Effects of Limiting Medicaid Drug-Reimbursement Benefits on the Use of Psychotropic Agents and Acute Mental Health Services by Patients with Schizophrenia
Stephen B. Soumerai, Thomas J. McLaughlin, Dennis Ross-Degnan, Christina S. Casteris, and Paola Bollini
Background We examined the effects of a three-prescription monthlypayment limit (cap) on the use of psychotropic drugs and acutemental health care by noninstitutionalized patients with schizophrenia.We hypothesized that reducing access to such drugs would increasethe use of emergency mental health services and the rate ofpartial hospitalizations (full-day or half-day treatment programs)and psychiatric-hospital admissions.
Methods We linked Medicaid claims data for a period of 42 monthswith clinical records from two community mental health centers(CMHCs) and the single state psychiatric hospital in New Hampshire,where Medicaid imposed a three-prescription limit on reimbursementfor drugs during 11 months (months 15 through 25) of the study.For comparison, we used Medicaid claims for a period of 42 monthsin New Jersey, which had no limit on drug reimbursement. Thestudy patients (n = 268) and the comparison patients (n = 1959)were permanently disabled, noninstitutionalized patients withschizophrenia, 19 through 60 years of age, who were insuredby Medicaid. We conducted interrupted time-series regressionanalyses to estimate the effects of the cap on the use of medicationsand mental health services.
Results The cap resulted in immediate reductions (range, 15to 49 percent) in the use of antipsychotic drugs, antidepressantsand lithium, and anxiolytic and hypnotic drugs (P<0.01).It also resulted in coincident increases of one to two visitsper patient per month to CMHCs (range of increase, 43 to 57percent; P<0.001) and sharp increases in the use of emergencymental health services and partial hospitalization (1.2 to 1.4episodes per patient per month), but no change in the frequencyof hospital admissions. After the cap was discontinued, theuse of medications and most mental health services revertedto base-line levels (measured in the first 14 months of thestudy). The estimated average increase in mental health carecosts per patient during the cap ($1,530) exceeded the savingsin drug costs to Medicaid by a factor of 17.
Conclusions Limits on coverage for the costs of prescriptiondrugs can increase the use of acute mental health services amonglow-income patients with chronic mental illnesses and increasecosts to the government, even aside from the increases causedin pain and suffering on the part of patients.
Source Information
From the Departments of Ambulatory Care (S.B.S., T.J.M., D.R.-D., C.S.C.) and Prevention and Social Medicine (D.R.-D.), Harvard Medical School and Harvard Community Health Plan, Boston; and the International Organization for Migration, Geneva (P.B.).
West, J. C., Wilk, J. E., Rae, D. S., Muszynski, I. S., Stipec, M. R., Alter, C. L., Sanders, K. E., Crystal, S., Regier, D. A.
(2009). Medicaid Prescription Drug Policies and Medication Access and Continuity: Findings From Ten States. Psychiatr. Serv.
60: 601-610
[Abstract][Full Text]
Wang, P. S., Ulbricht, C. M., Schoenbaum, M.
(2009). Improving Mental Health Treatments Through Comparative Effectiveness Research. Health Aff (Millwood)
28: 783-791
[Abstract][Full Text]
Solomon, M. D., Goldman, D. P., Joyce, G. F., Escarce, J. J.
(2009). Cost Sharing and the Initiation of Drug Therapy for the Chronically Ill. Arch Intern Med
169: 740-748
[Abstract][Full Text]
Yang, Z., Gilleskie, D. B., Norton, E. C.
(2009). Health Insurance, Medical Care, and Health Outcomes: A Model of Elderly Health Dynamics. J. Human Resources
44: 47-114
[Abstract]
Paez, K. A., Zhao, L., Hwang, W.
(2009). Rising Out-Of-Pocket Spending For Chronic Conditions: A Ten-Year Trend. Health Aff (Millwood)
28: 15-25
[Abstract][Full Text]
Volpp, K. G., Pauly, M. V., Loewenstein, G., Bangsberg, D.
(2009). P4P4P: An Agenda For Research On Pay-For-Performance For Patients. Health Aff (Millwood)
28: 206-214
[Abstract][Full Text]
Chernew, M., Gibson, T. B.
(2008). Cost Sharing and HEDIS Performance. Med Care Res Rev
65: 713-728
[Abstract]
Jackevicius, C. A., Tu, J. V., Demers, V., Melo, M., Cox, J., Rinfret, S., Kalavrouziotis, D., Johansen, H., Behlouli, H., Newman, A., Pilote, L.
(2008). Cardiovascular Outcomes after a Change in Prescription Policy for Clopidogrel. NEJM
359: 1802-1810
[Abstract][Full Text]
Rosenheck, R. A., Leslie, D. L., Doshi, J. A.
(2008). Second-Generation Antipsychotics: Cost-Effectiveness, Policy Options, and Political Decision Making. Psychiatr. Serv.
59: 515-520
[Abstract][Full Text]
Duckworth, K., Fitzpatrick, M. J.
(2008). NAMI Perspective on CATIE: Policy and Research Implications. Psychiatr. Serv.
59: 537-539
[Abstract][Full Text]
Law, M. R., Ross-Degnan, D., Soumerai, S. B.
(2008). Effect of Prior Authorization of Second-Generation Antipsychotic Agents on Pharmacy Utilization and Reimbursements. Psychiatr. Serv.
59: 540-546
[Abstract][Full Text]
Kliethermes, M. A., Schullo-Feulner, A. M., Tilton, J., Kim, S., Pellegrino, A. N.
(2008). Model for medication therapy management in a university clinic. Am J Health Syst Pharm
65: 844-856
[Abstract][Full Text]
Soumerai, S. B., Zhang, F., Ross-Degnan, D., Ball, D. E., LeCates, R. F., Law, M. R., Hughes, T. E., Chapman, D., Adams, A. S.
(2008). Use Of Atypical Antipsychotic Drugs For Schizophrenia In Maine Medicaid Following A Policy Change. Health Aff (Millwood)
27: w185-w195
[Abstract][Full Text]
Goldman, D. P., Joyce, G. F.
(2008). Medicare Part D: A Successful Start With Room for Improvement. JAMA
299: 1954-1955
[Full Text]
Wang, P. S., Patrick, A. R., Dormuth, C. R., Avorn, J., Maclure, M., Canning, C. F., Schneeweiss, S.
(2008). The Impact of Cost Sharing on Antidepressant Use Among Older Adults in British Columbia. Psychiatr. Serv.
59: 377-383
[Abstract][Full Text]
Demers, V. BSc, Melo, M. BScPharm M, Jackevicius, C. PharmD MSc, Cox, J. MD, Kalavrouziotis, D. MD, Rinfret, S. MD MSc, Humphries, K. H. DSc, Johansen, H. PhD, Tu, J. V. MD PhD, Pilote, L. MD PhD
(2008). Comparison of provincial prescription drug plans and the impact on patients' annual drug expenditures. CMAJ
178: 405-409
[Abstract][Full Text]
Donohue, J. M., Frank, R. G.
(2007). Estimating Medicare Part D's Impact on Medication Access Among Dually Eligible Beneficiaries With Mental Disorders. Psychiatr. Serv.
58: 1285-1291
[Abstract][Full Text]
Bayliss, E. A., Ellis, J. L., Steiner, J. F.
(2007). Barriers to Self-Management and Quality-of-Life Outcomes in Seniors With Multimorbidities. Ann Fam Med
5: 395-402
[Abstract][Full Text]
Joyce, G. F., Goldman, D. P., Karaca-Mandic, P., Zheng, Y.
(2007). Pharmacy Benefit Caps And The Chronically Ill. Health Aff (Millwood)
26: 1333-1344
[Abstract][Full Text]
Goldman, D. P., Joyce, G. F., Zheng, Y.
(2007). Prescription Drug Cost Sharing: Associations With Medication and Medical Utilization and Spending and Health. JAMA
298: 61-69
[Abstract][Full Text]
Lostao, L., Regidor, E., Geyer, S., Aiach, P.
(2007). Patient cost sharing and physician visits by socioeconomic position: findings in three Western European countries. J. Epidemiol. Community Health
61: 416-420
[Abstract][Full Text]
Rosenberg, J. M.
(2007). Overview of Medicare Part D prescription drug benefit: Potential implications for patients with psychotic disorders. Am J Health Syst Pharm
64: S18-S23
[Abstract][Full Text]
Soumerai, S. B., Pierre-Jacques, M., Zhang, F., Ross-Degnan, D., Adams, A. S., Gurwitz, J., Adler, G., Safran, D. G.
(2006). Cost-related medication nonadherence among elderly and disabled medicare beneficiaries: a national survey 1 year before the medicare drug benefit.. Arch Intern Med
166: 1829-1835
[Abstract][Full Text]
Smith, D. H., Perrin, N., Feldstein, A., Yang, X., Kuang, D., Simon, S. R., Sittig, D. F., Platt, R., Soumerai, S. B.
(2006). The impact of prescribing safety alerts for elderly persons in an electronic medical record: an interrupted time series evaluation.. Arch Intern Med
166: 1098-1104
[Abstract][Full Text]
Bambauer, K. Z., Adams, A. S., Zhang, F., Minkoff, N., Grande, A., Weisblatt, R., Soumerai, S. B., Ross-Degnan, D.
(2006). Physician alerts to increase antidepressant adherence: fax or fiction?. Arch Intern Med
166: 498-504
[Abstract][Full Text]
Pearson, S.-A., Soumerai, S., Mah, C., Zhang, F., Simoni-Wastila, L., Salzman, C., Cosler, L. E., Fanning, T., Gallagher, P., Ross-Degnan, D.
(2006). Racial disparities in access after regulatory surveillance of benzodiazepines.. Arch Intern Med
166: 572-579
[Abstract][Full Text]
Morden, N. E., Garrison, L. P. Jr.
(2006). Implications of part d for mentally ill dual eligibles: a challenge for medicare.. Health Aff (Millwood)
25: 491-500
[Abstract][Full Text]
Levinson, W., Laupacis, A.
(2006). A Call for Fairness in Formulary Decisions. Arch Intern Med
166: 16-18
[Full Text]
Bambauer, K. Z., Sabin, J. E., Soumerai, S. B.
(2005). The Exclusion of Benzodiazepine Coverage in Medicare: Simple Steps for Avoiding a Public Health Crisis. Psychiatr. Serv.
56: 1143-1146
[Full Text]
Weiden, P. J., Rao, N.
(2005). Teaching Medication Compliance to Psychiatric Residents: Placing an Orphan Topic Into a Training Curriculum. Acad. Psychiatry
29: 203-210
[Abstract][Full Text]
Piette, J. D., Heisler, M., Wagner, T. H.
(2004). Cost-Related Medication Underuse Among Chronically III Adults: the Treatments People Forgo, How Often, and Who Is at Risk. Am. J. Public Health
94: 1782-1787
[Abstract][Full Text]
Piette, J. D., Heisler, M., Wagner, T. H.
(2004). Cost-Related Medication Underuse: Do Patients With Chronic Illnesses Tell Their Doctors?. Arch Intern Med
164: 1749-1755
[Abstract][Full Text]
Mechanic, D., Bilder, S.
(2004). Treatment Of People With Mental Illness: A Decade-Long Perspective. Health Aff (Millwood)
23: 84-95
[Abstract][Full Text]
Rector, T. S., Venus, P. J.
(2004). Do Drug Benefits Help Medicare Beneficiaries Afford Prescribed Drugs?. Health Aff (Millwood)
23: 213-222
[Abstract][Full Text]
Villagra, V. G., Ahmed, T.
(2004). Effectiveness Of A Disease Management Program For Patients With Diabetes. Health Aff (Millwood)
23: 255-266
[Abstract][Full Text]
Meara, E., Kotagal, U. R., Atherton, H. D., Lieu, T. A.
(2004). Impact of Early Newborn Discharge Legislation and Early Follow-up Visits on Infant Outcomes in a State Medicaid Population. Pediatrics
113: 1619-1627
[Abstract][Full Text]
Soumerai, S. B., Mah, C., Zhang, F., Adams, A., Barton, M., Fajtova, V., Ross-Degnan, D.
(2004). Effects of Health Maintenance Organization Coverage of Self-monitoring Devices on Diabetes Self-care and Glycemic Control. Arch Intern Med
164: 645-652
[Abstract][Full Text]
Piette, J. D., Heisler, M., Wagner, T. H.
(2004). Problems Paying Out-of-Pocket Medication Costs Among Older Adults With Diabetes. Diabetes Care
27: 384-391
[Abstract][Full Text]
Frayne, S. M., Freund, K. M., Skinner, K. M., Ash, A. S., Moskowitz, M. A.
(2004). Depression Management in Medical Clinics: Does Healthcare Sector Make a Difference?. American Journal of Medical Quality
19: 28-36
[Abstract]
Newhouse, J. P.
(2004). How Much Should Medicare Pay For Drugs?. Health Aff (Millwood)
23: 89-102
[Abstract][Full Text]
Soumerai, S. B.
(2004). Benefits And Risks Of Increasing Restrictions On Access To Costly Drugs In Medicaid. Health Aff (Millwood)
23: 135-146
[Abstract][Full Text]
Murray, M. D., Callahan, C. M.
(2003). Improving Medication Use for Older Adults: An Integrated Research Agenda. ANN INTERN MED
139: 425-429
[Abstract][Full Text]
Soumerai, S. B., Simoni-Wastila, L., Singer, C., Mah, C., Gao, X., Salzman, C., Ross-Degnan, D.
(2003). Lack of Relationship Between Long-Term Use of Benzodiazepines and Escalation to High Dosages. Psychiatr. Serv.
54: 1006-1011
[Abstract][Full Text]
Mojtabai, R., Olfson, M.
(2003). Medication Costs, Adherence, And Health Outcomes Among Medicare Beneficiaries. Health Aff (Millwood)
22: 220-229
[Abstract][Full Text]
Ray, W. A., Daugherty, J. R., Meador, K. G.
(2003). Effect of a Mental Health "Carve-Out" Program on the Continuity of Antipsychotic Therapy. NEJM
348: 1885-1894
[Abstract][Full Text]
Maynard, A., Bloor, K.
(2003). Dilemmas In Regulation Of The Market For Pharmaceuticals. Health Aff (Millwood)
22: 31-41
[Abstract][Full Text]
Joyce, G. F., Escarce, J. J., Solomon, M. D., Goldman, D. P.
(2002). Employer Drug Benefit Plans and Spending on Prescription Drugs. JAMA
288: 1733-1739
[Abstract][Full Text]
Landrigan, C. P., Srivastava, R., Muret-Wagstaff, S., Soumerai, S. B., Ross-Degnan, D., Graef, J. W., Homer, C. J., Goldmann, D. A.
(2002). Impact of a Health Maintenance Organization Hospitalist System in Academic Pediatrics. Pediatrics
110: 720-728
[Abstract][Full Text]
Pilote, L., Beck, C., Richard, H., Eisenberg, M. J.
(2002). The effects of cost-sharing on essential drug prescriptions, utilization of medical care and outcomes after acute myocardial infarction in elderly patients. CMAJ
167: 246-252
[Abstract][Full Text]
Schneeweiss, S., Soumerai, S. B., Glynn, R. J., Maclure, M., Dormuth, C., Walker, A. M.
(2002). Impact of reference-based pricing for angiotensin-converting enzyme inhibitors on drug utilization. CMAJ
166: 737-745
[Abstract][Full Text]
Yanos, P. T., Crystal, S., Kumar, R., Walkup, J. T.
(2001). Characteristics and Service Use Patterns of Nonelderly Medicare Beneficiaries With Schizophrenia. Psychiatr. Serv.
52: 1644-1650
[Abstract][Full Text]
Federman, A. D., Adams, A. S., Ross-Degnan, D., Soumerai, S. B., Ayanian, J. Z.
(2001). Supplemental Insurance and Use of Effective Cardiovascular Drugs Among Elderly Medicare Beneficiaries With Coronary Heart Disease. JAMA
286: 1732-1739
[Abstract][Full Text]
Kozyrskyj, A. L., Mustard, C. A., Cheang, M. S., Simons, F.
(2001). Income-based drug benefit policy: impact on receipt of inhaled corticosteroid prescriptions by Manitoba children with asthma. CMAJ
165: 897-902
[Abstract][Full Text]
Svarstad, B. L., Shireman, T. I., Sweeney, J. K.
(2001). Using Drug Claims Data to Assess the Relationship of Medication Adherence With Hospitalization and Costs. Psychiatr. Serv.
52: 805-811
[Abstract][Full Text]
Mitchell, J., Mathews, H. F., Hunt, L. M., Cobb, K. H., Watson, R. W.
(2001). Mismanaging Prescription Medications Among Rural Elders: The Effects of Socioeconomic Status, Health Status, and Medication Profile Indicators. Gerontologist
41: 348-356
[Abstract][Full Text]
Harvey, P. D., Keefe, R. S.E.
(2001). Studies of Cognitive Change in Patients With Schizophrenia Following Novel Antipsychotic Treatment. Am. J. Psychiatry
158: 176-184
[Abstract][Full Text]
Tamblyn, R., Laprise, R., Hanley, J. A., Abrahamowicz, M., Scott, S., Mayo, N., Hurley, J., Grad, R., Latimer, E., Perreault, R., McLeod, P., Huang, A., Larochelle, P., Mallet, L.
(2001). Adverse Events Associated With Prescription Drug Cost-Sharing Among Poor and Elderly Persons. JAMA
285: 421-429
[Abstract][Full Text]
Adams, A. S., Soumerai, S. B., Ross-Degnan, D.
(2001). Use Of Antihypertensive Drugs By Medicare Enrollees: Does Type Of Drug Coverage Matter?. Health Aff (Millwood)
20: 276-286
[Abstract][Full Text]
Lo, B., Alpers, A.
(2000). Uses and Abuses of Prescription Drug Information in Pharmacy Benefits Management Programs. JAMA
283: 801-806
[Abstract][Full Text]
Soumerai, S. B., Ross-Degnan, D.
(1999). Inadequate Prescription-Drug Coverage for Medicare Enrollees -- A Call to Action. NEJM
340: 722-728
[Full Text]
Burke, J. P.
(1998). Antibiotic Resistance--Squeezing the Balloon?. JAMA
280: 1270-1271
[Full Text]
Young, A. S., Sullivan, G., Burnam, M. A., Brook, R. H.
(1998). Measuring the Quality of Outpatient Treatment for Schizophrenia. Arch Gen Psychiatry
55: 611-617
[Abstract][Full Text]
Brown, M. E., Bindman, A. B., Lurie, N.
(1998). Monitoring the Consequences of Uninsurance: A Review of Methodologies. Med Care Res Rev
55: 177-210
[Abstract]
Soumerai, S. B., McLaughlin, T. J., Spiegelman, D., Hertzmark, E., Thibault, G., Goldman, L.
(1997). Adverse Outcomes of Underuse of {beta}-Blockers in Elderly Survivors of Acute Myocardial Infarction. JAMA
277: 115-121
[Abstract]
Brook, R. H., Kamberg, C. J., McGlynn, E. A.
(1996). Health System Reform and Quality. JAMA
276: 476-480
[Abstract]
Freemantle, N., Bloor, K.
(1996). Lessons from international experience in controlling pharmaceutical expenditure. I: influencing patients. BMJ
312: 1469-1471
[Full Text]
Sanders, C. A.
(1995). Industry's Efforts: Devices and Pharmaceuticals. Ann. Thorac. Surg.
60: 1537-1540
[Abstract][Full Text]
Gustin, N. J., Berman, W. H., Hurt, S. W., Roff, M.
(1995). The Effect of Utilization Management on the Treatment of Schizophrenic Inpatients. American Journal of Medical Quality
10: 138-140
Smalley, W. E., Griffin, M. R., Fought, R. L., Sullivan, L., Ray, W. A.
(1995). Effect of a Prior-Authorization Requirement on the Use of Nonsteroidal Antiinflammatory Drugs by Medicaid Patients. NEJM
332: 1612-1617
[Abstract][Full Text]
Soumerai, S. B., Lipton, H. L.
(1995). Computer-Based Drug-Utilization Review -- Risk, Benefit, or Boondoggle?. NEJM
332: 1641-1645
[Full Text]