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Volume 341:1413-1419 November 4, 1999 Number 19 Next

	Full Text PDF Editorial by Faxon, D. P. Letters Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

ABSTRACT

Background As compared with thrombolytic therapy, primary coronary angioplasty results in a higher rate of patency of the infarct-related coronary artery, lower rates of stroke and reinfarction, and higher in-hospital or 30-day survival rates. However, the comparative long-term efficacy of these two approaches has not been carefully studied.

Methods We randomly assigned a total of 395 patients with acute myocardial infarction to treatment with angioplasty or intravenous streptokinase. Clinical information was collected for a mean (±SD) of 5±2 years, and medical charges associated with the two treatments were compared.

Results A total of 194 patients were assigned to undergo primary angioplasty, and 201 to receive streptokinase. Mortality was 13 percent in the angioplasty group, as compared with 24 percent in the streptokinase group (relative risk, 0.54; 95 percent confidence interval, 0.36 to 0.87). Nonfatal reinfarction occurred in 6 percent and 22 percent of the two groups, respectively (relative risk, 0.27; 95 percent confidence interval, 0.15 to 0.52). The combined incidence of death and nonfatal reinfarction was also lower among patients assigned to angioplasty than among those assigned to streptokinase, with a relative risk of 0.13 (95 percent confidence interval, 0.05 to 0.37) for early events (within the first 30 days) and a relative risk of 0.62 (95 percent confidence interval, 0.43 to 0.91) for late events (after 30 days). The rates of readmission for heart failure and ischemia were also lower among patients in the angioplasty group than among patients in the streptokinase group. Total medical charges per patient were lower in the angioplasty group ($16,090) than in the streptokinase group ($16,813, P=0.05).

Conclusions As compared with thrombolytic therapy with streptokinase, primary coronary angioplasty is associated with better clinical outcomes over five years.

Source Information

From the Departments of Cardiology (F.Z., J.C.A.H., M.-J.B., J.P.O., A.W.J.H., H.S.), Nuclear Medicine (S.R.), and Clinical Chemistry (K.M.), Hospital De Weezenlanden, Zwolle, the Netherlands.

Address reprint requests to Dr. Zijlstra at the Department of Cardiology, Hospital De Weezenlanden, Groot Wezenland 20, 8011 JW Zwolle, the Netherlands, or at v.derks{at}diagram-zwolle.nl.

Full Text of this Article

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Primary Angioplasty versus Thrombolysis for Acute Myocardial Infarction
Boersma E., Akkerhuis M., Simoons M. L., Zijlstra F., de Boer M.-J., Faxon D. P., Heger J. W.
Extract | Full Text  
N Engl J Med 2000; 342:890-892, Mar 23, 2000. Correspondence

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• Hollenbeak, C. S., Fitzgibbons, J. P., Rossi, M., Morris, D. L., Stillman, P. (2007). The Impact of Percutaneous Coronary Interventions on Outcomes for Acute Myocardial Infarction in Pennsylvania. American Journal of Medical Quality 22: 85-94 [Abstract]  
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• Laarman, G. J., Suttorp, M. J., Dirksen, M. T., van Heerebeek, L., Kiemeneij, F., Slagboom, T., van der Wieken, L. R., Tijssen, J. G.P., Rensing, B. J., Patterson, M. (2006). Paclitaxel-Eluting versus Uncoated Stents in Primary Percutaneous Coronary Intervention. NEJM 355: 1105-1113 [Abstract] [Full Text]  
• Henriques, J P S, Zijlstra, F, van 't Hof, A W J, de Boer, M-J, Dambrink, J-H E, Gosselink, A T M, Hoorntje, J C A, Ottervanger, J P, Suryapranata, H (2006). Primary percutaneous coronary intervention versus thrombolytic treatment: long term follow up according to infarct location. Heart 92: 75-79 [Abstract] [Full Text]  
• Smith, E J, Mathur, A, Rothman, M T (2005). Recent advances in primary percutaneous intervention for acute myocardial infarction. Heart 91: 1533-1536 [Full Text]  
• de Belder, A (2005). Should primary angioplasty be available for all patients with an ST elevation myocardial infarction?. Heart 91: 1509-1511 [Abstract] [Full Text]  
• Parodi, G, Memisha, G, Valenti, R, Trapani, M, Migliorini, A, Santoro, G M, Antoniucci, D (2005). Five year outcome after primary coronary intervention for acute ST elevation myocardial infarction: results from a single centre experience. Heart 91: 1541-1544 [Abstract] [Full Text]  
• (2005). Part 5: Acute Coronary Syndromes. Circulation 112: III-55-III-72 [Full Text]  
• Tarantini, G., Cacciavillani, L., Corbetti, F., Ramondo, A., Marra, M. P., Bacchiega, E., Napodano, M., Bilato, C., Razzolini, R., Iliceto, S. (2005). Duration of Ischemia Is a Major Determinant of Transmurality and Severe Microvascular Obstruction After Primary Angioplasty: A Study Performed With Contrast-Enhanced Magnetic Resonance. J Am Coll Cardiol 46: 1229-1235 [Abstract] [Full Text]  
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• De Luca, G., Suryapranata, H., Grimaldi, R., Chiariello, M. (2005). Coronary stenting and abciximab in primary angioplasty for ST-segment-elevation myocardial infarction. QJM 98: 633-641 [Abstract] [Full Text]  
• Lefevre, T., Garcia, E., Reimers, B., Lang, I., di Mario, C., Colombo, A., Neumann, F.-J., Chavarri, M. V., Brunel, P., Grube, E., Thomas, M., Glatt, B., Ludwig, J., on behalf of the X AMINE ST Investigators, (2005). X-Sizer for Thrombectomy in Acute Myocardial Infarction Improves ST-Segment Resolution: Results of the X-Sizer in AMI for Negligible Embolization and Optimal ST Resolution (X AMINE ST) Trial. J Am Coll Cardiol 46: 246-252 [Abstract] [Full Text]  
• Ivanusa, M. (2005). Reducing mortality in myocardial infarction: Goal should be interhospital transfer for primary angioplasty. BMJ 330: 1271-1271 [Full Text]  
• Suryapranata, H, De Luca, G, van 't Hof, A W J, Ottervanger, J P, Hoorntje, J C A, Dambrink, J-H E, Gosselink, A T M, Zijlstra, F, de Boer, M-J (2005). Is routine stenting for acute myocardial infarction superior to balloon angioplasty? A randomised comparison in a large cohort of unselected patients. Heart 91: 641-645 [Abstract] [Full Text]  
• De Luca, G., Suryapranata, H., Stone, G. W., Antoniucci, D., Tcheng, J. E., Neumann, F.-J., Van de Werf, F., Antman, E. M., Topol, E. J. (2005). Abciximab as Adjunctive Therapy to Reperfusion in Acute ST-Segment Elevation Myocardial Infarction: A Meta-analysis of Randomized Trials. JAMA 293: 1759-1765 [Abstract] [Full Text]  
• Lansky, A. J., Pietras, C., Costa, R. A., Tsuchiya, Y., Brodie, B. R., Cox, D. A., Aymong, E. D., Stuckey, T. D., Garcia, E., Tcheng, J. E., Mehran, R., Negoita, M., Fahy, M., Cristea, E., Turco, M., Leon, M. B., Grines, C. L., Stone, G. W. (2005). Gender Differences in Outcomes After Primary Angioplasty Versus Primary Stenting With and Without Abciximab for Acute Myocardial Infarction: Results of the Controlled Abciximab and Device Investigation to Lower Late Angioplasty Complications (CADILLAC) Trial. Circulation 111: 1611-1618 [Abstract] [Full Text]  
• Authors/Task Force Members, , Silber, S., Albertsson, P., Aviles, F. F., Camici, P. G., Colombo, A., Hamm, C., Jorgensen, E., Marco, J., Nordrehaug, J.-E., Ruzyllo, W., Urban, P., Stone, G. W., Wijns, W. (2005). Guidelines for Percutaneous Coronary Interventions: The Task Force for Percutaneous Coronary Interventions of the European Society of Cardiology. Eur Heart J 26: 804-847 [Full Text]  
• De Luca, G., van 't Hof, A. W.J., Ottervanger, J. P., Hoorntje, J. C.A., Gosselink, A.T. M., Dambrink, J.-H. E., de Boer, M.-J., Suryapranata, H. (2005). Ageing, impaired myocardial perfusion, and mortality in patients with ST-segment elevation myocardial infarction treated by primary angioplasty. Eur Heart J 26: 662-666 [Abstract] [Full Text]  
• Maier, W., Altwegg, L. A., Corti, R., Gay, S., Hersberger, M., Maly, F. E., Sutsch, G., Roffi, M., Neidhart, M., Eberli, F. R., Tanner, F. C., Gobbi, S., von Eckardstein, A., Luscher, T. F. (2005). Inflammatory Markers at the Site of Ruptured Plaque in Acute Myocardial Infarction: Locally Increased Interleukin-6 and Serum Amyloid A but Decreased C-Reactive Protein. Circulation 111: 1355-1361 [Abstract] [Full Text]  
• Marenzi, G., Lauri, G., Assanelli, E., Campodonico, J., De Metrio, M., Marana, I., Grazi, M., Veglia, F., Bartorelli, A. L. (2004). Contrast-induced nephropathy in patients undergoing primary angioplasty for acute myocardial infarction. J Am Coll Cardiol 44: 1780-1785 [Abstract] [Full Text]  
• Ndrepepa, G., Kastrati, A., Neumann, F.-J., Schmitt, C., Mehilli, J., Schomig, A. (2004). Five-year outcome of patients with acute myocardial infarction enrolled in a randomised trial assessing the value of abciximab during coronary artery stenting. Eur Heart J 25: 1635-1640 [Abstract] [Full Text]  
• Hobbs, M S T, McCaul, K A, Knuiman, M W, Rankin, J M, Gilfillan, I (2004). Trends in coronary artery revascularisation procedures in Western Australia, 1980-2001. Heart 90: 1036-1041 [Abstract] [Full Text]  
• Menon, V., Harrington, R. A., Hochman, J. S., Cannon, C. P., Goodman, S. D., Wilcox, R. G., Schunemann, H. J., Ohman, E. M. (2004). Thrombolysis and Adjunctive Therapy in Acute Myocardial Infarction: The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest 126: 549S-575S [Abstract] [Full Text]  
• Keeley, E. C., Grines, C. L. (2004). Primary Percutaneous Coronary Intervention for Every Patient with ST-Segment Elevation Myocardial Infarction: What Stands in the Way?. ANN INTERN MED 141: 298-304 [Abstract] [Full Text]  
• Khan, I. A. (2004). Initial Therapy for Acute Myocardial Infarction in the Real World. Chest 126: 331-333 [Full Text]  
• Timmer, J. R, Ottervanger, J. P., Thomas, K., Hoorntje, J. C.A, de Boer, M.-J., Suryapranata, H., Zijlstra, F., on behalf of the Zwolle myocardial infarction stud, (2004). Long-term, cause-specific mortality after myocardial infarction in diabetes. Eur Heart J 25: 926-931 [Abstract] [Full Text]  
• Montalescot, G, Andersen, H R, Antoniucci, D, Betriu, A, de Boer, M J, Grip, L, Neumann, F J, Rothman, M T (2004). Recommendations on percutaneous coronary intervention for the reperfusion of acute ST elevation myocardial infarction. Heart 90: e37-e37 [Abstract] [Full Text]  
• van't Hof, A. W.J, Ernst, N., de Boer, M.-J., de Winter, R., Boersma, E., Bunt, T., Petronio, S., Marcel Gosselink, A.T, Jap, W., Hollak, F., Hoorntje, J. C.A, Suryapranata, H., Dambrink, J.-H. E, Zijlstra, F., on behalf of the On-TIME study group, (2004). Facilitation of primary coronary angioplasty by early start of a glycoprotein 2b/3a inhibitor: results of the ongoing tirofiban in myocardial infarction evaluation (On-TIME) trial. Eur Heart J 25: 837-846 [Abstract] [Full Text]  
• Elsman, P, van `t Hof, A.W.J, de Boer, M.J, Hoorntje, J.C.A, Suryapranata, H, Dambrink, J.H.E, Zijlstra, F, on behalf of the Zwolle Myocardial Infarction Stud, (2004). Role of collateral circulation in the acute phase of ST-segment-elevation myocardial infarction treated with primary coronary intervention. Eur Heart J 25: 854-858 [Abstract] [Full Text]  
• De Luca, G., Ernst, N., Zijlstra, F., van't Hof, A. W. J., Hoorntje, J. C. A., Dambrink, J.-H. E., Gosslink, A. T. M., de Boer, M.-J., Suryapranata, H. (2004). Preprocedural TIMI flow and mortality in patients with acute myocardial infarction treated by primary angioplasty. J Am Coll Cardiol 43: 1363-1367 [Abstract] [Full Text]  
• Dirksen, M. T, Laarman, G., van 't Hof, A. W.J, Guagliumi, G., Tonino, W. A.L, Tavazzi, L., Duncker, D. J.G.M, Simoons, M. L, on behalf of the PARI-MI Investigators, (2004). The effect of ITF-1697 on reperfusion in patients undergoing primary angioplasty: Safety and efficacy of a novel tetrapeptide, ITF-1697. Eur Heart J 25: 392-400 [Abstract] [Full Text]  
• Bakhai, A., Stone, G. W., Grines, C. L., Murphy, S. A., Githiora, L., Berezin, R. H., Cox, D. A., Stuckey, T., Griffin, J. J., Tcheng, J. E., Cohen, D. J., for the CADILLAC Investigators, (2003). Cost-Effectiveness of Coronary Stenting and Abciximab for Patients With Acute Myocardial Infarction: Results From the CADILLAC (Controlled Abciximab and Device Investigation to Lower Late Angioplasty Complications) Trial. Circulation 108: 2857-2863 [Abstract] [Full Text]  
• Le May, M. R., Davies, R. F., Labinaz, M., Sherrard, H., Marquis, J.-F., Laramee, L. A., O'Brien, E. R., Williams, W. L., Beanlands, R. S., Nichol, G., Higginson, L. A. (2003). Hospitalization Costs of Primary Stenting Versus Thrombolysis in Acute Myocardial Infarction: Cost Analysis of the Canadian STAT Study. Circulation 108: 2624-2630 [Abstract] [Full Text]  
• Napodano, M., Pasquetto, G., Sacca, S., Cernetti, C., Scarabeo, V., Pascotto, P., Reimers, B. (2003). Intracoronary thrombectomy improves myocardial reperfusion in patients undergoing direct angioplasty for acute myocardial infarction. J Am Coll Cardiol 42: 1395-1402 [Abstract] [Full Text]  
• De Luca, G., Suryapranata, H., Zijlstra, F., van't Hof, A. W. J., Hoorntje, J. C. A., Gosselink, A. T. M., Dambrink, J.-H., de Boer, M.-J., ZWOLLE Myocardial Infarction Study Group, (2003). Symptom-onset-to-balloon time and mortality in patients with acute myocardial infarction treated by primary angioplasty. J Am Coll Cardiol 42: 991-997 [Abstract] [Full Text]  
• van der Horst, I. C. C., Zijlstra, F., van't Hof, A. W. J., Doggen, C. J. M., de Boer, M.-J., Suryapranata, H., Hoorntje, J. C. A., Dambrink, J.-H. E., Gans, R. O. B., Bilo, H. J. G., Zwolle Infarct Study Group, (2003). Glucose-insulin-potassium infusion inpatients treated with primary angioplasty for acute myocardial infarction: The glucose-insulin-potassium study: a randomized trial. J Am Coll Cardiol 42: 784-791 [Abstract] [Full Text]  
• Limbruno, U., Micheli, A., De Carlo, M., Amoroso, G., Rossini, R., Palagi, C., Di Bello, V., Petronio, A. S., Fontanini, G., Mariani, M. (2003). Mechanical Prevention of Distal Embolization During Primary Angioplasty: Safety, Feasibility, and Impact on Myocardial Reperfusion. Circulation 108: 171-176 [Abstract] [Full Text]  
• Schilling, J., Gerstl, P., Kapetanios, E., Lee, C.-Y., Bertel, O. (2003). Assessment of Indications in Interventional Cardiology: Appropriateness and Necessity of Coronary Angiography and Revascularization. American Journal of Medical Quality 18: 155-163 [Abstract]  
• Lee, D. P., Herity, N. A., Hiatt, B. L., Fearon, W. F., Rezaee, M., Carter, A. J., Huston, M., Schreiber, D., DiBattiste, P. M., Yeung, A. C. (2003). Adjunctive Platelet Glycoprotein IIb/IIIa Receptor Inhibition With Tirofiban Before Primary Angioplasty Improves Angiographic Outcomes: Results of the TIrofiban Given in the Emergency Room before Primary Angioplasty (TIGER-PA) Pilot Trial. Circulation 107: 1497-1501 [Abstract] [Full Text]  
• Beygui, F, Le Feuvre, C, Helft, G, Maunoury, C, Metzger, J P (2003). Myocardial viability, coronary flow reserve, and in-hospital predictors of late recovery of contractility following successful primary stenting for acute myocardial infarction. Heart 89: 179-183 [Abstract] [Full Text]  
• Wong, G. C., Giugliano, R. P., Antman, E. M. (2003). Use of Low-Molecular-Weight Heparins in the Management of Acute Coronary Artery Syndromes and Percutaneous Coronary Intervention. JAMA 289: 331-342 [Abstract] [Full Text]  
• The Task Force on the Management of Acute Myocardi, , Van de Werf, F., Ardissino, D., Betriu, A., Cokkinos, D. V., Falk, E., Fox, K. A.A., Julian, D., Lengyel, M., Neumann, F.-J., Ruzyllo, W., Thygesen, C., Underwood, S. R., Vahanian, A., Verheugt, F. W.A., Wijns, W. (2003). Management of acute myocardial infarction in patients presenting with ST-segment elevation. Eur Heart J 24: 28-66 [Full Text]  
• Schoen, F. J., Padera, R. F. Jr. (2003). Cardiac Surgical Pathology. Card Surg Adult 2: 119-185 [Full Text]  
• Bolognese, L., Neskovic, A. N., Parodi, G., Cerisano, G., Buonamici, P., Santoro, G. M., Antoniucci, D. (2002). Left Ventricular Remodeling After Primary Coronary Angioplasty: Patterns of Left Ventricular Dilation and Long-Term Prognostic Implications. Circulation 106: 2351-2357 [Abstract] [Full Text]  
• Geggie, D. (2002). Why I'm needled by thrombolysis target. BMJ 325: 911-911 [Full Text]  
• Beygui, F., Le Feuvre, C., Maunoury, C., Helft, G.e., Metzger, J. P. (2002). Coronary vasodilator reserve: a clue to the explanation of 201Tl redistribution patterns early after successful primary stenting for acute myocardial infarction. J Am Coll Cardiol 40: 877-881 [Abstract] [Full Text]  
• Hsu, L F, Mak, K H, Lau, K W, Sim, L L, Chan, C, Koh, T H, Chuah, S C, Kam, R, Ding, Z P, Teo, W S, Lim, Y L (2002). Clinical outcomes of patients with diabetes mellitus and acute myocardial infarction treated with primary angioplasty or fibrinolysis. Heart 88: 260-265 [Abstract] [Full Text]  
• Ribichini, F., Wijns, W. (2002). ACUTE MYOCARDIAL INFARCTION: REPERFUSION TREATMENT. Heart 88: 298-305 [Full Text]  
• Henriques, J.P.S., Zijlstra, F., Ottervanger, J.P., de Boer, M.-J., van 't Hof, A.W.J., Hoorntje, J.C.A., Suryapranata, H. (2002). Incidence and clinical significance of distal embolization during primary angioplasty for acute myocardial infarction. Eur Heart J 23: 1112-1117 [Abstract] [Full Text]  
• Singh, M., Ting, H. H., Berger, P. B., Garratt, K. N., Holmes, D. R. Jr, Gersh, B. J. (2002). Rationale for on-site cardiac surgery for primary angioplasty: a time for reappraisal. J Am Coll Cardiol 39: 1881-1889 [Abstract] [Full Text]  
• Aversano, T., Aversano, L. T., Passamani, E., Knatterud, G. L., Terrin, M. L., Williams, D. O., Forman, S. A., for the Atlantic Cardiovascular Patient Outcomes R, (2002). Thrombolytic Therapy vs Primary Percutaneous Coronary Intervention for Myocardial Infarction in Patients Presenting to Hospitals Without On-site Cardiac Surgery: A Randomized Controlled Trial. JAMA 287: 1943-1951 [Abstract] [Full Text]  
• Zijlstra, F, Patel, A, Jones, M, Grines, C.L, Ellis, S, Garcia, E, Grinfeld, L, Gibbons, R.J, Ribeiro, E.E, Ribichini, F, Granger, C, Akhras, F, Weaver, W.D, Simes, R.J (2002). Clinical characteristics and outcome of patients with early (<2h), intermediate (2-4h) and late (>4h) presentation treated by primary coronary angioplasty or thrombolytic therapy for acute myocardial infarction. Eur Heart J 23: 550-557 [Abstract] [Full Text]  
• Stone, G. W., Grines, C. L., Cox, D. A., Garcia, E., Tcheng, J. E., Griffin, J. J., Guagliumi, G., Stuckey, T., Turco, M., Carroll, J. D., Rutherford, B. D., Lansky, A. J., the Controlled Abciximab and Device Investigation, (2002). Comparison of Angioplasty with Stenting, with or without Abciximab, in Acute Myocardial Infarction. NEJM 346: 957-966 [Abstract] [Full Text]  
• Corti, R., Fuster, V., Badimon, J.J. (2002). Strategy for ensuring a better future for the vessel wall. Eur Heart J Suppl 4: A31-A41 [Abstract]  
• Sciagra, R., Sestini, S., Bolognese, L., Cerisano, G., Buonamici, P., Pupi, A. (2002). Comparison of Dobutamine Echocardiography and 99mTc-Sestamibi Tomography for Prediction of Left Ventricular Ejection Fraction Outcome After Acute Myocardial Infarction Treated with Successful Primary Coronary Angioplasty. JNM 43: 8-14 [Abstract] [Full Text]  
• Helft, G., Beygui, F., Worthley, S. G., Ohman, M. (2001). Fibrinolysis or Angioplasty in Acute Myocardial Infarction?. Chest 120: 1747-1747 [Full Text]  
• Bonacchi, M., Prifti, E., Giunti, G., Frati, G., Sani, G. (2001). Urgent surgical revascularization of unstable angina. Influence of double mammary arteries. Eur. J. Cardiothorac. Surg. 20: 747-754 [Abstract] [Full Text]  
• SCHULMAN, S. P., FESSLER, H. E. (2001). Management of Acute Coronary Syndromes. Am. J. Respir. Crit. Care Med. 164: 917-922 [Full Text]  
• Maier, W, Windecker, S, Boersma, E, Meier, B (2001). Evolution of percutaneous transluminal coronary angioplasty in Europe from 1992-1996. Eur Heart J 22: 1733-1740 [Abstract]  
• Singh, M., Reeder, G. S., Ohman, E. M., Mathew, V., Hillegass, W. B., Anderson, R. D., Gallup, D. S., Garratt, K. N., Holmes, D. R. Jr (2001). Does the presence of thrombus seen on a coronary angiogram affect the outcome after percutaneous coronary angioplasty? An angiographic trials pool data experience. J Am Coll Cardiol 38: 624-630 [Abstract] [Full Text]  
• Wright, J. (2001). The role of non-invasive ventilation in the emergency department. Emerg. Med. J. 18: 413-413 [Full Text]  
• Loubeyre, C, Lefevre, T, Louvard, Y, Dumas, P, Piechaud, J.-F, Lanore, J.-J, Angellier, J.-F, Le Tarnec, J.-Y, Karrillon, G, Margenet, A, Pouges, C, Morice, M.-C (2001). Outcome after combined reperfusion therapy for acute myocardial infarction, combining pre-hospital thrombolysis with immediate percutaneous coronary intervention and stent. Eur Heart J 22: 1128-1135 [Abstract]  
• Suryapranata, H, Ottervanger, J P, Nibbering, E, van't Hof, A W J, Hoorntje, J C A, de Boer, M J, Al, M J, Zijlstra, F (2001). Long term outcome and cost-effectiveness of stenting versus balloon angioplasty for acute myocardial infarction. Heart 85: 667-671 [Abstract] [Full Text]  
• Zijlstra, F. (2001). CORONARY DISEASE: Acute myocardial infarction: primary angioplasty. Heart 85: 705-709 [Full Text]  
• Widimsky, P. (2001). Pharmacological versus catheter-based reperfusion: What is present state of the art?. Eur Heart J Suppl 3: C47-C54 [Abstract]  
• Ottervanger, J.P, Van't Hof, A.W.J, Reiffers, S, Hoorntje, J.C.A, Suryapranata, H, de Boer, M.J, Zijlstra, F (2001). Long-term recovery of left ventricular function after primary angioplasty for acute myocardial infarction. Eur Heart J 22: 785-790 [Abstract]  
• Herrmann, H.C., Li, R.H., Ohman, E.M. (2001). Facilitated percutaneous coronary intervention: results from the SPEED trial. Eur Heart J Suppl 3: A26-A34 [Abstract]  
• Destro, G., Marino, P., Barbieri, E., Zorzi, A., Brighetti, G., Maines, M., Carletti, M., Zardini, P. (2001). Postinfarctional remodeling: increased dye intensity in the myocardial risk area after angioplasty of infarct-related coronary artery is associated with reduction of ventricular volumes. J Am Coll Cardiol 37: 1239-1245 [Abstract] [Full Text]  
• Le May, M. R., Labinaz, M., Davies, R. F., Marquis, J.-F., Laramee, L. A., O'Brien, E. R., Williams, W. L., Beanlands, R. S., Nichol, G., Higginson, L. A. (2001). Stenting versus thrombolysis in acute myocardial infarction trial (STAT). J Am Coll Cardiol 37: 985-991 [Abstract] [Full Text]  
• Magid, D. J., Calonge, B. N., Rumsfeld, J. S., Canto, J. G., Frederick, P. D., Every, N. R., Barron, H. V., for the National Registry of Myocardial Infarction, (2000). Relation Between Hospital Primary Angioplasty Volume and Mortality for Patients With Acute MI Treated With Primary Angioplasty vs Thrombolytic Therapy. JAMA 284: 3131-3138 [Abstract] [Full Text]  
• Zijlstra, F. (2000). Long-term benefit of primary angioplasty compared to thrombolytic therapy for acute myocardial infarction. Eur Heart J 21: 1487-1489  
• Schomig, A., Kastrati, A., Dirschinger, J., Mehilli, J., Schricke, U., Pache, J., Martinoff, S., Neumann, F.-J., Schwaiger, M., The Stent versus Thrombolysis for Occluded Coronar, (2000). Coronary Stenting plus Platelet Glycoprotein IIb/IIIa Blockade Compared with Tissue Plasminogen Activator in Acute Myocardial Infarction. NEJM 343: 385-391 [Abstract] [Full Text]  
• Dodek, A. (2000). Acute myocardial infarction in Canada: improvement with time. CMAJ 163: 41-42 [Full Text]  
• Robinson, N. M, Timmis, A. D (2000). Reperfusion in acute myocardial infarction. BMJ 320: 1354-1355 [Full Text]  
• (2000). Additional articles abstracted in ACP Journal Club. Evid. Based Med. 5: 67-67 [Full Text]  
• Boersma, E., Akkerhuis, M., Simoons, M. L., Zijlstra, F., de Boer, M.-J., Faxon, D. P., Heger, J. W. (2000). Primary Angioplasty versus Thrombolysis for Acute Myocardial Infarction. NEJM 342: 890-892 [Full Text]  
• (2000). Tackling myocardial infarction. DTB 38: 17-22 [Abstract] [Full Text]  
• (2000). Emergent Angioplasty Better Than Streptokinase for Acute MI. JWatch Emergency Med. 2000: 4-4 [Full Text]  
• (1999). Long-Term Benefit of Primary PTCA vs. Thrombolytic Therapy. Journal Watch Cardiology 1999: 2-2 [Full Text]  
• (1999). Angioplasty vs. Thrombolysis in Acute MI: Long-Term Outcomes. JWatch General 1999: 1-1 [Full Text]  
• Faxon, D. P., Heger, J. W. (1999). Primary Angioplasty -- Enduring the Test of Time. NEJM 341: 1464-1465 [Full Text]