R.
(2001). Genetic Pathways in the Evolution of Morphologically Distinct Colorectal Neoplasms. Cancer Res.
61: 2676-2683
[Abstract][Full Text]
Frazier, A. L., Colditz, G. A., Fuchs, C. S., Kuntz, K. M.
(2000). Cost-effectiveness of Screening for Colorectal Cancer in the General Population. JAMA
284: 1954-1961
[Abstract][Full Text]
Jenkins, P. J., Frajese, V., Jones, A-M., Camacho-Hubner, C., Lowe, D. G., Fairclough, P. D., Chew, S. L., Grossman, A. B., Monson, J. P., Besser, G. M.
(2000). Insulin-Like Growth Factor I and the Development of Colorectal Neoplasia in Acromegaly. J. Clin. Endocrinol. Metab.
85: 3218-3221
[Abstract][Full Text]
Renehan, A. G., Painter, J. E., O’Halloran, D., Atkin, W. S., Potten, C. S., O’Dwyer, S. T., Shalet, S. M.
(2000). Circulating Insulin-Like Growth Factor II and Colorectal Adenomas. J. Clin. Endocrinol. Metab.
85: 3402-3408
[Abstract][Full Text]
Luboldt, W., Bauerfeind, P., Wildermuth, S., Marincek, B., Fried, M., Debatin, J. F.
(2000). Colonic Masses: Detection with MR Colonography. Radiology
216: 383-388
[Abstract][Full Text]
Lieberman, D. A., Weiss, D. G., Bond, J. H., Ahnen, D. J., Garewal, H., Chejfec, G., Harford, W. V., Provenzale, D., Sontag, S., Schnell, T., Durbin, T. E., Nelson, D. B., Ewing, S. L., Triadafilopoulos, G., Ramirez, F. C., Lee, J. G., Collins, J. F., Fennerty, M. B., Johnston, T. K., Corless, C. L., McQuaid, K. R., Sampliner, R. E., Morales, T. G., Fass, R., Smith, R., Maheshwari, Y., The Veterans Affairs Cooperative Study Group 380,
(2000). Use of Colonoscopy to Screen Asymptomatic Adults for Colorectal Cancer. NEJM
343: 162-168
[Abstract][Full Text]
Imperiale, T. F., Wagner, D. R., Lin, C. Y., Larkin, G. N., Rogge, J. D., Ransohoff, D. F.
(2000). Risk of Advanced Proximal Neoplasms in Asymptomatic Adults According to the Distal Colorectal Findings. NEJM
343: 169-174
[Abstract][Full Text]
Nusko, G, Schneider, B, Schneider, I, Wittekind, C., Hahn, E G
(2000). Anthranoid laxative use is not a risk factor for colorectal neoplasia: results of a prospective case control study. Gut
46: 651-655
[Abstract][Full Text]
Gazelle, G. S., McMahon, P. M., Scholz, F. J.
(2000). Screening for Colorectal Cancer. Radiology
215: 327-335
[Abstract][Full Text]
Atkin, W. S., Whynes, D. K.
(2000). Improving the Cost-Effectiveness of Colorectal Cancer Screening. JNCI J Natl Cancer Inst
92: 513-514
[Full Text]
Stevenson, G. W.
(2000). 1998 RSNA Annual Oration in Diagnostic Radiology : Colorectal Cancer Imaging: A Challenge for Radiologists. Radiology
214: 615-621
[Full Text]
Konishi, K, Fujii, T, Boku, N, Kato, S, Koba, I, Ohtsu, A, Tajiri, H, Ochiai, A, Yoshida, S
(1999). Clinicopathological differences between colonic and rectal carcinomas: are they based on the same mechanism of carcinogenesis?. Gut
45: 818-821
[Abstract][Full Text]
Thiis-Evensen, E, Hoff, G S, Sauar, J, Majak, B M, Vatn, M H
(1999). Flexible sigmoidoscopy or colonoscopy as a screening modality for colorectal adenomas in older age groups? Findings in a cohort of the normal population aged 63-72 years. Gut
45: 834-839
[Abstract][Full Text]
Atkin, W.
(1999). Implementing screening for colorectal cancer. BMJ
319: 1212-1213
[Full Text]
Alberts, D. S.
(1999). A Unifying Vision of Cancer Therapy for the 21st Century. JCO
17: 13-21
[Full Text]
Schoen, R. E., Tangen, C. M., Kuller, L. H., Burke, G. L., Cushman, M., Tracy, R. P., Dobs, A., Savage, P. J.
(1999). Increased Blood Glucose and Insulin, Body Size, and Incident Colorectal Cancer. JNCI J Natl Cancer Inst
91: 1147-1154
[Abstract][Full Text]
McKelvey, W., Greenland, S., Chen, M.-J., Longnecker, M. P., Frankl, H. D., Lee, E. R., Haile, R. W.
(1999). A Case-Control Study of Colorectal Adenomatous Polyps and Consumption of Foods Containing Partially Hydrogenated Oils. Cancer Epidemiol. Biomarkers Prev.
8: 519-524
[Abstract][Full Text]
Levin, T. R., Palitz, A., Grossman, S., Conell, C., Finkler, L., Ackerson, L., Rumore, G., Selby, J. V.
(1999). Predicting Advanced Proximal Colonic Neoplasia With Screening Sigmoidoscopy. JAMA
281: 1611-1617
[Abstract][Full Text]
Paillot, B, Czernichow, P, Michel, P, Merle, V, Queuniet, A-M, Duval, C, Daubert, H
(1999). Incidence of rectosigmoid adenomatous polyps in subjects without prior colorectal adenoma or cancer: a prospective cohort study. Gut
44: 372-376
[Abstract][Full Text]
Verne, J. E C W, Aubrey, R., Love, S. B, Talbot, I. C, Northover, J. M A
(1998). Population based randomised study of uptake and yield of screening by flexible sigmoidoscopy compared with screening by faecal occult blood testing. BMJ
317: 182-185
[Abstract][Full Text]
Selby, J. V., Levin, T.R., Read, T. E., Read, J. D., Butterly, L. F.
(1997). Importance of Colonic Adenomas 5 mm or Less in Diameter. NEJM
336: 1761-1762
[Full Text]
Read, T. E., Read, J. D., Butterly, L. F.
(1997). Importance of Adenomas 5 mm or Less in Diameter That Are Detected by Sigmoidoscopy. NEJM
336: 8-12
[Abstract][Full Text]
Zarchy, T. M., Ershoff, D., Zauber, A. G., Bishop, D. T., Winawer, S. J.
(1996). Risk of Colorectal Cancer in Families of Patients with Adenomatous Polyps. NEJM
334: 1339-1340
[Full Text]
Muller, A. D., Sonnenberg, A.
(1995). Prevention of Colorectal Cancer by Flexible Endoscopy and Polypectomy: A Case-Control Study of 32 702 Veterans. ANN INTERN MED
123: 904-910
[Abstract][Full Text]
Sampliner, R. E., Garewal, H. S.
(1995). Endoscopic Polypectomy Reduces Mortality From Colorectal Cancer. Arch Intern Med
155: 1711-1712
[Abstract]
Muller, A. D., Sonnenberg, A.
(1995). Protection by Endoscopy Against Death From Colorectal Cancer: A Case-Control Study Among Veterans. Arch Intern Med
155: 1741-1748
[Abstract]
Wayne, M. S., Cath, A., Pamies, R. J.
(1995). Colorectal Cancer: A Practical Review for the Primary Care Physician. Arch Fam Med
4: 357-366
[Abstract]
Toribara, N. W., Sleisenger, M. H.
(1995). Screening for Colorectal Cancer. NEJM
332: 861-867
[Full Text]
Dinning, J. P., Hixson, L. J., Clark, L. C.
(1994). Prevalence of Distal Colonic Neoplasia Associated With Proximal Colon Cancers. Arch Intern Med
154: 853-857
[Abstract]
Maule, W. F.
(1994). Screening for Colorectal Cancer by Nurse Endoscopists. NEJM
330: 183-187
[Abstract][Full Text]
Winawer, S. J., Zauber, A. G., Ho, M. N., O'Brien, M. J., Gottlieb, L. S., Sternberg, S. S., Waye, J. D., Schapiro, M., Bond, J. H., Panish, J. F., Ackroyd, F., Shike, M., Kurtz, R. C., Hornsby-Lewis, L., Gerdes, H., Stewart, E. T., The National Polyp Study Workgroup,
(1993). Prevention of Colorectal Cancer by Colonoscopic Polypectomy. NEJM
329: 1977-1981
[Abstract][Full Text]
Ransohoff, D. F.
(1993). Gastroenterology. JAMA
270: 206-209
[Abstract]
Cady, B., Stone, M. D., Wayne, J.
(1993). Continuing Trends in the Prevalence of Right-Sided Lesions Among Colorectal Carcinomas. Arch Surg
128: 505-509
[Abstract]
Winawer, S. J., Zauber, A. G., O'Brien, M. J., Ho, M. N., Gottlieb, L., Sternberg, S. S., Waye, J. D., Bond, J., Schapiro, M., Stewart, E. T., Panish, J., Ackroyd, F., Kurtz, R. C., Shike, M., The National Polyp Study Workgroup,
(1993). Randomized Comparison of Surveillance Intervals after Colonoscopic Removal of Newly Diagnosed Adenomatous Polyps. NEJM
328: 901-906
[Abstract][Full Text]
Ransohoff, D. F., Lang, C. A.
(1993). Sigmoidoscopic Screening in the 1990s. JAMA
269: 1278-1281
[Abstract]
Selby, J. V.
(1993). How Should We Screen for Colorectal Cancer?. JAMA
269: 1294-1296
[Abstract]
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