Lack of Effect of a High-Fiber Cereal Supplement on the Recurrence of Colorectal Adenomas
David S. Alberts, M.D., María Elena Martínez, Ph.D., Denise J. Roe, Dr.P.H., José M. Guillén-Rodríguez, M.S., James R. Marshall, Ph.D., J. Barbara van Leeuwen, M.A., Mary E. Reid, Ph.D., Cheryl Ritenbaugh, Ph.D., Perla A. Vargas, Ph.D., A.B. Bhattacharyya, M.D., David L. Earnest, M.D., Richard E. Sampliner, M.D., Dianne Parish, Kris Koonce, Lianne Fales, for The Phoenix Colon Cancer Prevention Physicians' Network
Background The risks of colorectal cancer and adenoma, the precursorlesion, are believed to be influenced by dietary factors. Epidemiologicevidence that cereal fiber protects against colorectal canceris equivocal. We conducted a randomized trial to determine whetherdietary supplementation with wheat-bran fiber reduces the rateof recurrence of colorectal adenomas.
Methods We randomly assigned 1429 men and women who were 40to 80 years of age and who had had one or more histologicallyconfirmed colorectal adenomas removed within three months beforerecruitment to a supervised program of dietary supplementationwith either high amounts (13.5 g per day) or low amounts (2g per day) of wheat-bran fiber. The primary end point was thepresence or absence of new adenomas at the time of follow-upcolonoscopy. Subjects and physicians, including colonoscopists,were unaware of the group assignments.
Results Of the 1303 subjects who completed the study, 719 hadbeen randomly assigned to the high-fiber group and 584 to thelow-fiber group. The median times from randomization to thelast follow-up colonoscopy were 34 months in the high-fibergroup and 36 months in the low-fiber group. By the time of thelast follow-up colonoscopy, at least one adenoma had been identifiedin 338 subjects in the high-fiber group (47.0 percent) and in299 subjects in the low-fiber group (51.2 percent). The multivariateadjusted odds ratio for recurrent adenoma in the high-fibergroup, as compared with the low-fiber group, was 0.88 (95 percentconfidence interval, 0.70 to 1.11; P=0.28), and the relativerisk of recurrence according to the number of adenomas, in thehigh-fiber group as compared with the low-fiber group, was 0.99(95 percent confidence interval, 0.71 to 1.36; P=0.93).
Conclusions As used in this study, a dietary supplement of wheat-branfiber does not protect against recurrent colorectal adenomas.
Source Information
From the Arizona Cancer Center (D.S.A., M.E.M., D.J.R., J.M.G.-R., J.R.M., J.B.L., M.E.R.), the College of Public Health (D.S.A., M.E.M., D.J.R., J.R.M., M.E.R.), and the Departments of Pathology (A.B.B.) and Medicine (D.S.A., D.L.E., R.E.S.), University of Arizona, Tucson; the Center for Health Research, Portland, Oreg. (C.R.); the Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock (P.A.V.); and Veterans Affairs Medical Center, Tucson, Ariz. (R.E.S.). Other authors were Dianne Parish, B.S., Kris Koonce, B.S., and Lianne Fales, M.P.H., Arizona Cancer Center, University of Arizona, Tucson.Presented in abstract form at the 91st annual meeting of the American Association for Cancer Research, San Francisco, April 1–5, 2000.
Address reprint requests to Dr. Alberts at the Arizona Cancer Center, P.O. Box 245024, Tucson, AZ 85724-5024, or at dalberts{at}azcc.arizona.edu.
Levin, B., Lieberman, D. A., McFarland, B., Smith, R. A., Brooks, D., Andrews, K. S., Dash, C., Giardiello, F. M., Glick, S., Levin, T. R., Pickhardt, P., Rex, D. K., Thorson, A., Winawer, S. J., for the American Cancer Society Colorectal Cancer,
(2008). Screening and Surveillance for the Early Detection of Colorectal Cancer and Adenomatous Polyps, 2008: A Joint Guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology. CA Cancer J Clin
58: 130-160
[Abstract][Full Text]
Hubner, R. A., Muir, K. R., Liu, J.-F., Logan, R. F.A., Grainge, M. J., Houlston, R. S., Members of the UKCAP Consortium,
(2008). Ornithine Decarboxylase G316A Genotype Is Prognostic for Colorectal Adenoma Recurrence and Predicts Efficacy of Aspirin Chemoprevention. Clin. Cancer Res.
14: 2303-2309
[Abstract][Full Text]
Jacobs, E. T., Martinez, M. E., Alberts, D. S., Ashbeck, E. L., Gapstur, S. M., Lance, P., Thompson, P. A.
(2008). Plasma Insulin-Like Growth Factor I Is Inversely Associated with Colorectal Adenoma Recurrence: A Novel Hypothesis. Cancer Epidemiol. Biomarkers Prev.
17: 300-305
[Abstract][Full Text]
Sommer, A.
(2008). Misclassification: Who Really Lives in This Neighborhood?. Arch Ophthalmol
126: 265-266
[Full Text]
Alberts, D. S., Einspahr, J. G., Krouse, R. S., Prasad, A., Ranger-Moore, J., Hamilton, P., Ismail, A., Lance, P., Goldschmid, S., Hess, L. M., Yozwiak, M., Bartels, H. G., Bartels, P. H.
(2007). Karyometry of the Colonic Mucosa. Cancer Epidemiol. Biomarkers Prev.
16: 2704-2716
[Abstract][Full Text]
Chu, D. Z. J., Gibson, G., David, D., Yen, Y.
(2007). The Surgeon's Role in Cancer Prevention. The Model in Colorectal Carcinoma. Ann. Surg. Oncol.
14: 3054-3069
[Abstract][Full Text]
Kolar, S. S. N., Barhoumi, R., Callaway, E. S., Fan, Y.-Y., Wang, N., Lupton, J. R., Chapkin, R. S.
(2007). Synergy between docosahexaenoic acid and butyrate elicits p53-independent apoptosis via mitochondrial Ca2+ accumulation in colonocytes. Am. J. Physiol. Gastrointest. Liver Physiol.
293: G935-G943
[Abstract][Full Text]
Lanza, E., Yu, B., Murphy, G., Albert, P. S., Caan, B., Marshall, J. R., Lance, P., Paskett, E. D., Weissfeld, J., Slattery, M., Burt, R., Iber, F., Shike, M., Kikendall, J. W., Brewer, B. K., Schatzkin, A., the Polyp Prevention Trial Study Group,
(2007). The Polyp Prevention Trial Continued Follow-up Study: No Effect of a Low-Fat, High-Fiber, High-Fruit, and -Vegetable Diet on Adenoma Recurrence Eight Years after Randomization. Cancer Epidemiol. Biomarkers Prev.
16: 1745-1752
[Abstract][Full Text]
O'Dwyer, P. J., Eckhardt, S. G., Haller, D. G., Tepper, J., Ahnen, D., Hamilton, S., Benson, A. B. III, Rothenberg, M., Petrelli, N., Lenz, H.-J., Diasio, R., DuBois, R., Sargent, D., Sloan, J., Johnson, C. D., Comis, R. L., O'Connell, M. J.
(2007). Priorities in Colorectal Cancer Research: Recommendations From the Gastrointestinal Scientific Leadership Council of the Coalition of Cancer Cooperative Groups. JCO
25: 2313-2321
[Abstract][Full Text]
Kolar, S. S. N., Barhoumi, R., Lupton, J. R., Chapkin, R. S.
(2007). Docosahexaenoic Acid and Butyrate Synergistically Induce Colonocyte Apoptosis by Enhancing Mitochondrial Ca2+ Accumulation. Cancer Res.
67: 5561-5568
[Abstract][Full Text]
Schatzkin, A., Mouw, T., Park, Y., Subar, A. F, Kipnis, V., Hollenbeck, A., Leitzmann, M. F, Thompson, F. E
(2007). Dietary fiber and whole-grain consumption in relation to colorectal cancer in the NIH-AARP Diet and Health Study. Am. J. Clin. Nutr.
85: 1353-1360
[Abstract][Full Text]
Wakai, K., Date, C., Fukui, M., Tamakoshi, K., Watanabe, Y., Hayakawa, N., Kojima, M., Kawado, M., Suzuki, K., Hashimoto, S., Tokudome, S., Ozasa, K., Suzuki, S., Toyoshima, H., Ito, Y., Tamakoshi, A., for the JACC Study Group,
(2007). Dietary Fiber and Risk of Colorectal Cancer in the Japan Collaborative Cohort Study. Cancer Epidemiol. Biomarkers Prev.
16: 668-675
[Abstract][Full Text]
Hsu, C.-H.
(2007). A weighted zero-inflated Poisson model for estimation of recurrence of adenomas. Stat Methods Med Res
16: 155-166
Hawk, E., Viner, J. L.
(2007). The Adenoma Prevention with Celecoxib and Prevention of Colorectal Sporadic Adenomatous Polyps Trials: Stepping Stones to Progress. Cancer Epidemiol. Biomarkers Prev.
16: 185-187
[Full Text]
Levine, J. S., Ahnen, D. J.
(2006). Adenomatous Polyps of the Colon. NEJM
355: 2551-2557
[Full Text]
Lieberman, D.
(2006). A Call to Action -- Measuring the Quality of Colonoscopy. NEJM
355: 2588-2589
[Full Text]
Boolchand, V., Olds, G., Singh, J., Singh, P., Chak, A., Cooper, G. S.
(2006). Colorectal screening after polypectomy: a national survey study of primary care physicians.. ANN INTERN MED
145: 654-659
[Abstract][Full Text]
Hudson, T. S., Forman, M. R., Cantwell, M. M., Schatzkin, A., Albert, P. S., Lanza, E.
(2006). Dietary Fiber Intake: Assessing the Degree of Agreement between Food Frequency Questionnaires and 4-Day Food Records.. J. Am. Coll. Nutr.
25: 370-381
[Abstract][Full Text]
Kushi, L. H., Byers, T., Doyle, C., Bandera, E. V., McCullough, M., Gansler, T., Andrews, K. S., Thun, M. J., The American Cancer Society 2006 Nutrition and Phy,
(2006). American Cancer Society Guidelines on Nutrition and Physical Activity for Cancer Prevention: Reducing the Risk of Cancer With Healthy Food Choices and Physical Activity. CA Cancer J Clin
56: 254-281
[Abstract][Full Text]
Einspahr, J. G., Martinez, M. E., Jiang, R., Hsu, C.-H., Bhattacharrya, A. K., Ahnen, D. J., Jacobs, E. T., Houlihan, P. S., Webb, C. R., Alberts, D. S., Hamilton, S. R.
(2006). Associations of Ki-ras Proto-oncogene Mutation and p53 Gene Overexpression in Sporadic Colorectal Adenomas with Demographic and Clinicopathologic Characteristics.. Cancer Epidemiol. Biomarkers Prev.
15: 1443-1450
[Abstract][Full Text]
Davies, A. A., Davey Smith, G., Harbord, R., Bekkering, G. E., Sterne, J. A. C., Beynon, R., Thomas, S.
(2006). Nutritional interventions and outcome in patients with cancer or preinvasive lesions: systematic review.. JNCI J Natl Cancer Inst
98: 961-973
[Abstract][Full Text]
Singh, H., Turner, D., Xue, L., Targownik, L. E., Bernstein, C. N.
(2006). Risk of developing colorectal cancer following a negative colonoscopy examination: evidence for a 10-year interval between colonoscopies.. JAMA
295: 2366-2373
[Abstract][Full Text]
Tanaka, S., Haruma, K., Yoshihara, M., Kajiyama, G., Kira, K., Amagase, H., Chayama, K.
(2006). Aged Garlic Extract Has Potential Suppressive Effect on Colorectal Adenomas in Humans. J. Nutr.
136: 821S-826S
[Abstract][Full Text]
Beresford, S. A. A., Johnson, K. C., Ritenbaugh, C., Lasser, N. L., Snetselaar, L. G., Black, H. R., Anderson, G. L., Assaf, A. R., Bassford, T., Bowen, D., Brunner, R. L., Brzyski, R. G., Caan, B., Chlebowski, R. T., Gass, M., Harrigan, R. C., Hays, J., Heber, D., Heiss, G., Hendrix, S. L., Howard, B. V., Hsia, J., Hubbell, F. A., Jackson, R. D., Kotchen, J. M., Kuller, L. H., LaCroix, A. Z., Lane, D. S., Langer, R. D., Lewis, C. E., Manson, J. E., Margolis, K. L., Mossavar-Rahmani, Y., Ockene, J. K., Parker, L. M., Perri, M. G., Phillips, L., Prentice, R. L., Robbins, J., Rossouw, J. E., Sarto, G. E., Stefanick, M. L., Van Horn, L., Vitolins, M. Z., Wactawski-Wende, J., Wallace, R. B., Whitlock, E.
(2006). Low-Fat Dietary Pattern and Risk of Colorectal Cancer: The Women's Health Initiative Randomized Controlled Dietary Modification Trial. JAMA
295: 643-654
[Abstract][Full Text]
Jacobs, E. T, Lanza, E., Alberts, D. S, Hsu, C.-H., Jiang, R., Schatzkin, A., Thompson, P. A, Martinez, M. E.
(2006). Fiber, sex, and colorectal adenoma: results of a pooled analysis. Am. J. Clin. Nutr.
83: 343-349
[Abstract][Full Text]
Park, Y., Hunter, D. J., Spiegelman, D., Bergkvist, L., Berrino, F., van den Brandt, P. A., Buring, J. E., Colditz, G. A., Freudenheim, J. L., Fuchs, C. S., Giovannucci, E., Goldbohm, R. A., Graham, S., Harnack, L., Hartman, A. M., Jacobs, D. R. Jr, Kato, I., Krogh, V., Leitzmann, M. F., McCullough, M. L., Miller, A. B., Pietinen, P., Rohan, T. E., Schatzkin, A., Willett, W. C., Wolk, A., Zeleniuch-Jacquotte, A., Zhang, S. M., Smith-Warner, S. A.
(2005). Dietary Fiber Intake and Risk of Colorectal Cancer: A Pooled Analysis of Prospective Cohort Studies. JAMA
294: 2849-2857
[Abstract][Full Text]
Baron, J. A.
(2005). Dietary Fiber and Colorectal Cancer: An Ongoing Saga. JAMA
294: 2904-2906
[Full Text]
Hsu, C.-H.
(2005). Joint modelling of recurrence and progression of adenomas: a latent variable approach. Statistical Modelling
5: 201-215
[Abstract]
Hartman, T. J., Yu, B., Albert, P. S., Slattery, M. L., Paskett, E., Kikendall, J. W., Iber, F., Brewer, B. K., Schatzkin, A., Lanza, E., The Polyp Prevention Study Group,
(2005). Does Nonsteroidal Anti-inflammatory Drug Use Modify the Effect of a Low-Fat, High-Fiber Diet on Recurrence of Colorectal Adenomas?. Cancer Epidemiol. Biomarkers Prev.
14: 2359-2365
[Abstract][Full Text]
Goodlad, R A, Cummings, J, Coleman, N, Goodlad, R A, Alferez, D, Cummings, J, Coleman, N
(2005). Defective denominators * Author's reply * Author's reply * Author's reply. Gut
54: 1502-1503
[Full Text]
Eisen, G. M., Weinberg, D. S.
(2005). Narrative Review: Screening for Colorectal Cancer in Patients with a First-Degree Relative with Colonic Neoplasia. ANN INTERN MED
143: 190-198
[Abstract][Full Text]
Lichtenstein, A. H., Russell, R. M.
(2005). Essential Nutrients: Food or Supplements?: Where Should the Emphasis Be?. JAMA
294: 351-358
[Abstract][Full Text]
Brown, P. H., Rashid, A.
(2005). Cancer Prevention: The Importance of Accurate Risk Assessment. Cancer Epidemiol. Biomarkers Prev.
14: 1357-1358
[Full Text]
Mizoue, T., Yamaji, T., Tabata, S., Yamaguchi, K., Shimizu, E., Mineshita, M., Ogawa, S., Kono, S.
(2005). Dietary Patterns and Colorectal Adenomas in Japanese Men: The Self-Defense Forces Health Study. Am J Epidemiol
161: 338-345
[Abstract][Full Text]
Hawk, E. T., Levin, B.
(2005). Colorectal Cancer Prevention. JCO
23: 378-391
[Abstract][Full Text]
Roberts, C. K., Barnard, R. J.
(2005). Effects of exercise and diet on chronic disease. J. Appl. Physiol.
98: 3-30
[Abstract][Full Text]
Barnard, R. J.
(2004). Prevention of Cancer Through Lifestyle Changes. Evid Based Complement Alternat Med
1: 233-239
[Abstract][Full Text]
Sanders, L. M., Henderson, C. E., Hong, M. Y., Barhoumi, R., Burghardt, R. C., Wang, N., Spinka, C. M., Carroll, R. J., Turner, N. D., Chapkin, R. S., Lupton, J. R.
(2004). An Increase in Reactive Oxygen Species by Dietary Fish Oil Coupled with the Attenuation of Antioxidant Defenses by Dietary Pectin Enhances Rat Colonocyte Apoptosis. J. Nutr.
134: 3233-3238
[Abstract][Full Text]
Duffield-Lillico, A. J., Shureiqi, I., Lippman, S. M.
(2004). Can Selenium Prevent Colorectal Cancer? A Signpost From Epidemiology. JNCI J Natl Cancer Inst
96: 1645-1647
[Full Text]
Lieberman, D.
(2004). Colonoscopy: As Good as Gold?. ANN INTERN MED
141: 401-403
[Full Text]
Prentice, R. L., Willett, W. C., Greenwald, P., Alberts, D., Bernstein, L., Boyd, N. F., Byers, T., Clinton, S. K., Fraser, G., Freedman, L., Hunter, D., Kipnis, V., Kolonel, L. N., Kristal, B. S., Kristal, A., Lampe, J. W., McTiernan, A., Milner, J., Patterson, R. E., Potter, J. D., Riboli, E., Schatzkin, A., Yates, A., Yetley, E.
(2004). Nutrition and Physical Activity and Chronic Disease Prevention: Research Strategies and Recommendations. JNCI J Natl Cancer Inst
96: 1276-1287
[Abstract][Full Text]
Papas, M. A., Giovannucci, E., Platz, E. A.
(2004). Fiber from Fruit and Colorectal Neoplasia. Cancer Epidemiol. Biomarkers Prev.
13: 1267-1270
[Full Text]
Muir, J. G, Yeow, E. G., Keogh, J., Pizzey, C., Bird, A. R, Sharpe, K., O'Dea, K., Macrae, F. A
(2004). Combining wheat bran with resistant starch has more beneficial effects on fecal indexes than does wheat bran alone. Am. J. Clin. Nutr.
79: 1020-1028
[Abstract][Full Text]
Tsao, A. S., Kim, E. S., Hong, W. K.
(2004). Chemoprevention of Cancer. CA Cancer J Clin
54: 150-180
[Abstract][Full Text]
Martinez, M. E., Henning, S. M, Alberts, D. S
(2004). Folate and colorectal neoplasia: relation between plasma and dietary markers of folate and adenoma recurrence. Am. J. Clin. Nutr.
79: 691-697
[Abstract][Full Text]
Nakaji, S., Ishiguro, S., Iwane, S., Ohta, M., Sugawara, K., Sakamoto, J., Fukuda, S.
(2004). The Prevention of Colon Carcinogenesis in Rats by Dietary Cellulose Is Greater than the Promotive Effect of Dietary Lard as Assessed by Repeated Endoscopic Observation. J. Nutr.
134: 935-939
[Abstract][Full Text]
Lupton, J. R.
(2004). Microbial Degradation Products Influence Colon Cancer Risk: the Butyrate Controversy. J. Nutr.
134: 479-482
[Abstract][Full Text]
Arasaradnam, R P, Riley, S A, Corfe, B M
(2004). Diet and colorectal cancer: fibre back on the menu?. Gut
53: 155-156
[Full Text]
Lieberman, D. A., Prindiville, S., Weiss, D. G., Willett, W.
(2003). Risk Factors for Advanced Colonic Neoplasia and Hyperplastic Polyps in Asymptomatic Individuals. JAMA
290: 2959-2967
[Abstract][Full Text]
Boyd, D. B.
(2003). Insulin and Cancer. Integr Cancer Ther
2: 315-329
[Abstract]
Erhardt, J. G, Meisner, C., Bode, J C., Bode, C.
(2003). Lycopene, {beta}-carotene, and colorectal adenomas. Am. J. Clin. Nutr.
78: 1219-1224
[Abstract][Full Text]
Satia-Abouta, J., Galanko, J. A., Potter, J. D., Ammerman, A., Martin, C. F., Sandler, R. S.
(2003). Associations of Total Energy and Macronutrients with Colon Cancer Risk in African Americans and Whites: Results from the North Carolina Colon Cancer Study. Am J Epidemiol
158: 951-962
[Abstract][Full Text]
Kritchevsky, D.
(2003). Diet and Cancer: What's Next?. J. Nutr.
133: 3827S-3829
[Abstract][Full Text]
Reid, M. E., Marshall, J. R., Roe, D., Lebowitz, M., Alberts, D., Battacharyya, A. K., Martinez, M. E.
(2003). Smoking Exposure as a Risk Factor for Prevalent and Recurrent Colorectal Adenomas. Cancer Epidemiol. Biomarkers Prev.
12: 1006-1011
[Abstract][Full Text]
Sabichi, A. L., Demierre, M.-F., Hawk, E. T., Lerman, C. E., Lippman, S. M.
(2003). Frontiers in Cancer Prevention Research. Cancer Res.
63: 5649-5655
[Full Text]
Einspahr, J. G., Krouse, R. S., Yochim, J. M., Danenberg, P. V., Danenberg, K. D., Bhattacharyya, A. K., Martinez, M. E., Alberts, D. S.
(2003). Association between Cyclooxygenase Expression and Colorectal Adenoma Characteristics. Cancer Res.
63: 3891-3893
[Abstract][Full Text]
Boyle, P., Autier, P., Bartelink, H., Baselga, J., Boffetta, P., Burn, J., Burns, H. J. G., Christensen, L., Denis, L., Dicato, M., Diehl, V., Doll, R., Franceschi, S., Gillis, C. R., Gray, N., Griciute, L., Hackshaw, A., Kasler, M., Kogevinas, M., Kvinnsland, S., La Vecchia, C., Levi, F., McVie, J. G., Maisonneuve, P., Martin-Moreno, J. M., Newton Bishop, J., Oleari, F., Perrin, P., Quinn, M., Richards, M., Ringborg, U., Scully, C., Siracka, E., Storm, H., Tubiana, M., Tursz, T., Veronesi, U., Wald, N., Weber, W., Zaridze, D. G., Zatonski, W., zur Hausen, H.
(2003). European Code Against Cancer and scientific justification: third version (2003). Ann Oncol
14: 973-1005
[Full Text]
Wargovich, M. J., Cunningham, J. E.
(2003). Diet, Individual Responsiveness and Cancer Prevention. J. Nutr.
133: 2400S-2403
[Abstract][Full Text]
Martinez, M. E., O'Brien, T. G., Fultz, K. E., Babbar, N., Yerushalmi, H., Qu, N., Guo, Y., Boorman, D., Einspahr, J., Alberts, D. S., Gerner, E. W.
(2003). Pronounced reduction in adenoma recurrence associated with aspirin use and a polymorphism in the ornithine decarboxylase gene. Proc. Natl. Acad. Sci. USA
100: 7859-7864
[Abstract][Full Text]
Corpet, D. E., Pierre, F.
(2003). Point: From Animal Models to Prevention of Colon Cancer. Systematic Review of Chemoprevention in Min Mice and Choice of the Model System. Cancer Epidemiol. Biomarkers Prev.
12: 391-400
[Abstract][Full Text]
Mai, V., Flood, A., Peters, U., Lacey, J. V Jr, Schairer, C., Schatzkin, A.
(2003). Dietary fibre and risk of colorectal cancer in the Breast Cancer Detection Demonstration Project (BCDDP) follow-up cohort. Int J Epidemiol
32: 234-239
[Abstract][Full Text]
Lawlor, D. A, Ness, A. R
(2003). Commentary: The rough world of nutritional epidemiology: Does dietary fibre prevent large bowel cancer?. Int J Epidemiol
32: 239-243
[Full Text]
Sandler, R. S., Halabi, S., Baron, J. A., Budinger, S., Paskett, E., Keresztes, R., Petrelli, N., Pipas, J. M., Karp, D. D., Loprinzi, C. L., Steinbach, G., Schilsky, R.
(2003). A Randomized Trial of Aspirin to Prevent Colorectal Adenomas in Patients with Previous Colorectal Cancer. NEJM
348: 883-890
[Abstract][Full Text]
Alberts, D. S., Einspahr, J. G., Earnest, D. L., Krutzsch, M. F., Lin, P., Hess, L. M., Heddens, D. K., Roe, D. J., Martinez, M. E., Salen, G., Batta, A. K.
(2003). Fecal Bile Acid Concentrations in a Subpopulation of the Wheat Bran Fiber Colon Polyp Trial. Cancer Epidemiol. Biomarkers Prev.
12: 197-200
[Abstract][Full Text]
Butler, L. M., Sinha, R., Millikan, R. C., Martin, C. F., Newman, B., Gammon, M. D., Ammerman, A. S., Sandler, R. S.
(2003). Heterocyclic Amines, Meat Intake, and Association with Colon Cancer in a Population-based Study. Am J Epidemiol
157: 434-445
[Abstract][Full Text]
Fung, T., Hu, F. B., Fuchs, C., Giovannucci, E., Hunter, D. J., Stampfer, M. J., Colditz, G. A., Willett, W. C.
(2003). Major Dietary Patterns and the Risk of Colorectal Cancer in Women. Arch Intern Med
163: 309-314
[Abstract][Full Text]
Fallon, U. B
(2003). Commentary: Colon cancer, folate and genetic status. Int J Epidemiol
32: 67-70
[Full Text]
Boyle, P., Leon, M. E.
(2002). Epidemiology of colorectal cancer. Br Med Bull
64: 1-25
[Abstract][Full Text]
Mitchell, R. J., Farrington, S. M., Dunlop, M. G., Campbell, H.
(2002). Mismatch Repair Genes hMLH1 and hMSH2 and Colorectal Cancer: A HuGE Review. Am J Epidemiol
156: 885-902
[Abstract][Full Text]
Jacobs, E. T., Giuliano, A. R., Roe, D. J., Guillen-Rodriguez, J. M., Alberts, D. S., Martinez, M. E.
(2002). Baseline Dietary Fiber Intake and Colorectal Adenoma Recurrence in the Wheat Bran Fiber Randomized Trial. JNCI J Natl Cancer Inst
94: 1620-1625
[Abstract][Full Text]
Lippman, S. M., Hong, W. K.
(2002). Cancer Prevention Science and Practice. Cancer Res.
62: 5119-5125
[Full Text]
Jacobs, E. T., Giuliano, A. R., Roe, D. J., Guillen-Rodriguez, J. M., Hess, L. M., Alberts, D. S., Martinez, M. E.
(2002). Intake of Supplemental and Total Fiber and Risk of Colorectal Adenoma Recurrence in the Wheat Bran Fiber Trial. Cancer Epidemiol. Biomarkers Prev.
11: 906-914
[Abstract][Full Text]
Wacker, M., Wanek, P., Eder, E., Hylla, S., Gostner, A., Scheppach, W.
(2002). Effect of Enzyme-resistant Starch on Formation of 1,N2-Propanodeoxyguanosine Adducts of trans-4-Hydroxy-2-nonenal and Cell Proliferation in the Colonic Mucosa of Healthy Volunteers. Cancer Epidemiol. Biomarkers Prev.
11: 915-920
[Abstract][Full Text]
Coleman, L. J., Landstrom, E. K., Royle, P. J., Bird, A. R., McIntosh, G. H.
(2002). A Diet Containing {alpha}-Cellulose and Fish Oil Reduces Aberrant Crypt Foci Formation and Modulates Other Possible Markers for Colon Cancer Risk in Azoxymethane-Treated Rats. J. Nutr.
132: 2312-2318
[Abstract][Full Text]
Colangelo, L. A., Gapstur, S. M., Gann, P. H., Dyer, A. R., Liu, K.
(2002). Colorectal Cancer Mortality and Factors Related to the Insulin Resistance Syndrome. Cancer Epidemiol. Biomarkers Prev.
11: 385-391
[Abstract][Full Text]
Temple, N. J., Balay-Karperien, A. L.
(2002). Nutrition in Cancer Prevention: An Integrated Approach. J. Am. Coll. Nutr.
21: 79-83
[Abstract][Full Text]
Byers, T., Nestle, M., McTiernan, A., Doyle, C., Currie-Williams, A., Gansler, T., Thun, M., the American Cancer Society 2001 Nutrition and Phy,
(2002). American Cancer Society Guidelines on Nutrition and Physical Activity for Cancer Prevention: Reducing the Risk of Cancer with Healthy Food Choices and Physical Activity. CA Cancer J Clin
52: 92-119
[Abstract][Full Text]
Young, R. C., Wilson, C. M.
(2002). Cancer Prevention: Past, Present, and Future. Clin. Cancer Res.
8: 11-16
[Abstract][Full Text]
Schlenker, E. D.
(2001). The Evolution of Research in Family and Consumer Sciences: Food, Nutrition, and Health. Family and Consumer Sciences Research Journal
30: 140-196
[Abstract]
Giovannucci, E.
(2001). Insulin, Insulin-Like Growth Factors and Colon Cancer: A Review of the Evidence. J. Nutr.
131: 3109S-3120
[Abstract][Full Text]
Topping, D. L., Clifton, P. M.
(2001). Short-Chain Fatty Acids and Human Colonic Function: Roles of Resistant Starch and Nonstarch Polysaccharides. Physiol. Rev.
81: 1031-1064
[Abstract][Full Text]
Sandhu, M. S., White, I. R., McPherson, K.
(2001). Systematic Review of the Prospective Cohort Studies on Meat Consumption and Colorectal Cancer Risk: A Meta-Analytical Approach. Cancer Epidemiol. Biomarkers Prev.
10: 439-446
[Abstract][Full Text]
Brown, J., Byers, T., Thompson, K., Eldridge, B., Doyle, C., Williams, A. M., American Cancer Society Workgroup on Nutrition and,
(2001). Nutrition During and After Cancer Treatment: A Guide for Informed Choices by Cancer Survivors. CA Cancer J Clin
51: 153-181
[Abstract][Full Text]
Terry, P., Giovannucci, E., Michels, K. B., Bergkvist, L., Hansen, H., Holmberg, L., Wolk, A.
(2001). Fruit, Vegetables, Dietary Fiber, and Risk of Colorectal Cancer. JNCI J Natl Cancer Inst
93: 525-533
[Abstract][Full Text]
Willett, W. C.
(2001). Diet and Cancer: One View at the Start of the Millennium. Cancer Epidemiol. Biomarkers Prev.
10: 3-8
[Abstract][Full Text]
(2001). Additional articles abstracted in ACP Journal Club. Evid. Based Med.
6: 3-3
[Full Text]
Weyant, M. J., Carothers, A. M., Dannenberg, A. J., Bertagnolli, M. M.
(2001). (+)-Catechin Inhibits Intestinal Tumor Formation and Suppresses Focal Adhesion Kinase Activation in the Min/+ Mouse. Cancer Res.
61: 118-125
[Abstract][Full Text]
Whorton, J.
(2000). Civilisation and the colon: constipation as the "disease of diseases". BMJ
321: 1586-1589
[Full Text]
Hill, M.J., Davies, G.J., Davies, G. J.
(2000). Dietary advice on cancer prevention: time for a change?. The Journal of the Royal Society for the Promotion of Health
120: 227-229
[Abstract]
Michels, K. B., Edward Giovannucci, , Joshipura, K. J., Rosner, B. A., Stampfer, M. J., Fuchs, C. S., Colditz, G. A., Speizer, F. E., Willett, W. C.
(2000). Prospective Study of Fruit and Vegetable Consumption and Incidence of Colon and Rectal Cancers. JNCI J Natl Cancer Inst
92: 1740-1752
[Abstract][Full Text]
Chen, B. H.
(2000). New doubts about the diet-and-cancer connection. CMAJ
163: 1043-1043
[Full Text]
Ornish, D., Davis, B. M., Gerber, M., Lowenfels, A., Maisonneuve, P., Muller, R. J., Duprey, P. A., Schatzkin, A., Lanza, E., Freedman, L., Alberts, D. S., Martinez, M. E., Marshall, J. R.
(2000). High-Fiber Diet and Colorectal Adenomas. NEJM
343: 736-738
[Full Text]
A correction has been published: N Engl J Med 2000;343(13):980.
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