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Previous Volume 338:1516-1520 May 21, 1998 Number 21 Next

	Full Text PDF Editorial by Steinbrook, R. Letters Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

ABSTRACT

Background Patients can have several illnesses concurrently, yet some of these diseases may be neglected if one problem consumes attention. We conducted a population-based analysis in Ontario, Canada — where universal health insurance is provided — to determine whether unrelated disorders are less likely to be treated in patients with chronic diseases.

Methods We studied the 1,344,145 residents of Ontario in 1995 who were 65 or older and eligible to receive prescription medications free of charge as part of the Ontario Drug Benefit program. Patients with diabetes mellitus were identified by prescriptions for insulin, pulmonary emphysema by prescriptions for ipratropium bromide, and psychotic syndromes by prescriptions for haloperidol. For each chronic disease, we selected an unrelated treatment: estrogen-replacement therapy for patients with diabetes mellitus, lipid-lowering medications for those with pulmonary emphysema, and medical treatment of arthritis for those with psychotic syndromes.

Results The 30,669 patients with diabetes mellitus were less likely to receive estrogen-replacement therapy than the other subjects in the study (2.4 percent vs. 5.9 percent, P<0.001). The disease was associated with a 60 percent reduction in the odds of estrogen treatment (odds ratio, 0.40; 95 percent confidence interval, 0.37 to 0.43). Findings were similar for the 56,779 patients with pulmonary emphysema, who were less likely to receive lipid-lowering medications (odds ratio, 0.69; 95 percent confidence interval, 0.67 to 0.72; P<0.001), and the 17,336 patients with psychotic syndromes, who were less likely to receive medical treatments for arthritis (odds ratio, 0.59; 95 percent confidence interval, 0.57 to 0.62; P<0.001).

Conclusions In patients 65 or older who have chronic medical diseases and who receive prescription medications free of charge, unrelated disorders are undertreated. Clinicians caring for patients with chronic diseases should remain alert to other disorders and minimize the number of missed opportunities for treating them.

Source Information

From the Department of Medicine, University of Toronto (D.A.R., G.L.B.); the Clinical Epidemiology and Health Care Research Program, Sunnybrook Health Science Centre (D.A.R., S.H.T., G.L.B.); and the Institute for Clinical Evaluative Sciences in Ontario (D.A.R., S.H.T.) — all in Toronto.

Address reprint requests to Dr. Redelmeier at the Sunnybrook Health Science Centre, G-151, 2075 Bayview Ave., Toronto, ON M4N 3M5, Canada.

Full Text of this Article

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Treating Unrelated Disorders in Patients with Chronic Disease
Kent D. M., Hayward R., Rubins H. B., Friedman E. A., Poses R. M., Redelmeier D. A., Tan S. H., Booth G. L.
Extract | Full Text  
N Engl J Med 1998; 339:926-928, Sep 24, 1998. Correspondence

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• Keating, N. L., Cleary, P. D., Rossi, A. S., Zaslavsky, A. M., Ayanian, J. Z. (1999). Use of Hormone Replacement Therapy by Postmenopausal Women in the United States. ANN INTERN MED 130: 545-553 [Abstract] [Full Text]  
• Fisher, E. S., Welch, H. G. (1999). Avoiding the Unintended Consequences of Growth in Medical Care: How Might More Be Worse?. JAMA 281: 446-453 [Abstract] [Full Text]  
• Kent, D. M., Hayward, R., Rubins, H. B., Friedman, E. A., Poses, R. M., Redelmeier, D. A., Tan, S. H., Booth, G. L. (1998). Treating Unrelated Disorders in Patients with Chronic Disease. NEJM 339: 926-928 [Full Text]  
• Steinbrook, R. (1998). Patients with Multiple Chronic Conditions -- How Many Medications Are Enough?. NEJM 338: 1541-1542 [Full Text]