FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 340:1071-1074 April 8, 1999 Number 14 Next

	Full Text PDF Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

ABSTRACT

Background Bronchioloalveolar carcinoma is a distinctive subtype of typical adenocarcinoma of the lung that tends to metastasize widely throughout the lungs but less commonly elsewhere. Because conventional therapies for intrapulmonary metastatic bronchioloalveolar carcinoma are generally ineffective, we treated seven patients who had intrapulmonary metastatic bronchioloalveolar carcinoma with lung transplantation.

Methods Seven patients with biopsy-proved bronchioloalveolar carcinoma and no evidence of extrapulmonary disease received transplants of either one or two cadaveric lungs. At transplantation, all native lung tissue was removed and replaced with a donor lung or lungs. The patients received the usual post-transplantation care given at the institution.

Results Four of the seven patients had recurrent bronchioloalveolar carcinoma within the donor lungs; the recurrences appeared from 10 to 48 months after transplantation. All recurrences were limited to the donor lungs. Histologic and molecular analyses showed that the recurrent tumors in three patients originated from the recipients of the transplants.

Conclusions Lung transplantation for bronchioloalveolar carcinoma is technically feasible, but recurrence of the original tumor within the donor lungs up to four years after transplantation was common.

Source Information

From the Departments of Medicine (R.I.G., X.W., K.R.Y.), Surgery (G.L.Z., D.C.M.), and Pathology (N.B.P.), University of Alabama at Birmingham; and the Lung Transplant Program (G.L.Z., D.C.M., K.R.Y.) and Lung Cancer Program (R.I.G., G.L.Z.), UAB Hospital, Birmingham, Ala.

Address reprint requests to Dr. Garver at the School of Medicine, University of Alabama at Birmingham, 701 South 19th St./LHRB 339, Birmingham, AL 35294, or at robgarver{at}sprintmail.com.

Full Text of this Article

This article has been cited by other articles:

• Nakamura, H., Makino, Y., Okamoto, K., Poellinger, L., Ohnuma, K., Morimoto, C., Tanaka, H. (2005). TCR Engagement Increases Hypoxia-Inducible Factor-1{alpha} Protein Synthesis via Rapamycin-Sensitive Pathway under Hypoxic Conditions in Human Peripheral T Cells. J. Immunol. 174: 7592-7599 [Abstract] [Full Text]  
• de Perrot, M., Chernenko, S., Waddell, T. K., Shargall, Y., Pierre, A. F., Hutcheon, M., Keshavjee, S. (2004). Role of Lung Transplantation in the Treatment of Bronchogenic Carcinomas for Patients With End-Stage Pulmonary Disease. JCO 22: 4351-4356 [Abstract] [Full Text]  
• Mal, H., Guignabert, C., Thabut, G., d'Ortho, M. P., Brugiere, O., Dauriat, G., Marrash-Chahla, R., Rangheard, A.-S., Leseche, G., Fournier, M. (2004). Recurrence of Pulmonary Emphysema in an {alpha}-1 Proteinase Inhibitor-deficient Lung Transplant Recipient. Am. J. Respir. Crit. Care Med. 170: 811-814 [Abstract] [Full Text]  
• Kotloff, R.M., Ahya, V.N. (2004). Medical complications of lung transplantation. Eur Respir J 23: 334-342 [Abstract] [Full Text]  
• Barlesi, F., Doddoli, C., Gimenez, C., Chetaille, B., Giudicelli, R., Fuentes, P., Kleisbauer, J.-P., Thomas, P. (2003). Bronchioloalveolar carcinoma: myths and realities in the surgical management. Eur. J. Cardiothorac. Surg. 24: 159-164 [Abstract] [Full Text]  
• Egan, T. M., Detterbeck, F. C. (2003). The ABCs of LTX for BAC. J. Thorac. Cardiovasc. Surg. 125: 20-22 [Full Text]  
• Zorn, G. L. Jr, McGiffin, D. C., Young, K. R. Jr, Alexander, C. B., Weill, D., Kirklin, J. K. (2003). Pulmonary transplantation for advanced bronchioloalveolar carcinoma. J. Thorac. Cardiovasc. Surg. 125: 45-48 [Abstract] [Full Text]  
• Barlesi, F., Doddoli, C., Thomas, P., Kleisbauer, J.-P., Giudicelli, R., Fuentes, P. (2001). Bilateral bronchioloalveolar lung carcinoma: is there a place for palliative pneumonectomy?. Eur. J. Cardiothorac. Surg. 20: 1113-1116 [Abstract] [Full Text]  
• Collins, J., Hartman, M. J., Warner, T. F., Müller, N. L., Kazerooni, E. A., McAdams, H. P., Slone, R. M., Parker, L. A. (2001). Frequency and CT Findings of Recurrent Disease after Lung Transplantation. Radiology 219: 503-509 [Abstract] [Full Text]