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Previous Volume 337:295-300 July 31, 1997 Number 5 Next

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ABSTRACT

Background We conducted a randomized, prospective trial comparing external irradiation with external irradiation plus goserelin (an agonist analogue of gonadotropin-releasing hormone that reduces testosterone secretion) in patients with locally advanced prostate cancer.

Methods From 1987 to 1995, 415 patients with locally advanced prostate cancer were randomly assigned to receive radiotherapy alone or radiotherapy plus immediate treatment with goserelin. The patients had a median age of 71 years (range, 51 to 80). Patients in both groups received 50 Gy of radiation to the pelvis over a period of five weeks and an additional 20 Gy over an additional two weeks as a prostatic boost. Patients in the combined-treatment group received 3.6 mg of goserelin (Zoladex) subcutaneously every four weeks starting on the first day of irradiation and continuing for three years; those patients also received cyproterone acetate (150 mg orally per day) during the first month of treatment to inhibit the transient rise in testosterone associated with the administration of goserelin.

Results Data were available for analysis on 401 patients. The median follow-up was 45 months. Kaplan–Meier estimates of overall survival at five years were 79 percent (95 percent confidence interval, 72 to 86 percent) in the combined-treatment group and 62 percent (95 percent confidence interval, 52 to 72 percent) in the radiotherapy group (P = 0.001). The proportion of surviving patients who were free of disease at five years was 85 percent (95 percent confidence interval, 78 to 92 percent) in the combined-treatment group and 48 percent (95 percent confidence interval, 38 to 58 percent) in the radiotherapy group (P<0.001).

Conclusions Adjuvant treatment with goserelin, when started simultaneously with external irradiation, improves local control and survival in patients with locally advanced prostate cancer.

Source Information

From University Hospital, Grenoble, France (M.B.); Akademisch Medisch Centrum, Amsterdam, the Netherlands (D.G.); Princess Margaret Hospital, Toronto (P.W.); Centre Régional de Lutte contre le Cancer Val d'Aurelle, Montpellier, France (J.B.D.); Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland (R.-O.M.); Oncologisch Centrum, Brussels (G.S.); Ospedale San Giovanni, Bellinzona, Switzerland (J.B.); Rambam Medical Center, Haifa, Israel (A.K.); Ufficio Sternberg & Pansadoro, Rome (C.S.); and the European Organization for Research and Treatment of Cancer Data Center, Brussels (T.G., L.C., M.P.).

Address reprint requests to Dr. Bolla at the Radiotherapy Department, University Hospital, B.P. 217 38043 Grenoble CEDEX 9, France.

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Treatment of Prostate Cancer with Goserelin and Radiotherapy
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N Engl J Med 1997; 337:1693-1694, Dec 4, 1997. Correspondence

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• D'Amico, A. V., Schultz, D., Loffredo, M., Dugal, R., Hurwitz, M., Kaplan, I., Beard, C. J., Renshaw, A. A., Kantoff, P. W. (2000). Biochemical Outcome Following External Beam Radiation Therapy With or Without Androgen Suppression Therapy for Clinically Localized Prostate Cancer. JAMA 284: 1280-1283 [Abstract] [Full Text]  
• Kestin, L. L., Martinez, A. A., Stromberg, J. S., Edmundson, G. K., Gustafson, G. S., Brabbins, D. S., Chen, P. Y., Vicini, F. A. (2000). Matched-Pair Analysis of Conformal High-Dose-Rate Brachytherapy Boost Versus External-Beam Radiation Therapy Alone for Locally Advanced Prostate Cancer. JCO 18: 2869-2880 [Abstract] [Full Text]  
• Zelefsky, M. J., Kelly, W. K., Scher, H. I., Lee, H., Smart, T., Metz, E., Schwartz, L., Fuks, Z., Leibel, S. A. (2000). Results of a Phase II Study Using Estramustine Phosphate and Vinblastine in Combination With High-Dose Three-Dimensional Conformal Radiotherapy for Patients With Locally Advanced Prostate Cancer. JCO 18: 1936-1941 [Abstract] [Full Text]  
• Swanson, G. P., Messing, E. M., Manola, J. (2000). Early Hormonal Therapy in Prostate Cancer. NEJM 342: 1215-1216 [Full Text]  
• Cook, T., Sheridan, W. P. (2000). Development of GnRH Antagonists for Prostate Cancer: New Approaches to Treatment. The Oncologist 5: 162-168 [Abstract] [Full Text]  
• Potters, L., Torre, T., Ashley, R., Leibel, S. (2000). Examining the Role of Neoadjuvant Androgen Deprivation in Patients Undergoing Prostate Brachytherapy. JCO 18: 1187-1192 [Abstract] [Full Text]  
• Strum, S. B., Scholz, M. C., McDermed, J. E. (2000). Intermittent Androgen Deprivation in Prostate Cancer Patients: Factors Predictive of Prolonged Time Off Therapy. The Oncologist 5: 45-52 [Abstract] [Full Text]  
• Prior, T., Waxman, J. (2000). Localised prostate cancer: can we do better?. BMJ 320: 69-70 [Full Text]  
• Messing, E. M., Manola, J., Sarosdy, M., Wilding, G., Crawford, E. D., Trump, D. (1999). Immediate Hormonal Therapy Compared with Observation after Radical Prostatectomy and Pelvic Lymphadenectomy in Men with Node-Positive Prostate Cancer. NEJM 341: 1781-1788 [Abstract] [Full Text]  
• Raghavan, D. (1999). Prostate Cancer Management Under Scrutiny: One Man's Meta-Analysis Is Another Man's Poisson. JCO 17: 3371-3373 [Full Text]  
• Weber, D. C., Bieri, S., Kurtz, J. M., Miralbell, R. (1999). Prospective Pilot Study of Sildenafil for Treatment of Postradiotherapy Erectile Dysfunction in Patients With Prostate Cancer. JCO 17: 3444-3449 [Abstract] [Full Text]  
• Oh, W. K., Kantoff, P. W. (1999). Treatment of Locally Advanced Prostate Cancer: Is Chemotherapy the Next Step?. JCO 17: 3664-3675 [Abstract] [Full Text]  
• Pisters, L. L., Perrotte, P., Scott, S. M., Greene, G. F., von Eschenbach, A. C. (1999). Patient Selection for Salvage Cryotherapy for Locally Recurrent Prostate Cancer After Radiation Therapy. JCO 17: 2514-2514 [Abstract] [Full Text]