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Previous Volume 332:635-641 March 9, 1995 Number 10 Next

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ABSTRACT

Background Increased levels of certain hemostatic factors may play a part in the development of acute coronary syndromes and may be associated with an increased risk of coronary events in patients with angina pectoris.

Methods We conducted a prospective multicenter study of 3043 patients with angina pectoris who underwent coronary angiography and were followed for two years. Base-line measurements included the concentrations of selected hemostatic factors indicative of a thrombophilic state or endothelial injury. The results were analyzed in relation to the subsequent incidence of myocardial infarction or sudden coronary death.

Results After adjustment for the extent of coronary artery disease and other risk factors, an increased incidence of myocardial infarction or sudden death was associated with higher base-line concentrations of fibrinogen (mean ±SD, 3.28±0.74 g per liter in patients who subsequently had coronary events, as compared with 3.00±0.71 g per liter in those who did not; P = 0.01), von Willebrand factor antigen (138±49 percent vs. 125±49 percent, P = 0.05), and tissue plasminogen activator (t-PA) antigen (11.9±4.7 ng per milliliter vs. 10.0±4.2 ng per milliliter, P = 0.02). The concentration of C-reactive protein was also directly correlated with the incidence of coronary events (P = 0.05), except when we adjusted for the fibrinogen concentration. In patients with high serum cholesterol levels, the risk of coronary events rose with increasing levels of fibrinogen and C-reactive protein, but the risk remained low even given high serum cholesterol levels in the presence of low fibrinogen concentrations.

Conclusions In patients with angina pectoris, the levels of fibrinogen, von Willebrand factor antigen, and t-PA antigen are independent predictors of subsequent acute coronary syndromes. In addition, low fibrinogen concentrations characterize patients at low risk for coronary events despite increased serum cholesterol levels. Our data are consistent with a pathogenetic role of impaired fibrinolysis, endothelial-cell injury, and inflammatory activity in the progression of coronary artery disease.

Source Information

From the Medical Statistics Unit, London School of Hygiene and Tropical Medicine, London (S.G.T., S.D.M.P.); the Department of Internal Medicine, University of Münster, Münster, Germany (J.K., J.C.W.L.); and the Gaubius Laboratory, Leiden, the Netherlands (F.H.).

Address reprint requests to Dr. van de Loo at the Department of Internal Medicine, University of Münster, Albert-Schweitzer-Str. 33, D-48129 Münster, Germany.

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Hemostatic Factors and the Risk of Myocardial Infarction
Otto C., Richter W. O., Ridker P. M., Vaughan D. E., van de Loo J. C.W., Haverkate F., Thompson S. G.
Extract | Full Text  
N Engl J Med 1995; 333:389-390, Aug 10, 1995. Correspondence

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• Anand, S. S., Yi, Q., Gerstein, H., Lonn, E., Jacobs, R., Vuksan, V., Teo, K., Davis, B., Montague, P., Yusuf, S. (2003). Relationship of Metabolic Syndrome and Fibrinolytic Dysfunction to Cardiovascular Disease. Circulation 108: 420-425 [Abstract] [Full Text]  
• Luc, G., Bard, J.-M., Juhan-Vague, I., Ferrieres, J., Evans, A., Amouyel, P., Arveiler, D., Fruchart, J.-C., Ducimetiere, P. (2003). C-Reactive Protein, Interleukin-6, and Fibrinogen as Predictors of Coronary Heart Disease: The PRIME Study. Arterioscler. Thromb. Vasc. Bio. 23: 1255-1261 [Abstract] [Full Text]  
• Liem, A., Reynierse-Buitenwerf, G. H., Zwinderman, A. H., Jukema, J. W., van Veldhuisen, D. J. (2003). Secondary prevention with folic acid: effects on clinical outcomes. J Am Coll Cardiol 41: 2105-2113 [Abstract] [Full Text]  
• Smith, J. C., Lane, H. A., Lewis, J., Dann, S., Goodfellow, J., Collins, P., Evans, L. M., Scanlon, M. F., Davies, J. S. (2003). Endothelial Function and Coagulant Factors in Growth Hormone-Treated Hypopituitary Adults Receiving Desmopressin. J. Clin. Endocrinol. Metab. 88: 2152-2156 [Abstract] [Full Text]  
• Heper, G., Bayraktaroglu, M. (2003). The Importance of von Willebrand Factor Level and Heart Rate Changes in Acute Coronary Syndromes: A Comparison with Chronic Ischemic Conditions. ANGIOLOGY 54: 287-299 [Abstract]  
• Curb, J. D., Abbott, R. D., Rodriguez, B. L., Sakkinen, P., Popper, J. S., Yano, K., Tracy, R. P. (2003). C-Reactive Protein and the Future Risk of Thromboembolic Stroke in Healthy Men. Circulation 107: 2016-2020 [Abstract] [Full Text]  
• Matsumoto, T., Minai, K., Horie, H., Ohira, N., Takashima, H., Tarutani, Y., Yasuda, Y. o, Ozawa, T., Matsuo, S., Kinoshita, M., Horie, M. (2003). Angiotensin-converting enzyme inhibition but not angiotensin II type 1 receptor antagonism augments coronary release of tissue plasminogen activator in hypertensive patients. J Am Coll Cardiol 41: 1373-1379 [Abstract] [Full Text]  
• Martiskainen, M., Pohjasvaara, T., Mikkelsson, J., Mantyla, R., Kunnas, T., Laippala, P., Ilveskoski, E., Kaste, M., Karhunen, P.J., Erkinjuntti, T. (2003). Fibrinogen Gene Promoter -455 A Allele as a Risk Factor for Lacunar Stroke. Stroke 34: 886-891 [Abstract] [Full Text]  
• Eidelman, R. S, Hennekens, C. H (2003). Fibrinogen: a predictor of stroke and marker of atherosclerosis. Eur Heart J 24: 499-500 [Full Text]  
• Glader, C.A, Birgander, L.S, Soderberg, S, Ildgruben, H.P, Saikku, P, Waldenstrom, A, Dahlen, G.H (2003). Lipoprotein(a), Chlamydia pneumoniae, leptin and tissue plasminogen activator as risk markers for valvular aortic stenosis. Eur Heart J 24: 198-208 [Abstract] [Full Text]  
• Oldgren, J, Wallentin, L, Grip, L, Linder, R, Norgaard, B.L, Siegbahn, A (2003). Myocardial damage, inflammation and thrombin inhibition in unstable coronary artery disease. Eur Heart J 24: 86-93 [Abstract] [Full Text]  
• Rabbani, L. E., Seminario, N. A., Sciacca, R. R., Chen, H. J., Giardina, E.-G. V. (2002). Oral conjugated equine estrogen increases plasma von Willebrand factor in postmenopausal women. J Am Coll Cardiol 40: 1991-1999 [Abstract] [Full Text]  
• Engstrom, G., Lind, P., Hedblad, B., Stavenow, L., Janzon, L., Lindgarde, F. (2002). Long-Term Effects of Inflammation-Sensitive Plasma Proteins and Systolic Blood Pressure on Incidence of Stroke. Stroke 33: 2744-2749 [Abstract] [Full Text]  
• Stangl, V., Baumann, G., Stangl, K. (2002). Coronary atherogenic risk factors in women. Eur Heart J 23: 1738-1752 [Full Text]  
• Whincup, P.H., Danesh, J., Walker, M., Lennon, L., Thomson, A., Appleby, P., Rumley, A., Lowe, G.D.O. (2002). von Willebrand factor and coronary heart disease. Prospective study and meta-analysis. Eur Heart J 23: 1764-1770 [Abstract] [Full Text]  
• Ruberg, F. L, Loscalzo, J. (2002). Prothrombotic determinants of coronary atherothrombosis. Vasc Med 7: 289-299 [Abstract]