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Volume 341:1949-1956 December 23, 1999 Number 26 Next

	Full Text PDF Editorial by Jacobs, A. K. Letters Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

ABSTRACT

Background Coronary-stent implantation is frequently performed for treatment of acute myocardial infarction. However, few studies have compared stent implantation with primary angioplasty alone.

Methods We designed a multicenter study to compare primary angioplasty with angioplasty accompanied by implantation of a heparin-coated Palmaz–Schatz stent. Patients with acute myocardial infarction underwent emergency catheterization and angioplasty. Those with vessels suitable for stenting were randomly assigned to undergo angioplasty with stenting (452 patients) or angioplasty alone (448 patients).

Results The mean (±SD) minimal luminal diameter was larger after stenting than after angioplasty alone (2.56±0.44 mm vs. 2.12±0.45 mm, P<0.001), although fewer patients assigned to stenting had grade 3 blood flow (according to the classification of the Thrombolysis in Myocardial Infarction trial) (89.4 percent, vs. 92.7 percent in the angioplasty group; P=0.10). After six months, fewer patients in the stent group than in the angioplasty group had angina (11.3 percent vs. 16.9 percent, P=0.02) or needed target-vessel revascularization because of ischemia (7.7 percent vs. 17.0 percent, P<0.001). In addition, the combined primary end point of death, reinfarction, disabling stroke, or target-vessel revascularization because of ischemia occurred in fewer patients in the stent group than in the angioplasty group (12.6 percent vs. 20.1 percent, P<0.01). The decrease in the combined end point was due entirely to the decreased need for target-vessel revascularization. The six-month mortality rates were 4.2 percent in the stent group and 2.7 percent in the angioplasty group (P=0.27). Angiographic follow-up at 6.5 months demonstrated a lower incidence of restenosis in the stent group than in the angioplasty group (20.3 percent vs. 33.5 percent, P<0.001).

Conclusions In patients with acute myocardial infarction, routine implantation of a stent has clinical benefits beyond those of primary coronary angioplasty alone.

Source Information

From the Division of Cardiology, William Beaumont Hospital, Royal Oak, Mich. (C.L.G., W.W.O.); Mid Carolina Cardiology, Charlotte, N.C. (D.A.C.); Washington Hospital Center, Washington, D.C. (G.W.S., A.J.L.); Hospital Gregorio Maranon, Madrid (E.G.); Instituto Dante Pazzanese de Cardiologia, São Paulo, Brazil (L.A.M.); St. Joseph's Hospital, Syracuse, N.Y. (A.G.); LeBauer Health Care, Greensboro, N.C. (B.R.B.); Cordis, Johnson & Johnson, Paris (O.M.); Cardialysis, Rotterdam, the Netherlands (M.E.); and Institut Cardiovasculaire Paris Sud, Antony, France (M.-C.M.).

Address reprint requests to Dr. Grines at the Cardiac Catheterization Laboratories, William Beaumont Hospital, 3601 W. Thirteen Mile Rd., Royal Oak, MI 48073-6769.

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Coronary-Artery Stenting in Acute Myocardial Infarction
Hoffman R. M., Allen L., Baumel M. J., Alfonso F., Grines C. L.
Extract | Full Text  
N Engl J Med 2000; 342:1447-1448, May 11, 2000. Correspondence

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• De Luca, G., Suryapranata, H., Timmer, J., Ottervanger, J. P., van't Hof, A. W.J., Hoorntje, J. C.A., Dambrink, J.-H., Gosselink, A.T. M., de Boer, M.-J. (2006). Impact of Routine Stenting on Clinical Outcome in Diabetic Patients Undergoing Primary Angioplasty for ST-Segment Elevation Myocardial Infarction. Diabetes Care 29: 920-923 [Full Text]  
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• (2006). Additional Information. JAMA 295: E7-E14 [Full Text]  
• Kim, W., Jeong, M. H., Kim, K. H., Sohn, I. S., Hong, Y. J., Park, H. W., Kim, J. H., Ahn, Y. K., Cho, J. G., Park, J. C., Cho, D. L., Kang, J. C. (2006). The Clinical Results of a Platelet Glycoprotein IIb/IIIa Receptor Blocker (Abciximab: ReoPro)-Coated Stent in Acute Myocardial Infarction. J Am Coll Cardiol 47: 933-938 [Abstract] [Full Text]  
• Serruys, P. W., Kutryk, M. J.B., Ong, A. T.L. (2006). Coronary-Artery Stents. NEJM 354: 483-495 [Full Text]  
• The ADMIRAL Investigators, (2005). Three-year duration of benefit from abciximab in patients receiving stents for acute myocardial infarction in the randomized double-blind ADMIRAL study. Eur Heart J 26: 2520-2523 [Abstract] [Full Text]  
• Smith, E J, Mathur, A, Rothman, M T (2005). Recent advances in primary percutaneous intervention for acute myocardial infarction. Heart 91: 1533-1536 [Full Text]  
• Wharton, T. P. Jr, Keeley, E. C., Grines, C. L., Wharton, T. P. Jr, Keeley, E. C., Grines, C. L. (2005). The Case for Community Hospital Angioplasty. Circulation 112: 3509-3534 [Full Text]  
• Bilge, A. K., Nisanci, Y., Yilmaz, E., Ozben, B., Oncul, A., Mercanoglu, F., Meric, M. (2005). Effects of Percutaneous Coronary Thrombectomywith the X-Sizer Catheter on Epicardial Flow and Microvascular Function in Acute Coronary Syndromes. CLIN APPL THROMB HEMOST 11: 461-466 [Abstract]  
• Hang, C.-L., Wang, C.-P., Yip, H.-K., Yang, C.-H., Guo, G. B.-F., Wu, C.-J., Chen, S.-M. (2005). Early Administration of Intracoronary Verapamil Improves Myocardial Perfusion During Percutaneous Coronary Interventions for Acute Myocardial Infarction. Chest 128: 2593-2598 [Abstract] [Full Text]  
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• Huber, K., Caterina, R. D., Kristensen, S. D., Verheugt, F. W.A., Montalescot, G., Maestro, L. B., Werf, F. V. d., for the Task Force on Pre-hospital Reperfusion The, (2005). Pre-hospital reperfusion therapy: a strategy to improve therapeutic outcome in patients with ST-elevation myocardial infarction. Eur Heart J 26: 2063-2074 [Full Text]  
• Migliorini, A., Antoniucci, D. (2005). Patient selection bias in primary percutaneous coronary intervention trials: a critical issue. Eur Heart J Suppl 7: I21-I26 [Abstract] [Full Text]  
• Steffel, J., Latini, R. A., Akhmedov, A., Zimmermann, D., Zimmerling, P., Luscher, T. F., Tanner, F. C. (2005). Rapamycin, but Not FK-506, Increases Endothelial Tissue Factor Expression: Implications for Drug-Eluting Stent Design. Circulation 112: 2002-2011 [Abstract] [Full Text]  
• De Luca, G., Suryapranata, H., Grimaldi, R., Chiariello, M. (2005). Coronary stenting and abciximab in primary angioplasty for ST-segment-elevation myocardial infarction. QJM 98: 633-641 [Abstract] [Full Text]  
• Mizote, I., Ueda, Y., Ohtani, T., Shimizu, M., Takeda, Y., Oka, T., Tsujimoto, M., Hirayama, A., Hori, M., Kodama, K. (2005). Distal Protection Improved Reperfusion and Reduced Left Ventricular Dysfunction in Patients With Acute Myocardial Infarction Who Had Angioscopically Defined Ruptured Plaque. Circulation 112: 1001-1007 [Abstract] [Full Text]  
• Lefevre, T., Garcia, E., Reimers, B., Lang, I., di Mario, C., Colombo, A., Neumann, F.-J., Chavarri, M. V., Brunel, P., Grube, E., Thomas, M., Glatt, B., Ludwig, J., on behalf of the X AMINE ST Investigators, (2005). X-Sizer for Thrombectomy in Acute Myocardial Infarction Improves ST-Segment Resolution: Results of the X-Sizer in AMI for Negligible Embolization and Optimal ST Resolution (X AMINE ST) Trial. J Am Coll Cardiol 46: 246-252 [Abstract] [Full Text]  
• Ilkay, E., Karaca, I., Yavuzkir, M., Akbulut, M., Pekdemir, M. (2005). The Effect of Interventional Treatment in Acute Myocardial Infarction on ST Resolution: A Comparison of Coronary Angioplasty with Excimer Laser Angioplasty. ANGIOLOGY 56: 377-384 [Abstract]  
• Valgimigli, M., Percoco, G., Malagutti, P., Campo, G., Ferrari, F., Barbieri, D., Cicchitelli, G., McFadden, E. P., Merlini, F., Ansani, L., Guardigli, G., Bettini, A., Parrinello, G., Boersma, E., Ferrari, R., for the STRATEGY Investigators, (2005). Tirofiban and Sirolimus-Eluting Stent vs Abciximab and Bare-Metal Stent for Acute Myocardial Infarction: A Randomized Trial. JAMA 293: 2109-2117 [Abstract] [Full Text]  
• Cohen, M. G., Ohman, E. M. (2005). Drug-Eluting Stents in Acute Myocardial Infarction: Is Science Catching Up With Practice?. JAMA 293: 2154-2156 [Full Text]  
• Halkin, A., Singh, M., Nikolsky, E., Grines, C. L., Tcheng, J. E., Garcia, E., Cox, D. A., Turco, M., Stuckey, T. D., Na, Y., Lansky, A. J., Gersh, B. J., O'Neill, W. W., Mehran, R., Stone, G. W. (2005). Prediction of Mortality After Primary Percutaneous Coronary Intervention for Acute Myocardial Infarction: The CADILLAC Risk Score. J Am Coll Cardiol 45: 1397-1405 [Abstract] [Full Text]  
• Sciagra, R., Parodi, G., Pupi, A., Migliorini, A., Valenti, R., Moschi, G., Santoro, G. M., Memisha, G., Antoniucci, D. (2005). Gated SPECT Evaluation of Outcome After Abciximab-Supported Primary Infarct Artery Stenting for Acute Myocardial Infarction: The Scintigraphic Data of the Abciximab and Carbostent Evaluation (ACE) Randomized Trial. JNM 46: 722-727 [Abstract] [Full Text]  
• Suryapranata, H, De Luca, G, van 't Hof, A W J, Ottervanger, J P, Hoorntje, J C A, Dambrink, J-H E, Gosselink, A T M, Zijlstra, F, de Boer, M-J (2005). Is routine stenting for acute myocardial infarction superior to balloon angioplasty? A randomised comparison in a large cohort of unselected patients. Heart 91: 641-645 [Abstract] [Full Text]  
• Authors/Task Force Members, , Silber, S., Albertsson, P., Aviles, F. F., Camici, P. G., Colombo, A., Hamm, C., Jorgensen, E., Marco, J., Nordrehaug, J.-E., Ruzyllo, W., Urban, P., Stone, G. W., Wijns, W. (2005). Guidelines for Percutaneous Coronary Interventions: The Task Force for Percutaneous Coronary Interventions of the European Society of Cardiology. Eur Heart J 26: 804-847 [Full Text]  
• Maier, W., Altwegg, L. A., Corti, R., Gay, S., Hersberger, M., Maly, F. E., Sutsch, G., Roffi, M., Neidhart, M., Eberli, F. R., Tanner, F. C., Gobbi, S., von Eckardstein, A., Luscher, T. F. (2005). Inflammatory Markers at the Site of Ruptured Plaque in Acute Myocardial Infarction: Locally Increased Interleukin-6 and Serum Amyloid A but Decreased C-Reactive Protein. Circulation 111: 1355-1361 [Abstract] [Full Text]  
• Stone, G. W., Webb, J., Cox, D. A., Brodie, B. R., Qureshi, M., Kalynych, A., Turco, M., Schultheiss, H. P., Dulas, D., Rutherford, B. D., Antoniucci, D., Krucoff, M. W., Gibbons, R. J., Jones, D., Lansky, A. J., Mehran, R., for the Enhanced Myocardial Efficacy and Recovery, (2005). Distal Microcirculatory Protection During Percutaneous Coronary Intervention in Acute ST-Segment Elevation Myocardial Infarction: A Randomized Controlled Trial. JAMA 293: 1063-1072 [Abstract] [Full Text]  
• Lansky, A. J., Hochman, J. S., Ward, P. A., Mintz, G. S., Fabunmi, R., Berger, P. B., New, G., Grines, C. L., Pietras, C. G., Kern, M. J., Ferrell, M., Leon, M. B., Mehran, R., White, C., Mieres, J. H., Moses, J. W., Stone, G. W., Jacobs, A. K., Endorsed by the American College of Cardiology Fou, (2005). Percutaneous Coronary Intervention and Adjunctive Pharmacotherapy in Women: A Statement for Healthcare Professionals From the American Heart Association. Circulation 111: 940-953 [Abstract] [Full Text]  
• Schomig, A., Ndrepepa, G., Mehilli, J., Dirschinger, J., Nekolla, S. G., Schmitt, C., Martinoff, S., Seyfarth, M., Schwaiger, M., Kastrati, A., STOPAMI-4 Study Investigators{section}, (2004). A randomized trial of coronary stenting versus balloon angioplasty as a rescue intervention after failed thrombolysis in patients with acute myocardial infarction. J Am Coll Cardiol 44: 2073-2079 [Abstract] [Full Text]  
• Heggunje, P. S., Harjai, K. J., Stone, G. W., Mehta, R. H., Marsalese, D. L., Boura, J. A., O'Neill, W. W., Grines, C. L. (2004). Procedural success versus clinical risk status in determining discharge of patients after primary angioplasty for acute myocardial infarction. J Am Coll Cardiol 44: 1400-1407 [Abstract] [Full Text]  
• Menon, V., Harrington, R. A., Hochman, J. S., Cannon, C. P., Goodman, S. D., Wilcox, R. G., Schunemann, H. J., Ohman, E. M. (2004). Thrombolysis and Adjunctive Therapy in Acute Myocardial Infarction: The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest 126: 549S-575S [Abstract] [Full Text]  
• Keeley, E. C., Grines, C. L. (2004). Primary Percutaneous Coronary Intervention for Every Patient with ST-Segment Elevation Myocardial Infarction: What Stands in the Way?. ANN INTERN MED 141: 298-304 [Abstract] [Full Text]  
• Writing Committee Members, , Antman, E. M., Anbe, D. T., Armstrong, P. W., Bates, E. R., Green, L. A., Hand, M., Hochman, J. S., Krumholz, H. M., Kushner, F. G., Lamas, G. A., Mullany, C. J., Ornato, J. P., Pearle, D. L., Sloan, M. A., Smith, S. C. Jr, Task Force Members, , Antman, E. M., Smith, S. C. Jr, Alpert, J. S., Anderson, J. L., Faxon, D. P., Fuster, V., Gibbons, R. J., Gregoratos, G., Halperin, J. L., Hiratzka, L. F., Hunt, S. A., Jacobs, A. K., Ornato, J. P. (2004). ACC/AHA guidelines for the management of patients with ST-Elevation myocardial infarction--executive summary: A report of the American College of Cardiology/American Heart Association Task Force on practice guidelines (writing committee to revise the 1999 guidelines for the management of patients with acute myocardial infarction) . J Am Coll Cardiol 44: 671-719 [Full Text]  
• Antman, E. M., Anbe, D. T., Armstrong, P. W., Bates, E. R., Green, L. A., Hand, M., Hochman, J. S., Krumholz, H. M., Kushner, F. G., Lamas, G. A., Mullany, C. J., Ornato, J. P., Pearle, D. L., Sloan, M. A., Smith, S. C. Jr, Antman, E. M., Smith, S. C. Jr, Alpert, J. S., Anderson, J. L., Faxon, D. P., Fuster, V., Gibbons, R. J., Gregoratos, G., Halperin, J. L., Hiratzka, L. F., Hunt, S. A., Jacobs, A. K., Ornato, J. P. (2004). ACC/AHA Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction--Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 1999 Guidelines for the Management of Patients With Acute Myocardial Infarction). Circulation 110: 588-636 [Full Text]  
• Kloner, R. A., Rezkalla, S. H. (2004). Cardiac protection during acute myocardial infarction: Where do we stand in 2004?. J Am Coll Cardiol 44: 276-286 [Abstract] [Full Text]  
• Grines, C. L., O'Neill, W. W. (2004). Rescue angioplasty: Does the concept need to be rescued?. J Am Coll Cardiol 44: 297-299 [Full Text]  
• Costantini, C. O., Stone, G. W., Mehran, R., Aymong, E., Grines, C. L., Cox, D. A., Stuckey, T., Turco, M., Gersh, B. J., Tcheng, J. E., Garcia, E., Griffin, J. J., Guagliumi, G., Leon, M. B., Lansky, A. J. (2004). Frequency, correlates, and clinical implications of myocardial perfusion after primary angioplasty and stenting, with and without glycoprotein IIb/IIIa inhibition, in acute myocardial infarction. J Am Coll Cardiol 44: 305-312 [Abstract] [Full Text]  
• Chaitman, B. R., Lim, M. J. (2004). No reflow and the quest to achieve optimal perfusion during the acute phase of myocardial infarction. J Am Coll Cardiol 44: 313-315 [Full Text]  
• Wu, W.-C., Gordon, P. C. (2004). Invasive Management of Patients With ST Elevation Myocardial Infarction With > 12-h Delay in Presentation: The Question Remains Unanswered. Chest 126: 2-4 [Full Text]  
• Wharton, T. P. Jr, Grines, L. L., Turco, M. A., Johnston, J. D., Souther, J., Lew, D. C., Shaikh, A. Z., Bilnoski, W., Singhi, S. K., Atay, A. E., Sinclair, N., Shaddinger, D. E., Barsamian, M., Graham, M., Boura, J., Grines, C. L. (2004). Primary Angioplasty in Acute Myocardial Infarction at Hospitals With No Surgery On-Site (the PAMI-No SOS study) versus transfer to surgical centers for primary angioplasty. J Am Coll Cardiol 43: 1943-1950 [Abstract] [Full Text]  
• Mehta, R. H., Harjai, K. J., Grines, L., Stone, G. W., Boura, J., Cox, D., O'Neill, W., Grines, C. L., Primary Angioplasty in Myocardial Infarction (PAMI, (2004). Sustained ventricular tachycardia or fibrillation in the cardiac catheterization laboratory among patients receiving primary percutaneous coronary intervention: Incidence, predictors, and outcomes. J Am Coll Cardiol 43: 1765-1772 [Abstract] [Full Text]  
• Kastrati, A., Mehilli, J., Nekolla, S., Bollwein, H., Martinoff, S., Pache, J., Schuhlen, H., Seyfarth, M., Gawaz, M., Neumann, F.-J., Dirschinger, J., Schwaiger, M., Schomig, A., STOPAMI-3 Study Investigators, (2004). A randomized trial comparing myocardial salvage achieved by coronary stenting versus balloon angioplasty in patients with acute myocardial infarction considered ineligible for reperfusion therapy. J Am Coll Cardiol 43: 734-741 [Abstract] [Full Text]  
• Dirksen, M. T, Laarman, G., van 't Hof, A. W.J, Guagliumi, G., Tonino, W. A.L, Tavazzi, L., Duncker, D. J.G.M, Simoons, M. L, on behalf of the PARI-MI Investigators, (2004). The effect of ITF-1697 on reperfusion in patients undergoing primary angioplasty: Safety and efficacy of a novel tetrapeptide, ITF-1697. Eur Heart J 25: 392-400 [Abstract] [Full Text]  
• Lemos, P. A., Saia, F., Hofma, S. H., Daemen, J., Ong, A. T. L., Arampatzis, C. A., Hoye, A., McFadden, E., Sianos, G., Smits, P. C., van der Giessen, W. J., de Feyter, P., van Domburg, R. T., Serruys, P. W. (2004). Short- and long-term clinical benefit of sirolimus-eluting stents compared to conventional bare stents for patients with acute myocardial infarction. J Am Coll Cardiol 43: 704-708 [Abstract] [Full Text]  
• Keeley, E. C., Grines, C. L. (2004). Primary Coronary Intervention for Acute Myocardial Infarction. JAMA 291: 736-739 [Full Text]  
• Zeymer, U., Vogt, A., Zahn, R., Weber, M. A, Tebbe, U., Gottwik, M., Bonzel, T., Senges, J., Neuhaus, K.-L., for the Arbeitsgemeinschaft Leitende Kardiologisch, (2004). Predictors of in-hospital mortality in 1333 patients with acute myocardial infarction complicated by cardiogenic shock treated with primary percutaneous coronary intervention (PCI): Results of the primary PCI registry of the Arbeitsgemeinschaft Leitende Kardiologische Krankenhausarzte (ALKK). Eur Heart J 25: 322-328 [Abstract] [Full Text]  
• Cole, J. H., Weintraub, W. S. (2003). Are Stenting and Glycoprotein IIb/IIIa Blockade of Good Value in Primary Percutaneous Coronary Intervention?. Circulation 108: 2831-2833 [Full Text]  
• Bakhai, A., Stone, G. W., Grines, C. L., Murphy, S. A., Githiora, L., Berezin, R. H., Cox, D. A., Stuckey, T., Griffin, J. J., Tcheng, J. E., Cohen, D. J., for the CADILLAC Investigators, (2003). Cost-Effectiveness of Coronary Stenting and Abciximab for Patients With Acute Myocardial Infarction: Results From the CADILLAC (Controlled Abciximab and Device Investigation to Lower Late Angioplasty Complications) Trial. Circulation 108: 2857-2863 [Abstract] [Full Text]  
• Antoniucci, D., Rodriguez, A., Hempel, A., Valenti, R., Migliorini, A., Vigo, F., Parodi, G., Fernandez-Pereira, C., Moschi, G., Bartorelli, A., Santoro, G. M., Bolognese, L., Colombo, A. (2003). A randomized trial comparing primary infarct artery stenting with or without abciximab in acute myocardial infarction. J Am Coll Cardiol 42: 1879-1885 [Abstract] [Full Text]  
• Sadeghi, H. M., Stone, G. W., Grines, C. L., Mehran, R., Dixon, S. R., Lansky, A. J., Fahy, M., Cox, D. A., Garcia, E., Tcheng, J. E., Griffin, J. J., Stuckey, T. D., Turco, M., Carroll, J. D. (2003). Impact of Renal Insufficiency in Patients Undergoing Primary Angioplasty for Acute Myocardial Infarction. Circulation 108: 2769-2775 [Abstract] [Full Text]