A Comparison of Balloon-Expandable-Stent Implantation with Balloon Angioplasty in Patients with Coronary Artery Disease
Patrick W. Serruys, Peter de Jaegere, Ferdinand Kiemeneij, Carlos Macaya, Wolfgang Rutsch, Guy Heyndrickx, Hakan Emanuelsson, Jean Marco, Victor Legrand, Pierre Materne, Jorge Belardi, Ulrich Sigwart, Antonio Colombo, Jean Jacques Goy, Paul van den Heuvel, Juan Delcan, Marie-angele Morel, for The Benestent Study Group
Background Balloon-expandable coronary-artery stents were developedto prevent coronary restenosis after coronary angioplasty. Thesedevices hold coronary vessels open at sites that have been dilated.However, it is unknown whether stenting improves long-term angiographicand clinical outcomes as compared with standard balloon angioplasty.
Methods A total of 520 patients with stable angina and a singlecoronary-artery lesion were randomly assigned to either stentimplantation (262 patients) or standard balloon angioplasty(258 patients). The primary clinical end points were death,the occurrence of a cerebrovascular accident, myocardial infarction,the need for coronary-artery bypass surgery, or a second percutaneousintervention involving the previously treated lesion, eitherat the time of the initial procedure or during the subsequentseven months. The primary angiographic end point was the minimalluminal diameter at follow-up, as determined by quantitativecoronary angiography.
Results After exclusions, 52 patients in the stent group (20percent) and 76 patients in the angioplasty group (30 percent)reached a primary clinical end point (relative risk, 0.68; 95percent confidence interval, 0.50 to 0.92; P = 0.02). The differencein clinical-event rates was explained mainly by a reduced needfor a second coronary angioplasty in the stent group (relativerisk, 0.58; 95 percent confidence interval, 0.40 to 0.85; P= 0.005). The mean (±SD) minimal luminal diameters immediatelyafter the procedure were 2.48 ±0.39 mm in the stent groupand 2.05 ±0.33 mm in the angioplasty group; at follow-up,the diameters were 1.82 ±0.64 mm in the stent group and1.73 ±0.55 mm in the angioplasty group (P = 0.09), whichcorrespond to rates of restenosis (diameter of stenosis, 50percent) of 22 and 32 percent, respectively (P = 0.02). Peripheralvascular complications necessitating surgery, blood transfusion,or both were more frequent after stenting than after balloonangioplasty (13.5 vs. 3.1 percent, P<0.001). The mean hospitalstay was significantly longer in the stent group than in theangioplasty group (8.5 vs. 3.1 days, P<0.001).
Conclusions Over seven months of follow-up, the clinical andangiographic outcomes were better in patients who received astent than in those who received standard coronary angioplasty.However, this benefit was achieved at the cost of a significantlyhigher risk of vascular complications at the access site anda longer hospital stay.
Source Information
From the University Hospital Rotterdam Dijkzigt, Thorax Center, Rotterdam, the Netherlands (P.W.S., P.J., M.A.M.); Onze Lieve Vrouwe Gasthuis, Amsterdam, the Netherlands (F.K.); University Hospital San Carlos, Madrid, Spain (C.M.); Universitatsklinikum Rudolf Virchow, Charlottenburg, Berlin, Germany (W.R.); Onze Lieve Vrouwe Kliniek, Aalst, Belgium (G.H.); Sahlgrenska Hospital, Goteborg, Sweden (H.E.); Clinique Pasteur, Toulouse, France (J.M.); Sart-Tilman Centre Hospitalier Universitaire, Liege, Belgium (V.L.); Hopital de la Citadelle, Liege, Belgium (P.M.); Instituto Cardiovascular de Buenos Aires, Buenos Aires, Argentina (J.B.); Royal Brompton National Heart and Lung Institute, London (U.S.); Centro Cuore Columbus, Milan, Italy (A.C.); Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland (J.J.G.); Middelheim Ziekenhuis, Antwerp, Belgium (P.H.); and Gregorio Maranon, Madrid, Spain (J.D.). The remaining investigators in the Benestent Study Group are listed in the Appendix.
Address reprint requests to Dr. Serruys at the Catheterization Laboratory, Thorax Center, Erasmus University Rotterdam, P.O. Box 1738, 3000 DR Rotterdam, the Netherlands.
Yokoyama, S., Takano, M., Yamamoto, M., Inami, S., Sakai, S., Okamatsu, K., Okuni, S., Seimiya, K., Murakami, D., Ohba, T., Uemura, R., Seino, Y., Hata, N., Mizuno, K.
(2009). Extended Follow-Up by Serial Angioscopic Observation for Bare-Metal Stents in Native Coronary Arteries: From Healing Response to Atherosclerotic Transformation of Neointima. Circ Cardiovasc Intervent
2: 205-212
[Abstract][Full Text]
Nakazawa, G., Vorpahl, M., Finn, A. V., Narula, J., Virmani, R.
(2009). One step forward and two steps back with drug-eluting-stents from preventing restenosis to causing late thrombosis and nouveau atherosclerosis.. J Am Coll Cardiol Img
2: 625-628
[Full Text]
Steinhubl, S. R., Berger, P. B.
(2009). Aspirin following PCI: too much of a good thing?. Eur Heart J
30: 882-884
[Full Text]
Waksman, R., Erbel, R., Di Mario, C., Bartunek, J., de Bruyne, B., Eberli, F. R., Erne, P., Haude, M., Horrigan, M., Ilsley, C., Bose, D., Bonnier, H., Koolen, J., Luscher, T. F., Weissman, N. J., on behalf of the PROGRESS-AMS (Clinical Performanc,
(2009). Early- and Long-Term Intravascular Ultrasound and Angiographic Findings After Bioabsorbable Magnesium Stent Implantation in Human Coronary Arteries. J Am Coll Cardiol Intv
2: 312-320
[Abstract][Full Text]
Shishehbor, M. H., Filby, S. J., Chhatriwalla, A. K., Christofferson, R. D., Jain, A., Kapadia, S. R., Lincoff, A. M., Bhatt, D. L., Ellis, S. G.
(2009). Impact of Drug-Eluting Versus Bare-Metal Stents on Mortality in Patients With Anemia. J Am Coll Cardiol Intv
2: 329-336
[Abstract][Full Text]
Russo, R. J., Silva, P. D., Teirstein, P. S., Attubato, M. J., Davidson, C. J., DeFranco, A. C., Fitzgerald, P. J., Goldberg, S. L., Hermiller, J. B., Leon, M. B., Ling, F. S., Lucisano, J. E., Schatz, R. A., Wong, S. C., Weissman, N. J., Zientek, D. M., for the AVID Investigators,
(2009). A Randomized Controlled Trial of Angiography Versus Intravascular Ultrasound-Directed Bare-Metal Coronary Stent Placement (The AVID Trial). Circ Cardiovasc Intervent
2: 113-123
[Abstract][Full Text]
Sourgounis, A., Lipiecki, J., Lo, T. S., Hamon, M.
(2009). Coronary Stents and Chronic Anticoagulation. Circulation
119: 1682-1688
[Full Text]
Bittl, J. A.
(2009). Drug-eluting stents for saphenous vein graft lesions: the limits of evidence.. J Am Coll Cardiol
53: 929-930
[Full Text]
Colombo, A., Bramucci, E., Sacca, S., Violini, R., Lettieri, C., Zanini, R., Sheiban, I., Paloscia, L., Grube, E., Schofer, J., Bolognese, L., Orlandi, M., Niccoli, G., Latib, A., Airoldi, F.
(2009). Randomized Study of the Crush Technique Versus Provisional Side-Branch Stenting in True Coronary Bifurcations: The CACTUS (Coronary Bifurcations: Application of the Crushing Technique Using Sirolimus-Eluting Stents) Study. Circulation
119: 71-78
[Abstract][Full Text]
Chhatriwalla, A. K., Bhatt, D. L.
(2008). Should dual antiplatelet therapy after drug-eluting stents be continued for more than 1 year?: Dual Antiplatelet Therapy After Drug-Eluting Stents Should Be Continued for More Than One Year and Preferably Indefinitely. Circ Cardiovasc Intervent
1: 217-225
[Full Text]
Shih, C., Berliner, E.
(2008). Diffusion Of New Technology And Payment Policies: Coronary Stents. Health Aff (Millwood)
27: 1566-1576
[Abstract][Full Text]
Firth, B. G., Cooper, L. M., Fearn, S.
(2008). The Appropriate Role Of Cost-Effectiveness In Determining Device Coverage: A Case Study Of Drug-Eluting Stents. Health Aff (Millwood)
27: 1577-1586
[Abstract][Full Text]
Niemela, K. O.
(2008). Biodegradable coating for drug-eluting stents--more than a facelift?. Eur Heart J
29: 1930-1931
[Full Text]
Holmes, D. R. Jr, Williams, D. O.
(2008). Catheter-Based Treatment of Coronary Artery Disease: Past, Present, and Future. Circ Cardiovasc Intervent
1: 60-73
[Abstract][Full Text]
Newsome, L. T., Kutcher, M. A., Royster, R. L.
(2008). Coronary Artery Stents: Part I. Evolution of Percutaneous Coronary Intervention. Anesth. Analg.
107: 552-569
[Abstract][Full Text]
Yao, E.-H., Fukuda, N., Ueno, T., Matsuda, H., Matsumoto, K., Nagase, H., Matsumoto, Y., Takasaka, A., Serie, K., Sugiyama, H., Sawamura, T.
(2008). Novel Gene Silencer Pyrrole-Imidazole Polyamide Targeting Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Attenuates Restenosis of the Artery After Injury. Hypertension
52: 86-92
[Abstract][Full Text]
Harrington, R. A., Becker, R. C., Cannon, C. P., Gutterman, D., Lincoff, A. M., Popma, J. J., Steg, G., Guyatt, G. H., Goodman, S. G.
(2008). Antithrombotic Therapy for Non-ST-Segment Elevation Acute Coronary Syndromes: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest
133: 670S-707S
[Abstract][Full Text]
Bhatt, S. H, Hauser, T. H
(2008). Very Late Stent Thrombosis After Dual Antiplatelet Therapy Discontinuation in a Patient with a History of Acute Stent Thrombosis. The Annals of Pharmacotherapy
42: 708-712
[Abstract][Full Text]
Mauri, L., Normand, S.-L. T.
(2008). Studies of Drug-Eluting Stents: To Each His Own?. Circulation
117: 2047-2050
[Full Text]
Hannan, E. L., Racz, M., Holmes, D. R., Walford, G., Sharma, S., Katz, S., Jones, R. H., King, S. B. III
(2008). Comparison of Coronary Artery Stenting Outcomes in the Eras Before and After the Introduction of Drug-Eluting Stents. Circulation
117: 2071-2078
[Abstract][Full Text]
Bonello, L., Camoin-Jau, L., Arques, S., Boyer, C., Panagides, D., Wittenberg, O., Simeoni, M.-C., Barragan, P., Dignat-George, F., Paganelli, F.
(2008). Adjusted Clopidogrel Loading Doses According to Vasodilator-Stimulated Phosphoprotein Phosphorylation Index Decrease Rate of Major Adverse Cardiovascular Events in Patients With Clopidogrel Resistance: A Multicenter Randomized Prospective Study. J Am Coll Cardiol
51: 1404-1411
[Abstract][Full Text]
Doyle, B. J., Ting, H. H., Bell, M. R., Lennon, R. J., Mathew, V., Singh, M., Holmes, D. R., Rihal, C. S.
(2008). Major Femoral Bleeding Complications After Percutaneous Coronary Intervention: Incidence, Predictors, and Impact on Long-Term Survival Among 17,901 Patients Treated at the Mayo Clinic From 1994 to 2005. J Am Coll Cardiol Intv
1: 202-209
[Abstract][Full Text]
Chadjichristos, C. E., Morel, S., Derouette, J.-P., Sutter, E., Roth, I., Brisset, A. C., Bochaton-Piallat, M.-L., Kwak, B. R.
(2008). Targeting Connexin 43 Prevents Platelet-Derived Growth Factor-BB-Induced Phenotypic Change in Porcine Coronary Artery Smooth Muscle Cells. Circ. Res.
102: 653-660
[Abstract][Full Text]
Pinto Slottow, T. L., Waksman, R.
(2008). Overview of the 2007 Food and Drug Administration Circulatory System Devices Panel Meeting on the Endeavor Zotarolimus-Eluting Coronary Stent. Circulation
117: 1603-1608
[Full Text]
Altin, T., Berkalp, B., Ozdol, C., Akyurek, O., Sayin, T., Kervancioglu, C., Oral, D., Erol, C.
(2008). Angiographic Restenosis in Ephesos Coronary Stents: Experience From a Large Medical Center in Ankara, Turkey. ANGIOLOGY
59: 47-51
[Abstract]
Brown, M. L., Sundt, T. M. III, Gersh, B. J.
(2008). Indications for Revascularization. Card Surg Adult
3: 551-572
[Full Text]
Wilson, J. M., Willerson, J. T.
(2008). Myocardial Revascularization with Percutaneous Devices. Card Surg Adult
3: 573-598
[Full Text]
Jensen, L. O., Thayssen, P., Thuesen, L., Hansen, H. S., Lassen, J. F., Kelbaek, H., Junker, A., Hansen, K. N., Boetker, H. E., Krusell, L. R., Pedersen, K. E.
(2007). Influence of a Pressure Gradient Distal to Implanted Bare-Metal Stent on In-Stent Restenosis After Percutaneous Coronary Intervention. Circulation
116: 2802-2808
[Abstract][Full Text]
Williams, D. O., Abbott, J. D.
(2007). Et Tu, Bare Metal Stent?. Circulation
116: 2363-2365
[Full Text]
Bode, C., Zehender, M.
(2007). The use of antiplatelet agents following percutaneous coronary intervention: focus on late stent thrombosis. Eur Heart J Suppl
9: D10-D19
[Abstract][Full Text]
Fiorella, D., Woo, H. H.
(2007). Emerging Endovascular Therapies for Symptomatic Intracranial Atherosclerotic Disease. Stroke
38: 2391-2396
[Full Text]
Katritsis, D. G., Ioannidis, J. P.A., Wharton, T. P. Jr., Umans, V. A., Peels, H. O., Shah, A. P., Shavelle, D. M., French, W. J., De Servi, S., Kiat, H., Nagajothi, N., Velazquez-Cecena, J.-L. E., Khosla, S., Mak, K.-H., Boden, W. E., Teo, K. K., Weintraub, W. S., the COURAGE Trial Investigators,
(2007). PCI for Stable Coronary Disease. NEJM
357: 414-418
[Full Text]
Cademartiri, F., Schuijf, J. D., Pugliese, F., Mollet, N. R., Jukema, J. W., Maffei, E., Kroft, L. J., Palumbo, A., Ardissino, D., Serruys, P. W., Krestin, G. P., Van der Wall, E. E., de Feyter, P. J., Bax, J. J.
(2007). Usefulness of 64-Slice Multislice Computed Tomography Coronary Angiography to Assess In-Stent Restenosis. J Am Coll Cardiol
49: 2204-2210
[Abstract][Full Text]
Wong, S. H, Wan, S., Underwood, M. J
(2007). Myocardial Revascularization: Surgery or Stenting?. Asian Cardiovasc. Thorac. Ann.
15: 264-269
[Abstract][Full Text]
Jaumdally, R., Varma, C., Macfadyen, R. J., Lip, G. Y.H.
(2007). Coronary sinus blood sampling: an insight into local cardiac pathophysiology and treatment?. Eur Heart J
28: 929-940
[Abstract][Full Text]
Tiroch, K., Koch, W., von Beckerath, N., Kastrati, A., Schomig, A.
(2007). Heme oxygenase-1 gene promoter polymorphism and restenosis following coronary stenting. Eur Heart J
28: 968-973
[Abstract][Full Text]
Ali, Z. A., Alp, N. J., Lupton, H., Arnold, N., Bannister, T., Hu, Y., Mussa, S., Wheatcroft, M., Greaves, D. R., Gunn, J., Channon, K. M.
(2007). Increased In-Stent Stenosis in ApoE Knockout Mice: Insights from a Novel Mouse Model of Balloon Angioplasty and Stenting. Arterioscler. Thromb. Vasc. Bio.
27: 833-840
[Abstract][Full Text]
Camenzind, E., Steg, P. G., Wijns, W.
(2007). A Cause for Concern. Circulation
115: 1440-1455
[Full Text]
Mauri, L., Hsieh, W.-h., Massaro, J. M., Ho, K. K.L., D'Agostino, R., Cutlip, D. E.
(2007). Stent Thrombosis in Randomized Clinical Trials of Drug-Eluting Stents. NEJM
356: 1020-1029
[Abstract][Full Text]
Luscher, T. F., Steffel, J., Eberli, F. R., Joner, M., Nakazawa, G., Tanner, F. C., Virmani, R.
(2007). Drug-Eluting Stent and Coronary Thrombosis: Biological Mechanisms and Clinical Implications. Circulation
115: 1051-1058
[Abstract][Full Text]
Denvir, M A, Lee, A J, Rysdale, J, Prescott, R J, Eteiba, H, Starkey, I R, Pell, J P, Walker, A
(2007). Effects of changing clinical practice on costs and outcomes of percutaneous coronary intervention between 1998 and 2002. Heart
93: 195-199
[Abstract][Full Text]
Tang, L., Chen, X., Tang, S., LaLonde, T., Gardin, J. M
(2007). Granulation encapsulated stent: a new therapeutic approach for vascular implantation. Heart
93: 238-243
[Abstract][Full Text]
Weisfeldt, M. L., Zieman, S. J.
(2007). Advances In The Prevention And Treatment Of Cardiovascular Disease. Health Aff (Millwood)
26: 25-37
[Abstract][Full Text]
Park, D.-W., Hong, M.-K., Mintz, G. S., Lee, C. W., Song, J.-M., Han, K.-H., Kang, D.-H., Cheong, S.-S., Song, J.-K., Kim, J.-J., Weissman, N. J., Park, S.-W., Park, S.-J.
(2006). Two-Year Follow-Up of the Quantitative Angiographic and Volumetric Intravascular Ultrasound Analysis After Nonpolymeric Paclitaxel-Eluting Stent Implantation: Late "Catch-Up" Phenomenon From ASPECT Study. J Am Coll Cardiol
48: 2432-2439
[Abstract][Full Text]
Ashley, E. A., Ferrara, R., King, J. Y., Vailaya, A., Kuchinsky, A., He, X., Byers, B., Gerckens, U., Oblin, S., Tsalenko, A., Soito, A., Spin, J. M., Tabibiazar, R., Connolly, A. J., Simpson, J. B., Grube, E., Quertermous, T.
(2006). Network Analysis of Human In-Stent Restenosis. Circulation
114: 2644-2654
[Abstract][Full Text]
Nordmann, A. J., Briel, M., Bucher, H. C.
(2006). Mortality in randomized controlled trials comparing drug-eluting vs. bare metal stents in coronary artery disease: a meta-analysis. Eur Heart J
27: 2784-2814
[Abstract][Full Text]
Camenzind, E.
(2006). Treatment of In-Stent Restenosis -- Back to the Future?. NEJM
355: 2149-2151
[Full Text]
Yan, S.-F., Harja, E., Andrassy, M., Fujita, T., Schmidt, A. M.
(2006). Protein Kinase C {beta}/Early Growth Response-1 Pathway: A Key Player in Ischemia, Atherosclerosis, and Restenosis. J Am Coll Cardiol
48: A47-A55
[Abstract][Full Text]
Eisenberg, M. J.
(2006). Drug-Eluting Stents: The Price Is Not Right. Circulation
114: 1745-1754
[Full Text]
Ilkay, E., Tirikli, L., Ozercan, I., Yavuzkir, M., Karaca, I., Rahman, A., Arslan, N.
(2006). Oral Mycophenolate Mofetil Prevents In-Stent Intimal Hyperplasia Without Edge Effect. ANGIOLOGY
57: 577-584
[Abstract]
Yokouchi, K., Numaguchi, Y., Kubota, R., Ishii, M., Imai, H., Murakami, R., Ogawa, Y., Kondo, T., Okumura, K., Ingber, D. E., Murohara, T.
(2006). l-Caldesmon Regulates Proliferation and Migration of Vascular Smooth Muscle Cells and Inhibits Neointimal Formation After Angioplasty. Arterioscler. Thromb. Vasc. Bio.
26: 2231-2237
[Abstract][Full Text]
Suttorp, M. J., Laarman, G. J., Rahel, B. M., Kelder, J. C., Bosschaert, M. A.R., Kiemeneij, F., ten Berg, J. M., Bal, E. T., Rensing, B. J., Eefting, F. D., Mast, E. G.
(2006). Primary Stenting of Totally Occluded Native Coronary Arteries II (PRISON II): A Randomized Comparison of Bare Metal Stent Implantation With Sirolimus-Eluting Stent Implantation for the Treatment of Total Coronary Occlusions. Circulation
114: 921-928
[Abstract][Full Text]
Cin, V. G., Pekdemir, H., Akkus, M. N., Camsari, A., Doven, O., Yenihan, S.
(2006). Cutting Balloon Angioplasty for the Treatment of In-Stent Restenosis in Diabetics: A Matched Comparison of 6 Months' Outcome With Conventional Balloon Angioplasty. ANGIOLOGY
57: 445-452
[Abstract]
Ozdemir, R., Sezgin, A. T., Barutcu, I., Topal, E., Gullu, H., Acikgoz, N.
(2006). Comparison of Direct Stenting Versus Conventional Stent Implantation on Blood Flow in Patients With ST-Segment Elevation Myocardial Infarction. ANGIOLOGY
57: 453-458
[Abstract]
Waksman, R, Leitch, I M, Roessler, J, Yazdi, H, Seabron, R, Tio, F, Scott, R W, Grove, R I, Rychnovsky, S, Robinson, B, Pakala, R, Cheneau, E
(2006). Intracoronary photodynamic therapy reduces neointimal growth without suppressing re-endothelialisation in a porcine model. Heart
92: 1138-1144
[Abstract][Full Text]
Ong, A. T.L., Serruys, P. W.
(2006). Complete Revascularization: Coronary Artery Bypass Graft Surgery Versus Percutaneous Coronary Intervention. Circulation
114: 249-255
[Full Text]
Numaguchi, Y., Sone, T., Okumura, K., Ishii, M., Morita, Y., Kubota, R., Yokouchi, K., Imai, H., Harada, M., Osanai, H., Kondo, T., Murohara, T.
(2006). The Impact of the Capability of Circulating Progenitor Cell to Differentiate on Myocardial Salvage in Patients With Primary Acute Myocardial Infarction. Circulation
114: I-114-I-119
[Abstract][Full Text]
Chadjichristos, C. E., Matter, C. M., Roth, I., Sutter, E., Pelli, G., Luscher, T. F., Chanson, M., Kwak, B. R.
(2006). Reduced Connexin43 Expression Limits Neointima Formation After Balloon Distension Injury in Hypercholesterolemic Mice. Circulation
113: 2835-2843
[Abstract][Full Text]
Alfonso, F., Perez-Vizcayno, M.-J., Hernandez, R., Bethencourt, A., Marti, V., Lopez-Minguez, J. R., Angel, J., Mantilla, R., Moris, C., Cequier, A., Sabate, M., Escaned, J., Moreno, R., Banuelos, C., Suarez, A., Macaya, C., for the RIBS-II Investigators,
(2006). A Randomized Comparison of Sirolimus-Eluting Stent With Balloon Angioplasty in Patients With In-Stent Restenosis: Results of the Restenosis Intrastent: Balloon Angioplasty Versus Elective Sirolimus-Eluting Stenting (RIBS-II) Trial. J Am Coll Cardiol
47: 2152-2160
[Abstract][Full Text]
Krueger, K D, Mitra, A K, DelCore, M G, Hunter, W J III, Agrawal, D K
(2006). A comparison of stent-induced stenosis in coronary and peripheral arteries. J. Clin. Pathol.
59: 575-579
[Abstract][Full Text]
Serruys, P. W.
(2006). Fourth Annual American College of Cardiology International Lecture: A Journey in the Interventional Field. J Am Coll Cardiol
47: 1754-1768
[Full Text]
Haan, C. K., O'Brien, S., Edwards, F. H., Peterson, E. D., Ferguson, T. B.
(2006). Trends in emergency coronary artery bypass grafting after percutaneous coronary intervention, 1994-2003.. Ann. Thorac. Surg.
81: 1658-1665
[Abstract][Full Text]
Roiron, C, Sanchez, P, Bouzamondo, A, Lechat, P, Montalescot, G
(2006). Drug eluting stents: an updated meta-analysis of randomised controlled trials. Heart
92: 641-649
[Abstract][Full Text]
Pugliese, F., Cademartiri, F., van Mieghem, C., Meijboom, W. B., Malagutti, P., Mollet, N. R. A., Martinoli, C., de Feyter, P. J., Krestin, G. P.
(2006). Multidetector CT for visualization of coronary stents.. RadioGraphics
26: 887-904
[Abstract][Full Text]
Rodriguez, A. E., Granada, J. F., Rodriguez-Alemparte, M., Vigo, C. F., Delgado, J., Fernandez-Pereira, C., Pocovi, A., Rodriguez-Granillo, A. M., Schulz, D., Raizner, A. E., Palacios, I., O'Neill, W., Kaluza, G. L., Stone, G., for the ORAR II Investigators,
(2006). Oral Rapamycin After Coronary Bare-Metal Stent Implantation to Prevent Restenosis: The Prospective, Randomized Oral Rapamycin in Argentina (ORAR II) Study. J Am Coll Cardiol
47: 1522-1529
[Abstract][Full Text]
Holmes, D. R. Jr, Teirstein, P., Satler, L., Sketch, M., O'Malley, J., Popma, J. J., Kuntz, R. E., Fitzgerald, P. J., Wang, H., Caramanica, E., Cohen, S. A., for the SISR Investigators,
(2006). Sirolimus-Eluting Stents vs Vascular Brachytherapy for In-Stent Restenosis Within Bare-Metal Stents: The SISR Randomized Trial. JAMA
295: 1264-1273
[Abstract][Full Text]
Kim, W., Jeong, M. H., Kim, K. H., Sohn, I. S., Hong, Y. J., Park, H. W., Kim, J. H., Ahn, Y. K., Cho, J. G., Park, J. C., Cho, D. L., Kang, J. C.
(2006). The Clinical Results of a Platelet Glycoprotein IIb/IIIa Receptor Blocker (Abciximab: ReoPro)-Coated Stent in Acute Myocardial Infarction. J Am Coll Cardiol
47: 933-938
[Abstract][Full Text]
Mitra, A K, Agrawal, D K
(2006). In stent restenosis: bane of the stent era.. J. Clin. Pathol.
59: 232-239
[Abstract][Full Text]
Serruys, P. W., Kutryk, M. J.B., Ong, A. T.L.
(2006). Coronary-Artery Stents. NEJM
354: 483-495
[Full Text]
Lee, C.-H., Tan, H.-C., Lim, Y.-T.
(2006). Update on Drug-Eluting Stents for Prevention of Restenosis. Asian Cardiovasc. Thorac. Ann.
14: 75-82
[Abstract][Full Text]
Mehilli, J., Dibra, A., Kastrati, A., Pache, J., Dirschinger, J., Schomig, A., for the Intracoronary Drug-Eluting Stenting to Abr,
(2006). Randomized trial of paclitaxel- and sirolimus-eluting stents in small coronary vessels. Eur Heart J
27: 260-266
[Abstract][Full Text]
Batyraliev, T. A., Pershukov, I. V., Niyazova-Karben, Z. A., Karaus, A., Calenici, O., Guler, N., Eryonucu, B., Temamogullari, A., Ozgul, S., Akgul, F., Sengul, H., Dogru, O., Demirbas, O., Timoshin, I. S., Gaigukov, A. V., Petrakova, L. N., Peresypko, M. K., Sidorenko, B. A., International Invasive Cardiology Research Group,
(2006). Current Role of Laser Angioplasty of Restenotic Coronary Stents. ANGIOLOGY
57: 21-32
[Abstract]
Alvarez, W. Jr, Kapur, N. K.
(2005). Drug Eluting Stent Technology: A Paradigm Shift in the Treatment and Prevention of Restenosis. Journal of Pharmacy Practice
18: 461-478
[Abstract]
Dawkins, K D, Gershlick, T, de Belder, M, Chauhan, A, Venn, G, Schofield, P, Smith, D, Watkins, J, Gray, H H, Joint Working Group on Percutaneous Coronary Inter,
(2005). Percutaneous coronary intervention: recommendations for good practice and training. Heart
91: vi1-vi27
[Abstract][Full Text]
Pislaru, S., Simari, R. D.
(2005). The Translation of Transcription. Circ. Res.
97: 1083-1084
[Full Text]
De Luca, G., Suryapranata, H., Gregorio, G., Lange, H., Chiariello, M.
(2005). Homocysteine and Its Effects on In-Stent Restenosis. Circulation
112: e307-e311
[Full Text]
Nawarskas, J. J., Osborn, L. A.
(2005). Paclitaxel-eluting stents in coronary artery disease. Am J Health Syst Pharm
62: 2241-2251
[Abstract][Full Text]
Douglas, J. S. Jr, Holmes, D. R. Jr, Kereiakes, D. J., Grines, C. L., Block, E., Ghazzal, Z. M.B., Morris, D. C., Liberman, H., Parker, K., Jurkovitz, C., Murrah, N., Foster, J., Hyde, P., Mancini, G.B. J., Weintraub, W. S., for the Cilostazol for Restenosis Trial (CREST) In,
(2005). Coronary Stent Restenosis in Patients Treated With Cilostazol. Circulation
112: 2826-2832
[Abstract][Full Text]
Stone, G. W., Kandzari, D. E., Mehran, R., Colombo, A., Schwartz, R. S., Bailey, S., Moussa, I., Teirstein, P. S., Dangas, G., Baim, D. S., Selmon, M., Strauss, B. H., Tamai, H., Suzuki, T., Mitsudo, K., Katoh, O., Cox, D. A., Hoye, A., Mintz, G. S., Grube, E., Cannon, L. A., Reifart, N. J., Reisman, M., Abizaid, A., Moses, J. W., Leon, M. B., Serruys, P. W.
(2005). Percutaneous Recanalization of Chronically Occluded Coronary Arteries: A Consensus Document: Part I. Circulation
112: 2364-2372
[Full Text]
Inami, N., Nomura, S., Kajiura, T., Yamada, K., Nakamori, H., Takahashi, N., Tsuda, N., Fukuhara, S., Iwasaka, T.
(2005). Significance of {alpha}IIb{beta}3 in Subacute Stent ThrombosisAfter Percutaneous Coronary Intervention. CLIN APPL THROMB HEMOST
11: 455-459
[Abstract]
Valgimigli, M., Percoco, G., Cicchitelli, G., Campo, G., Gardini, E., Pellegrino, L., Malagutti, P., Giretti, C., Ferrari, R.
(2005). New and old strategies to afford the liberal use of drug-eluting stents in real-life scenarios. Eur Heart J Suppl
7: K31-K35
[Abstract][Full Text]
Alfonso, F., Auge, J. M., Zueco, J., Bethencourt, A., Lopez-Minguez, J. R., Hernandez, J. M., Bullones, J. A., Calvo, I., Esplugas, E., Perez-Vizcayno, M. J., Moreno, R., Fernandez, C., Hernandez, R., Gama-Ribeiro, V., for the RIBS Investigators,
(2005). Long-Term Results (Three to Five Years) of the Restenosis Intrastent: Balloon Angioplasty Versus Elective Stenting (RIBS) Randomized Study. J Am Coll Cardiol
46: 756-760
[Abstract][Full Text]
Zimarino, M., Calafiore, A. M., De Caterina, R.
(2005). Complete myocardial revascularization: between myth and reality. Eur Heart J
26: 1824-1830
[Abstract][Full Text]
Malenka, D. J., Leavitt, B. J., Hearne, M. J., Robb, J. F., Baribeau, Y. R., Ryan, T. J., Helm, R. E., Kellett, M. A., Dauerman, H. L., Dacey, L. J., Silver, M. T., VerLee, P. N., Weldner, P. W., Hettleman, B. D., Olmstead, E. M., Piper, W. D., O'Connor, G. T., for the Northern New England Cardiovascular Diseas,
(2005). Comparing Long-Term Survival of Patients With Multivessel Coronary Disease After CABG or PCI: Analysis of BARI-Like Patients in Northern New England. Circulation
112: I-371-I-376
[Abstract][Full Text]
Windecker, S., Remondino, A., Eberli, F. R., Juni, P., Raber, L., Wenaweser, P., Togni, M., Billinger, M., Tuller, D., Seiler, C., Roffi, M., Corti, R., Sutsch, G., Maier, W., Luscher, T., Hess, O. M., Egger, M., Meier, B.
(2005). Sirolimus-Eluting and Paclitaxel-Eluting Stents for Coronary Revascularization. NEJM
353: 653-662
[Abstract][Full Text]
Rodriguez, A. E., Baldi, J., Pereira, C. F., Navia, J., Alemparte, M. R., Delacasa, A., Vigo, F., Vogel, D., O'Neill, W., Palacios, I. F., on behalf of the ERACI II Investigators,
(2005). Five-Year Follow-Up of the Argentine Randomized Trial of Coronary Angioplasty With Stenting Versus Coronary Bypass Surgery in Patients With Multiple Vessel Disease (ERACI II). J Am Coll Cardiol
46: 582-588
[Abstract][Full Text]
50 percent) of 22 and 32 percent, respectively (P = 0.02). Peripheral vascular complications necessitating surgery, blood transfusion, or both were more frequent after stenting than after balloon angioplasty (13.5 vs. 3.1 percent, P<0.001). The mean hospital stay was significantly longer in the stent group than in the angioplasty group (8.5 vs. 3.1 days, P<0.001). 
