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Previous Volume 334:693-700 March 14, 1996 Number 11 Next

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ABSTRACT

Background The role of orthotopic liver transplantation in the treatment of patients with cirrhosis and hepatocellular carcinoma is controversial, and determining which patients are likely to have a good outcome after liver transplantation is difficult.

Methods We studied 48 patients with cirrhosis who had small, unresectable hepatocellular carcinomas and who underwent liver transplantation. In 94 percent of the patients, the cirrhosis was related to infection with hepatitis B virus, hepatitis C virus, or both. The presence of tumor was confirmed by biopsy or serum alpha-fetoprotein assay. The criteria for eligibility for transplantation were the presence of a tumor 5 cm or less in diameter in patients with single hepatocellular carcinomas and no more than three tumor nodules, each 3 cm or less in diameter, in patients with multiple tumors. Twenty-eight patients with sufficient hepatic function underwent treatment for the tumor, mainly chemoembolization, before transplantation. After liver transplantation, the patients were followed prospectively for a median of 26 months (range, 9 to 54). No anticancer treatment was given after transplantation.

Results The overall mortality rate was 17 percent. After four years, the actuarial survival rate was 75 percent and the rate of recurrence-free survival was 83 percent. Hepatocellular carcinoma recurred in four patients (8 percent). The overall and recurrence-free survival rates at four years among the 35 patients (73 percent of the total) who met the predetermined criteria for the selection of small hepatocellular carcinomas at pathological review of the explanted liver were 85 percent and 92 percent, respectively, whereas the rates in the 13 patients (27 percent) whose tumors exceeded these limits were 50 percent and 59 percent, respectively (P = 0.01 for overall survival; P = 0.002 for recurrence-free survival). In this group of 48 patients with early-stage tumors, tumor–node–metastasis status, the number of tumors, the serum alpha-fetoprotein concentration, treatment received before transplantation, and 10 other variables were not significantly correlated with survival.

Conclusions Liver transplantation is an effective treatment for small, unresectable hepatocellular carcinomas in patients with cirrhosis.

Source Information

From the Liver Transplantation Unit, Department of Surgery (V.M., E.R., R.D., A.P., F.B., F.M., L.G.), and the Departments of Pathology (S.A.) and Anesthesia (M.A.), National Cancer Institute, and the Institute of Medical Statistics and Biometry, University of Milan (A.M.) — all in Milan, Italy.

Address reprint requests to Dr. Gennari at the Liver Transplantation Unit, Istituto Nazionale Tumori, Via Venezian 1, 20133 Milan, Italy.

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• Steingruber, I. E., Mallouhi, A., Czermak, B. V., Waldenberger, P., Gassner, E., Offner, F., Chemelli, A., Koenigsrainer, A., Vogel, W., Jaschke, W. R. (2003). Pretransplantation Evaluation of the Cirrhotic Liver with Explantation Correlation: Accuracy of CT Arterioportography and Digital Subtraction Hepatic Angiography in Revealing Hepatocellular Carcinoma. Am. J. Roentgenol. 181: 99-108 [Abstract] [Full Text]  
• Laurent, A., Cherqui, D., Lesurtel, M., Brunetti, F., Tayar, C., Fagniez, P.-L. (2003). Laparoscopic Liver Resection for Subcapsular Hepatocellular Carcinoma Complicating Chronic Liver Disease. Arch Surg 138: 763-769 [Abstract] [Full Text]  
• Santagostino, E., Colombo, M., Rivi, M., Rumi, M. G., Rocino, A., Linari, S., Mannucci, P. M. (2003). A 6-month versus a 12-month surveillance for hepatocellular carcinoma in 559 hemophiliacs infected with the hepatitis C virus. Blood 102: 78-82 [Abstract] [Full Text]  
• Brancatelli, G., Baron, R. L., Peterson, M. S., Marsh, W. (2003). Helical CT Screening for Hepatocellular Carcinoma in Patients with Cirrhosis: Frequency and Causes of False-Positive Interpretation. Am. J. Roentgenol. 180: 1007-1014 [Abstract] [Full Text]  
• Chan, S.-C., Liu, C.-L., Lo, C.-M., Lam, C.-M., Poon, R. T.-P., Yuen, W.-K., Fan, S.-T., Wong, J. (2003). Value of Live Donor Liver Transplantation Experience in Major Hepatectomy for Hepatocellular Carcinoma. Arch Surg 138: 265-271 [Abstract] [Full Text]  
• Bhartia, B., Ward, J., Guthrie, J. A., Robinson, P. J. (2003). Hepatocellular Carcinoma in Cirrhotic Livers: Double-Contrast Thin-Section MR Imaging with Pathologic Correlation of Explanted Tissue. Am. J. Roentgenol. 180: 577-584 [Abstract] [Full Text]  
• Shiratori, Y., Shiina, S., Teratani, T., Imamura, M., Obi, S., Sato, S., Koike, Y., Yoshida, H., Omata, M. (2003). Interferon Therapy after Tumor Ablation Improves Prognosis in Patients with Hepatocellular Carcinoma Associated with Hepatitis C Virus. ANN INTERN MED 138: 299-306 [Abstract] [Full Text]  
• Teefey, S. A., Hildeboldt, C. C., Dehdashti, F., Siegel, B. A., Peters, M. G., Heiken, J. P., Brown, J. J., McFarland, E. G., Middleton, W. D., Balfe, D. M., Ritter, J. H. (2003). Detection of Primary Hepatic Malignancy in Liver Transplant Candidates: Prospective Comparison of CT, MR Imaging, US, and PET. Radiology 226: 533-542 [Abstract] [Full Text]  
• Wiesner, R. H., Rakela, J., Ishitani, M. B., Mulligan, D. C., Spivey, J. R., Steers, J. L., Krom, R. A. F. (2003). Recent Advances in Liver Transplantation. Mayo Clin Proc. 78: 197-210 [Abstract]