FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 340:1623-1629 May 27, 1999 Number 21 Next

	Full Text PDF Letters Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited Related Article PubMed Citation

ABSTRACT

Background In patients with refractory unstable angina, the platelet glycoprotein IIb/IIIa–receptor antibody abciximab reduces the incidence of cardiac events before and during coronary angioplasty. We investigated whether serum troponin T levels identify patients most likely to benefit from therapy with this drug.

Methods Among 1265 patients with unstable angina who were enrolled in the c7E3 Fab Antiplatelet Therapy in Unstable Refractory Angina (CAPTURE) trial, serum samples drawn at the time of randomization to abciximab or placebo were available from 890 patients; we used these samples for the determination of troponin T and creatine kinase MB levels. Patients with postinfarction angina were not included.

Results Serum troponin T levels at the time of study entry were elevated (above 0.1 ng per milliliter) in 275 patients (30.9 percent). Among patients receiving placebo, the risk of death or nonfatal myocardial infarction was related to troponin T levels. The six-month cumulative event rate was 23.9 percent among patients with elevated troponin T levels, as compared with 7.5 percent among patients without elevated troponin T levels (P<0.001). Among patients treated with abciximab, the respective six-month event rates were 9.5 percent for patients with elevated troponin T levels and 9.4 percent for those without elevated levels. As compared with placebo, the relative risk of death or nonfatal myocardial infarction associated with treatment with abciximab in patients with elevated troponin T levels was 0.32 (95 percent confidence interval, 0.14 to 0.62; P=0.002). The lower event rates in patients receiving abciximab were attributable to a reduction in the rate of myocardial infarction (odds ratio, 0.23; 95 percent confidence interval, 0.12 to 0.49; P<0.001). In patients without elevated troponin T levels, there was no benefit of treatment with respect to the relative risk of death or myocardial infarction at six months (odds ratio, 1.26; 95 percent confidence interval, 0.74 to 2.31; P=0.47).

Conclusions The serum troponin T level, which is considered to be a surrogate marker for thrombus formation, identifies a high-risk subgroup of patients with refractory unstable angina suitable for coronary angioplasty who will particularly benefit from antiplatelet treatment with abciximab.

Source Information

From the Department of Cardiology (C.W.H., C.H., B.G.) and the Institute of Mathematics and Computer Science in Medicine (J.B.), University Hospital Eppendorf, Hamburg, Germany; the Service de Cardiologie, Hôpital Tenon, Paris (A.V.); the Cardiac Department of the Royal Victoria Hospital, Belfast, Northern Ireland (J.A.); Unidad de Hemodinamica, Hospital Universitario San Carlos, Madrid (C.M.M.); the Department of Cardiology, Charité University Hospital, Berlin, Germany (W.R.); and Cardialysis and Erasmus University, Rotterdam, the Netherlands (J.K., M.L.S.). Presented in part at the 47th Annual Scientific Session of the American College of Cardiology, Atlanta, March 29–April 1, 1998.

Address reprint requests to Dr. Hamm at Kerckhoff Heart Center, Benekestrasse 2-8, D-61231 Bad Nauheim, Germany, or at christian. hamm{at}kerckhoff.med.uni-giessen.de.

Full Text of this Article

Related Letters:

Troponin T Levels and Abciximab Therapy in Unstable Angina
Lev E. I., Osende J. I., Zaman A. G., Hamm C. W., Heeschen C.
Extract | Full Text  
N Engl J Med 1999; 341:1084-1085, Sep 30, 1999. Correspondence

This article has been cited by other articles:

• Kumar, A., Cannon, C. P. (2009). Acute Coronary Syndromes: Diagnosis and Management, Part I. Mayo Clin Proc. 84: 917-938 [Abstract] [Full Text]  
• Reichlin, T., Hochholzer, W., Bassetti, S., Steuer, S., Stelzig, C., Hartwiger, S., Biedert, S., Schaub, N., Buerge, C., Potocki, M., Noveanu, M., Breidthardt, T., Twerenbold, R., Winkler, K., Bingisser, R., Mueller, C. (2009). Early Diagnosis of Myocardial Infarction with Sensitive Cardiac Troponin Assays. NEJM 361: 858-867 [Abstract] [Full Text]  
• Rohatgi, A., de Lemos, J. A. (2009). The Report Card on Growth Differentiation Factor 15: Consistent Marks But Not Yet Ready for Promotion. Circ Cardiovasc Genet 2: 209-211 [Full Text]  
• Halim, S. A., Mulgund, J., Chen, A. Y., Roe, M. T., Peterson, E. D., Gibler, W. B., Ohman, E. M., Newby, L. K. (2009). Use of Guidelines-Recommended Management and Outcomes Among Women and Men With Low-Level Troponin Elevation: Insights From CRUSADE. Circ Cardiovasc Qual Outcomes 2: 199-206 [Abstract] [Full Text]  
• Hamm, C. W., Möllmann, H., Bassand, J.-P., van de Werf, F. (2009). CHAPTER 16 Acute Coronary Syndromes. ESC Textbook of Cardiovascular Medicine 2: med-9780199566990-chapter-med-9780199566990-chapter [Abstract] [Full Text]  
• Jeremias, A., Kleiman, N. S., Nassif, D., Hsieh, W.-H., Pencina, M., Maresh, K., Parikh, M., Cutlip, D. E., Waksman, R., Goldberg, S., Berger, P. B., Cohen, D. J., for the Evaluation of Drug Eluting Stents and Isch, (2008). Prevalence and Prognostic Significance of Preprocedural Cardiac Troponin Elevation Among Patients With Stable Coronary Artery Disease Undergoing Percutaneous Coronary Intervention: Results From the Evaluation of Drug Eluting Stents and Ischemic Events Registry. Circulation 118: 632-638 [Abstract] [Full Text]  
• Prasad, A., Rihal, C. S., Lennon, R. J., Singh, M., Jaffe, A. S., Holmes, D. R. Jr (2008). Significance of Periprocedural Myonecrosis on Outcomes After Percutaneous Coronary Intervention: An Analysis of Preintervention and Postintervention Troponin T Levels in 5487 Patients. Circ Cardiovasc Interv 1: 10-19 [Abstract] [Full Text]  
• Dobesh, P. P., Phillips, K. W., Haines, S. T. (2008). Optimizing antithrombotic therapy in patients with non-ST-segment elevation acute coronary syndrome. Am J Health Syst Pharm 65: S22-S28 [Abstract] [Full Text]  
• Weber, M., Hamm, C. (2008). Novel biomarkers--the long march from bench to bedside. Eur Heart J 29: 1079-1081 [Full Text]  
• Weber, M., Bazzino, O., Navarro Estrada, J. L., Fuselli, J. J., Botto, F., Perez de Arenaza, D., Mollmann, H., Nef, H. N., Elsasser, A., Hamm, C. W. (2008). N-Terminal B-Type Natriuretic Peptide Assessment Provides Incremental Prognostic Information in Patients With Acute Coronary Syndromes and Normal Troponin T Values Upon Admission. J Am Coll Cardiol 51: 1188-1195 [Abstract] [Full Text]  
• Anderson, J. L., Adams, C. D., Antman, E. M., Bridges, C. R., Califf, R. M., Casey, D. E. Jr, Chavey, W. E. II, Fesmire, F. M., Hochman, J. S., Levin, T. N., Lincoff, A. M., Peterson, E. D., Theroux, P., Wenger, N. K., Wright, R. S., Smith, S. C. Jr, Jacobs, A. K., Adams, C. D., Anderson, J. L., Antman, E. M., Halperin, J. L., Hunt, S. A., Krumholz, H. M., Kushner, F. G., Lytle, B. W., Nishimura, R., Ornato, J. P., Page, R. L., Riegel, B. (2007). ACC/AHA 2007 Guidelines for the Management of Patients With Unstable Angina/Non-ST-Elevation Myocardial Infarction: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines for the Management of Patients With Unstable Angina/Non-ST-Elevation Myocardial Infarction) Developed in Collaboration with the American College of Emergency Physicians, the Society for Cardiovascular Angiography and Interventions, and the Society of Thoracic Surgeons Endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation and the Society for Academic Emergency Medicine. J Am Coll Cardiol 50: e1-e157 [Full Text]  
• Anderson, J. L., Adams, C. D., Antman, E. M., Bridges, C. R., Califf, R. M., Casey, D. E. Jr, Chavey, W. E. II, Fesmire, F. M., Hochman, J. S., Levin, T. N., Lincoff, A. M., Peterson, E. D., Theroux, P., Wenger, N. K., Wright, R. S., Smith, S. C. Jr, Jacobs, A. K., Adams, C. D., Anderson, J. L., Antman, E. M., Halperin, J. L., Hunt, S. A., Krumholz, H. M., Kushner, F. G., Lytle, B. W., Nishimura, R., Ornato, J. P., Page, R. L., Riegel, B. (2007). ACC/AHA 2007 Guidelines for the Management of Patients With Unstable Angina/Non ST-Elevation Myocardial Infarction Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines for the Management of Patients With Unstable Angina/Non ST-Elevation Myocardial Infarction) Developed in Collaboration with the American College of Emergency Physicians, the Society for Cardiovascular Angiography and Interventions, and the Society of Thoracic Surgeons Endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation and the Society for Academic Emergency Medicine. J Am Coll Cardiol 50: 652-726 [Full Text]  
• Authors/Task Force Members, , Bassand, J.-P., Hamm, C. W., Ardissino, D., Boersma, E., Budaj, A., Fernandez-Aviles, F., Fox, K. A.A., Hasdai, D., Ohman, E. M., Wallentin, L., Wijns, W., ESC Committee for Practice Guidelines (CPG), , Vahanian, A., Camm, J., De Caterina, R., Dean, V., Dickstein, K., Filippatos, G., Kristensen, S. D., Widimsky, P., McGregor, K., Sechtem, U., Tendera, M., Hellemans, I., Gomez, J. L. Z., Silber, S., Funck-Brentano, C., Document Reviewers, , Kristensen, S. D., Andreotti, F., Benzer, W., Bertrand, M., Betriu, A., De Caterina, R., DeSutter, J., Falk, V., Ortiz, A. F., Gitt, A., Hasin, Y., Huber, K., Kornowski, R., Lopez-Sendon, J., Morais, J., Nordrehaug, J. E., Silber, S., Steg, P. G., Thygesen, K., Tubaro, M., Turpie, A. G.G., Verheugt, F., Windecker, S. (2007). Guidelines for the diagnosis and treatment of non-ST-segment elevation acute coronary syndromes: The Task Force for the Diagnosis and Treatment of Non-ST-Segment Elevation Acute Coronary Syndromes of the European Society of Cardiology. Eur Heart J 28: 1598-1660 [Full Text]  
• Alonso, A., Della Martina, A., Stroick, M., Fatar, M., Griebe, M., Pochon, S., Schneider, M., Hennerici, M., Allemann, E., Meairs, S. (2007). Molecular Imaging of Human Thrombus With Novel Abciximab Immunobubbles and Ultrasound. Stroke 38: 1508-1514 [Abstract] [Full Text]  
• NACB WRITING GROUP MEMBERS, , Morrow, D. A., Cannon, C. P., Jesse, R. L., Newby, L. K., Ravkilde, J., Storrow, A. B., Wu, A. H.B., Christenson, R. H. (2007). National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines: Clinical Characteristics and Utilization of Biochemical Markers in Acute Coronary Syndromes. Circulation 115: e356-e375 [Full Text]  
• NACB WRITING GROUP MEMBERS, , Morrow, D. A., Cannon, C. P., Jesse, R. L., Newby, L. K., Ravkilde, J., Storrow, A. B., Wu, A. H.B., Christenson, R. H., NACB COMMITTEE MEMBERS, , Christenson, R. H., Apple, F. S., Cannon, C. P., Francis, G., Jesse, R. L., Morrow, D. A., Newby, L. K., Ravkilde, J., Storrow, A. B., Tang, W., Wu, A. H.B. (2007). National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines: Clinical Characteristics and Utilization of Biochemical Markers in Acute Coronary Syndromes. Clin. Chem. 53: 552-574 [Full Text]  
• Stone, G. W., Bertrand, M. E., Moses, J. W., Ohman, E. M., Lincoff, A. M., Ware, J. H., Pocock, S. J., McLaurin, B. T., Cox, D. A., Jafar, M. Z., Chandna, H., Hartmann, F., Leisch, F., Strasser, R. H., Desaga, M., Stuckey, T. D., Zelman, R. B., Lieber, I. H., Cohen, D. J., Mehran, R., White, H. D., for the ACUITY Investigators, (2007). Routine Upstream Initiation vs Deferred Selective Use of Glycoprotein IIb/IIIa Inhibitors in Acute Coronary Syndromes: The ACUITY Timing Trial. JAMA 297: 591-602 [Abstract] [Full Text]  
• Antoniucci, D. (2007). Differences among GP IIb/IIIa inhibitors: different clinical benefits in non-ST-segment elevation acute coronary syndrome percutaneous coronary intervention patients. Eur Heart J Suppl 9: A32-A36 [Abstract] [Full Text]  
• Bertrand, O. F., De Larochelliere, R., Rodes-Cabau, J., Proulx, G., Gleeton, O., Manh Nguyen, C., Dery, J.-P., Barbeau, G., Noel, B., Larose, E., Poirier, P., Roy, L., for the Early Discharge After Transradial Stenting, (2006). A Randomized Study Comparing Same-Day Home Discharge and Abciximab Bolus Only to Overnight Hospitalization and Abciximab Bolus and Infusion After Transradial Coronary Stent Implantation. Circulation 114: 2636-2643 [Abstract] [Full Text]  
• Christenson, R. H., Duh, S. H., Apple, F. S., Bodor, G. S., Bunk, D. M., Panteghini, M., Welch, M. J., Wu, A. H.B., Kahn, S. E., for the American Association for Clinical Chemistr, (2006). Toward Standardization of Cardiac Troponin I Measurements Part II: Assessing Commutability of Candidate Reference Materials and Harmonization of Cardiac Troponin I Assays. Clin. Chem. 52: 1685-1692 [Abstract] [Full Text]  
• Malarstig, A., Lindahl, B., Wallentin, L., Siegbahn, A. (2006). Soluble CD40L Levels Are Regulated by the -3459 A>G Polymorphism and Predict Myocardial Infarction and the Efficacy of Antithrombotic Treatment in Non-ST Elevation Acute Coronary Syndrome. Arterioscler. Thromb. Vasc. Bio. 26: 1667-1673 [Abstract] [Full Text]  
• Steinhubl, S. R., Charnigo, R. (2006). Clopidogrel Treatment Prior to Percutaneous Coronary Intervention: When Enough Isn't Enough. JAMA 295: 1581-1582 [Full Text]  
• Kastrati, A., Mehilli, J., Neumann, F.-J., Dotzer, F., ten Berg, J., Bollwein, H., Graf, I., Ibrahim, M., Pache, J., Seyfarth, M., Schuhlen, H., Dirschinger, J., Berger, P. B., Schomig, A., for the Intracoronary Stenting and Antithrombotic, (2006). Abciximab in Patients With Acute Coronary Syndromes Undergoing Percutaneous Coronary Intervention After Clopidogrel Pretreatment: The ISAR-REACT 2 Randomized Trial. JAMA 295: 1531-1538 [Abstract] [Full Text]  
• Ben-Yehuda, O. (2006). Upstream/Downstream: Glycoprotein IIb/IIIa in Non-ST-Segment Elevation Myocardial Infarction. J Am Coll Cardiol 47: 538-540 [Full Text]  
• Newby, L. K., Roe, M. T., Chen, A. Y., Ohman, E. M., Christenson, R. H., Pollack, C. V. Jr, Hoekstra, J. W., Peacock, W. F., Harrington, R. A., Jesse, R. L., Gibler, W. B., Peterson, E. D., for the CRUSADE Investigators, (2006). Frequency and Clinical Implications of Discordant Creatine Kinase-MB and Troponin Measurements in Acute Coronary Syndromes. J Am Coll Cardiol 47: 312-318 [Abstract] [Full Text]  
• Lenderink, T., Heeschen, C., Fichtlscherer, S., Dimmeler, S., Hamm, C. W., Zeiher, A. M., Simoons, M. L., Boersma, E., for the CAPTURE Investigators, (2006). Elevated Placental Growth Factor Levels Are Associated With Adverse Outcomes at Four-Year Follow-Up in Patients With Acute Coronary Syndromes. J Am Coll Cardiol 47: 307-311 [Abstract] [Full Text]  
• Herrmann, J. (2005). Peri-procedural myocardial injury: 2005 update. Eur Heart J 26: 2493-2519 [Abstract] [Full Text]  
• Lauer, M. S. (2005). Cardiac Troponins and Renal Failure: The Evolution of a Clinical Test. Circulation 112: 3036-3037 [Full Text]  
• Babuin, L., Jaffe, A. S. (2005). Troponin: the biomarker of choice for the detection of cardiac injury. CMAJ 173: 1191-1202 [Abstract] [Full Text]  
• Ginsburg, G. S., Donahue, M. P., Newby, L. K. (2005). Prospects for Personalized Cardiovascular Medicine: The Impact of Genomics. J Am Coll Cardiol 46: 1615-1627 [Abstract] [Full Text]  
• Heeschen, C. (2005). Biomarkers in acute coronary syndromes and their role in diabetic patients. Diabetes and Vascular Disease Research 2: 122-127 [Abstract]  
• Roe, M. T., Peterson, E. D., Li, Y., Pollack, C. V. Jr, Christenson, R. H., Peacock, W. F., Fesmire, F. M., Newby, L. K., Jesse, R. L., Hoekstra, J. W., Gibler, W. B., Ohman, E. M. (2005). Relationship Between Risk Stratification by Cardiac Troponin Level and Adherence to Guidelines for Non-ST-Segment Elevation Acute Coronary Syndromes. Arch Intern Med 165: 1870-1876 [Abstract] [Full Text]  
• Yilmaz, H., Basarici, I. (2005). Troponin Levels and Acute Coronary Syndrome. J Am Coll Cardiol 46: 741-741 [Full Text]  
• Schomig, A., Schmitt, C., Dibra, A., Mehilli, J., Volmer, C., Schuhlen, H., Dirschinger, J., Dotzer, F., ten Berg, J. M., Neumann, F.-J., Berger, P. B., Kastrati, A., for the Intracoronary Stenting and Antithrombotic, (2005). One year outcomes with abciximab vs. placebo during percutaneous coronary intervention after pre-treatment with clopidogrel. Eur Heart J 26: 1379-1384 [Abstract] [Full Text]  
• Rajappan, K., Murphy, E., Amber, V., Meakin, F., Muller, B., Fox, K.F., Baker, C.S.R. (2005). Usage of troponin in the real world: a lesson for the introduction of biochemical assays. QJM 98: 337-342 [Abstract] [Full Text]  
• Authors/Task Force Members, , Silber, S., Albertsson, P., Aviles, F. F., Camici, P. G., Colombo, A., Hamm, C., Jorgensen, E., Marco, J., Nordrehaug, J.-E., Ruzyllo, W., Urban, P., Stone, G. W., Wijns, W. (2005). Guidelines for Percutaneous Coronary Interventions: The Task Force for Percutaneous Coronary Interventions of the European Society of Cardiology. Eur Heart J 26: 804-847 [Full Text]  
• Heeschen, C., Dimmeler, S., Hamm, C. W., Fichtlscherer, S., Simoons, M. L., Zeiher, A. M., CAPTURE Study Investigators, (2005). Pregnancy-associated plasma protein-A levels in patients with acute coronary syndromes: Comparison with markers of systemic inflammation, platelet activation, and myocardial necrosis. J Am Coll Cardiol 45: 229-237 [Abstract] [Full Text]  
• Heeschen, C., Hamm, C. W., Mitrovic, V., Lantelme, N.-H., White, H. D., for the Platelet Receptor Inhibition in Ischemic S, (2004). N-Terminal Pro-B-Type Natriuretic Peptide Levels for Dynamic Risk Stratification of Patients With Acute Coronary Syndromes. Circulation 110: 3206-3212 [Abstract] [Full Text]  
• Sharma, S, Jackson, P G, Makan, J (2004). Cardiac troponins. J. Clin. Pathol. 57: 1025-1026 [Full Text]  
• Popma, J. J., Berger, P., Ohman, E. M., Harrington, R. A., Grines, C., Weitz, J. I. (2004). Antithrombotic Therapy During Percutaneous Coronary Intervention: The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest 126: 576S-599S [Abstract] [Full Text]  
• Norgaard, B L, Andersen, K, Thygesen, K, Ravkilde, J, Abrahamsson, P, Grip, L, Dellborg, M (2004). Long term risk stratification of patients with acute coronary syndromes: characteristics of troponin T testing and continuous ST segment monitoring. Heart 90: 739-744 [Abstract] [Full Text]  
• Leoncini, M., Bellandi, F., Sciagra, R., Maioli, M., Toso, A., Coppola, A., Sestini, S., Mennuti, A., Dabizzi, R. P., Pupi, A. (2004). Gated SPECT Evaluation of the Relationship Between Admission Troponin I, Myocardial Salvage, and Functional Recovery in Acute Myocardial Infarction Treated by Abciximab and Early Primary Angioplasty. JNM 45: 739-744 [Abstract] [Full Text]  
• Ross, G. E., Bever, F. N., Uddin, Z., Devireddy, L., Gardin, J. M. (2004). Common Scenarios to Clarify the Interpretation of Cardiac Markers. JAOA: Journal of the American Osteopathic Association 104: 165-176 [Abstract] [Full Text]  
• Kontos, M. C., Shah, R., Fritz, L. M., Anderson, F. P., Tatum, J. L., Ornato, J. P., Jesse, R. L. (2004). Implication of different cardiac troponin I levels for clinical outcomes and prognosis of acute chest pain patients. J Am Coll Cardiol 43: 958-965 [Abstract] [Full Text]  
• Wiviott, S. D., Cannon, C. P., Morrow, D. A., Murphy, S. A., Gibson, C. M., McCabe, C. H., Sabatine, M. S., Rifai, N., Giugliano, R. P., DiBattiste, P. M., Demopoulos, L. A., Antman, E. M., Braunwald, E. (2004). Differential Expression of Cardiac Biomarkers by Gender in Patients With Unstable Angina/Non-ST-Elevation Myocardial Infarction: A TACTICS-TIMI 18 (Treat Angina with Aggrastat and determine Cost of Therapy with an Invasive or Conservative Strategy-Thrombolysis In Myocardial Infarction 18) Substudy. Circulation 109: 580-586 [Abstract] [Full Text]  
• Okamatsu, K., Takano, M., Sakai, S., Ishibashi, F., Uemura, R., Takano, T., Mizuno, K. (2004). Elevated Troponin T Levels and Lesion Characteristics in Non-ST-Elevation Acute Coronary Syndromes. Circulation 109: 465-470 [Abstract] [Full Text]  
• Heeschen, C., Dimmeler, S., Fichtlscherer, S., Hamm, C. W., Berger, J., Simoons, M. L., Zeiher, A. M. (2004). Prognostic Value of Placental Growth Factor in Patients With Acute Chest Pain. JAMA 291: 435-441 [Abstract] [Full Text]  
• Ritter, D., Lee, P. A., Taylor, J. F., Hsu, L., Cohen, J. D., Chung, H. D., Virgo, K. S. (2004). Troponin I in Patients without Chest Pain. Clin. Chem. 50: 112-119 [Abstract] [Full Text]  
• Jaffe, A. S. (2003). A small step for man, a leap forward for postoperative management. J Am Coll Cardiol 42: 1555-1557 [Full Text]  
• Kennon, S, Timmis, A D, Whitbourn, R, Knight, C (2003). C reactive protein for risk stratification in acute coronary syndromes? Verdict: unproven. Heart 89: 1288-1290 [Abstract] [Full Text]  
• Granger, C. B., Goldberg, R. J., Dabbous, O., Pieper, K. S., Eagle, K. A., Cannon, C. P., Van de Werf, F., Avezum, A., Goodman, S. G., Flather, M. D., Fox, K. A. A. (2003). Predictors of Hospital Mortality in the Global Registry of Acute Coronary Events. Arch Intern Med 163: 2345-2353 [Abstract] [Full Text]  
• Baldus, S., Heeschen, C., Meinertz, T., Zeiher, A. M., Eiserich, J. P., Munzel, T., Simoons, M. L., Hamm, C. W., on behalf of the CAPTURE Investigators, (2003). Myeloperoxidase Serum Levels Predict Risk in Patients With Acute Coronary Syndromes. Circulation 108: 1440-1445 [Abstract] [Full Text]  
• Prasad, A., Mathew, V., Holmes, D. R Jr., Gersh, B. J (2003). Current management of non-ST-segment-elevation acute coronary syndrome: reconciling the results of randomized controlled trials. Eur Heart J 24: 1544-1553 [Abstract] [Full Text]  
• Kizer, J. R., Muttrej, M. R., Matthai, W. H., McConnell, J., Nardone, H., Sonel, A. F., Keane, M. G., Wilensky, R. L. (2003). Role of cardiac troponin T in the long-term risk stratification of patients undergoing percutaneous coronary intervention. Eur Heart J 24: 1314-1322 [Abstract] [Full Text]  
• Wong, C.-K., White, H. D. (2003). Myocardial infarction: why can't we get the diagnosis right?. Eur Heart J 24: 1177-1179 [Full Text]  
• Kritharides, L., Lau, G. T., Freedman, B., Conde, I. D., Kleiman, N. S., Heeschen, C., Hamm, C. W., Zeiher, A. M. (2003). Soluble CD40 Ligand in Acute Coronary Syndromes. NEJM 348: 2575-2577 [Full Text]  
• Cannon, C. P., Turpie, A. G.G. (2003). Unstable Angina and Non-ST-Elevation Myocardial Infarction: Initial Antithrombotic Therapy and Early Invasive Strategy. Circulation 107: 2640-2645 [Full Text]  
• Heeschen, C., Dimmeler, S., Hamm, C. W., van den Brand, M. J., Boersma, E., Zeiher, A. M., Simoons, M. L., the CAPTURE Study Investigators, (2003). Soluble CD40 Ligand in Acute Coronary Syndromes. NEJM 348: 1104-1111 [Abstract] [Full Text]  
• Hellstrom, H. R., Rioufol, G., Finet, G., Ginon, I., Andre-Fouet, X., Rossi, R., Vialle, E., Desjoyaux, E., Convert, G., Huret, J.-F., Tabib, A. (2003). Multiple Plaque Rupture in Acute Coronary Syndrome * Response. Circulation 107 : e64-e64 [Full Text]  
• Thambyrajah, J, De Belder, M.A (2003). Management of non ST-segment elevation acute coronary syndromes--continuing the search for the bad guys. Eur Heart J 24: 490-493 [Full Text]  
• Collinson, P O, Stubbs, P J, Kessler, A-C (2003). Multicentre evaluation of the diagnostic value of cardiac troponin T, CK-MB mass, and myoglobin for assessing patients with suspected acute coronary syndromes in routine clinical practice. Heart 89: 280-286 [Abstract] [Full Text]  
• Newby, L. K., Goldmann, B. U., Ohman, E. M. (2003). Troponin: an important prognostic marker and risk-stratification tool in non-ST-segment elevation acute coronary syndromes. J Am Coll Cardiol 41: 31S-36S [Abstract] [Full Text]  
• Cannon, C. P. (2003). Small molecule glycoprotein IIb/IIIa receptor inhibitors as upstream therapy in acute coronary syndromes: Insights from the TACTICS TIMI-18 trial. J Am Coll Cardiol 41: 43S-48S [Abstract] [Full Text]  
• Boden, W. E. (2003). "Routine invasive" versus "selective invasive" approaches to non-ST-segment elevation acute coronary syndromes management in the post-stent/platelet inhibition era. J Am Coll Cardiol 41: 113S-122S [Abstract] [Full Text]  
• Hellstrom, H. R. (2003). Platelet Glycoprotein IIb/IIIa Inhibitors. Circulation 107 : e39-e39 [Full Text]  
• Kaul, P., Newby, L. K., Fu, Y., Hasselblad, V., Mahaffey, K. W., Christenson, R. H., Harrington, R. A., Ohman, E. M., Topol, E. J., Califf, R. M., Van de Werf, F., Armstrong, P. W., the PARAGON-B Investigators, (2003). Troponin T and quantitative ST-segment depression offer complementary prognostic information in the risk stratification of acute coronary syndrome patients. J Am Coll Cardiol 41: 371-380 [Abstract] [Full Text]  
• Heeschen, C., Dimmeler, S., Hamm, C. W., Boersma, E., Zeiher, A. M., Simoons, M. L., on Behalf of the CAPTURE (c7E3 Anti-Platelet Thera, (2003). Prognostic Significance of Angiogenic Growth Factor Serum Levels in Patients With Acute Coronary Syndromes. Circulation 107: 524-530 [Abstract] [Full Text]  
• Lenderink, T, Boersma, E, Heeschen, C, Vahanian, A, de Boer, M.-J, Umans, V, van den Brand, M.J.B.M, Hamm, C.W, Simoons, M.L, for the CAPTURE investigators, (2003). Elevated troponin T and C-reactive protein predict impaired outcome for 4 years in patients with refractory unstable angina, and troponin T predicts benefit of treatment with abciximab in combination with PTCA. Eur Heart J 24: 77-85 [Abstract] [Full Text]  
• Freda, B. J., Tang, W. H. W., Van Lente, F., Peacock, W. F., Francis, G. S. (2002). Cardiac troponins in renal insufficiency: Review and clinical implications. J Am Coll Cardiol 40: 2065-2071 [Abstract] [Full Text]  
• Bertrand, M. E., Simoons, M. L., Fox, K. A.A., Wallentin, L. C., Hamm, C. W., McFadden, E., De Feyter, P. J., Specchia, G., Ruzyllo, W. (2002). Management of acute coronary syndromes in patients presenting without persistent ST-segment elevation. Eur Heart J 23: 1809-1840 [Full Text]  
• Hentschel, D. M., Aviles, R. J., Topol, E. J., Lauer, M. S. (2002). Troponin T Levels and Acute Coronary Syndromes. NEJM 347: 1722-1723 [Full Text]  
• Neumann, F.-J., Jander, N. (2002). How to best counteract the enemies? By ensuring adequate oxygen delivery. Eur Heart J Suppl 4: G35-G42 [Abstract]  
• Ferguson, J L, Beckett, G J, Stoddart, M, Walker, S W, Fox, K A A (2002). Myocardial infarction redefined: the new ACC/ESC definition, based on cardiac troponin, increases the apparent incidence of infarction. Heart 88: 343-347 [Abstract] [Full Text]  
• Cannon, C. P. (2002). Evidence-Based Risk Stratification to Target Therapies in Acute Coronary Syndromes. Circulation 106: 1588-1591 [Full Text]  
• Jernberg, T., Stridsberg, M., Venge, P., Lindahl, B. (2002). N-terminal pro brain natriuretic peptide on admission for early risk stratification of patients with chest pain and no ST-segment elevation. J Am Coll Cardiol 40: 437-445 [Abstract] [Full Text]  
• Erhardt, L., Herlitz, J., Bossaert, L., Halinen, M., Keltai, M., Koster, R., Marcassa, C., Quinn, T., van Weert, H. (2002). Task force on the management of chest pain. Eur Heart J 23: 1153-1176 [Full Text]  
• Hamm, C. (2002). Acute coronary syndrome: the struggle for the best in risk stratification and therapy. Eur Heart J 23: 1074-1076 [Full Text]  
• Jernberg, T., Abrahamsson, P., Lindahl, B., Johanson, P., Wallentin, L., Dellborg, M. (2002). Continuous multilead ST-monitoring identifies patients with unstable coronary artery disease who benefit from extended antithrombotic treatment. Eur Heart J 23: 1093-1101 [Abstract] [Full Text]  
• Cusack, M. R., Marber, M. S., Lambiase, P. D., Bucknall, C. A., Redwood, S. R. (2002). Systemic inflammation in unstable angina is the result of myocardial necrosis. J Am Coll Cardiol 39: 1917-1923 [Abstract] [Full Text]  
• Ray, K. K., Lincoff, A. M., Topol, E. J., Kereiakes, D. J., Mascelli, M. A., Deckelbaum, L. I., Barnathan, E. S., Patel, K. K., Frederick, B., Nakada, M. T. (2002). Abciximab Suppresses the Rise in Levels of Circulating Inflammatory Markers After Percutaneous Coronary Revascularization * Response. Circulation 105 : e74-e74 [Full Text]  
• Reffelmann, T., Kloner, R. A (2002). The "no-reflow" phenomenon: basic science and clinical correlates. Heart 87: 162-168 [Full Text]  
• Owen, A., Peverill, R. E., Moir, S., Tahiliani, N., Trivedi, A., Deshmukh, H. G., Yende, S., Yusuf, S., Mehta, S. R. (2002). Treatment of Acute Coronary Syndromes. NEJM 346: 206-208 [Full Text]  
• Alp, N.J., Bell, J.A., Shahi, M. (2001). A rapid troponin-I-based protocol for assessing acute chest pain. QJM 94: 687-694 [Abstract] [Full Text]  
• Morrow, D. A., Cannon, C. P., Rifai, N., Frey, M. J., Vicari, R., Lakkis, N., Robertson, D. H., Hille, D. A., DeLucca, P. T., DiBattiste, P. M., Demopoulos, L. A., Weintraub, W. S., Braunwald, E., for the TACTICS-TIMI 18 Investigators, (2001). Ability of Minor Elevations of Troponins I and T to Predict Benefit From an Early Invasive Strategy in Patients With Unstable Angina and Non-ST Elevation Myocardial Infarction: Results From a Randomized Trial. JAMA 286: 2405-2412 [Abstract] [Full Text]  
• Quinn, M. J., Moliterno, D. J. (2001). Troponins in Acute Coronary Syndromes: More TACTICS for an Early Invasive Strategy. JAMA 286: 2461-2462 [Full Text]  
• Akkerhuis, K.M., Klootwijk, P.A.J., Lindeboom, W., Umans, V.A.W.M., Meij, S., Kint, P.-P., Simoons, M.L. (2001). Recurrent ischaemia during continuous multilead ST-segment monitoring identifies patients with acute coronary syndromes at high risk of adverse cardiac events; meta-analysis of three studies involving 995 patients. Eur Heart J 22: 1997-2006 [Abstract]  
• de Lemos, J. A., Morrow, D. A., Bentley, J. H., Omland, T., Sabatine, M. S., McCabe, C. H., Hall, C., Cannon, C. P., Braunwald, E. (2001). The Prognostic Value of B-Type Natriuretic Peptide in Patients with Acute Coronary Syndromes. NEJM 345: 1014-1021 [Abstract] [Full Text]