Background Aortocoronary bypass surgery has been performed mostoften with the patient's saphenous vein as the conduit. Theinternal-thoracic-artery graft, which has superior patency rates,has been shown to have clinical advantages, but it is not knownhow long these advantages persist.
Methods We identified all the patients in the registry of theCoronary artery surgery study who had undergone first-time coronary-arterybypass grafting. Those with internal-thoracic-artery bypassgrafts (749 patients) were compared with those with saphenous-veinbypass grafts only (4888 patients) with respect to survivalover a 15-year follow-up period.
Results In a multivariate analysis to account for differencesbetween the two groups, the presence of an internal-thoracic-arterygraft was an independent predictor of improved survival andwas associated with a relative risk of dying of 0.73 (95 percentconfidence interval, 0.64 to 0.83). This improved survival wasalso observed in subgroups including patients 65 years of ageor older, both men and women, and patients with impaired ventricularfunction. The survival curves of the two groups showed furtherseparation over the years of follow-up, with a more marked downslopingafter eight years in the curve for the group with saphenous-veingrafts only than in that for the group with internal-thoracic-arterygrafts.
Conclusions As compared with saphenous-vein coronary bypassgrafts, internal-thoracic-artery grafts conferred a survivaladvantage throughout a 15-year follow-up period. The survivaladvantage increased with time, suggesting that the initial selectionof the conduit was a more important factor in survival thanproblems appearing long after surgery, such as the progressionof coronary disease.
Source Information
From the Divisions of Cardiology and Cardiothoracic Surgery, St. Luke'sRoosevelt Hospital Center and the College of Physicians and Surgeons, Columbia University, New York (A.C., G.G.); the Departments of Biostatistics and Medicine, University of Washington, Seattle (K.B.D.); and the Mayo Clinic, Rochester, Minn. (H.V.S.).
Address reprint requests to Dr. Cameron at the Division of Cardiology, St. Luke'sRoosevelt Hospital Center, 1111 Amsterdam Ave., New York, NY 10025.
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