A Randomized, Controlled Trial of a Behavioral Intervention to Prevent Sexually Transmitted Disease among Minority Women
Rochelle N. Shain, Ph.D., Jeanna M. Piper, M.D., Edward R. Newton, M.D., Sondra T. Perdue, Dr.P.H., Reyes Ramos, Ph.D., Jane Dimmitt Champion, Ph.D., and Fernando A. Guerra, M.D., M.P.H.
Background African-American and Hispanic women are disproportionatelyaffected by sexually transmitted diseases, including the acquiredimmunodeficiency syndrome (AIDS). In the effort to reduce infectionrates, it is important to create and evaluate behavioral interventionsthat are specific to the target populations.
Methods We enrolled women with nonviral sexually transmitteddiseases in a randomized trial of a sex- and culture-specificbehavioral intervention. The intervention consisted of threesmall-group sessions of three to four hours each designed tohelp women recognize personal susceptibility, commit to changingtheir behavior, and acquire necessary skills. The control groupreceived standard counseling about sexually transmitted diseases.The design of the intervention was based on the AIDS Risk ReductionModel and ethnographic data on the study populations. Participantsin both groups underwent screening, counseling, and an interviewbefore randomization and at the 6- and 12-month follow-up visits.The principal outcome variable was subsequent chlamydial orgonorrheal infection, which was evaluated on an intention-to-treatbasis by logistic-regression analysis.
Results A total of 424 Mexican-American and 193 African-Americanwomen were enrolled; 313 were assigned to the intervention groupand 304 to the control group. The rate of participation in theintervention was 90 percent. The rates of retention in the samplewere 82 and 89 percent at the 6- and 12-month visits, respectively.Rates of subsequent infection were significantly lower in theintervention group than in the control group during the first6 months (11.3 vs. 17.2 percent, P=0.05), during the second6 months (9.1 vs. 17.7 percent, P=0.008), and over the entire12-month study period (16.8 vs. 26.9 percent, P=0.004).
Conclusions A risk-reduction intervention consisting of threesmall-group sessions significantly decreased the rates of chlamydialand gonorrheal infection among Mexican-American and African-Americanwomen at high risk for sexually transmitted disease.
Source Information
From the Departments of Obstetrics and Gynecology (R.N.S., J.M.P.) and Microbiology (S.T.P.) and the School of Nursing (S.T.P., J.D.C.), University of Texas Health Science Center at San Antonio, San Antonio; the Department of Obstetrics and Gynecology, East Carolina University, Greenville, N.C. (E.R.N.); Research and Evaluation, Mujeres Project, San Antonio, Tex. (R.R.); and the San Antonio Metropolitan Health District, San Antonio, Tex. (F.A.G.).
Address reprint requests to Dr. Shain at the Department of Obstetrics and Gynecology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr., San Antonio, TX 78284-7836.
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