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Previous Volume 331:502-507 August 25, 1994 Number 8 Next

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ABSTRACT

Background The combination of radiation therapy and chemotherapy with fluorouracil plus semustine after surgery has been established as an effective approach to decreasing the risk of tumor relapse and improving survival in patients with rectal cancer who are at high risk for relapse or death. We sought to determine whether the efficacy of chemotherapy could be improved by administering fluorouracil by protracted infusion throughout the duration of radiation therapy and whether the omission of semustine would reduce the toxicity and delayed complications of chemotherapy without decreasing its antitumor efficacy.

Methods Six hundred sixty patients with TNM stage II or III rectal cancer received intermittent bolus injections or protracted venous infusions of fluorouracil during postoperative radiation to the pelvis. They also received systemic chemotherapy with semustine plus fluorouracil or with fluorouracil alone in a higher dose, both before and after the pelvic irradiation.

Results With a median follow-up of 46 months among surviving patients, patients who received a protracted infusion of fluorouracil had a significantly increased time to relapse (P = 0.01) and improved survival (P = 0.005). There was no evidence of a beneficial effect in the patients who received semustine plus fluorouracil.

Conclusions A protracted infusion of fluorouracil during pelvic irradiation improved the effect of combined-treatment postoperative adjuvant therapy in patients with high-risk rectal cancer. Semustine plus fluorouracil was not more effective than a higher dose of systemic fluorouracil given alone.

Source Information

From the Mayo Clinic, Rochester, Minn. (M.J.O., J.A.M., H.S.W., L.L.G.); the Duluth Clinic, Duluth, Minn. (J.E.K.); Temple University School of Medicine (J.S.M.) and the University of Pennsylvania Cancer Center (D.G.H.), Philadelphia; the Dana-Farber Cancer Institute, Boston (R.J.M.); and the M.D. Anderson Cancer Center, Houston (T.A.R.).Coordinated by the North Central Cancer Treatment Group, Rochester, Minn. Other participants include the Southwest Oncology Group, the Eastern Cooperative Oncology Group, Cancer and Acute Leukemia Group B, the Radiation Therapy Oncology Group, and the M.D. Anderson Cancer Center.

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• Dorudi, S., Steele, R. J., McArdle, C. S (2002). Surgery for colorectal cancer. Br Med Bull 64: 101-118 [Abstract] [Full Text]  
• Dunst, J., Reese, T., Sutter, T., Zuhlke, H., Hinke, A., Kolling-Schlebusch, K., Frings, S. (2002). Phase I Trial Evaluating the Concurrent Combination of Radiotherapy and Capecitabine in Rectal Cancer. JCO 20: 3983-3991 [Abstract] [Full Text]  
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• Potosky, A. L., Harlan, L. C., Kaplan, R. S., Johnson, K. A., Lynch, C. F. (2002). Age, Sex, and Racial Differences in the Use of Standard Adjuvant Therapy for Colorectal Cancer. JCO 20: 1192-1202 [Abstract] [Full Text]  
• Onaitis, M. W., Noone, R. B., Fields, R., Hurwitz, H., Morse, M., Jowell, P., McGrath, K., Lee, C., Anscher, M. S., Clary, B., Mantyh, C., Pappas, T. N., Ludwig, K., Seigler, H. F., Tyler, D. S. (2001). Complete Response to Neoadjuvant Chemoradiation for Rectal Cancer Does Not Influence Survival. Ann. Surg. Oncol. 8: 801-806 [Abstract] [Full Text]  
• Stocchi, L., Nelson, H., Sargent, D. J., O'Connell, M. J., Tepper, J. E., Krook, J. E., Beart, R. Jr (2001). Impact of Surgical and Pathologic Variables in Rectal Cancer: A United States Community and Cooperative Group Report. JCO 19: 3895-3902 [Abstract] [Full Text]  
• Glynne-Jones, R., Debus, J. (2001). Improving Chemoradiotherapy in Rectal Cancer. The Oncologist 6: 29-34 [Abstract] [Full Text]  
• Freyer, G., Bossard, N., Romestaing, P., Mornex, F., Chapet, O., Trillet-Lenoir, V., Gerard, J.-P. (2001). Addition of Oxaliplatin to Continuous Fluorouracil, L-Folinic Acid, and Concomitant Radiotherapy in Rectal Cancer: The Lyon R 97-03 Phase I Trial. JCO 19: 2433-2438 [Abstract] [Full Text]  
• Kuvshinoff, B., Maghfoor, I., Miedema, B., Bryer, M., Westgate, S., Wilkes, J., Ota, D. (2001). Distal Margin Requirements After Preoperative Chemoradiotherapy for Distal Rectal Carcinomas: Are <= 1 cm Distal Margins Sufficient?. Ann. Surg. Oncol. 8: 163-169 [Abstract] [Full Text]  
• Hoff, P. M., Janjan, N., Saad, E. D., Skibber, J., Crane, C., Lassere, Y., Cleary, K. R., Benner, S., Randolph, J., Abbruzzese, J. L., Pazdur, R. (2000). Phase I Study of Preoperative Oral Uracil and Tegafur Plus Leucovorin and Radiation Therapy in Rectal Cancer. JCO 18: 3529-3534 [Abstract] [Full Text]  
• Tempero, M., Leichner, P., Baranowska-Kortylewicz, J., Harrison, K., Augustine, S., Schlom, J., Anderson, J., Wisecarver, J., Colcher, D. (2000). High-Dose Therapy with 90Yttrium-labeled Monoclonal Antibody CC49: A Phase I Trial. Clin. Cancer Res. 6: 3095-3102 [Abstract] [Full Text]  
• Papamichael, D. (2000). The Use of Thymidylate Synthase Inhibitors in the Treatment of Advanced Colorectal Cancer: Current Status. Stem Cells 18: 166-175 [Abstract] [Full Text]  
• Martenson, J. A., Bollinger, J. W., Sloan, J. A., Novotny, P. J., Urias, R. E., Michalak, J. C., Shanahan, T. G., Mailliard, J. A., Levitt, R. (2000). Sucralfate in the Prevention of Treatment-Induced Diarrhea in Patients Receiving Pelvic Radiation Therapy: A North Central Cancer Treatment Group Phase III Double-Blind Placebo-Controlled Trial. JCO 18: 1239-1245 [Abstract] [Full Text]  
• Wolmark, N., Wieand, H. S., Hyams, D. M., Colangelo, L., Dimitrov, N. V., Romond, E. H., Wexler, M., Prager, D., Cruz, A. B. Jr., Gordon, P. H., Petrelli, N. J., Deutsch, M., Mamounas, E., Wickerham, D. L., Fisher, E. R., Rockette, H., Fisher, B. (2000). Randomized Trial of Postoperative Adjuvant Chemotherapy With or Without Radiotherapy for Carcinoma of the Rectum: National Surgical Adjuvant Breast and Bowel Project Protocol R-02. JNCI J Natl Cancer Inst 92: 388-396 [Abstract] [Full Text]  
• Hwang, H.-S., Davis, T. W., Houghton, J. A., Kinsella, T. J. (2000). Radiosensitivity of Thymidylate Synthase-deficient Human Tumor Cells Is Affected by Progression through the G1 Restriction Point into S-Phase: Implications for Fluoropyrimidine Radiosensitization. Cancer Res. 60: 92-100 [Abstract] [Full Text]  
• Papamichael, D. (1999). The Use of Thymidylate Synthase Inhibitors in the Treatment of Advanced Colorectal Cancer: Current Status. The Oncologist 4: 478-487 [Abstract] [Full Text]  
• Halling, K. C., French, A. J., McDonnell, S. K., Burgart, L. J., Schaid, D. J., Peterson, B. J., Moon-Tasson, L., Mahoney, M. R., Sargent, D. J., O'Connell, M. J., Witzig, T. E., Farr, G. H. Jr., Goldberg, R. M., Thibodeau, S. N. (1999). Microsatellite Instability and 8p Allelic Imbalance in Stage B2 and C Colorectal Cancers. JNCI J Natl Cancer Inst 91: 1295-1303 [Abstract] [Full Text]  
• Francois, Y., Nemoz, C. J., Baulieux, J., Vignal, J., Grandjean, J.-P., Partensky, C., Souquet, J. C., Adeleine, P., Gerard, J.-P. (1999). Influence of the Interval Between Preoperative Radiation Therapy and Surgery on Downstaging and on the Rate of Sphincter-Sparing Surgery for Rectal Cancer: The Lyon R90-01 Randomized Trial. JCO 17: 2396-2396 [Abstract] [Full Text]  
• Schlemmer, H.-P., Becker, M., Bachert, P., Dietz, A., Rudat, V., Vanselow, B., Wollensack, P., Zuna, I., Knopp, M. V., Weidauer, H., Wannenmacher, M., van Kaick, G. (1999). Alterations of Intratumoral Pharmacokinetics of 5-Fluorouracil in Head and Neck Carcinoma during Simultaneous Radiochemotherapy. Cancer Res. 59: 2363-2369 [Abstract] [Full Text]  
• Morris, M., Eifel, P. J., Lu, J., Grigsby, P. W., Levenback, C., Stevens, R. E., Rotman, M., Gershenson, D. M., Mutch, D. G. (1999). Pelvic Radiation with Concurrent Chemotherapy Compared with Pelvic and Para-Aortic Radiation for High-Risk Cervical Cancer. NEJM 340: 1137-1143 [Abstract] [Full Text]  
• Mac Manus, M., Lamborn, K., Khan, W., Varghese, A., Graef, L., Knox, S. (1997). Radiotherapy-Associated Neutropenia and Thrombocytopenia: Analysis of Risk Factors and Development of a Predictive Model. Blood 89: 2303-2310 [Abstract] [Full Text]  
• Saltz, L. B., Kemeny, N. E. (1996). Adjuvant Chemotherapy of Colorectal Cancer. The Oncologist 1: 22-29 [Abstract] [Full Text]