Melissa K. Thomas, M.D., Ph.D., Donald M. Lloyd-Jones, M.D., Ravi I. Thadhani, M.D., M.P.H., Albert C. Shaw, M.D., Ph.D., Donald J. Deraska, M.D., Barrett T. Kitch, M.D., Eleftherios C. Vamvakas, M.D., Ph.D., Ian M. Dick, M.Sc., Richard L. Prince, M.D., and Joel S. Finkelstein, M.D.
Background Vitamin D deficiency is a major risk factor for boneloss and fracture. Although hypovitaminosis D has been detectedfrequently in elderly and housebound people, the prevalenceof vitamin D deficiency among patients hospitalized on a generalmedical service is unknown.
Methods We assessed vitamin D intake, ultraviolet-light exposure,and risk factors for hypovitaminosis D and measured serum 25-hydroxyvitaminD, parathyroid hormone, and ionized calcium in 290 consecutivepatients on a general medical ward.
Results A total of 164 patients (57 percent) were consideredvitamin D–deficient (serum concentration of 25-hydroxyvitaminD, <15 ng per milliliter), of whom 65 (22 percent) were consideredseverely vitamin D–deficient (serum concentration of 25-hydroxyvitaminD, <8 ng per milliliter). Serum 25-hydroxyvitamin D concentrationswere related inversely to parathyroid hormone concentrations.Lower vitamin D intake, less exposure to ultraviolet light,anticonvulsant-drug therapy, renal dialysis, nephrotic syndrome,hypertension, diabetes mellitus, winter season, higher serumconcentrations of parathyroid hormone and alkaline phosphatase,and lower serum concentrations of ionized calcium and albuminwere significant univariate predictors of hypovitaminosis D.Sixty-six percent of the patients who consumed less than therecommended daily amount of vitamin D and 37 percent of thepatients with intakes above the recommended daily amount werevitamin D–deficient. Inadequate vitamin D intake, winterseason, and housebound status were independent predictors ofhypovitaminosis D in a multivariate model. In a subgroup of77 patients less than 65 years of age without known risk factorsfor hypovitaminosis D, the prevalence of vitamin D deficiencywas 42 percent.
Conclusions Hypovitaminosis D is common in general medical inpatients,including those with vitamin D intakes exceeding the recommendeddaily amount and those without apparent risk factors for vitaminD deficiency.
Source Information
From the Endocrine Unit (M.K.T., D.J.D., J.S.F.), Department of Medicine (D.M.L.-J., R.I.T., A.C.S., B.T.K.), and the Department of Pathology (E.C.V.), Massachusetts General Hospital and Harvard Medical School, Boston; and the Department of Medicine, University of Western Australia, Perth (I.M.D.), and the Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands (R.L.P.) — both in Australia.
Address reprint requests to Dr. Finkelstein at the Endocrine Unit, Bulfinch 327, Massachusetts General Hospital, 55 Fruit St., Boston, MA 02114.
Thadhani, R.
(2009). Is Calcitriol Life-Protective for Patients with Chronic Kidney Disease?. J. Am. Soc. Nephrol.
20: 2285-2290
[Full Text]
Mullin, G. E., Turnbull, L., Kines, K., Mullin, G. E.
(2009). Vitamin D: A D-Lightful Health Supplement. Nutr Clin Pract
24: 642-644
[Full Text]
NURNBERG, B., GRABER, S., GARTNER, B., GEISEL, J., PFOHLER, C., SCHADENDORF, D., TILGEN, W., REICHRATH, J.
(2009). Reduced Serum 25-Hydroxyvitamin D Levels in Stage IV Melanoma Patients. Anticancer Res
29: 3669-3674
[Abstract][Full Text]
Kalantar-Zadeh, K., Kovesdy, C. P.
(2009). Clinical Outcomes with Active versus Nutritional Vitamin D Compounds in Chronic Kidney Disease. CJASN
4: 1529-1539
[Abstract][Full Text]
Kumar, J., Muntner, P., Kaskel, F. J., Hailpern, S. M., Melamed, M. L.
(2009). Prevalence and Associations of 25-Hydroxyvitamin D Deficiency in US Children: NHANES 2001-2004. Pediatrics
124: e362-e370
[Abstract][Full Text]
Tucci, J R
(2009). Vitamin D therapy in patients with primary hyperparathyroidism and hypovitaminosis D. Eur J Endocrinol
161: 189-193
[Abstract][Full Text]
Zittermann, A., Frisch, S., Berthold, H. K, Gotting, C., Kuhn, J., Kleesiek, K., Stehle, P., Koertke, H., Koerfer, R.
(2009). Vitamin D supplementation enhances the beneficial effects of weight loss on cardiovascular disease risk markers. Am. J. Clin. Nutr.
89: 1321-1327
[Abstract][Full Text]
Kuchuk, N. O., Pluijm, S. M. F., van Schoor, N. M., Looman, C. W. N., Smit, J. H., Lips, P.
(2009). Relationships of Serum 25-Hydroxyvitamin D to Bone Mineral Density and Serum Parathyroid Hormone and Markers of Bone Turnover in Older Persons. J. Clin. Endocrinol. Metab.
94: 1244-1250
[Abstract][Full Text]
Orwoll, E., Nielson, C. M., Marshall, L. M., Lambert, L., Holton, K. F., Hoffman, A. R., Barrett-Connor, E., Shikany, J. M., Dam, T., Cauley, J. A., for the Osteoporotic Fractures in Men (MrOS) Study,
(2009). Vitamin D Deficiency in Older Men. J. Clin. Endocrinol. Metab.
94: 1214-1222
[Abstract][Full Text]
Smith, S. M, Gardner, K. K, Locke, J., Zwart, S. R
(2009). Vitamin D supplementation during Antarctic winter. Am. J. Clin. Nutr.
89: 1092-1098
[Abstract][Full Text]
Adams, J. S., Ren, S., Liu, P. T., Chun, R. F., Lagishetty, V., Gombart, A. F., Borregaard, N., Modlin, R. L., Hewison, M.
(2009). Vitamin D-Directed Rheostatic Regulation of Monocyte Antibacterial Responses. J. Immunol.
182: 4289-4295
[Abstract][Full Text]
Nelson, M. L., Blum, J. M., Hollis, B. W., Rosen, C., Sullivan, S. S.
(2009). Supplements of 20 {micro}g/d Cholecalciferol Optimized Serum 25-Hydroxyvitamin D Concentrations in 80% of Premenopausal Women in Winter. J. Nutr.
139: 540-546
[Abstract][Full Text]
Eastell, R., Arnold, A., Brandi, M. L., Brown, E. M., D'Amour, P., Hanley, D. A., Rao, D. S., Rubin, M. R., Goltzman, D., Silverberg, S. J., Marx, S. J., Peacock, M., Mosekilde, L., Bouillon, R., Lewiecki, E. M.
(2009). Diagnosis of Asymptomatic Primary Hyperparathyroidism: Proceedings of the Third International Workshop. J. Clin. Endocrinol. Metab.
94: 340-350
[Abstract][Full Text]
Hegge, K. A., Fornoff, A. S., Gutierres, S. L., Haack, S. L.
(2009). New Therapies for Osteoporosis. Journal of Pharmacy Practice
22: 53-64
[Abstract]
Shardell, M., Hicks, G. E., Miller, R. R., Kritchevsky, S., Andersen, D., Bandinelli, S., Cherubini, A., Ferrucci, L.
(2009). Association of Low Vitamin D Levels With the Frailty Syndrome in Men and Women. J Gerontol A Biol Sci Med Sci
0: gln007v1-gln007
[Abstract][Full Text]
Yoho, R. M., Frerichs, J., Dodson, N. B., Greenhagen, R., Geletta, S.
(2009). A Comparison of Vitamin D Levels in Nondiabetic and Diabetic Patient Populations. J. Am. Podiatr. Med. Assoc.
99: 35-41
[Abstract][Full Text]
Weaver, C. M., McCabe, L. D., McCabe, G. P., Braun, M., Martin, B. R., DiMeglio, L. A., Peacock, M.
(2008). Vitamin D Status and Calcium Metabolism in Adolescent Black and White Girls on a Range of Controlled Calcium Intakes. J. Clin. Endocrinol. Metab.
93: 3907-3914
[Abstract][Full Text]
White, J. H.
(2008). Vitamin D Signaling, Infectious Diseases, and Regulation of Innate Immunity. Infect. Immun.
76: 3837-3843
[Full Text]
Cauley, J. A., LaCroix, A. Z., Wu, L., Horwitz, M., Danielson, M. E., Bauer, D. C., Lee, J. S., Jackson, R. D., Robbins, J. A., Wu, C., Stanczyk, F. Z., LeBoff, M. S., Wactawski-Wende, J., Sarto, G., Ockene, J., Cummings, S. R.
(2008). Serum 25-Hydroxyvitamin D Concentrations and Risk for Hip Fractures. ANN INTERN MED
149: 242-250
[Abstract][Full Text]
Melamed, M. L., Michos, E. D., Post, W., Astor, B.
(2008). 25-Hydroxyvitamin D Levels and the Risk of Mortality in the General Population. Arch Intern Med
168: 1629-1637
[Abstract][Full Text]
Gardner, R. L., Harris, F., Vittinghoff, E., Cummings, S. R.
(2008). The Risk of Fracture Following Hospitalization in Older Women and Men. Arch Intern Med
168: 1671-1677
[Abstract][Full Text]
Dawson-Hughes, B.
(2008). Serum 25-hydroxyvitamin D and functional outcomes in the elderly. Am. J. Clin. Nutr.
88: 537S-540S
[Abstract][Full Text]
Misra, M., Pacaud, D., Petryk, A., Collett-Solberg, P. F., Kappy, M., on behalf of the Drug and Therapeutics Committee o,
(2008). Vitamin D Deficiency in Children and Its Management: Review of Current Knowledge and Recommendations. Pediatrics
122: 398-417
[Abstract][Full Text]
Wagner, D., Sidhom, G., Whiting, S. J., Rousseau, D., Vieth, R.
(2008). The Bioavailability of Vitamin D from Fortified Cheeses and Supplements Is Equivalent in Adults. J. Nutr.
138: 1365-1371
[Abstract][Full Text]
Mehrotra, R., Kermah, D., Budoff, M., Salusky, I. B., Mao, S. S., Gao, Y. L., Takasu, J., Adler, S., Norris, K.
(2008). Hypovitaminosis D in Chronic Kidney Disease. CJASN
3: 1144-1151
[Abstract][Full Text]
Wolf, M., Betancourt, J., Chang, Y., Shah, A., Teng, M., Tamez, H., Gutierrez, O., Camargo, C. A. Jr., Melamed, M., Norris, K., Stampfer, M. J., Powe, N. R., Thadhani, R.
(2008). Impact of Activated Vitamin D and Race on Survival among Hemodialysis Patients. J. Am. Soc. Nephrol.
19: 1379-1388
[Abstract][Full Text]
Wang-Gillam, A., Miles, D. A., Hutchins, L. F.
(2008). Evaluation of Vitamin D Deficiency in Breast Cancer Patients on Bisphosphonates. The Oncologist
13: 821-827
[Abstract][Full Text]
Sievenpiper, J. L, McIntyre, E. A, Verrill, M., Quinton, R., Pearce, S. H S
(2008). Unrecognised severe vitamin D deficiency. BMJ
336: 1371-1374
[Full Text]
Giovannucci, E., Liu, Y., Hollis, B. W., Rimm, E. B.
(2008). 25-Hydroxyvitamin D and Risk of Myocardial Infarction in Men: A Prospective Study. Arch Intern Med
168: 1174-1180
[Abstract][Full Text]
Gordon, C. M., Feldman, H. A., Sinclair, L., Williams, A. L., Kleinman, P. K., Perez-Rossello, J., Cox, J. E.
(2008). Prevalence of Vitamin D Deficiency Among Healthy Infants and Toddlers. Arch Pediatr Adolesc Med
162: 505-512
[Abstract][Full Text]
Bowden, S. A., Robinson, R. F., Carr, R., Mahan, J. D.
(2008). Prevalence of Vitamin D Deficiency and Insufficiency in Children With Osteopenia or Osteoporosis Referred to a Pediatric Metabolic Bone Clinic. Pediatrics
121: e1585-e1590
[Abstract][Full Text]
Holick, M. F, Chen, T. C
(2008). Vitamin D deficiency: a worldwide problem with health consequences. Am. J. Clin. Nutr.
87: 1080S-1086S
[Abstract][Full Text]
Blum, M., Dallal, G. E., Dawson-Hughes, B.
(2008). Body Size and Serum 25 Hydroxy Vitamin D Response to Oral Supplements in Healthy Older Adults. J. Am. Coll. Nutr.
27: 274-279
[Abstract][Full Text]
Isakova, T., Gutierrez, O., Shah, A., Castaldo, L., Holmes, J., Lee, H., Wolf, M.
(2008). Postprandial Mineral Metabolism and Secondary Hyperparathyroidism in Early CKD. J. Am. Soc. Nephrol.
19: 615-623
[Abstract][Full Text]
Soilu-Hanninen, M, Laaksonen, M, Laitinen, I, Eralinna, J-P, Lilius, E-M, Mononen, I
(2008). A longitudinal study of serum 25-hydroxyvitamin D and intact parathyroid hormone levels indicate the importance of vitamin D and calcium homeostasis regulation in multiple sclerosis. J. Neurol. Neurosurg. Psychiatry
79: 152-157
[Abstract][Full Text]
Wang, T. J., Pencina, M. J., Booth, S. L., Jacques, P. F., Ingelsson, E., Lanier, K., Benjamin, E. J., D'Agostino, R. B., Wolf, M., Vasan, R. S.
(2008). Vitamin D Deficiency and Risk of Cardiovascular Disease. Circulation
117: 503-511
[Abstract][Full Text]
Dawson-Hughes, B., Chen, P., Krege, J. H.
(2007). Response to Teriparatide in Patients with Baseline 25-Hydroxyvitamin D Insufficiency or Sufficiency. J. Clin. Endocrinol. Metab.
92: 4630-4636
[Abstract][Full Text]
Rowling, M. J., Gliniak, C., Welsh, J., Fleet, J. C.
(2007). High Dietary Vitamin D Prevents Hypocalcemia and Osteomalacia in CYP27B1 Knockout Mice. J. Nutr.
137: 2608-2615
[Abstract][Full Text]
Bouillon, R., Norman, A. W., Lips, P., Cava, R. C., Javier, A. N. D., Howe, W. R., Dellavalle, R., Baroncelli, G. I., Holick, M. F.
(2007). Vitamin D Deficiency. NEJM
357: 1980-1982
[Full Text]
Tylavsky, F. A., Ryder, K. M., Li, R., Park, V., Womack, C., Norwood, J., Carbone, L. D., Cheng, S.
(2007). Preliminary Findings: 25(OH)D Levels and PTH Are Indicators of Rapid Bone Accrual in Pubertal Children. J. Am. Coll. Nutr.
26: 462-470
[Abstract][Full Text]
Burleigh, E., McColl, J., Potter, J.
(2007). Does vitamin D stop inpatients falling? A randomised controlled trial. Age Ageing
36: 507-513
[Abstract][Full Text]
Holick, M. F.
(2007). Vitamin D Deficiency. NEJM
357: 266-281
[Full Text]
Wallis, D. E., Penckofer, S.
(2007). Letter by Wallis and Penckofer Regarding Article, "Calcium/Vitamin D Supplementation and Cardiovascular Events". Circulation
116: e86-e86
[Full Text]
Weng, F. L, Shults, J., Leonard, M. B, Stallings, V. A, Zemel, B. S
(2007). Risk factors for low serum 25-hydroxyvitamin D concentrations in otherwise healthy children and adolescents. Am. J. Clin. Nutr.
86: 150-158
[Abstract][Full Text]
Martins, D., Wolf, M., Pan, D., Zadshir, A., Tareen, N., Thadhani, R., Felsenfeld, A., Levine, B., Mehrotra, R., Norris, K.
(2007). Prevalence of Cardiovascular Risk Factors and the Serum Levels of 25-Hydroxyvitamin D in the United States: Data From the Third National Health and Nutrition Examination Survey. Arch Intern Med
167: 1159-1165
[Abstract][Full Text]
Shinchuk, L., Holick, M. F.
(2007). Vitamin D and Rehabilitation: Improving Functional Outcomes. Nutr Clin Pract
22: 297-304
[Abstract][Full Text]
Wicherts, I. S., van Schoor, N. M., Boeke, A. J. P., Visser, M., Deeg, D. J. H., Smit, J., Knol, D. L., Lips, P.
(2007). Vitamin D Status Predicts Physical Performance and Its Decline in Older Persons. J. Clin. Endocrinol. Metab.
92: 2058-2065
[Abstract][Full Text]
Pittas, A. G., Lau, J., Hu, F. B., Dawson-Hughes, B.
(2007). The Role of Vitamin D and Calcium in Type 2 Diabetes. A Systematic Review and Meta-Analysis. J. Clin. Endocrinol. Metab.
92: 2017-2029
[Abstract][Full Text]
Schwalfenberg, G.
(2007). Not enough vitamin D: Health consequences for Canadians. cfp
53: 841-854
[Abstract][Full Text]
Forman, J. P., Giovannucci, E., Holmes, M. D., Bischoff-Ferrari, H. A., Tworoger, S. S., Willett, W. C., Curhan, G. C.
(2007). Plasma 25-Hydroxyvitamin D Levels and Risk of Incident Hypertension. Hypertension
49: 1063-1069
[Abstract][Full Text]
Camargo, C. A Jr, Rifas-Shiman, S. L, Litonjua, A. A, Rich-Edwards, J. W, Weiss, S. T, Gold, D. R, Kleinman, K., Gillman, M. W
(2007). Maternal intake of vitamin D during pregnancy and risk of recurrent wheeze in children at 3 y of age. Am. J. Clin. Nutr.
85: 788-795
[Abstract][Full Text]
Zhou, W., Heist, R. S., Liu, G., Asomaning, K., Neuberg, D. S., Hollis, B. W., Wain, J. C., Lynch, T. J., Giovannucci, E., Su, L., Christiani, D. C.
(2007). Circulating 25-Hydroxyvitamin D Levels Predict Survival in Early-Stage Non-Small-Cell Lung Cancer Patients. JCO
25: 479-485
[Abstract][Full Text]
Fuhrman, M. P.
(2006). Micronutrient Assessment in Long-Term Home Parenteral Nutrition Patients. Nutr Clin Pract
21: 566-575
[Abstract][Full Text]
Lappe, J. M., Davies, K. M., Travers-Gustafson, D., Heaney, R. P.
(2006). Vitamin d status in a rural postmenopausal female population.. J. Am. Coll. Nutr.
25: 395-402
[Abstract][Full Text]
Wesseling, K., Salusky, I. B.
(2006). Current treatment options in secondary hyperparathyroidism. Nephrol Dial Transplant
21: 2986-2987
[Full Text]
McMahon, M. M., Sarr, M. G., Clark, M. M., Gall, M. M., Knoetgen, J. III, Service, F. J., Laskowski, E. R., Hurley, D. L.
(2006). Clinical Management After Bariatric Surgery: Value of a Multidisciplinary Approach. Mayo Clin Proc.
81: S34-S45
[Abstract][Full Text]
Aloia, J. F, Talwar, S. A, Pollack, S., Feuerman, M., Yeh, J. K
(2006). Optimal vitamin D status and serum parathyroid hormone concentrations in African American women.. Am. J. Clin. Nutr.
84: 602-609
[Abstract][Full Text]
Visser, M., Deeg, D. J., Puts, M. T., Seidell, J. C, Lips, P.
(2006). Low serum concentrations of 25-hydroxyvitamin D in older persons and the risk of nursing home admission.. Am. J. Clin. Nutr.
84: 616-622
[Abstract][Full Text]
Felsenfeld, A. J., Levine, B. S.
(2006). Milk Alkali Syndrome and the Dynamics of Calcium Homeostasis. CJASN
1: 641-654
[Full Text]
Das, G, Crocombe, S, McGrath, M, Berry, J L, Mughal, M Z
(2006). Hypovitaminosis D among healthy adolescent girls attending an inner city school. Arch. Dis. Child.
91: 569-572
[Abstract][Full Text]
Heaney, R. P.
(2006). Barriers to Optimizing Vitamin D3 Intake for the Elderly. J. Nutr.
136: 1123-1125
[Abstract][Full Text]
Allain, T. J., Kirthisingha, V., Beresford, P. A., Bell, N. J.
(2006). Use of vitamin D supplements and vitamin D status in patients taking bisphosphonate drugs. Rheumatology (Oxford)
45: 486-487
[Full Text]
Wong, T. S. F., Lau, V. M. H., Lim, W., Fung, G.
(2006). A survey of vitamin D level in people with learning disability in long-stay hospital wards in Hong Kong.. J Intellect Disabil
10: 47-59
[Abstract]
Cigolini, M., Iagulli, M. P., Miconi, V., Galiotto, M., Lombardi, S., Targher, G.
(2006). Serum 25-hydroxyvitamin d3 concentrations and prevalence of cardiovascular disease among type 2 diabetic patients.. Diabetes Care
29: 722-724
[Full Text]
Holick, M. F.
(2006). High Prevalence of Vitamin D Inadequacy and Implications for Health. Mayo Clin Proc.
81: 353-373
[Abstract][Full Text]
Bischoff-Ferrari, H. A., Orav, E. J., Dawson-Hughes, B.
(2006). Effect of cholecalciferol plus calcium on falling in ambulatory older men and women: a 3-year randomized controlled trial.. Arch Intern Med
166: 424-430
[Abstract][Full Text]
Poole, K. E. S., Loveridge, N., Barker, P. J., Halsall, D. J., Rose, C., Reeve, J., Warburton, E. A.
(2006). Reduced Vitamin D in Acute Stroke. Stroke
37: 243-245
[Abstract][Full Text]
Wright, R. J.
(2005). Make No Bones About It: Increasing Epidemiologic Evidence Links Vitamin D to Pulmonary Function and COPD. Chest
128: 3781-3783
[Full Text]
Steingrimsdottir, L., Gunnarsson, O., Indridason, O. S., Franzson, L., Sigurdsson, G.
(2005). Relationship Between Serum Parathyroid Hormone Levels, Vitamin D Sufficiency, and Calcium Intake. JAMA
294: 2336-2341
[Abstract][Full Text]
Rockell, J. E., Green, T. J., Skeaff, C. M., Whiting, S. J., Taylor, R. W., Williams, S. M., Parnell, W. R., Scragg, R., Wilson, N., Schaaf, D., Fitzgerald, E. D., Wohlers, M. W.
(2005). Season and Ethnicity Are Determinants of Serum 25-Hydroxyvitamin D Concentrations in New Zealand Children Aged 5-14 y. J. Nutr.
135: 2602-2608
[Abstract][Full Text]
Tylavsky, F. A., Ryder, K. A., Lyytikainen, A., Cheng, S.
(2005). Vitamin D, Parathyroid Hormone, and Bone Mass in Adolescents. J. Nutr.
135: 2735S-2738S
[Abstract][Full Text]
Holick, M. F.
(2005). The Vitamin D Epidemic and its Health Consequences. J. Nutr.
135: 2739S-2748S
[Abstract][Full Text]
Rajakumar, K., Fernstrom, J. D., Janosky, J. E., Greenspan, S. L.
(2005). Vitamin D Insufficiency in Preadolescent African-American Children. CLIN PEDIATR
44: 683-692
[Abstract]
Zhou, W., Suk, R., Liu, G., Park, S., Neuberg, D. S., Wain, J. C., Lynch, T. J., Giovannucci, E., Christiani, D. C.
(2005). Vitamin D Is Associated with Improved Survival in Early-Stage Non-Small Cell Lung Cancer Patients. Cancer Epidemiol. Biomarkers Prev.
14: 2303-2309
[Abstract][Full Text]
Moore, C. E., Murphy, M. M., Holick, M. F.
(2005). Vitamin D Intakes by Children and Adults in the United States Differ among Ethnic Groups. J. Nutr.
135: 2478-2485
[Abstract][Full Text]
Broadbent, A., Glare, P., Crawford, B.
(2005). Bisphosphonate-induced hypocalcemia associated with vitamin D deficiency in a patient with advanced cancer. AM J HOSP PALLIAT CARE
22: 382-384
[Abstract]
Holick, M. F, Tangpricha, V.
(2005). Reply to MA Weinstock and D Lazovich. Am. J. Clin. Nutr.
82: 707-708
[Full Text]
Antoniucci, D. M., Vittinghoff, E., Blackwell, T., Black, D. M., Sellmeyer, D. E.
(2005). Vitamin D Insufficiency Does Not Affect Bone Mineral Density Response to Raloxifene. J. Clin. Endocrinol. Metab.
90: 4566-4572
[Abstract][Full Text]
Gutierrez, O., Isakova, T., Rhee, E., Shah, A., Holmes, J., Collerone, G., Juppner, H., Wolf, M.
(2005). Fibroblast Growth Factor-23 Mitigates Hyperphosphatemia but Accentuates Calcitriol Deficiency in Chronic Kidney Disease. J. Am. Soc. Nephrol.
16: 2205-2215
[Abstract][Full Text]
Favus, M. J.
(2005). Postmenopausal Osteoporosis and the Detection of So-Called Secondary Causes of Low Bone Density. J. Clin. Endocrinol. Metab.
90: 3800-3801
[Full Text]
Rodd, C., Mushcab, S. A.l.
(2005). Hypocalcemic Seizures Secondary to Nutritional Vitamin D Deficiency in 3 Infants Fed Soy Formula. CLIN PEDIATR
44: 455-457
Soilu-Hanninen, M, Airas, L, Mononen, I, Heikkila, A, Viljanen, M, Hanninen, A
(2005). 25-Hydroxyvitamin D levels in serum at the onset of multiple sclerosis. Mult Scler
11: 266-271
[Abstract]
Greenspan, S. L., Resnick, N. M., Parker, R. A.
(2005). Vitamin D Supplementation in Older Women. Journals of Gerontology Series A: Biological Sciences and Medical Sciences
60: 754-759
[Abstract][Full Text]
Holick, M. F., Siris, E. S., Binkley, N., Beard, M. K., Khan, A., Katzer, J. T., Petruschke, R. A., Chen, E., de Papp, A. E.
(2005). Prevalence of Vitamin D Inadequacy among Postmenopausal North American Women Receiving Osteoporosis Therapy. J. Clin. Endocrinol. Metab.
90: 3215-3224
[Abstract][Full Text]
Sachan, A., Gupta, R., Das, V., Agarwal, A., Awasthi, P. K, Bhatia, V.
(2005). High prevalence of vitamin D deficiency among pregnant women and their newborns in northern India. Am. J. Clin. Nutr.
81: 1060-1064
[Abstract][Full Text]
Teng, M., Wolf, M., Ofsthun, M. N., Lazarus, J. M., Hernan, M. A., Camargo, C. A. Jr, Thadhani, R.
(2005). Activated Injectable Vitamin D and Hemodialysis Survival: A Historical Cohort Study. J. Am. Soc. Nephrol.
16: 1115-1125
[Abstract][Full Text]
Sato, Y., Iwamoto, J., Kanoko, T., Satoh, K.
(2005). Risedronate therapy for prevention of hip fracture after stroke in elderly women. Neurology
64: 811-816
[Abstract][Full Text]
Levis, S., Gomez, A., Jimenez, C., Veras, L., Ma, F., Lai, S., Hollis, B., Roos, B. A.
(2005). Vitamin D Deficiency and Seasonal Variation in an Adult South Florida Population. J. Clin. Endocrinol. Metab.
90: 1557-1562
[Abstract][Full Text]
Smith, S. M., Zwart, S. R., Block, G., Rice, B. L., Davis-Street, J. E.
(2005). The Nutritional Status of Astronauts Is Altered after Long-Term Space Flight Aboard the International Space Station. J. Nutr.
135: 437-443
[Abstract][Full Text]
Calvo, M. S., Whiting, S. J., Barton, C. N.
(2005). Vitamin D Intake: A Global Perspective of Current Status. J. Nutr.
135: 310-316
[Abstract][Full Text]
Hanley, D. A., Davison, K. S.
(2005). Vitamin D Insufficiency in North America. J. Nutr.
135: 332-337
[Abstract][Full Text]
Antoniucci, D. M., Black, D. M., Sellmeyer, D. E.
(2005). Serum 25-Hydroxyvitamin D Is Unaffected by Multiple Freeze-Thaw Cycles. Clin. Chem.
51: 258-261
[Full Text]
Holick, M. F
(2004). Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Am. J. Clin. Nutr.
80: 1678S-1688S
[Abstract][Full Text]
Heaney, R. P
(2004). Functional indices of vitamin D status and ramifications of vitamin D deficiency. Am. J. Clin. Nutr.
80: 1706S-1709S
[Abstract][Full Text]
Calvo, M. S, Whiting, S. J, Barton, C. N
(2004). Vitamin D fortification in the United States and Canada: current status and data needs. Am. J. Clin. Nutr.
80: 1710S-1716S
[Abstract][Full Text]
Fleet, J. C
(2004). Genomic and proteomic approaches for probing the role of vitamin D in health. Am. J. Clin. Nutr.
80: 1730S-1734S
[Abstract][Full Text]
Weaver, C. M, Fleet, J. C
(2004). Vitamin D requirements: current and future. Am. J. Clin. Nutr.
80: 1735S-1739S
[Abstract][Full Text]
Greer, F. R
(2004). Issues in establishing vitamin D recommendations for infants and children. Am. J. Clin. Nutr.
80: 1759S-1762S
[Abstract][Full Text]
