Background In patients with acute ischemic stroke, early treatmentwith thrombolytic agents is thought to permit reperfusion ofischemic neurons and to promote recovery of function. The MulticenterAcute Stroke Trial — Europe (MAST-E) was designed to assessthe efficacy and safety of streptokinase in patients with acuteischemic stroke.
Methods Patients with moderate-to-severe ischemia in the territoryof the middle cerebral artery were randomly assigned to receivestreptokinase (1.5 million units over a period of one hour)or placebo within six hours after the onset of stroke. The primaryefficacy outcome was a binary criterion combining mortalityand severe disability at six months, with severe disabilitydefined as a score of 3 or higher on the Rankin scale. The primarysafety outcomes were mortality at 10 days and cerebral hemorrhage.
Results All randomized patients (156 in the streptokinase groupand 154 in the placebo group) were evaluated at six months.The incidence of the primary efficacy outcome was similar inthe two groups (124 patients in the streptokinase group and126 in the placebo group died or had a Rankin score >3).However, the mortality rate at 10 days was significantly higherin the streptokinase group than in the placebo group (34.0 percentvs. 18.2 percent, P = 0.002). The higher rate in the streptokinasegroup was mainly due to the hemorrhagic transformation of ischemiccerebral infarcts. At six months, more deaths had occurred inthe streptokinase group than in the placebo group (73 vs. 59,P = 0.06).
Conclusions In patients with acute ischemic stroke, treatmentwith streptokinase resulted in an increase in mortality. Theroutine use of streptokinase cannot be recommended in acuteischemic stroke.
Source Information
Address reprint requests to Dr. Marc Hommel, Stroke Unit, Clinique Neurologique, Centre Hospitalier Universitaire de Grenoble, B.P. 217, 38043 Grenoble CEDEX 9, France.
Hommel, M, Trabucco-Miguel, S, Joray, S, Naegele, B, Gonnet, N, Jaillard, A
(2009). Social dysfunctioning after mild to moderate first-ever stroke at vocational age. J. Neurol. Neurosurg. Psychiatry
80: 371-375
[Abstract][Full Text]
Sare, G. M., Bath, P. M.W., Gray, L. J., Moulin, T., Woimant, F., England, T., Geeganage, C., Christensen, H., De Deyn, P. P., Leys, D., O'Neill, D., Ringelstein, E. B., for the TAIST Investigators,
(2009). The Relationship Between Baseline Blood Pressure and Computed Tomography Findings in Acute Stroke: Data From the Tinzaparin in Acute Ischaemic Stroke Trial (TAIST). Stroke
40: 41-46
[Abstract][Full Text]
Kendall, J
(2008). Thrombolysis for acute ischaemic stroke: a new challenge for emergency medicine. Emerg. Med. J.
25: 471-475
[Abstract][Full Text]
Thanvi, B R, Treadwell, S, Robinson, T
(2008). Haemorrhagic transformation in acute ischaemic stroke following thrombolysis therapy: classification, pathogenesis and risk factors. Postgrad. Med. J.
84: 361-367
[Abstract][Full Text]
Goldstein, L. B.
(2007). Acute Ischemic Stroke Treatment in 2007. Circulation
116: 1504-1514
[Full Text]
The Optimising Analysis of Stroke Trials (OAST) Co,
(2007). Can We Improve the Statistical Analysis of Stroke Trials?: Statistical Reanalysis of Functional Outcomes in Stroke Trials * OAST Supplemental Appendix I: Statistical Tests Compared (see Table I) * OAST Supplemental Appendix II: Supplementary Analyses * OAST Supplemental Appendix III: Trial Data (see Tables II and III) * OAST Supplemental Appendix IV: Results (see Table IV). Stroke
38: 1911-1915
[Abstract][Full Text]
Adams, H. P. Jr, del Zoppo, G., Alberts, M. J., Bhatt, D. L., Brass, L., Furlan, A., Grubb, R. L., Higashida, R. T., Jauch, E. C., Kidwell, C., Lyden, P. D., Morgenstern, L. B., Qureshi, A. I., Rosenwasser, R. H., Scott, P. A., Wijdicks, E. F.M.
(2007). Guidelines for the Early Management of Adults With Ischemic Stroke: A Guideline From the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: The American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists.. Circulation
115: e478-e534
[Abstract][Full Text]
Adams, H. P. Jr, del Zoppo, G., Alberts, M. J., Bhatt, D. L., Brass, L., Furlan, A., Grubb, R. L., Higashida, R. T., Jauch, E. C., Kidwell, C., Lyden, P. D., Morgenstern, L. B., Qureshi, A. I., Rosenwasser, R. H., Scott, P. A., Wijdicks, E. F.M.
(2007). Guidelines for the Early Management of Adults With Ischemic Stroke: A Guideline From the American Heart Association/ American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: The American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists. Stroke
38: 1655-1711
[Abstract][Full Text]
Brekenfeld, C, Remonda, L, Nedeltchev, K, Arnold, M, Mattle, H P, Fischer, U, Kappeler, L, Schroth, G
(2007). Symptomatic intracranial haemorrhage after intra-arterial thrombolysis in acute ischaemic stroke: assessment of 294 patients treated with urokinase. J. Neurol. Neurosurg. Psychiatry
78: 280-285
[Abstract][Full Text]
Khatri, P., Wechsler, L. R., Broderick, J. P.
(2007). Intracranial Hemorrhage Associated With Revascularization Therapies. Stroke
38: 431-440
[Abstract][Full Text]
Elkins, J. S., Khatabi, T., Fung, L., Rootenberg, J., Johnston, S. C.
(2006). Recruiting Subjects for Acute Stroke Trials: A Meta-Analysis. Stroke
37: 123-128
[Abstract][Full Text]
Camerlingo, M., Salvi, P., Belloni, G., Gamba, T., Cesana, B. M., Mamoli, A.
(2005). Intravenous Heparin Started Within the First 3 Hours After Onset of Symptoms as a Treatment for Acute Nonlacunar Hemispheric Cerebral Infarctions. Stroke
36: 2415-2420
[Abstract][Full Text]
Kassner, A., Roberts, T., Taylor, K., Silver, F., Mikulis, D.
(2005). Prediction of Hemorrhage in Acute Ischemic Stroke Using Permeability MR Imaging. Am. J. Neuroradiol.
26: 2213-2217
[Abstract][Full Text]
Schwamm, L. H., Rosenthal, E. S., Swap, C. J., Rosand, J., Rordorf, G., Buonanno, F. S., Vangel, M. G., Koroshetz, W. J., Lev, M. H.
(2005). Hypoattenuation on CT Angiographic Source Images Predicts Risk of Intracerebral Hemorrhage and Outcome after Intra-Arterial Reperfusion Therapy. Am. J. Neuroradiol.
26: 1798-1803
[Abstract][Full Text]
Tsao, J. W., Hemphill, J. C. III, Johnston, S. C., Smith, W. S., Bonovich, D. C.
(2005). Initial Glasgow Coma Scale Score Predicts Outcome Following Thrombolysis for Posterior Circulation Stroke. Arch Neurol
62: 1126-1129
[Abstract][Full Text]
Hill, M. D., Buchan, A. M., for The Canadian Alteplase for Stroke Effectivenes,
(2005). Thrombolysis for acute ischemic stroke: results of the Canadian Alteplase for Stroke Effectiveness Study. CMAJ
172: 1307-1312
[Abstract][Full Text]
Ergin, A., Ergin, N.
(2005). Is Thrombolytic Therapy Associated With Increased Mortality?: Meta-analysis of Randomized Controlled Trials. Arch Neurol
62: 362-366
[Abstract][Full Text]
Albers, G. W., Amarenco, P., Easton, J. D., Sacco, R. L., Teal, P.
(2004). Antithrombotic and Thrombolytic Therapy for Ischemic Stroke: The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest
126: 483S-512S
[Abstract][Full Text]
Weir, C. J., Kaste, M., Lees, K. R., for the Glycine Antagonist in Neuroprotection Int,
(2004). Targeting Neuroprotection Clinical Trials to Ischemic Stroke Patients With Potential to Benefit From Therapy. Stroke
35: 2111-2116
[Abstract][Full Text]
Cestari, D. M., Weine, D. M., Panageas, K. S., Segal, A. Z., DeAngelis, L. M.
(2004). Stroke in patients with cancer: Incidence and etiology. Neurology
62: 2025-2030
[Abstract][Full Text]
Trouillas, P., Derex, L., Philippeau, F., Nighoghossian, N., Honnorat, J., Hanss, M., Ffrench, P., Adeleine, P., Dechavanne, M.
(2004). Early Fibrinogen Degradation Coagulopathy Is Predictive of Parenchymal Hematomas in Cerebral rt-PA Thrombolysis: A Study of 157 Cases. Stroke
35: 1323-1328
[Abstract][Full Text]
Weaver, C. S., Leonardi-Bee, J., Bath-Hextall, F. J., Bath, P. M.W.
(2004). Sample Size Calculations in Acute Stroke Trials: A Systematic Review of Their Reporting, Characteristics, and Relationship With Outcome. Stroke
35: 1216-1224
[Abstract][Full Text]
Provenzale, J. M., Jahan, R., Naidich, T. P., Fox, A. J.
(2003). Assessment of the Patient with Hyperacute Stroke: Imaging and Therapy. Radiology
229: 347-359
[Abstract][Full Text]
Stahl, J. E., Furie, K. L., Gleason, S., Gazelle, G. S.
(2003). Stroke: Effect of Implementing an Evaluation and Treatment Protocol Compliant with NINDS Recommendations. Radiology
228: 659-668
[Abstract][Full Text]
Wardlaw, J.M., Sandercock, P.A.G., Berge, E.
(2003). Thrombolytic Therapy With Recombinant Tissue Plasminogen Activator for Acute Ischemic Stroke: Where Do We Go From Here? A Cumulative Meta-Analysis. Stroke
34: 1437-1442
[Abstract][Full Text]
Adams, H. P. Jr, Adams, R. J., Brott, T., del Zoppo, G. J., Furlan, A., Goldstein, L. B., Grubb, R. L., Higashida, R., Kidwell, C., Kwiatkowski, T. G., Marler, J. R., Hademenos, G. J.
(2003). Guidelines for the Early Management of Patients With Ischemic Stroke: A Scientific Statement From the Stroke Council of the American Stroke Association. Stroke
34: 1056-1083
[Full Text]
Nakano, S., Iseda, T., Yoneyama, T., Kawano, H., Wakisaka, S.
(2002). Direct Percutaneous Transluminal Angioplasty for Acute Middle Cerebral Artery Trunk Occlusion: An Alternative Option to Intra-arterial Thrombolysis. Stroke
33: 2872-2876
[Abstract][Full Text]
Baker, W. F. Jr
(2002). Thrombolytic Therapy. CLIN APPL THROMB HEMOST
8: 291-314
Broderick, J. P., Hacke, W.
(2002). Treatment of Acute Ischemic Stroke: Part I: Recanalization Strategies. Circulation
106: 1563-1569
[Full Text]
Gilligan, A.K., Markus, R., Read, S., Srikanth, V., Hirano, T., Fitt, G., Arends, M., Chambers, B.R., Davis, S.M., Donnan, G.A.
(2002). Baseline Blood Pressure but Not Early Computed Tomography Changes Predicts Major Hemorrhage After Streptokinase in Acute Ischemic Stroke. Stroke
33: 2236-2242
[Abstract][Full Text]
Iseda, T., Nakano, S., Yano, T., Suzuki, Y., Wakisaka, S.
(2002). Time-Threshold Curve Determined by Single Photon Emission CT in Patients with Acute Middle Cerebral Artery Occlusion. Am. J. Neuroradiol.
23: 572-576
[Abstract][Full Text]
Molina, C. A., Montaner, J., Abilleira, S., Arenillas, J. F., Ribo, M., Huertas, R., Romero, F., Alvarez-Sabin, J.
(2001). Time Course of Tissue Plasminogen Activator-Induced Recanalization in Acute Cardioembolic Stroke: A Case-Control Study. Stroke
32: 2821-2827
[Abstract][Full Text]
Nakano, S., Iseda, T., Kawano, H., Yoneyama, T., Ikeda, T., Wakisaka, S.
(2001). Parenchymal Hyperdensity on Computed Tomography After Intra-Arterial Reperfusion Therapy for Acute Middle Cerebral Artery Occlusion: Incidence and Clinical Significance. Stroke
32: 2042-2048
[Abstract][Full Text]
McPherson, C. M., Woo, D., Cohen, P. L., Pancioli, A. M., Kissela, B. M., Carrozzella, J. A., Tomsick, T. A., Zuccarello, M., Chaturvedi, S.
(2001). Early Carotid Endarterectomy for Critical Carotid Artery Stenosis After Thrombolysis Therapy in Acute Ischemic Stroke in the Middle Cerebral Artery Editorial Comment. Stroke
32: 2075-2080
[Abstract][Full Text]
Barthel, H., Hesse, S., Dannenberg, C., Rossler, A., Schneider, D., Knapp, W. H., Dietrich, J., Berrouschot, J.
(2001). Prospective Value of Perfusion and X-Ray Attenuation Imaging With Single-Photon Emission and Transmission Computed Tomography in Acute Cerebral Ischemia. Stroke
32: 1588-1597
[Abstract][Full Text]
Berger, C., Fiorelli, M., Steiner, T., Schabitz, W.-R., Bozzao, L., Bluhmki, E., Hacke, W., von Kummer, R.
(2001). Hemorrhagic Transformation of Ischemic Brain Tissue : Asymptomatic or Symptomatic?. Stroke
32: 1330-1335
[Abstract][Full Text]
Nagai, N., De Mol, M., Van Hoef, B., Verstreken, M., Collen, D.
(2001). Depletion of circulating {alpha}2-antiplasmin by intravenous plasmin or immunoneutralization reduces focal cerebral ischemic injury in the absence of arterial recanalization. Blood
97: 3086-3092
[Abstract][Full Text]
Tong, D. C., Adami, A., Moseley, M. E., Marks, M. P.
(2001). Prediction of Hemorrhagic Transformation Following Acute Stroke: Role of Diffusion- and Perfusion-Weighted Magnetic Resonance Imaging. Arch Neurol
58: 587-593
[Abstract][Full Text]
Uchino, K., Billheimer, D., Cramer, S. C.
(2001). Entry Criteria and Baseline Characteristics Predict Outcome in Acute Stroke Trials. Stroke
32: 909-916
[Abstract][Full Text]
Pereira, A C, Martin, P J, Warburton, E A
(2001). Thrombolysis in acute ischaemic stroke. Postgrad. Med. J.
77: 166-171
[Full Text]
Keris, V., Rudnicka, S., Vorona, V., Enina, G., Tilgale, B., Fricbergs, J.
(2001). Combined Intraarterial/Intravenous Thrombolysis for Acute Ischemic Stroke. Am. J. Neuroradiol.
22: 352-358
[Abstract][Full Text]
Albers, G. W., Amarenco, P., Easton, J. D., Sacco, R. L., Teal, P.
(2001). Antithrombotic and Thrombolytic Therapy for Ischemic Stroke. Chest
119: 300S-320S
[Full Text]
Hinchey, J. A., Benesch, C.
(2000). Thrombolytic Therapy in Patients With Acute Ischemic Stroke. Arch Neurol
57: 1430-1436
[Full Text]
Brott, T., Bogousslavsky, J.
(2000). Treatment of Acute Ischemic Stroke. NEJM
343: 710-722
[Full Text]
Berrouschot, J., Barthel, H., Hesse, S., Knapp, W. H., Schneider, D., von Kummer, R.
(2000). Reperfusion and Metabolic Recovery of Brain Tissue and Clinical Outcome After Ischemic Stroke and Thrombolytic Therapy. Stroke
31: 1545-1551
[Abstract][Full Text]
Cornu, C., Boutitie, F., Candelise, L., Boissel, J. P., Donnan, G. A., Hommel, M., Jaillard, A., Lees, K. R.
(2000). Streptokinase in Acute Ischemic Stroke: An Individual Patient Data Meta-Analysis : The Thrombolysis in Acute Stroke Pooling Project. Stroke
31: 1555-1560
[Abstract][Full Text]
Kalafut, M. A., Schriger, D. L., Saver, J. L., Starkman, S.
(2000). Detection of Early CT Signs of >1/3 Middle Cerebral Artery Infarctions : Interrater Reliability and Sensitivity of CT Interpretation by Physicians Involved in Acute Stroke Care. Stroke
31: 1667-1671
[Abstract][Full Text]
Duncan, P. W., Jorgensen, H. S., Wade, D. T.
(2000). Outcome Measures in Acute Stroke Trials : A Systematic Review and Some Recommendations to Improve Practice. Stroke
31: 1429-1438
[Abstract][Full Text]
Sherman, D. G., Atkinson, R. P., Chippendale, T., Levin, K. A., Ng, K., Futrell, N., Hsu, C. Y., Levy, D. E., for the STAT Participants,
(2000). Intravenous Ancrod for Treatment of Acute Ischemic Stroke: The STAT Study: A Randomized Controlled Trial. JAMA
283: 2395-2403
[Abstract][Full Text]
Trouillas, P., Derex, L., Nighoghossian, N., Honnorat, J., Li, W., Neuschwander, P., Riche, G., Getenet, J. C., Berthezene, Y., Turjman, F., Froment, J. C.
(2000). rtPA intravenous thrombolysis in anterior choroidal artery territory stroke. Neurology
54: 666-666
[Abstract][Full Text]
Buchan, A. M., Barber, P. A., Newcommon, N., Karbalai, H. G., Demchuk, A. M., Hoyte, K. M., Klein, G. M., Feasby, T. E.
(2000). Effectiveness of t-PA in acute ischemic stroke: Outcome relates to appropriateness. Neurology
54: 679-679
[Abstract][Full Text]
Nagai, N., Vanlinthout, I., Collen, D.
(1999). Comparative Effects of Tissue Plasminogen Activator, Streptokinase, and Staphylokinase on Cerebral Ischemic Infarction and Pulmonary Clot Lysis in Hamster Models. Circulation
100: 2541-2546
[Abstract][Full Text]
Furlan, A., Higashida, R., Wechsler, L., Gent, M., Rowley, H., Kase, C., Pessin, M., Ahuja, A., Callahan, F., Clark, W. M., Silver, F., Rivera, F., for the PROACT Investigators,
(1999). Intra-arterial Prourokinase for Acute Ischemic Stroke: The PROACT II Study: A Randomized Controlled Trial. JAMA
282: 2003-2011
[Abstract][Full Text]
DEVUYST, G, BOGOUSSLAVSKY, J
(1999). Recent progress in drug treatment for acute stroke. J. Neurol. Neurosurg. Psychiatry
67: 420-425
[Full Text]
Darby, D. G., Barber, P. A., Gerraty, R. P., Desmond, P. M., Yang, Q., Parsons, M., Li, T., Tress, B. M., Davis, S. M.
(1999). Pathophysiological Topography of Acute Ischemia by Combined Diffusion-Weighted and Perfusion MRI. Stroke
30: 2043-2052
[Abstract][Full Text]
Beauchamp, N. J. Jr, Barker, P. B., Wang, P. Y., vanZijl, P. C. M.
(1999). Imaging of Acute Cerebral Ischemia. Radiology
212: 307-324
[Abstract][Full Text]
Sulter, G., Steen, C., Jacques De Keyser,
(1999). Use of the Barthel Index and Modified Rankin Scale in Acute Stroke Trials. Stroke
30: 1538-1541
[Abstract][Full Text]
ELLIS, S. J, MATTHEWS, C.
(1999). What has gone wrong in stroke research?. Postgrad. Med. J.
75: 449-450
[Full Text]
Choudhri, T. F., Hoh, B. L., Prestigiacomo, C. J., Huang, J., Kim, L. J., Schmidt, A. M., Kisiel, W., Connolly, E. S. , Jr., Pinsky, D. J.
(1999). Targeted Inhibition of Intrinsic Coagulation Limits Cerebral Injury in Stroke without Increasing Intracerebral Hemorrhage. JEM
190: 91-100
[Abstract][Full Text]
Zivin, J. A.
(1999). Thrombolytic stroke therapy: Past, present, and future. Neurology
53: 14-14
[Abstract][Full Text]
Jaillard, A., Cornu, C., Durieux, A., Moulin, T., Boutitie, F., Lees, K. R., Hommel, M.
(1999). Hemorrhagic Transformation in Acute Ischemic Stroke : The MAST-E Study. Stroke
30: 1326-1332
[Abstract][Full Text]
Andersen, M., Overgaard, K., Meden, P., Boysen, G., Choi, S. C.
(1999). Effects of Citicoline Combined With Thrombolytic Therapy in a Rat Embolic Stroke Model • Editorial Comment. Stroke
30: 1464-1471
[Abstract][Full Text]
Kwiatkowski, T. G., Libman, R. B., Frankel, M., Tilley, B. C., Morgenstern, L. B., Lu, M., Broderick, J. P., Lewandowski, C. A., Marler, J. R., Levine, S. R., Brott, T., The National Institute of Neurological Disorders a,
(1999). Effects of Tissue Plasminogen Activator for Acute Ischemic Stroke at One Year. NEJM
340: 1781-1787
[Abstract][Full Text]
Prestigiacomo, C. J., Kim, S. C., Connolly, E. S. Jr, Liao, H., Yan, S.-F., Pinsky, D. J., Feuerstein, G.
(1999). CD18-Mediated Neutrophil Recruitment Contributes to the Pathogenesis of Reperfused but Not Nonreperfused Stroke • Editorial Comment. Stroke
30: 1110-1117
[Abstract][Full Text]
Kasirajan, V., Smedira, N. G., Perl, J. II, McCarthy, P. M.
(1999). Cerebral embolism associated with left ventricular assist device support and successful therapy with intraarterial urokinase. Ann. Thorac. Surg.
67: 1148-1150
[Abstract][Full Text]
Berrouschot, J., Barthel, H., Koster, J., Hesse, S., Rossler, A., Knapp, W. H., Schneider, D.
(1999). Extracorporeal Rheopheresis in the Treatment of Acute Ischemic Stroke : A Randomized Pilot Study. Stroke
30: 787-792
[Abstract][Full Text]
Sorensen, A. G., Copen, W. A., Østergaard, L., Buonanno, F. S., Gonzalez, R. G., Rordorf, G., Rosen, B. R., Schwamm, L. H., Weisskoff, R. M., Koroshetz, W. J.
(1999). Hyperacute Stroke: Simultaneous Measurement of Relative Cerebral Blood Volume, Relative Cerebral Blood Flow, and Mean Tissue Transit Time. Radiology
210: 519-527
[Abstract][Full Text]
Trouillas, P., Nighoghossian, N., Derex, L., Adeleine, P., Honnorat, J., Neuschwander, P., Riche, G., Getenet, J.-C., Li, W., Froment, J.-C., Turjman, F., Malicier, D., Fournier, G., Gabry, A. L., Ledoux, X., Berthezene, Y., Ffrench, P., Dechavanne, M.
(1998). Thrombolysis With Intravenous rtPA in a Series of 100 Cases of Acute Carotid Territory Stroke : Determination of Etiological, Topographic, and Radiological Outcome Factors. Stroke
29: 2529-2540
[Abstract][Full Text]
Ueda, T., Sakaki, S., Nochide, I., Kumon, Y., Kohno, K., Ohta, S.
(1998). Angioplasty after Intra-Arterial Thrombolysis for Acute Occlusion of Intracranial Arteries. Stroke
29: 2568-2574
[Abstract][Full Text]
Brott, T., Lu, M., Kothari, R., Fagan, S. C., Frankel, M., Grotta, J. C., Broderick, J., Kwiatkowski, T., Lewandowski, C., Haley, E. C. Jr, Marler, J. R., Tilley, B. C.
(1998). Hypertension and Its Treatment in the NINDS rt-PA Stroke Trial. Stroke
29: 1504-1509
[Abstract][Full Text]
Slyter, H.
(1998). Ethical Challenges in Stroke Research. Stroke
29: 1725-1729
[Abstract][Full Text]
DEL ZOPPO, G. J, VON KUMMER, R., HAMANN, G. F
(1998). Ischaemic damage of brain microvessels: inherent risks for thrombolytic treatment in stroke. J. Neurol. Neurosurg. Psychiatry
65: 1-9
[Full Text]
Schriger, D. L., Kalafut, M., Starkman, S., Krueger, M., Saver, J. L.
(1998). Cranial Computed Tomography Interpretation in Acute Stroke: Physician Accuracy in Determining Eligibility for Thrombolytic Therapy. JAMA
279: 1293-1297
[Abstract][Full Text]
Fisher, M., Bogousslavsky, J.
(1998). Further Evolution Toward Effective Therapy for Acute Ischemic Stroke. JAMA
279: 1298-1303
[Abstract][Full Text]
Gensini, G. F., Comeglio, M., Colella, A.
(1998). Coronary and Peripheral Thrombolysis: Current Status and Recommendations. CLIN APPL THROMB HEMOST
4: 82-86
[Abstract]
Gebel, J. M., Sila, C. A., Sloan, M. A., Granger, C. B., Mahaffey, K. W., Weisenberger, J., Green, C. L., White, H. D., Gore, J. M., Weaver, W. D., Califf, R. M., Topol, E. J.
(1998). Thrombolysis-Related Intracranial Hemorrhage : A Radiographic Analysis of 244 Cases From the GUSTO-1 Trial With Clinical Correlation. Stroke
29: 563-569
[Abstract][Full Text]
Sobel, J. H., Trakht, I., Pileggi, N., Qi Wu, H.
(1998). Antipeptide Monoclonal Antibodies to Defined Fibrinogen Aalpha Chain Regions: Anti-Aalpha 487-498, a Structural Probe for Fibrinogenolysis. Blood
91: 1590-1598
[Abstract][Full Text]
Horowitz, S. H.
(1998). Thrombolytic Therapy in Acute Stroke: Neurologists, Get Off Your Hands!. Arch Neurol
55: 155-157
[Full Text]
Chiu, D., Krieger, D., Villar-Cordova, C., Kasner, S. E., Morgenstern, L. B., Bratina, P. L., Yatsu, F. M., Grotta, J. C.
(1998). Intravenous Tissue Plasminogen Activator for Acute Ischemic Stroke : Feasibility, Safety, and Efficacy in the First Year of Clinical Practice. Stroke
29: 18-22
[Abstract][Full Text]
Group, T. N. t-P. S. S.
(1997). Intracerebral Hemorrhage After Intravenous t-PA Therapy for Ischemic Stroke. Stroke
28: 2109-2118
[Abstract][Full Text]
Firlik, A. D., Kaufmann, A. M., Wechsler, L. R., Firlik, K. S., Fukui, M. B., Yonas, H.
(1997). Quantitative Cerebral Blood Flow Determinations in Acute Ischemic Stroke : Relationship to Computed Tomography and Angiography. Stroke
28: 2208-2213
[Abstract][Full Text]
Choudhri, T. F., Hoh, B. L., Solomon, R. A., Connolly, E. S. Jr, Pinsky, D. J.
(1997). Use of a Spectrophotometric Hemoglobin Assay to Objectively Quantify Intracerebral Hemorrhage in Mice. Stroke
28: 2296-2302
[Abstract][Full Text]
Caplan, L. R., Mohr, J. P., Kistler, J. P., Koroshetz, W., Grotta, J., Caplan, L. R., Mohr, J. P., Kistler, J. P., Koroshetz, W., Grotta, J.
(1997). Should Thrombolytic Therapy Be the First-Line Treatment for Acute Ischemic Stroke?. NEJM
337: 1309-1313
[Full Text]
Connolly, E. S. Jr, Winfree, C. J., Prestigiacomo, C. J., Kim, S. C., Choudhri, T. F., Hoh, B. L., Naka, Y., Solomon, R. A., Pinsky, D. J.
(1997). Exacerbation of Cerebral Injury in Mice That Express the P-Selectin Gene : Identification of P-Selectin Blockade as a New Target for the Treatment of Stroke. Circ. Res.
81: 304-310
[Abstract][Full Text]
Vanderschueren, S., Van Vlaenderen, I., Collen, D.
(1997). Intravenous Thrombolysis With Recombinant Staphylokinase Versus Tissue-Type Plasminogen Activator in a Rabbit Embolic Stroke Model. Stroke
28: 1783-1788
[Abstract][Full Text]
Alexandrov, A. V., Masdeu, J. C., Devous, M. D. Sr, Black, S. E., Grotta, J. C.
(1997). Brain Single-Photon Emission CT With HMPAO and Safety of Thrombolytic Therapy in Acute Ischemic Stroke : Proceedings of the Meeting of the SPECT Safe Thrombolysis Study Collaborators and the Members of the Brain Imaging Council of the Society of Nuclear Medicine. Stroke
28: 1830-1834
[Abstract][Full Text]
Watson, J. C., Doppenberg, E. M. R., Bullock, M. R., Zauner, A., Rice, M. R., Abraham, D., Young, H. F., Ulatowski, J. A.
(1997). Effects of the Allosteric Modification of Hemoglobin on Brain Oxygen and Infarct Size in a Feline Model of Stroke. Stroke
28: 1624-1630
[Abstract][Full Text]
Siewert, B., Wielopolski, P. A., Schlaug, G., Edelman, R. R., Warach, S.
(1997). STAR MR Angiography for Rapid Detection of Vascular Abnormalities in Patients With Acute Cerebrovascular Disease. Stroke
28: 1211-1215
[Abstract][Full Text]
Young, A. R., Touzani, O., Derlon, J.-M., Sette, G., MacKenzie, E. T., Baron, J.-C.
(1997). Early Reperfusion in the Anesthetized Baboon Reduces Brain Damage Following Middle Cerebral Artery Occlusion : A Quantitative Analysis of Infarction Volume. Stroke
28: 632-638
[Abstract][Full Text]
Motto, C., Aritzu, E., Boccardi, E., De Grandi, C., Piana, A., Candelise, L.
(1997). Reliability of Hemorrhagic Transformation Diagnosis in Acute Ischemic Stroke. Stroke
28: 302-306
[Abstract][Full Text]
Frankel, M. R., Clark, W. M., Lyden, P. D., Madden, K. P., Zivin, J. A., Firstenberg, M. S., Hommel, M., Cornu, C., Boutitie, F.
(1997). Thrombolytic Therapy in Acute Ischemic Stroke. NEJM
336: 65-67
[Full Text]
Pincus, M. M.
(1997). Thrombolysis for Stroke. JAMA
277: 19-19
[Abstract]
Donnan, G. A., Davis, S. M., Chambers, B. R., Gates, P. C., Hankey, G. J., McNeil, J. J., Rosen, D., Stewart-Wynne, E. G., Tuck, R. R.
(1997). Thrombolysis for Stroke-Reply. JAMA
277: 19-20
[Abstract]
Furlan, A. J., Kanoti, G.
(1997). When Is Thrombolysis Justified in Patients With Acute Ischemic Stroke?: A Bioethical Perspective. Stroke
28: 214-218
[Abstract][Full Text]
Grotta, J.
(1996). Rodent Models of Stroke Limitations: What Can We Learn From Recent Clinical Trials of Thrombolysis?. Arch Neurol
53: 1067-1070
[Abstract]
Donnan, G. A., Davis, S. M., Chambers, B. R., Gates, P. C., Hankey, G. J., McNeil, J. J., Rosen, D., Stewart-Wynne, E. G., Tuck, R. R.
(1996). Streptokinase for Acute Ischemic Stroke With Relationship to Time of Administration. JAMA
276: 961-966
[Abstract]
Hachinski, V.
(1996). Thrombolysis in Stroke: Between the Promise and the Peril. JAMA
276: 995-996
[Abstract]
(1996). STREPTOKINASE AGAIN DISAPPOINTING IN STROKE. JWatch General
1996: 1-1
[Full Text]
