FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 331:1044-1050 October 20, 1994 Number 16 Next

	Full Text Letters Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

ABSTRACT

Background The clinical benefit of percutaneous transluminal coronary angioplasty (PTCA) as compared with coronary-artery bypass grafting (CABG) for patients with multivessel coronary artery disease has not been established. To determine the outcomes of these treatments in patients referred for the first time for coronary revascularization, we conducted a three-year prospective, randomized trial comparing the two procedures.

Methods Revascularization was performed by accepted methods. Follow-up clinical information was collected every six months, and coronary arteriography and thallium stress scanning were performed at one and three years. The primary end point was a composite of death, Q-wave myocardial infarction, and a large ischemic defect identified on thallium scanning at three years. Secondary end points included clinical and angiographic status and the need for additional revascularization procedures. Data were analyzed according to the intention-to-treat principle.

Results Of the 5118 patients screened for the trial, 842 (16.5 percent) were eligible for enrollment, and 392 (7.7 percent) agreed to participate. A total of 194 patients were randomly assigned to the CABG group, and 198 to the PTCA group. The primary end point occurred in 27.3 percent of the CABG group and 28.8 percent of the PTCA group (P = 0.81). Death occurred in 6.2 percent of the CABG group and 7.1 percent of the PTCA group (P = 0.73 by log-rank test). At three years, the proportions of patients in the CABG group who required repeated bypass surgery (1 percent) or angioplasty (13 percent) were significantly lower than the proportions in the PTCA group (22 and 41 percent, respectively; P<0.001). Angiographic studies at three years showed a greater degree of revascularization in the CABG group. Angina was more frequent in the PTCA group (20 percent) than in the CABG group (12 percent).

Conclusions We found that CABG and PTCA did not differ significantly with respect to the occurrence of the composite primary end point. Consequently, the selection of one procedure over the other should be guided by patients' preferences regarding the quality of life and the possible need for subsequent procedures.

Source Information

From the Divisions of Cardiology (S.B.K., N.J.L., W.S.W.), Radiology (N.P.A.), and Cardiothoracic Surgery (R.A.G.), Emory University School of Medicine, Atlanta; the Division of Biostatistics (A.S.K., H.X.B., M.H.K.), Emory University School of Public Health, Atlanta; and the Division of Cardiology, University of Washington School of Medicine, Seattle (X.-Q.Z.). Study participants are listed in the Appendix.

Address reprint requests to Dr. King at Emory University Hospital, Suite F606, 1364 Clifton Rd. NE, Atlanta, GA 30322.

Full Text of this Article

Related Letters:

Coronary Angioplasty Compared with Bypass Grafting
Hartz A. J., Kuhn E. M., Doorey A. J., Fischer J. E., Leesar M. A., Joseph S. A., Prince C. R., Hamm C. W., Berger J., Kalmar P., King S. B., Hillis L. D., Rutherford J. D.
Extract | Full Text  
N Engl J Med 1995; 332:888-890, Mar 30, 1995. Correspondence

This article has been cited by other articles:

• DeMaria, A. N. (2008). Clinical trials and clinical judgment.. J Am Coll Cardiol 51: 1120-1122 [Full Text]  
• Carrozza, J. P. Jr. (2008). Drug-Eluting Stents -- Pushing the Envelope beyond the Labels?. NEJM 358: 405-407 [Full Text]  
• Martuscelli, E., Clementi, F., Gallagher, M. M., D'Eliseo, A., Chiricolo, G., Nigri, A., Marino, B., Romeo, F., on behalf of CABRI trialists, (2008). Revascularization strategy in patients with multivessel disease and a major vessel chronically occluded; data from the CABRI trial. Eur. J. Cardiothorac. Surg. 33: 4-8 [Abstract] [Full Text]  
• Bravata, D. M., Gienger, A. L., McDonald, K. M., Sundaram, V., Perez, M. V., Varghese, R., Kapoor, J. R., Ardehali, R., Owens, D. K., Hlatky, M. A. (2007). Systematic Review: The Comparative Effectiveness of Percutaneous Coronary Interventions and Coronary Artery Bypass Graft Surgery. ANN INTERN MED 147: 703-716 [Abstract] [Full Text]  
• Fang, C.-C., Yeun Tarl Fresner Ng Jao, , Yi-Chen, , Yu, C.-L., Chen, C.-L., Wang, S.-P. (2007). Angiographic and Clinical Outcomes of Rosiglitazone in Patients With Type 2 Diabetes Mellitus After Percutaneous Coronary Interventions: A Single Center Experience. ANGIOLOGY 58: 523-534 [Abstract]  
• Javaid, A., Steinberg, D. H., Buch, A. N., Corso, P. J., Boyce, S. W., Pinto Slottow, T. L., Roy, P. K., Hill, P., Okabe, T., Torguson, R., Smith, K. A., Xue, Z., Gevorkian, N., Suddath, W. O., Kent, K. M., Satler, L. F., Pichard, A. D., Waksman, R. (2007). Outcomes of Coronary Artery Bypass Grafting Versus Percutaneous Coronary Intervention With Drug-Eluting Stents for Patients With Multivessel Coronary Artery Disease. Circulation 116: I-200-I-206 [Abstract] [Full Text]  
• Bair, T. L., Muhlestein, J. B., May, H. T., Meredith, K. G., Horne, B. D., Pearson, R. R., Li, Q., Jensen, K. R., Anderson, J. L., Lappe, D. L. (2007). Surgical Revascularization Is Associated With Improved Long-Term Outcomes Compared With Percutaneous Stenting in Most Subgroups of Patients With Multivessel Coronary Artery Disease: Results From the Intermountain Heart Registry. Circulation 116: I-226-I-231 [Abstract] [Full Text]  
• Rodriguez, A. E., Maree, A. O., Mieres, J., Berrocal, D., Grinfeld, L., Fernandez-Pereira, C., Curotto, V., Rodriguez-Granillo, A., O'Neill, W., Palacios, I. F. (2007). Late loss of early benefit from drug-eluting stents when compared with bare-metal stents and coronary artery bypass surgery: 3 years follow-up of the ERACI III registry. Eur Heart J 28: 2118-2125 [Abstract] [Full Text]  
• King, S. B. III, Aversano, T., Ballard, W. L., Beekman, R. H. III, Cowley, M. J., Ellis, S. G., Faxon, D. P., Hannan, E. L., Hirshfeld, J. W. Jr, Jacobs, A. K., Kellett, M. A. Jr, Kimmel, S. E., Landzberg, J. S., McKeever, L. S., Moscucci, M., Pomerantz, R. M., Smith, K. M., Vetrovec, G. W., Creager, M. A., Hirshfeld, J. W. Jr, Holmes, D. R. Jr, Newby, L. K., Weitz, H. H., Merli, G., Pina, I., Rodgers, G. P., Tracy, C. M. (2007). ACCF/AHA/SCAI 2007 Update of the Clinical Competence Statement on Cardiac Interventional Procedures: A Report of the American College of Cardiology Foundation/American Heart Association/American College of Physicians Task Force on Clinical Competence and Training (Writing Committee to Update the 1998 Clinical Competence Statement on Recommendations for the Assessment and Maintenance of Proficiency in Coronary Interventional Procedures). J Am Coll Cardiol 50: 82-108 [Full Text]  
• King, S. B. III (2007). Five-Year Follow-Up of the Medicine, Angioplasty, or Surgery Study (MASS-II): Prologue to COURAGE. Circulation 115: 1064-1066 [Full Text]  
• Mangano, D. T., Miao, Y., Vuylsteke, A., Tudor, I. C., Juneja, R., Filipescu, D., Hoeft, A., Fontes, M. L., Hillel, Z., Ott, E., Titov, T., Dietzel, C., Levin, J., for the Investigators of The Multicenter Study of, (2007). Mortality Associated With Aprotinin During 5 Years Following Coronary Artery Bypass Graft Surgery. JAMA 297: 471-479 [Abstract] [Full Text]  
• Dzau, V. J., Antman, E. M., Black, H. R., Hayes, D. L., Manson, J. E., Plutzky, J., Popma, J. J., Stevenson, W. (2006). The Cardiovascular Disease Continuum Validated: Clinical Evidence of Improved Patient Outcomes: Part I: Pathophysiology and Clinical Trial Evidence (Risk Factors Through Stable Coronary Artery Disease). Circulation 114: 2850-2870 [Full Text]  
• Martin, B. K., Frangakis, C. E., Rosenberg, P. B., Mintzer, J. E., Katz, I. R., Porsteinsson, A. P., Schneider, L. S., Rabins, P. V., Munro, C. A., Meinert, C. L., Niederehe, G., Lyketsos, C. G. (2006). Design of Depression in Alzheimer's Disease Study-2.. AJGP 14: 920-930 [Abstract] [Full Text]  
• Yokouchi, K., Numaguchi, Y., Kubota, R., Ishii, M., Imai, H., Murakami, R., Ogawa, Y., Kondo, T., Okumura, K., Ingber, D. E., Murohara, T. (2006). l-Caldesmon Regulates Proliferation and Migration of Vascular Smooth Muscle Cells and Inhibits Neointimal Formation After Angioplasty. Arterioscler. Thromb. Vasc. Bio. 26: 2231-2237 [Abstract] [Full Text]  
• Ben-Yehuda, O. (2006). Physician Judgment in Cardiology: The Art of Medicine Lives On. J Am Coll Cardiol 48: 954-955 [Full Text]  
• Weintraub, W. S., Banbury, M. K. (2006). Invited commentary.. Ann. Thorac. Surg. 82: 810-811 [Full Text]  
• Guyton, R. A. (2006). Coronary Artery Bypass is Superior to Drug-Eluting Stents in Multivessel Coronary Artery Disease. Ann. Thorac. Surg. 81: 1949-1957 [Abstract] [Full Text]  
• Hordijk-Trion, M., Lenzen, M., Wijns, W., de Jaegere, P., Simoons, M. L., Scholte op Reimer, W. J.M., Bertrand, M. E., Mercado, N., Boersma, E., on behalf of the EHS-CR Investigators, (2006). Patients enrolled in coronary intervention trials are not representative of patients in clinical practice: results from the Euro Heart Survey on Coronary Revascularization. Eur Heart J 27: 671-678 [Abstract] [Full Text]  
• Klein, L. W. (2006). Are Drug-Eluting Stents the Preferred Treatment for Multivessel Coronary Artery Disease?. J Am Coll Cardiol 47: 22-26 [Abstract] [Full Text]  
• King, S. B. III (2005). Angioplasty Is Better Than Medical Therapy for Alleviating Chronic Angina Pectoris. Arch Intern Med 165: 2589-2592 [Full Text]  
• Stone, G. W., Reifart, N. J., Moussa, I., Hoye, A., Cox, D. A., Colombo, A., Baim, D. S., Teirstein, P. S., Strauss, B. H., Selmon, M., Mintz, G. S., Katoh, O., Mitsudo, K., Suzuki, T., Tamai, H., Grube, E., Cannon, L. A., Kandzari, D. E., Reisman, M., Schwartz, R. S., Bailey, S., Dangas, G., Mehran, R., Abizaid, A., Moses, J. W., Leon, M. B., Serruys, P. W. (2005). Percutaneous Recanalization of Chronically Occluded Coronary Arteries: A Consensus Document: Part II. Circulation 112: 2530-2537 [Full Text]  
• Stone, G. W., Kandzari, D. E., Mehran, R., Colombo, A., Schwartz, R. S., Bailey, S., Moussa, I., Teirstein, P. S., Dangas, G., Baim, D. S., Selmon, M., Strauss, B. H., Tamai, H., Suzuki, T., Mitsudo, K., Katoh, O., Cox, D. A., Hoye, A., Mintz, G. S., Grube, E., Cannon, L. A., Reifart, N. J., Reisman, M., Abizaid, A., Moses, J. W., Leon, M. B., Serruys, P. W. (2005). Percutaneous Recanalization of Chronically Occluded Coronary Arteries: A Consensus Document: Part I. Circulation 112: 2364-2372 [Full Text]  
• Kaehler, J., Koester, R., Billmann, W., Schroeder, C., Rupprecht, H.-J., Ischinger, T., Jahns, R., Vogt, A., Lampen, M., Hoffmann, R., Riessen, R., Berger, J., Meinertz, T., Hamm, C. W. (2005). 13-year follow-up of the German angioplasty bypass surgery investigation. Eur Heart J 26: 2148-2153 [Abstract] [Full Text]  
• Ramanathan, K. B., Weiman, D. S., Sacks, J., Morrison, D. A., Sedlis, S., Sethi, G., Henderson, W. G. (2005). Percutaneous Intervention Versus Coronary Bypass Surgery for Patients Older Than 70 Years of Age With High-Risk Unstable Angina. Ann. Thorac. Surg. 80: 1340-1346 [Abstract] [Full Text]  
• King, S. B. III, Dangas, G., Moses, J. W., King, S. B. III, Dangas, G., Moses, J. W. (2005). Surgery Is Preferred for the Diabetic With Multivessel Disease. Circulation 112: 1500-1515 [Full Text]  
• Rodriguez, A. E., Baldi, J., Pereira, C. F., Navia, J., Alemparte, M. R., Delacasa, A., Vigo, F., Vogel, D., O'Neill, W., Palacios, I. F., on behalf of the ERACI II Investigators, (2005). Five-Year Follow-Up of the Argentine Randomized Trial of Coronary Angioplasty With Stenting Versus Coronary Bypass Surgery in Patients With Multiple Vessel Disease (ERACI II). J Am Coll Cardiol 46: 582-588 [Abstract] [Full Text]  
• King, M., Nazareth, I., Lampe, F., Bower, P. (2005). Patient Preference and Validity of Randomized Controlled Trials--Reply. JAMA 294: 42-42 [Full Text]  
• Hannan, E. L., Racz, M. J., Walford, G., Jones, R. H., Ryan, T. J., Bennett, E., Culliford, A. T., Isom, O. W., Gold, J. P., Rose, E. A. (2005). Long-Term Outcomes of Coronary-Artery Bypass Grafting versus Stent Implantation. NEJM 352: 2174-2183 [Abstract] [Full Text]  
• van Domburg, R. T., Takkenberg, J. J.M., Noordzij, L. J., Saia, F., van Herwerden, L. A., Serruys, P. W.J.C., Bogers, A. J.J.C. (2005). Late Outcome After Stenting or Coronary Artery Bypass Surgery for the Treatment of Multivessel Disease: A Single-Center Matched-Propensity Controlled Cohort Study. Ann. Thorac. Surg. 79: 1563-1569 [Abstract] [Full Text]  
• King, M., Nazareth, I., Lampe, F., Bower, P., Chandler, M., Morou, M., Sibbald, B., Lai, R. (2005). Impact of Participant and Physician Intervention Preferences on Randomized Trials: A Systematic Review. JAMA 293: 1089-1099 [Abstract] [Full Text]  
• Ramsay, J., Shernan, S., Fitch, J., Finnegan, P., Todaro, T., Filloon, T., Nussmeier, N. A. (2005). Increased creatine kinase MB level predicts postoperative mortality after cardiac surgery independent of new Q waves. J. Thorac. Cardiovasc. Surg. 129: 300-306 [Abstract] [Full Text]  
• Carrozza, J. P. Jr, Sellke, F. W. (2004). A 69-Year-Old Woman With Left Main Coronary Artery Disease. JAMA 292: 2506-2514 [Full Text]  
• Srinivasan, A. K., Grayson, A. D., Fabri, B. M. (2004). On-Pump Versus Off-Pump Coronary Artery Bypass Grafting in Diabetic Patients: A Propensity Score Analysis. Ann. Thorac. Surg. 78: 1604-1609 [Abstract] [Full Text]  
• Kettelkamp, R., House, J., Garg, M., Stuart, R. S., Grantham, A., Spertus, J. (2004). Using the Risk of Restenosis as a Guide to Triaging Patients Between Surgical and Percutaneous Coronary Revascularization. Circulation 110: II-50-II-54 [Abstract] [Full Text]  
• Griffiths, H., Bakhai, A., West, D., Petrou, M., De Souza, T., Moat, N., Pepper, J., Di Mario, C. (2004). Feasibility and cost of treatment with drug eluting stents of surgical candidates with multi-vessel coronary disease. Eur. J. Cardiothorac. Surg. 26: 528-534 [Abstract] [Full Text]  
• Committee Members, , Eagle, K. A., Guyton, R. A., Davidoff, R., Edwards, F. H., Ewy, G. A., Gardner, T. J., Hart, J. C., Herrmann, H. C., Hillis, L. D., Hutter, A. M. Jr, Lytle, B. W., Marlow, R. A., Nugent, W. C., Orszulak, T. A., Task Force Members, , Antman, E. M., Smith, S. C. Jr, Alpert, J. S., Anderson, J. L., Faxon, D. P., Fuster, V., Gibbons, R. J., Gregoratos, G., Halperin, J. L., Hiratzka, L. F., Hunt, S. A., Jacobs, A. K., Ornato, J. P. (2004). ACC/AHA 2004 guideline update for coronary artery bypass graft surgery: Summary article: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Update the 1999 Guidelines for Coronary Artery Bypass Graft Surgery) . J Am Coll Cardiol 44: 1146-1154 [Full Text]  
• Beatt, K J, Morgan, K P, Kapur, A (2004). Revascularisation in diabetics with multivessel coronary artery disease. Heart 90: 999-1002 [Full Text]  
• McCaul, K A, Hobbs, M S T, Knuiman, M W, Rankin, J M, Gilfillan, I (2004). Trends in two year risk of repeat revascularisation or death from cardiovascular disease after coronary artery bypass grafting or percutaneous coronary intervention in Western Australia, 1980-2001. Heart 90: 1042-1046 [Abstract] [Full Text]  
• Eagle, K. A., Guyton, R. A., Davidoff, R., Edwards, F. H., Ewy, G. A., Gardner, T. J., Hart, J. C., Herrmann, H. C., Hillis, L. D., Hutter, A. M. Jr, Lytle, B. W., Marlow, R. A., Nugent, W. C., Orszulak, T. A., Antman, E. M., Smith, S. C. Jr, Alpert, J. S., Anderson, J. L., Faxon, D. P., Fuster, V., Gibbons, R. J., Gregoratos, G., Halperin, J. L., Hiratzka, L. F., Hunt, S. A., Jacobs, A. K., Ornato, J. P. (2004). ACC/AHA 2004 Guideline Update for Coronary Artery Bypass Graft Surgery: Summary Article: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Update the 1999 Guidelines for Coronary Artery Bypass Graft Surgery). Circulation 110: 1168-1176 [Full Text]  
• Weintraub, W S, Mahoney, E M, Zhang, Z, Chu, H, Hutton, J, Buxton, M, Booth, J, Nugara, F, Stables, R H, Dooley, P, Collinson, J, Stuteville, M, Delahunty, N, Wright, A, Flather, M D, De Cock, E (2004). One year comparison of costs of coronary surgery versus percutaneous coronary intervention in the stent or surgery trial. Heart 90: 782-788 [Abstract] [Full Text]  
• Crescenzi, G., Bove, T., Pappalardo, F., Scandroglio, A. M., Landoni, G., Aletti, G., Zangrillo, A., Alfieri, O. (2004). Clinical significance of a new Q wave after cardiac surgery. Eur. J. Cardiothorac. Surg. 25: 1001-1005 [Abstract] [Full Text]  
• Hueb, W., Soares, P. R., Gersh, B. J., Cesar, L. A. M., Luz, P. L., Puig, L. B., Martinez, E. M., Oliveira, S. A., Ramires, J. A. F. (2004). The medicine, angioplasty, or surgery study (MASS-II): a randomized, controlled clinical trial of three therapeutic strategies for multivessel coronary artery disease: One-year results. J Am Coll Cardiol 43: 1743-1751 [Abstract] [Full Text]  
• Brener, S. J., Lytle, B. W., Casserly, I. P., Schneider, J. P., Topol, E. J., Lauer, M. S. (2004). Propensity Analysis of Long-Term Survival After Surgical or Percutaneous Revascularization in Patients With Multivessel Coronary Artery Disease and High-Risk Features. Circulation 109: 2290-2295 [Abstract] [Full Text]  
• Mehran, R., Dangas, G. D., Kobayashi, Y., Lansky, A. J., Mintz, G. S., Aymong, E. D., Fahy, M., Moses, J. W., Stone, G. W., Leon, M. B. (2004). Short- and long-term results after multivessel stenting in diabetic patients. J Am Coll Cardiol 43: 1348-1354 [Abstract] [Full Text]  
• Berger, P. B., Sketch, M. H. Jr, Califf, R. M. (2004). Choosing Between Percutaneous Coronary Intervention and Coronary Artery Bypass Grafting for Patients With Multivessel Disease: What Can We Learn From the Arterial Revascularization Therapy Study (ARTS)?. Circulation 109: 1079-1081 [Full Text]  
• Qureshi, M. A., Safian, R. D., Grines, C. L., Goldstein, J. A., Westveer, D. C., Glazier, S., Balasubramanian, M., O'Neill, W. W. (2003). Simplified scoring system for predicting mortality after percutaneous coronary intervention. J Am Coll Cardiol 42: 1890-1895 [Abstract] [Full Text]  
• Smith, D (2003). The CARDia trial protocol. Heart 89: 1125-1126 [Full Text]  
• Mak, K.-H., Faxon, D. P. (2003). Clinical studies on coronary revascularization in patients with type 2 diabetes. Eur Heart J 24: 1087-1103 [Abstract] [Full Text]  
• Jain, A, Wadehra, V, Timmis, A D (2003). Management of stable angina. Postgrad. Med. J. 79: 332-336 [Abstract] [Full Text]  
• Rumsfeld, J. S., Magid, D. J., Plomondon, M. E., Sacks, J., Henderson, W., Hlatky, M., Sethi, G., Morrison, D. A., Veterans Affairs Angina With Extremely Serious Ope, (2003). Health-related quality of life after percutaneous coronary intervention versus coronary bypass surgery in high-risk patients with medically refractory ischemia. J Am Coll Cardiol 41: 1732-1738 [Abstract] [Full Text]  
• Schofield, P M (2003). Indications for percutaneous and surgical revascularisation: how far does the evidence base guide us?. Heart 89: 565-570 [Full Text]  
• Hoffman, S. N., TenBrook, J. A. Jr, Wolf, M. P., Pauker, S. G., Salem, D. N., Wong, J. B. (2003). A meta-analysis of randomized controlled trials comparing coronary artery bypass graft with percutaneous transluminal coronary angioplasty: one- to eight-year outcomes. J Am Coll Cardiol 41: 1293-1304 [Abstract] [Full Text]  
• Rodriguez, A, Rodriguez Alemparte, M, Baldi, J, Navia, J, Delacasa, A, Vogel, D, Oliveri, R, Fernandez Pereira, C, Bernardi, V, O'Neill, W, Palacios, I F (2003). Coronary stenting versus coronary bypass surgery in patients with multiple vessel disease and significant proximal LAD stenosis: results from the ERACI II study. Heart 89: 184-188 [Abstract] [Full Text]  
• Corr, L.A., Stables, R. (2003). Coronary revascularization: knife or catheter?. Eur Heart J Suppl 5: B43-B48 [Abstract]  
• Brener, S. J., Lytle, B. W., Schneider, J. P., Ellis, S. G., Topol, E. J. (2002). Association between CK-MB elevation after percutaneous or surgical revascularization and three-year mortality. J Am Coll Cardiol 40: 1961-1967 [Abstract] [Full Text]  
• Bertrand, M. E., Simoons, M. L., Fox, K. A.A., Wallentin, L. C., Hamm, C. W., McFadden, E., De Feyter, P. J., Specchia, G., Ruzyllo, W. (2002). Management of acute coronary syndromes in patients presenting without persistent ST-segment elevation. Eur Heart J 23: 1809-1840 [Full Text]  
• Sedlis, S. P., Morrison, D. A., Lorin, J. D., Esposito, R., Sethi, G., Sacks, J., Henderson, W., Grover, F., Ramanathan, K. B., Weiman, D., Saucedo, J., Antakli, T., Paramesh, V., Pett, S., Vernon, S., Birjiniuk, V., Welt, F., Krucoff, M., Wolfe, W., Lucke, J. C., Mediratta, S., Booth, D., Murphy, E., Ward, H., Miller, L., Kiesz, S., Barbiere, C., Lewis, D., Investigators of the Department of Veterans Affair, (2002). Percutaneous coronary intervention versus coronary bypass graft surgery for diabetic patients with unstable angina and risk factors for adverse outcomes with bypass: outcome of diabetic patients in the AWESOME randomized trial and registry. J Am Coll Cardiol 40: 1555-1566 [Abstract] [Full Text]  
• Amodeo, V. J., Donias, H. W., D'Ancona, G., Hoover, E. L., Karamanoukian, H. L. (2002). The Hybrid Approach to Coronary Artery Revascularization: Minimally Invasive Direct Coronary Artery Bypass with Percutaneous Coronary Intervention. ANGIOLOGY 53: 665-669 [Abstract]  
• Borkon, A. M., Muehlebach, G. F., House, J., Marso, S. P., Spertus, J. A. (2002). A comparison of the recovery of health status after percutaneous coronary intervention and coronary artery bypass. Ann. Thorac. Surg. 74: 1526-1530 [Abstract] [Full Text]  
• Charlson, M. E., Allegrante, J. P., McKinley, P. S., Peterson, J. C., Boutin-Foster, C., Ogedegbe, G., Young, C. R. (2002). Improving health behaviors and outcomes after angioplasty: using economic theory to inform intervention. Health Educ Res 17: 606-618 [Abstract] [Full Text]  
• Kapur, A, Malik, I S (2002). Is surgery still the preferred option for coronary revascularisation in diabetics with multivessel coronary disease?. Heart 87: 407-409 [Full Text]  
• van Domburg, R.T, Foley, D.P, Breeman, A, van Herwerden, L.A, Serruys, P.W (2002). Coronary artery bypass graft surgery and percutaneous transluminal coronary angioplasty. Twenty-year clinical outcome. Eur Heart J 23: 543-549 [Abstract] [Full Text]  
• van den Brand, M. J. B. M., Rensing, B. J. W. M., Morel, M.-a. M., Foley, D. P., de Valk, V., Breeman, A., Suryapranata, H., Haalebos, M. M. P., Wijns, W., Wellens, F., Balcon, R., Magee, P., Ribeiro, E., Buffolo, E., Unger, F., Serruys, P. W. (2002). The effect of completeness of revascularization on event-free survival at one year in the arts trial. J Am Coll Cardiol 39: 559-564 [Abstract] [Full Text]  
• Investigators of the Department of Veterans Affair, , the Angina With Extremely Serious Operative Mortal, , Morrison, D. A., Sethi, G., Sacks, J., Henderson, W., Grover, F., Sedlis, S., Esposito, R., Ramanathan, K. B., Weiman, D., Talley, J. D., Saucedo, J., Antakli, T., Paramesh, V., Pett, S., Vernon, S., Birjiniuk, V., Welt, F., Krucoff, M., Wolfe, W., Lucke, J. C., Mediratta, S., Booth, D., Barbiere, C., Lewis, D. (2002). Percutaneous coronary intervention versus coronary bypass graft surgery for patients with medically refractory myocardial ischemia and risk factors for adverse outcomes with bypass: the VA AWESOME multicenter registry: comparison with the randomized clinical trial. J Am Coll Cardiol 39: 266-273 [Abstract] [Full Text]  
• Fihn, S. D., Williams, S. V., Daley, J., Gibbons, R. J. (2001). Guidelines for the Management of Patients with Chronic Stable Angina: Treatment. ANN INTERN MED 135: 616-632 [Abstract] [Full Text]  
• Tan, W. A., Tamai, H., Park, S.-J., Plokker, H.W. T., Nobuyoshi, M., Suzuki, T., Colombo, A., Macaya, C., Holmes, D. R. Jr, Cohen, D. J., Whitlow, P. L., Ellis, S. G. (2001). Long-Term Clinical Outcomes After Unprotected Left Main Trunk Percutaneous Revascularization in 279 Patients. Circulation 104: 1609-1614 [Abstract] [Full Text]  
• Magee, M. J., Dewey, T. M., Acuff, T., Edgerton, J. R., Hebeler, J. F., Prince, S. L., Mack, M. J. (2001). Influence of diabetes on mortality and morbidity: off-pump coronary artery bypass grafting versus coronary artery bypass grafting with cardiopulmonary bypass. Ann. Thorac. Surg. 72: 776-781 [Abstract] [Full Text]  
• Herren, K R, Mackway-Jones, K, Richards, C R, Seneviratne, C J, France, M W, Cotter, L (2001). Is it possible to exclude a diagnosis of myocardial damage within six hours of admission to an emergency department? Diagnostic cohort study. BMJ 323: 372-372 [Abstract] [Full Text]  
• Abizaid, A., Costa, M. A., Centemero, M., Abizaid, A. S., Legrand, V. M.G., Limet, R. V., Schuler, G., Mohr, F. W., Lindeboom, W., Sousa, A. G.M.R., Sousa, J. E., van Hout, B., Hugenholtz, P. G., Unger, F., Serruys, P. W. (2001). Clinical and Economic Impact of Diabetes Mellitus on Percutaneous and Surgical Treatment of Multivessel Coronary Disease Patients: Insights From the Arterial Revascularization Therapy Study (ARTS) Trial. Circulation 104: 533-538 [Abstract] [Full Text]  
• Patil, C.V, Nikolsky, E, Boulos, M, Grenadier, E, Beyar, R (2001). Multivessel coronary artery disease: current revascularization strategies. Eur Heart J 22: 1183-1197  
• Morrison, D. A., Sethi, G., Sacks, J., Henderson, W., Grover, F., Sedlis, S., Esposito, R., Ramanathan, K., Weiman, D., Saucedo, J., Antakli, T., Paramesh, V., Pett, S., Vernon, S., Birjiniuk, V., Welt, F., Krucoff, M., Wolfe, W., Lucke, J. C., Mediratta, S., Booth, D., Barbiere, C., Lewis, D., for the Investigators of the Department of Veteran, (2001). Percutaneous coronary intervention versus coronary artery bypass graft surgery for patients with medically refractory myocardial ischemia and risk factors for adverse outcomes with bypass: a multicenter, randomized trial. J Am Coll Cardiol 38: 143-149 [Abstract] [Full Text]  
• Smith, S. C. Jr, Dove, J. T., Jacobs, A. K., Ward Kennedy, J., Kereiakes, D., Kern, M. J., Kuntz, R. E., Popma, J. J., Schaff, H. V., Williams, D. O., Gibbons, R. J., Alpert, J. P., Eagle, K. A., Faxon, D. P., Fuster, V., Gardner, T. J., Gregoratos, G., Russell, R. O., Smith, S. C. Jr (2001). ACC/AHA guidelines for percutaneous coronary intervention (revision of the 1993 PTCA guidelines): A report of the American College of Cardiology/ American Heart Association Task Force on practice guidelines (Committee to revise the 1993 guidelines for percutaneous transluminal coronary angioplasty) endorsed by the Society for Cardiac Angiography and Interventions. J Am Coll Cardiol 37: 2239-2239 [Full Text]  
• Metzdorff, M. T., Sapirstein, W., Zuckerman, B., Dillard, J., Eisenberg, M. J., Sheppard, R., Leon, M. B., Teirstein, P. S., Moses, J. W. (2001). Intracoronary Radiotherapy for Restenosis. NEJM 344: 1796-1797 [Full Text]  
• Pell, J P, Walsh, D, Norrie, J, Berg, G, Colquhoun, A D, Davidson, K, Eteiba, H, Faichney, A, Flapan, A, Hogg, K J, Jeffrey, R R, Jennings, K, McArthur, J, Mankad, P, Oldroyd, K, Pell, A C H, Starkey, I R (2001). Outcomes following coronary artery bypass grafting and percutaneous transluminal coronary angioplasty in the stent era: a prospective study of all 9890 consecutive patients operated on in Scotland over a two year period. Heart 85: 662-666 [Abstract] [Full Text]  
• Niles, N. W., McGrath, P. D., Malenka, D., Quinton, H., Wennberg, D., Shubrooks, S. J., Tryzelaar, J. F., Clough, R., Hearne, M. J., Hernandez, F. Jr, Watkins, M. W., O'Connor, G. T., for the Northern New England Cardiovascular Diseas, (2001). Survival of patients with diabetes and multivessel coronary artery disease after surgical or percutaneous coronary revascularization: results of a large regional prospective study. J Am Coll Cardiol 37: 1008-1015 [Abstract] [Full Text]  
• Pretre, R., Turina, M. I. (2001). Choice of Revascularization Strategy for Patients With Coronary Artery Disease. JAMA 285: 992-994 [Full Text]  
• Gibbons, R. J., Miller, D. D., Liu, P., Guo, P., Brooks, M. M., Schwaiger, M. (2001). Similarity of Ventricular Function in Patients Alive 5 Years After Randomization to Surgery or Angioplasty in the BARI Trial. Circulation 103: 1076-1082 [Abstract] [Full Text]  
• Rodriguez, A., Bernardi, V., Navia, J., Baldi, J., Grinfeld, L., Martinez, J., Vogel, D., Grinfeld, R., Delacasa, A., Garrido, M., Oliveri, R., Mele, E., Palacios, I., O'Neill, W., for the ERACI II Investigators, (2001). Argentine randomized study: coronary angioplasty with stenting versus coronary bypass surgery in patients with multiple-vessel disease (ERACI II): 30-day and one-year follow-up results. J Am Coll Cardiol 37: 51-58 [Abstract] [Full Text]  
• Ryan, T. J. (2001). Present-day PTCR versus CABG: a randomized comparison with a different focus and a new result. J Am Coll Cardiol 37: 59-62 [Full Text]  
• Herren, K R, Mackway-Jones, K (2001). Emergency management of cardiac chest pain: a review. Emerg. Med. J. 18: 6-10 [Full Text]  
• Williams, D. O., Holubkov, R., Yeh, W., Bourassa, M. G., Al-Bassam, M., Block, P. C., Coady, P., Cohen, H., Cowley, M., Dorros, G., Faxon, D., Holmes, D. R., Jacobs, A., Kelsey, S. F., King, S. B. III, Myler, R., Slater, J., Stanek, V., Vlachos, H. A., Detre, K. M. (2000). Percutaneous Coronary Intervention in the Current Era Compared With 1985-1986 : The National Heart, Lung, and Blood Institute Registries. Circulation 102: 2945-2951 [Abstract] [Full Text]  
• Bertrand, M.E, Simoons, M.L, Fox, K.A.A, Wallentin, L.C, Hamm, C.W, McFadden, E, de Feyter, P.J, Specchia, G, Ruzyllo, W (2000). Management of acute coronary syndromes: acute coronary syndromes without persistent ST segment elevation. Recommendations of the Task Force of the European Society of Cardiology: Recommendations of the Task Force of the European Society of Cardiology. Eur Heart J 21: 1406-1432  
• Hammoud, T., Tanguay, J.-F., Bourassa, M. G. (2000). Management of coronary artery disease: therapeutic options in patients with diabetes. J Am Coll Cardiol 36: 355-365 [Abstract] [Full Text]  
• Brooks, M. M., Jones, R. H., Bach, R. G., Chaitman, B. R., Kern, M. J., Orszulak, T. A., Follmann, D., Sopko, G., Blackstone, E. H., Califf, R. M. (2000). Predictors of Mortality and Mortality From Cardiac Causes in the Bypass Angioplasty Revascularization Investigation (BARI) Randomized Trial and Registry. Circulation 101: 2682-2689 [Abstract] [Full Text]  
• King, S. B. III, Kosinski, A. S., Guyton, R. A., Lembo, N. J., Weintraub, W. S., for the Emory Angioplasty Versus Surgery Trial (EA, (2000). Eight-year mortality in the Emory Angioplasty versus Surgery Trial (EAST). J Am Coll Cardiol 35: 1116-1121 [Abstract] [Full Text]  
• The BARI Investigators, (2000). Seven-year outcome in the Bypass Angioplasty Revascularization Investigation (BARI) by treatment and diabetic status. J Am Coll Cardiol 35: 1122-1129 [Abstract] [Full Text]  
• Ambrose, J. A., Dangas, G. (2000). Unstable Angina: Current Concepts of Pathogenesis and Treatment. Arch Intern Med 160: 25-37 [Abstract] [Full Text]  
• Rankin, J. M., Spinelli, J. J., Carere, R. G., Ricci, D. R., Penn, I. M., Hilton, J. D., Henderson, M. A., Hayden, R. I., Buller, C. E. (1999). Improved Clinical Outcome after Widespread Use of Coronary-Artery Stenting in Canada. NEJM 341: 1957-1965 [Abstract] [Full Text]  
• Ayanian, J.Z. (1999). Using administrative data to assess health care outcomes. Eur Heart J 20: 1689-1691  
• Lewsey, J.D, Murray, G.D, Leyland, A.H, Boddy, F.A (1999). Comparing outcomes of percutaneous transluminal coronary angioplasty with coronary artery bypass grafting. Can routine health service data complement and enhance randomized controlled trials?. Eur Heart J 20: 1731-1735 [Abstract]  
• Whitlow, P. L., Dimas, A. P., Bashore, T. M., Califf, R. M., Bourassa, M. G., Chaitman, B. R., Rosen, A. D., Kip, K. E., Stadius, M. L., Alderman, E. L., for the BARI Investigators, (1999). Relationship of extent of revascularization with angina at one year in the bypass angioplasty revascularization investigation (BARI). J Am Coll Cardiol 34: 1750-1759 [Abstract] [Full Text]  
• Hueb, W. A., Soares, P. R., Almeida de Oliveira, S., Arie, S., Cardoso, R. H. A., Wajsbrot, D. B., Cesar, L. A. M., Jatene, A. D., Ramires, J. A. F. (1999). Five-Year Follow-Up of the Medicine, Angioplasty, or Surgery Study (MASS) : A Prospective, Randomized Trial of Medical Therapy, Balloon Angioplasty, or Bypass Surgery for Single Proximal Left Anterior Descending Coronary Artery Stenosis. Circulation 100: II-107-113 [Abstract] [Full Text]