BACKGROUND. We hypothesized that successful reperfusion of an occluded infarct-related coronary artery even late after acute myocardial infarction would result in improved regional wall motion and that such improvement might be related to the presence of collateral blood flow within the infarct bed. METHODS. We assessed regional wall motion by two-dimensional echocardiography at base line and one month after angioplasty was attempted in the occluded infarct-related artery in 43 patients who had had a myocardial infarction two days to five weeks earlier. A wall-motion score was assigned to each patient on a five-point scale (from 1 [normal function] to 5 [dyskinesia]). The percentage of the infarct bed perfused by collateral flow was assessed with myocardial contrast echocardiography. RESULTS. In the 41 patients who had abnormal wall motion at base line, improvement in function was noted in 25 (78 percent) of the 32 in whom angioplasty was successful, as compared with only 1 (11 percent) of the 9 in whom it was unsuccessful (P < 0.001). The percentage of the infarct bed supplied by collateral flow at base line was directly correlated with wall function and inversely correlated with the wall-motion score one month after successful angioplasty (r = -0.64, P < 0.001). Among the patients in whom angioplasty was successful, the 23 in whom > 50 percent of the infarct bed was supplied by collateral flow had better wall motion (P < 0.001) and greater improvement in wall motion at one month (P = 0.004) than the 9 in whom < or = 50 percent of the bed was supplied by collateral flow. The degree of improvement in function was not influenced by the length of time between the infarction and the attempted angioplasty. CONCLUSIONS. The myocardium remains viable for a prolonged period in many patients with acute infarction and an occluded infarct-related artery. Viability appears to be associated with the presence of collateral blood flow within the infarct bed.
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Department of Medicine, University of Virginia School of Medicine, Charlottesville 22908.
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[Abstract][Full Text]
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110: 1738-1742
[Abstract][Full Text]
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[Abstract][Full Text]
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287: H450-H457
[Abstract][Full Text]
Priebe, H.-J.
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93: 9-20
[Abstract][Full Text]
Lloyd, S. G., Wang, P., Zeng, H., Chatham, J. C.
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287: H351-H362
[Abstract][Full Text]
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(2004). Myocardial Contrast Echocardiography. Circulation
109: 3132-3135
[Full Text]
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(2004). Role of collateral circulation in the acute phase of ST-segment-elevation myocardial infarction treated with primary coronary intervention. Eur Heart J
25: 854-858
[Abstract][Full Text]
Panchal, V. R., Rehman, J., Nguyen, A. T., Brown, J. W., Turrentine, M. W., Mahomed, Y., March, K. L.
(2004). Reduced pericardial levels of endostatin correlate with collateral development in patients with ischemic heart disease. J Am Coll Cardiol
43: 1383-1387
[Abstract][Full Text]
Fujita, M, Tambara, K
(2004). Recent insights into human coronary collateral development. Heart
90: 246-250
[Abstract][Full Text]
Schomig, A., Ndrepepa, G., Mehilli, J., Schwaiger, M., Schuhlen, H., Nekolla, S., Pache, J., Martinoff, S., Bollwein, H., Kastrati, A.
(2003). Therapy-Dependent Influence of Time-to-Treatment Interval on Myocardial Salvage in Patients With Acute Myocardial Infarction Treated With Coronary Artery Stenting or Thrombolysis. Circulation
108: 1084-1088
[Abstract][Full Text]
Koerselman, J., van der Graaf, Y., de Jaegere, P. P.Th., Grobbee, D. E.
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107: 2507-2511
[Full Text]
Lenihan, D. J., Osman, A., Sriram, V., Aitsebaomo, J., Patterson, C.
(2003). Evidence for association of coronary sinus levels of hepatocyte growth factor and collateralization in human coronary disease. Am. J. Physiol. Heart Circ. Physiol.
284: H1507-H1512
[Abstract][Full Text]
Shimoni, S., Frangogiannis, N. G., Aggeli, C. J., Shan, K., Verani, M. S., Quinones, M. A., Espada, R., Letsou, G. V., Lawrie, G. M., Winters, W. L., Reardon, M. J., Zoghbi, W. A.
(2003). Identification of Hibernating Myocardium With Quantitative Intravenous Myocardial Contrast Echocardiography: Comparison With Dobutamine Echocardiography and Thallium-201 Scintigraphy. Circulation
107: 538-544
[Abstract][Full Text]
Greaves, K, Dixon, S R, Fejka, M, O'Neill, W W, Redwood, S R, Marber, M S, Senior, R
(2003). Myocardial contrast echocardiography is superior to other known modalities for assessing myocardial reperfusion after acute myocardial infarction. Heart
89: 139-144
[Abstract][Full Text]
Beygui, F, Le Feuvre, C, Helft, G, Maunoury, C, Metzger, J P
(2003). Myocardial viability, coronary flow reserve, and in-hospital predictors of late recovery of contractility following successful primary stenting for acute myocardial infarction. Heart
89: 179-183
[Abstract][Full Text]
Bowers, T. R., O'Neill, W. W., Pica, M., Goldstein, J. A.
(2002). Patterns of Coronary Compromise Resulting in Acute Right Ventricular Ischemic Dysfunction. Circulation
106: 1104-1109
[Abstract][Full Text]
Goswami, N. J., Moody, J. M. Jr, Bailey, S. R.
(2002). Percutaneous Mechanical Reperfusion During Acute Myocardial Infarction. J Intensive Care Med
17: 162-173
[Abstract]
Kjoller, E, Kober, L, Jorgensen, S, Torp-Pedersen, C
(2002). Short and long term prognostic importance of regional dyskinesia versus akinesia in acute myocardial infarction. Heart
87: 410-414
[Abstract][Full Text]
Piscione, F, Perrone-Filardi, P, De Luca, G, Prastaro, M, Indolfi, C, Golino, P, Dellegrottaglie, S, Chiariello, M
(2001). Low dose dobutamine echocardiography for predicting functional recovery after coronary revascularisation. Heart
86: 679-686
[Abstract][Full Text]
de Marchi, S F, Schwerzmann, M, Fleisch, M, Billinger, M, Meier, B, Seiler, C
(2001). Quantitative contrast echocardiographic assessment of collateral derived myocardial perfusion during elective coronary angioplasty. Heart
86: 324-329
[Abstract][Full Text]
Kamp, O, Lepper, W, Vanoverschelde, J.-L, Aeschbacher, B.C, Rovai, D, Assayag, P, Voci, P, Kloster, Y, Distante, A, Visser, C.A
(2001). Serial evaluation of perfusion defects in patients with a first acute myocardial infarction referred for primary PTCA using intravenous myocardial contrast echocardiography. Eur Heart J
22: 1485-1495
[Abstract]
Sechtem, U.
(2001). Imaging myocardial area at risk and final infarct size. Eur Heart J Suppl
3: C36-C46
Goncalves, L. M., Epstein, S. E., Piek, J. J.
(2001). Controlling collateral development: the difficult task of mimicking mother nature. Cardiovasc Res
49: 495-496
[Full Text]
Matsunaga, T., Warltier, D. C., Weihrauch, D. W., Moniz, M., Tessmer, J., Chilian, W. M.
(2000). Ischemia-Induced Coronary Collateral Growth Is Dependent on Vascular Endothelial Growth Factor and Nitric Oxide. Circulation
102: 3098-3103
[Abstract][Full Text]
Semenza, G. L.
(2000). HIF-1 and human disease: one highly involved factor. Genes Dev.
14: 1983-1991
[Full Text]
Mills, J. D., Fischer, D., Villanueva, F. S.
(2000). Coronary collateral development during chronic ischemia: serial assessment using harmonic myocardial contrast echocardiography. J Am Coll Cardiol
36: 618-624
[Abstract][Full Text]
Lepper, W., Hoffmann, R., Kamp, O., Franke, A., de Cock, C. C., Kuhl, H. P., Sieswerda, G. T., Dahl, J. v., Janssens, U., Voci, P., Visser, C. A., Hanrath, P.
(2000). Assessment of Myocardial Reperfusion by Intravenous Myocardial Contrast Echocardiography and Coronary Flow Reserve After Primary Percutaneous Transluminal Coronary Angiography in Patients With Acute Myocardial Infarction. Circulation
101: 2368-2374
[Abstract][Full Text]
Schwarz, E. R., Speakman, M. T., Patterson, M., Hale, S. S., Isner, J. M., Kedes, L. H., Kloner, R. A.
(2000). Evaluation of the effects of intramyocardial injection of DNA expressing vascular endothelial growth factor (VEGF) in a myocardial infarction model in the rat--angiogenesis and angioma formation. J Am Coll Cardiol
35: 1323-1330
[Abstract][Full Text]
Lee, S. H., Wolf, P. L., Escudero, R., Deutsch, R., Jamieson, S. W., Thistlethwaite, P. A.
(2000). Early Expression of Angiogenesis Factors in Acute Myocardial Ischemia and Infarction. NEJM
342: 626-633
[Abstract][Full Text]
Landau, E., Tirosh, R., Pinson, A., Banai, S., Even-Ram, S., Maoz, M., Katzav, S., Bar-Shavit, R.
(2000). Protection of Thrombin Receptor Expression under Hypoxia. J. Biol. Chem.
275: 2281-2287
[Abstract][Full Text]
Goncalves, L. M
(2000). Angiogenic growth factors: potential new treatment for acute myocardial infarction?. Cardiovasc Res
45: 294-302
[Abstract][Full Text]
Karila-Cohen, D, Czitrom, D, Brochet, E, Faraggi, M, Seknadji, P, Himbert, D, Juliard, J.-M, Assayag, P, Steg, P.G
(1999). Decreased no-reflow in patients with anterior myocardial infarction and pre-infarction angina. Eur Heart J
20: 1724-1730
[Abstract]
Yasu, T., Schmid-Schonbein, G. W., Cotter, B., DeMaria, A. N.
(1999). Flow dynamics of QW7437, a new dodecafluoropentane ultrasound contrast agent, in the microcirculation: Microvascular mechanisms for persistent tissue echo enhancement. J Am Coll Cardiol
34: 578-586
[Abstract][Full Text]
Leclercq, F, Messner-Pellenc, P, Descours, Q, Daures, J-P, Pasquie, J-L, Hager, F-X, Davy, J-M, Grolleau-Raoux, R
(1999). Combined assessment of reflow and collateral blood flow by myocardial contrast echocardiography after acute reperfused myocardial infarction. Heart
82: 62-67
[Abstract][Full Text]
Faraggi, M, Montalescot, G, Sarda, L, Heintz, J F, Doumit, D, Drobinski, G, Sotirov, I, Le Guludec, D, Thomas, D
(1999). Spontaneous late improvement of myocardial viability in the chronic infarct zone is possible, depending on persistent TIMI 3 flow and a low grade stenosis of the infarct artery. Heart
81: 424-430
[Abstract][Full Text]
van Liebergen, R. A. M., Piek, J. J., Koch, K. T., de Winter, R. J., Schotborgh, C. E., Lie, K. I.
(1999). Quantification of collateral flow in humans: a comparison of angiographic, electrocardiographic and hemodynamic variables. J Am Coll Cardiol
33: 670-677
[Abstract][Full Text]
Barilla, F., De Vincentis, G., Mangieri, E., Ciavolella, M., Pannitteri, G., Scopinaro, F., Critelli, G., Campa, P. P.
(1999). Recovery of contractility of viable myocardium during inotropic stimulation is not dependent on an increase of myocardial blood flow in the absence of collateral filling. J Am Coll Cardiol
33: 697-704
[Abstract][Full Text]
Atkins, B. Z., Lewis, C. W., Kraus, W. E., Hutcheson, K. A., Glower, D. D., Taylor, D. A.
(1999). Intracardiac transplantation of skeletal myoblasts yields two populations of striated cells in situ. Ann. Thorac. Surg.
67: 124-129
[Abstract][Full Text]
Horie, H., Takahashi, M., Minai, K., Izumi, M., Takaoka, A., Nozawa, M., Yokohama, H., Fujita, T., Sakamoto, T., Kito, O., Okamura, H., Kinoshita, M.
(1998). Long-Term Beneficial Effect of Late Reperfusion for Acute Anterior Myocardial Infarction With Percutaneous Transluminal Coronary Angioplasty. Circulation
98: 2377-2382
[Abstract][Full Text]
Brodie, B. R., Stuckey, T. D., Wall, T. C., Kissling, G., Hansen, C. J., Muncy, D. B., Weintraub, R. A., Kelly, T. A.
(1998). Importance of time to reperfusion for 30-day and late survival and recovery of left ventricular function after primary angioplasty for acute myocardial infarction. J Am Coll Cardiol
32: 1312-1319
[Abstract][Full Text]
Lewis, C. W., Atkins, B. Z., Hutcheson, K. A., Gillen, C. T., Reedy, M. C., Glower, D. D., Taylor, D. A.
(1998). A load-independent in vivo model for evaluating therapeutic interventions in injured myocardium. Am. J. Physiol. Heart Circ. Physiol.
275: H1834-H1844
[Abstract][Full Text]
Carmel, S., Gueron, M., Ilia, R.
(1998). Patients with Coronary Collaterals and Normal Left Ventricular Systolic Function: Clinical, Hemodynamic, and Angiographic Characteristics. ANGIOLOGY
49: 631-635
[Abstract]
Pfusterer, M. E., Buser, P., Osswald, S., Weiss, P., Bremerich, J., Burkart, F.
(1998). Time dependence of left ventricular recovery after delayed recanalization of an occluded infarct-related coronary artery: findings of a pilot study. J Am Coll Cardiol
32: 97-102
[Abstract][Full Text]
Höper, M. M., Voelkel, N. F., Bates, T. O., Allard, J. D., Horan, M., Shepherd, D., Tuder, R. M.
(1997). Prostaglandins Induce Vascular Endothelial Growth Factor in a Human Monocytic Cell Line and Rat Lungs via cAMP. Am. J. Respir. Cell Mol. Bio.
17: 748-756
[Abstract][Full Text]
Salati, M., Lemma, M., Di Mattia, D. G., Danna, P., Cialfi, A., Salvaggio, A., Santoli, C.
(1997). Myocardial Revascularization in Patients With Ischemic Cardiomyopathy: Functional Observations. Ann. Thorac. Surg.
64: 1728-1734
[Abstract][Full Text]
Meza, M. F., Ramee, S., Collins, T., Stapleton, D., Milani, R. V., Murgo, J. P., Cheirif, J.
(1997). Knowledge of Perfusion and Contractile Reserve Improves the Predictive Value of Recovery of Regional Myocardial Function Postrevascularization : A Study Using the Combination of Myocardial Contrast Echocardiography and Dobutamine Echocardiography. Circulation
96: 3459-3465
[Abstract][Full Text]
Cave, A. C., Silverman, A. S., Apstein, C. S.
(1997). Ischemic Preconditioning Does Not Protect Against Contractile Dysfunction in the Presence of Residual Flow : Studies in the Isolated, Blood-Perfused Rat Heart. Circulation
96: 3087-3093
[Abstract][Full Text]
Bombardini, T., Picano, E., Bombardini, T.
(1997). The Coronary Angiogenetic Effect of Heparin: Experimental Basis and Clinical Evidence. ANGIOLOGY
48: 969-976
[Abstract]
Apstein, C. S., Taegtmeyer, H.
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48: 301-307
[Abstract]
Murray, G. L., Schad, N., Bush, A. J., Murray, G. L.
(1997). Viability After Myocardial Infarction: Can It Be Assessed Within Five Minutes by Low-Dose Dynamic Iodine-123-Iodophenylpentadecanoic Acid Imaging with a Multicrystal Gamma Camera?. ANGIOLOGY
48: 309-319
[Abstract]
Aronson, S.
(1997). Myocardial Contrast Echocardiography: Is it Ready to be Used as a Clinical Tool in the Operating Room?. SEMIN CARDIOTHORAC VASC ANESTH
1: 4-15
Caretta, Q., Voci, P., Acconcia, M. C., Chiarotti, F.
(1997). COLLATERAL FLOW PREVENTS UNINTENTIONAL MYOCARDIAL ISCHEMIA DURING ANTEGRADE CARDIOPLEGIA IN PATIENTS UNDERGOING CORONARY ARTERY BYPASS GRAFTING. J. Thorac. Cardiovasc. Surg.
113: 585-593
[Abstract][Full Text]
van't Hof, A. W., Zijlstra, F., de Boer, M.-J., Ay Lee Liem, , Hoorntje, J. C., Suryapranata, H., Suryapranata, H.
(1997). Patency and Reinfarction in Late-Entry Myocardial Infarct Patients Treated with Reperfusion Therapy. ANGIOLOGY
48: 215-222
[Abstract]
Bonow, R. O.
(1996). Identification of Viable Myocardium. Circulation
94: 2674-2680
[Full Text]
Horrigan, M. C.G., MacIsaac, A. I., Nicolini, F. A., Vince, D. G., Lee, P., Ellis, S. G., Topol, E. J.
(1996). Reduction in Myocardial Infarct Size by Basic Fibroblast Growth Factor After Temporary Coronary Occlusion in a Canine Model. Circulation
94: 1927-1933
[Abstract][Full Text]
Muhlhauser, J., Merrill, M. J., Pili, R., Maeda, H., Bacic, M., Bewig, B., Passaniti, A., Edwards, N. A., Crystal, R. G., Capogrossi, M. C.
(1995). VEGF165 Expressed by a Replication-Deficient Recombinant Adenovirus Vector Induces Angiogenesis In Vivo. Circ. Res.
77: 1077-1086
[Abstract][Full Text]
deFilippi, C. R., Willett, D. L., Irani, W. N., Eichhorn, E. J., Velasco, C. E., Grayburn, P. A.
(1995). Comparison of Myocardial Contrast Echocardiography and Low-Dose Dobutamine Stress Echocardiography in Predicting Recovery of Left Ventricular Function After Coronary Revascularization in Chronic Ischemic Heart Disease. Circulation
92: 2863-2868
[Abstract][Full Text]
Laperche, T., Steg, P. G., Dehoux, M., Benessiano, J., Grollier, G., Aliot, E., Mossard, J.-M., Aubry, P., Coisne, D., Hanssen, M., Iliou, M.-C.
(1995). A Study of Biochemical Markers of Reperfusion Early After Thrombolysis for Acute Myocardial Infarction. Circulation
92: 2079-2086
[Abstract][Full Text]
Lamas, G. A., Flaker, G. C., Mitchell, G., Smith, S. C. Jr, Gersh, B. J., Wun, C.-C., Moye, L., Rouleau, J. L., Rutherford, J. D., Pfeffer, M. A., Braunwald, E., Investigators, f. t. S. V. E.
(1995). Effect of Infarct Artery Patency on Prognosis After Acute Myocardial Infarction. Circulation
92: 1101-1109
[Abstract][Full Text]
Voci, P., Bilotta, F., Caretta, Q., Mercanti, C., Marino, B.
(1995). Papillary Muscle Perfusion Pattern : A Hypothesis for Ischemic Papillary Muscle Dysfunction. Circulation
91: 1714-1718
[Abstract][Full Text]
Bauters, C., Khanoyan, P., Mc Fadden, E. P., Quandalle, P., Lablanche, J.-M., Bertrand, M. E.
(1995). Restenosis After Delayed Coronary Angioplasty of the Culprit Vessel in Patients With a Recent Myocardial Infarction Treated by Thrombolysis. Circulation
91: 1410-1418
[Abstract][Full Text]
