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Volume 337:1405-1411 November 13, 1997 Number 20 Next

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ABSTRACT

Background The role of long-acting, inhaled ₂-agonists in treating asthma is uncertain. In a double-blind study, we evaluated the effects of adding inhaled formoterol to both lower and higher doses of the inhaled glucocorticoid budesonide.

Methods After a four-week run-in period of treatment with budesonide (800 µg twice daily), 852 patients being treated with glucocorticoids were randomly assigned to one of four treatments given twice daily by means of a dry-powder inhaler (Turbuhaler): 100 µg of budesonide plus placebo, 100 µg of budesonide plus 12 µg of formoterol, 400 µg of budesonide plus placebo, or 400 µg of budesonide plus 12 µg of formoterol. Terbutaline was permitted as needed. Treatment continued for one year; we compared the frequency of exacerbations of asthma, symptoms, and lung function in the four groups. A severe exacerbation was defined by the need for oral glucocorticoids or a decrease in the peak flow to more than 30 percent below the base-line value on two consecutive days.

Results The rates of severe and mild exacerbations were reduced by 26 percent and 40 percent, respectively, when formoterol was added to the lower dose of budesonide. The higher dose of budesonide alone reduced the rates of severe and mild exacerbations by 49 percent and 37 percent, respectively. Patients treated with formoterol and the higher dose of budesonide had the greatest reductions — 63 percent and 62 percent, respectively. Symptoms of asthma and lung function improved with both formoterol and the higher dose of budesonide, but the improvements with formoterol were greater.

Conclusions In patients who have persistent symptoms of asthma despite treatment with inhaled glucocorticoids, the addition of formoterol to budesonide therapy or the use of a higher dose of budesonide may be beneficial. The addition of formoterol to budesonide therapy improves symptoms and lung function without lessening the control of asthma.

Source Information

From the Department of Respiratory Diseases, University Hospital, Ghent, Belgium (R.A.P.); the Department of Respiratory Medicine, University Hospital, Lund, Sweden (C.-G.L.); the Division of Respiratory Disease, University Hospital, Groningen, the Netherlands (D.S.P.); the Division of Respiratory Medicine, City Hospital, Nottingham, United Kingdom (A.E.T.); the Department of Respirology, McMaster University, Hamilton, Ont., Canada (P.O.); the National Heart and Lung Institute, Imperial College, London (P.J.B.); and Clinical Research and Development, Astra Draco, Lund, Sweden (A.U.).

Address reprint requests to Dr. Pauwels at the Department of Respiratory Diseases, University Hospital, De Pintelaan 185, B9000 Ghent, Belgium.

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Effect of Inhaled Formoterol and Budesonide on Exacerbations of Asthma
FitzGerald J. M., Salvi S., Pauwels R. A., Tattersfield A. E., Löfdahl C.-G.
Extract | Full Text  
N Engl J Med 1998; 338:1071-1073, Apr 9, 1998. Correspondence

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• Bell, A., McIvor, R. A. (2006). SMART therapy.. CMAJ 175: 276-277 [Full Text]  
• Johnston, N W, Sears, M R (2006). Asthma exacerbations {middle dot} 1: Epidemiology.. Thorax 61: 722-728 [Abstract] [Full Text]  
• Reddel, H. K., Barnes, D. J. (2006). Pharmacological strategies for self-management of asthma exacerbations.. Eur Respir J 28: 182-199 [Abstract] [Full Text]  
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• Edwards, M. R., Johnson, M. W., Johnston, S. L. (2006). Combination Therapy: Synergistic Suppression of Virus-Induced Chemokines in Airway Epithelial Cells. Am. J. Respir. Cell Mol. Bio. 34: 616-624 [Abstract] [Full Text]  
• Rubinfeld, A. R., Scicchitano, R., Hunt, A., Thompson, P. J., Van Nooten, A., Selroos, O. (2006). Formoterol Turbuhaler as reliever medication in patients with acute asthma. Eur Respir J 27: 735-741 [Abstract] [Full Text]  
• Rees, J. (2006). Asthma control in adults.. BMJ 332: 767-771 [Full Text]  
• Koopmans, J G, Lutter, R, Jansen, H M, van der Zee, J S (2006). Adding salmeterol to an inhaled corticosteroid: long term effects on bronchial inflammation in asthma. Thorax 61: 306-313 [Abstract] [Full Text]  
• (2006). Endpoints in asthma drug trials - what do they mean?. DTB 44: 21-24 [Abstract] [Full Text]  
• Jayaram, L., Pizzichini, M. M., Cook, R. J., Boulet, L-P., Lemiere, C., Pizzichini, E., Cartier, A., Hussack, P., Goldsmith, C. H., Laviolette, M., Parameswaran, K., Hargreave, F. E. (2006). Determining asthma treatment by monitoring sputum cell counts: effect on exacerbations.. Eur Respir J 27: 483-494 [Abstract] [Full Text]  
• Cheung, D., van Klink, H. C. J., Aalbers, R., for the OZON study group, (2006). Improved lung function and symptom control with formoterol on demand in asthma.. Eur Respir J 27: 504-510 [Abstract] [Full Text]  
• Wechsler, M. E., Lehman, E., Lazarus, S. C., Lemanske, R. F. Jr., Boushey, H. A., Deykin, A., Fahy, J. V., Sorkness, C. A., Chinchilli, V. M., Craig, T. J., DiMango, E., Kraft, M., Leone, F., Martin, R. J., Peters, S. P., Szefler, S. J., Liu, W., Israel, E., for the National Heart Lung and Blood Institute's, (2006). beta-Adrenergic Receptor Polymorphisms and Response to Salmeterol. Am. J. Respir. Crit. Care Med. 173: 519-526 [Abstract] [Full Text]  
• Parameswaran, K. (2006). Treatment Strategy for Asthma: One for All and All for One?. Chest 129: 221-223 [Full Text]  
• Rabe, K. F., Pizzichini, E., Stallberg, B., Romero, S., Balanzat, A. M., Atienza, T., Lier, P. A., Jorup, C. (2006). Budesonide/Formoterol in a Single Inhaler for Maintenance and Relief in Mild-to-Moderate Asthma: A Randomized, Double-Blind Trial.. Chest 129: 246-256 [Abstract] [Full Text]  
• O'Byrne, P. M., Adelroth, E. (2006). {beta}2 Deja Vu. Chest 129: 3-5 [Full Text]  
• Todorova, L., Gurcan, E., Miller-Larsson, A., Westergren-Thorsson, G. (2006). Lung Fibroblast Proteoglycan Production Induced by Serum Is Inhibited by Budesonide and Formoterol. Am. J. Respir. Cell Mol. Bio. 34: 92-100 [Abstract] [Full Text]  
• Miller, M., Cho, J. Y., McElwain, K., McElwain, S., Shim, J. Y., Manni, M., Baek, J. S., Broide, D. H. (2006). Corticosteroids prevent myofibroblast accumulation and airway remodeling in mice. Am. J. Physiol. Lung Cell. Mol. Physiol. 290: L162-L169 [Abstract] [Full Text]  
• Harle, P, Straub, R H, Wiest, R, Mayer, A, Scholmerich, J, Atzeni, F, Carrabba, M, Cutolo, M, Sarzi-Puttini, P (2006). Increase of sympathetic outflow measured by neuropeptide Y and decrease of the hypothalamic-pituitary-adrenal axis tone in patients with systemic lupus erythematosus and rheumatoid arthritis: another example of uncoupling of response systems. Ann Rheum Dis 65: 51-56 [Abstract] [Full Text]  
• Barnes, P., Virchow, J. C., Sanchis, J., Welte, T., Pedersen, S. (2005). Asthma management: important issues. ERR 14: 147-151 [Abstract] [Full Text]  
• (2005). Leukotriene receptor antagonists - an update. DTB 43: 85-88 [Abstract] [Full Text]  
• Vogelmeier, C., D'Urzo, A., Pauwels{dagger}, R., Merino, J. M., Jaspal, M., Boutet, S., Naya, I., Price, D. (2005). Budesonide/formoterol maintenance and reliever therapy: an effective asthma treatment option?. Eur Respir J 26: 819-828 [Abstract] [Full Text]  
• Donohue, J. F. (2005). Combination Therapy for Chronic Obstructive Pulmonary Disease: Clinical Aspects. Proc Am Thorac Soc 2: 272-281 [Abstract] [Full Text]  
• Baouz, S., Giron-Michel, J., Azzarone, B., Giuliani, M., Cagnoni, F., Olsson, S., Testi, R., Gabbiani, G., Canonica, G. W. (2005). Lung myofibroblasts as targets of salmeterol and fluticasone propionate: inhibition of {alpha}-SMA and NF-{kappa}B. Int Immunol 17: 1473-1481 [Abstract] [Full Text]  
• Currie, G. P., Lee, D. K. C., Srivastava, P. (2005). Long-Acting Bronchodilator or Leukotriene Modifier as Add-on Therapy to Inhaled Corticosteroids in Persistent Asthma?. Chest 128: 2954-2962 [Abstract] [Full Text]  
• Usmani, O. S., Ito, K., Maneechotesuwan, K., Ito, M., Johnson, M., Barnes, P. J., Adcock, I. M. (2005). Glucocorticoid Receptor Nuclear Translocation in Airway Cells after Inhaled Combination Therapy. Am. J. Respir. Crit. Care Med. 172: 704-712 [Abstract] [Full Text]  
• Calverley, P., Pauwels{dagger}, R., Lofdahl, C-G., Svensson, K., Higenbottam, T., Carlsson, L-G., Stahl, E. (2005). Relationship between respiratory symptoms and medical treatment in exacerbations of COPD. Eur Respir J 26: 406-413 [Abstract] [Full Text]  
• Overbeek, S. E., Mulder, P. G., Baelemans, S. M., Hoogsteden, H. C., Prins, J.-B. (2005). Formoterol Added to Low-Dose Budesonide Has No Additional Antiinflammatory Effect in Asthmatic Patients. Chest 128: 1121-1127 [Abstract] [Full Text]  
• Littner, M. R., Leung, F. W., Ballard, E. D. II, Huang, B., Samra, N. K., on behalf of the Lansoprazole Asthma Study Group, (2005). Effects of 24 Weeks of Lansoprazole Therapy on Asthma Symptoms, Exacerbations, Quality of Life, and Pulmonary Function in Adult Asthmatic Patients With Acid Reflux Symptoms. Chest 128: 1128-1135 [Abstract] [Full Text]  
• Tattersfield, A E (2005). When should a long acting {beta} agonist be added to an inhaled corticosteroid?. Thorax 60: 710-710 [Full Text]  
• Masoli, M, Weatherall, M, Holt, S, Beasley, R (2005). Moderate dose inhaled corticosteroids plus salmeterol versus higher doses of inhaled corticosteroids in symptomatic asthma. Thorax 60: 730-734 [Abstract] [Full Text]  
• Silkoff, P. E., Corbetta, L., Fabbri, L. M., Currie, G. P., Lee, D. K.C., Smith, A. D., Taylor, D. R. (2005). Exhaled Nitric Oxide and Asthma. NEJM 353: 732-733 [Full Text]  
• Gaga, M., Papageorgiou, N., Zervas, E., Gioulekas, D., Konstantopoulos, S. (2005). Control of Asthma Under Specialist Care: Is It Achieved?. Chest 128: 78-84 [Abstract] [Full Text]  
• Nie, M., Knox, A. J., Pang, L. (2005). {beta}2-Adrenoceptor Agonists, Like Glucocorticoids, Repress Eotaxin Gene Transcription by Selective Inhibition of Histone H4 Acetylation. J. Immunol. 175: 478-486 [Abstract] [Full Text]  
• Peek, E. J., Richards, D. F., Faith, A., Lavender, P., Lee, T. H., Corrigan, C. J., Hawrylowicz, C. M. (2005). Interleukin-10-Secreting "Regulatory" T Cells Induced by Glucocorticoids and {beta}2-Agonists. Am. J. Respir. Cell Mol. Bio. 33: 105-111 [Abstract] [Full Text]  
• Jayaram, L, Pizzichini, E, Lemiere, C, Man, S F P, Cartier, A, Hargreave, F E, Pizzichini, M M M (2005). Steroid naive eosinophilic asthma: anti-inflammatory effects of fluticasone and montelukast. Thorax 60: 100-105 [Abstract] [Full Text]  
• O'Byrne, P. M., Bisgaard, H., Godard, P. P., Pistolesi, M., Palmqvist, M., Zhu, Y., Ekstrom, T., Bateman, E. D. (2005). Budesonide/Formoterol Combination Therapy as Both Maintenance and Reliever Medication in Asthma. Am. J. Respir. Crit. Care Med. 171: 129-136 [Abstract] [Full Text]  
• Reddel, H.K. (2004). Goals of asthma treatment: how high should we go?. Eur Respir J 24: 715-717 [Full Text]  
• Calverley, P. M. A. (2004). Effect of Corticosteroids on Exacerbations of Asthma and Chronic Obstructive Pulmonary Disease. Proc Am Thorac Soc 1: 161-166 [Abstract] [Full Text]  
• Lee, D K C, Jackson, C M, Bates, C E, Lipworth, B J (2004). Cross tolerance to salbutamol occurs independently of {beta}2 adrenoceptor genotype-16 in asthmatic patients receiving regular formoterol or salmeterol. Thorax 59: 662-667 [Abstract] [Full Text]  
• Larj, M. J., Bleecker, E. R. (2004). Therapeutic Responses in Asthma and COPD: Corticosteroids. Chest 126: 138S-149S [Abstract] [Full Text]  
• Sin, D. D., Man, J., Sharpe, H., Gan, W. Q., Man, S. F. P. (2004). Pharmacological Management to Reduce Exacerbations in Adults With Asthma: A Systematic Review and Meta-analysis. JAMA 292: 367-376 [Abstract] [Full Text]  
• Gaga, M. (2004). Fixed obstruction in severe asthma: not just a matter of time. Eur Respir J 24: 8-10 [Full Text]  
• Stempel, D. A., Roberts, C. S., Stanford, R. H. (2004). Treatment Patterns in the Months Prior to and After Asthma-Related Emergency Department Visit. Chest 126: 75-80 [Abstract] [Full Text]  
• Cazzola, M., Dahl, R. (2004). Inhaled Combination Therapy With Long-Acting {beta}2-Agonists and Corticosteroids in Stable COPD. Chest 126: 220-237 [Abstract] [Full Text]  
• Busse, W W, Lemanske, R F Jr (2004). Management of asthma exacerbations. Thorax 59: 545-546 [Full Text]  
• Perng, D.-W., Huang, H.-Y., Lee, Y.-C., Perng, R.-P. (2004). Leukotriene Modifier vs Inhaled Corticosteroid in Mild-to-Moderate Asthma: Clinical and Anti-inflammatory Effects. Chest 125: 1693-1699 [Abstract] [Full Text]  
• Masoli, M., Holt, S., Weatherall, M., Beasley, R. (2004). Dose-response relationship of inhaled budesonide in adult asthma: a meta-analysis. Eur Respir J 23: 552-558 [Abstract] [Full Text]  
• Pauwels, R. A. (2004). Similarities and Differences in Asthma and Chronic Obstructive Pulmonary Disease Exacerbations. Proc Am Thorac Soc 1: 73-76 [Abstract] [Full Text]  
• Holgate, S. T., Holloway, J., Wilson, S., Bucchieri, F., Puddicombe, S., Davies, D. E. (2004). Epithelial-Mesenchymal Communication in the Pathogenesis of Chronic Asthma. Proc Am Thorac Soc 1: 93-98 [Abstract] [Full Text]  
• O'Byrne, P. M. (2004). Pharmacologic Interventions to Reduce the Risk of Asthma Exacerbations. Proc Am Thorac Soc 1: 105-108 [Abstract] [Full Text]