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Previous Volume 340:14-22 January 7, 1999 Number 1 Next

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ABSTRACT

Background The combined thickness of the intima and media of the carotid artery is associated with the prevalence of cardiovascular disease. We studied the associations between the thickness of the carotid-artery intima and media and the incidence of new myocardial infarction or stroke in persons without clinical cardiovascular disease.

Methods Noninvasive measurements of the intima and media of the common and internal carotid artery were made with high-resolution ultrasonography in 5858 subjects 65 years of age or older. Cardiovascular events (new myocardial infarction or stroke) served as outcome variables in subjects without clinical cardiovascular disease (4476 subjects) over a median follow-up period of 6.2 years.

Results The incidence of cardiovascular events correlated with measurements of carotid-artery intima–media thickness. The relative risk of myocardial infarction or stroke increased with intima–media thickness (P<0.001). The relative risk of myocardial infarction or stroke (adjusted for age and sex) for the quintile with the highest thickness as compared with the lowest quintile was 3.87 (95 percent confidence interval, 2.72 to 5.51). The association between cardiovascular events and intima–media thickness remained significant after adjustment for traditional risk factors, showing increasing risks for each quintile of combined intima–media thickness, from the second quintile (relative risk, 1.54; 95 percent confidence interval, 1.04 to 2.28), to the third (relative risk, 1.84; 95 percent confidence interval, 1.26 to 2.67), fourth (relative risk, 2.01; 95 percent confidence interval, 1.38 to 2.91), and fifth (relative risk, 3.15; 95 percent confidence interval, 2.19 to 4.52). The results of separate analyses of myocardial infarction and stroke paralleled those for the combined end point.

Conclusions Increases in the thickness of the intima and media of the carotid artery, as measured noninvasively by ultrasonography, are directly associated with an increased risk of myocardial infarction and stroke in older adults without a history of cardiovascular disease.

Source Information

From the Department of Radiology, Tufts–New England Medical Center, Boston (D.H.O.); the Department of Radiology, Brigham and Women's Hospital, Boston (J.F.P.); the Department of Biostatistics, University of Washington, Seattle (R.A.K.); the Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, Md. (T.A.M.); the Department of Public Health Sciences, Bowman Gray School of Medicine, Winston-Salem, N.C. (G.L.B.); and the Department of Surgery, University of Pittsburgh, Pittsburgh (S.K.W.).

Address reprint requests to the CHS Coordinating Center, Century Sq., 1501 4th Ave., Suite 2025, Seattle, WA 98101, or to daniel.oleary{at}es.nemc.org.

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Carotid-Artery Intima and Media Thickness as a Risk Factor for Myocardial Infarction and Stroke
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Extract | Full Text  
N Engl J Med 1999; 340:1762-1763, Jun 3, 1999. Correspondence

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• Fernhall, B., Agiovlasitis, S. (2008). Arterial function in youth: window into cardiovascular risk. J. Appl. Physiol. 105: 325-333 [Abstract] [Full Text]  
• Kozakova, M., Muscelli, E., Flyvbjerg, A., Frystyk, J., Morizzo, C., Palombo, C., Ferrannini, E. (2008). Adiponectin and Left Ventricular Structure and Function in Healthy Adults. J. Clin. Endocrinol. Metab. 93: 2811-2818 [Abstract] [Full Text]  
• Utz, A. L., Yamamoto, A., Hemphill, L., Miller, K. K. (2008). Growth Hormone Deficiency by Growth Hormone Releasing Hormone-Arginine Testing Criteria Predicts Increased Cardiovascular Risk Markers in Normal Young Overweight and Obese Women. J. Clin. Endocrinol. Metab. 93: 2507-2514 [Abstract] [Full Text]  
• Afzal, A. R., Kiechl, S., Daryani, Y. P., Weerasinghe, A., Zhang, Y., Reindl, M., Mayr, A., Weger, S., Xu, Q., Willeit, J. (2008). Common CCR5-del32 Frameshift Mutation Associated With Serum Levels of Inflammatory Markers and Cardiovascular Disease Risk in the Bruneck Population. Stroke 39: 1972-1978 [Abstract] [Full Text]  
• O'Donnell, C. J., Demissie, S., Kimura, M., Levy, D., Gardner, J. P., White, C., D'Agostino, R. B., Wolf, P. A., Polak, J., Cupples, L. A., Aviv, A. (2008). Leukocyte Telomere Length and Carotid Artery Intimal Medial Thickness: The Framingham Heart Study. Arterioscler. Thromb. Vasc. Bio. 28: 1165-1171 [Abstract] [Full Text]  
• Juonala, M., Kahonen, M., Laitinen, T., Hutri-Kahonen, N., Jokinen, E., Taittonen, L., Pietikainen, M., Helenius, H., Viikari, J. S.A., Raitakari, O. T. (2008). Effect of age and sex on carotid intima-media thickness, elasticity and brachial endothelial function in healthy adults: The Cardiovascular Risk in Young Finns Study. Eur Heart J 29: 1198-1206 [Abstract] [Full Text]  
• Dursun, B., Dursun, E., Suleymanlar, G., Ozben, B., Capraz, I., Apaydin, A., Ozben, T. (2008). Carotid artery intima-media thickness correlates with oxidative stress in chronic haemodialysis patients with accelerated atherosclerosis. Nephrol Dial Transplant 23: 1697-1703 [Abstract] [Full Text]  
• Wintermark, M., Jawadi, S.S., Rapp, J.H., Tihan, T., Tong, E., Glidden, D.V., Abedin, S., Schaeffer, S., Acevedo-Bolton, G., Boudignon, B., Orwoll, B., Pan, X., Saloner, D. (2008). High-Resolution CT Imaging of Carotid Artery Atherosclerotic Plaques. Am. J. Neuroradiol. 29: 875-882 [Abstract] [Full Text]  
• Frontini, M. G., Srinivasan, S. R., Xu, J., Tang, R., Bond, M. G., Berenson, G. S. (2008). Usefulness of Childhood Non-High Density Lipoprotein Cholesterol Levels Versus Other Lipoprotein Measures in Predicting Adult Subclinical Atherosclerosis: The Bogalusa Heart Study. Pediatrics 121: 924-929 [Abstract] [Full Text]  
• Sardo, M. A., Campo, S., Mandraffino, G., Saitta, C., Bonaiuto, A., Castaldo, M., Cinquegrani, M., Pizzimenti, G., Saitta, A. (2008). Tissue Factor and Monocyte Chemoattractant Protein-1 Expression in Hypertensive Individuals with Normal or Increased Carotid Intima-Media Wall Thickness. Clin. Chem. 54: 814-823 [Abstract] [Full Text]  
• Puato, M., Palatini, P., Zanardo, M., Dorigatti, F., Tirrito, C., Rattazzi, M., Pauletto, P. (2008). Increase in Carotid Intima-Media Thickness in Grade I Hypertensive Subjects: White-Coat Versus Sustained Hypertension. Hypertension 51: 1300-1305 [Abstract] [Full Text]  
• Davidson, M., Meyer, P. M., Haffner, S., Feinstein, S., D'Agostino, R. Sr, Kondos, G. T., Perez, A., Chen, Z., Mazzone, T. (2008). Increased High-Density Lipoprotein Cholesterol Predicts the Pioglitazone-Mediated Reduction of Carotid Intima-Media Thickness Progression in Patients With Type 2 Diabetes Mellitus. Circulation 117: 2123-2130 [Abstract] [Full Text]  
• Peterson, E. D., Wang, T. Y. (2008). The Great Debate of 2008--How Low to Go in Preventive Cardiology?. JAMA 299: 1718-1720 [Full Text]  
• Kastelein, J. J.P., de Groot, E. (2008). Ultrasound imaging techniques for the evaluation of cardiovascular therapies. Eur Heart J 29: 849-858 [Abstract] [Full Text]  
• Esposito, K., Ciotola, M., Carleo, D., Schisano, B., Sardelli, L., Di Tommaso, D., Misso, L., Saccomanno, F., Ceriello, A., Giugliano, D. (2008). Post-Meal Glucose Peaks at Home Associate with Carotid Intima-Media Thickness in Type 2 Diabetes. J. Clin. Endocrinol. Metab. 93: 1345-1350 [Abstract] [Full Text]  
• Rundek, T., Arif, H., Boden-Albala, B., Elkind, M. S., Paik, M. C., Sacco, R. L. (2008). Carotid plaque, a subclinical precursor of vascular events: The Northern Manhattan Study. Neurology 70: 1200-1207 [Abstract] [Full Text]  
• Mattsson, N., Ronnemaa, T., Juonala, M., Viikari, J. S.A., Jokinen, E., Hutri-Kahonen, N., Kahonen, M., Laitinen, T., Raitakari, O. T. (2008). Arterial structure and function in young adults with the metabolic syndrome: the Cardiovascular Risk in Young Finns Study. Eur Heart J 29: 784-791 [Abstract] [Full Text]  
• Stangl, V., Witzel, V., Baumann, G., Stangl, K. (2008). Current diagnostic concepts to detect coronary artery disease in women. Eur Heart J 29: 707-717 [Abstract] [Full Text]  
• Skilton, M. R. (2008). Intrauterine Risk Factors for Precocious Atherosclerosis. Pediatrics 121: 570-574 [Abstract] [Full Text]  
• Feldman, D. R., Bosl, G. J., Sheinfeld, J., Motzer, R. J. (2008). Medical Treatment of Advanced Testicular Cancer. JAMA 299: 672-684 [Abstract] [Full Text]