Background Many lifestyle-related risk factors for coronaryheart disease have been identified, but little is known abouttheir effect on the risk of disease when they are consideredtogether.
Methods We followed 84,129 women participating in the Nurses'Health Study who were free of diagnosed cardiovascular disease,cancer, and diabetes at base line in 1980. Information on dietand lifestyle was updated periodically. During 14 years of follow-up,we documented 1128 major coronary events (296 deaths from coronaryheart disease and 832 nonfatal infarctions). We defined subjectsat low risk as those who were not currently smoking, had a body-massindex (the weight in kilograms divided by the square of theheight in meters) under 25, consumed an average of at leasthalf a drink of an alcoholic beverage per day, engaged in moderate-to-vigorousphysical activity (which could include brisk walking) for atleast half an hour per day, on average, and scored in the highest40 percent of the cohort for consumption of a diet high in cerealfiber, marine n–3 fatty acids, and folate, with a highratio of polyunsaturated to saturated fat, and low in transfat and glycemic load, which reflects the extent to which dietraises blood glucose levels.
Results Many of the factors were correlated, but each independentlyand significantly predicted risk, even after further adjustmentfor age, family history, presence or absence of diagnosed hypertensionor diagnosed high cholesterol level, and menopausal status.Women in the low-risk category (who made up 3 percent of thepopulation) had a relative risk of coronary events of 0.17 (95percent confidence interval, 0.07 to 0.41) as compared withall the other women. Eighty-two percent of coronary events inthe study cohort (95 percent confidence interval, 58 to 93 percent)could be attributed to lack of adherence to this low-risk pattern.
Conclusions Among women, adherence to lifestyle guidelines involvingdiet, exercise, and abstinence from smoking is associated witha very low risk of coronary heart disease.
Source Information
From the Channing Laboratory (M.J.S., J.E.M., E.B.R., W.C.W.) and the Division of Preventive Medicine (J.E.M.), Department of Medicine, Brigham and Women's Hospital and Harvard Medical School; and the Departments of Epidemiology (M.J.S., J.E.M., E.B.R., W.C.W.) and Nutrition (M.J.S., F.B.H., E.B.R., W.C.W.), Harvard School of Public Health — all in Boston.
Cardi, M., Munk, N., Zanjani, F., Kruger, T., Schaie, K. W., Willis, S. L.
(2009). Health Behavior Risk Factors Across Age as Predictors of Cardiovascular Disease Diagnosis. J Aging Health
21: 759-775
[Abstract]
Kris-Etherton, P. M
(2009). Adherence to dietary guidelines: benefits on atherosclerosis progression. Am. J. Clin. Nutr.
90: 13-14
[Full Text]
Imamura, F., Jacques, P. F, Herrington, D. M, Dallal, G. E, Lichtenstein, A. H
(2009). Adherence to 2005 Dietary Guidelines for Americans is associated with a reduced progression of coronary artery atherosclerosis in women with established coronary artery disease. Am. J. Clin. Nutr.
90: 193-201
[Abstract][Full Text]
Peart, J. N., Headrick, J. P.
(2009). Clinical cardioprotection and the value of conditioning responses. Am. J. Physiol. Heart Circ. Physiol.
296: H1705-H1720
[Abstract][Full Text]
Fraser, G. E
(2009). Vegetarian diets: what do we know of their effects on common chronic diseases?. Am. J. Clin. Nutr.
89: 1607S-1612S
[Abstract][Full Text]
Mozaffarian, D., Kamineni, A., Carnethon, M., Djousse, L., Mukamal, K. J., Siscovick, D.
(2009). Lifestyle Risk Factors and New-Onset Diabetes Mellitus in Older Adults: The Cardiovascular Health Study. Arch Intern Med
169: 798-807
[Abstract][Full Text]
Taubman, S. L, Robins, J. M, Mittleman, M. A, Hernan, M. A
(2009). Intervening on risk factors for coronary heart disease: an application of the parametric g-formula. Int J Epidemiol
0: dyp192v1-dyp192
[Abstract][Full Text]
Maruthur, N. M., Wang, N.-Y., Appel, L. J.
(2009). Lifestyle Interventions Reduce Coronary Heart Disease Risk: Results From the PREMIER Trial. Circulation
119: 2026-2031
[Abstract][Full Text]
Molenaar, E. A., Massaro, J. M., Jacques, P. F., Pou, K. M., Ellison, R. C., Hoffmann, U., Pencina, K., Shadwick, S. D., Vasan, R. S., O'Donnell, C. J., Fox, C. S.
(2009). Association of Lifestyle Factors With Abdominal Subcutaneous and Visceral Adiposity: The Framingham Heart Study. Diabetes Care
32: 505-510
[Abstract][Full Text]
WRITING GROUP MEMBERS, , Lloyd-Jones, D., Adams, R., Carnethon, M., De Simone, G., Ferguson, T. B., Flegal, K., Ford, E., Furie, K., Go, A., Greenlund, K., Haase, N., Hailpern, S., Ho, M., Howard, V., Kissela, B., Kittner, S., Lackland, D., Lisabeth, L., Marelli, A., McDermott, M., Meigs, J., Mozaffarian, D., Nichol, G., O'Donnell, C., Roger, V., Rosamond, W., Sacco, R., Sorlie, P., Stafford, R., Steinberger, J., Thom, T., Wasserthiel-Smoller, S., Wong, N., Wylie-Rosett, J., Hong, Y., for the American Heart Association Statistics Comm,
(2009). Heart Disease and Stroke Statistics--2009 Update: A Report From the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation
119: e21-e181
[Full Text]
Folsom, A. R., Yamagishi, K., Hozawa, A., Chambless, L. E., for the Atherosclerosis Risk in Communities Study,
(2009). Absolute and Attributable Risks of Heart Failure Incidence in Relation to Optimal Risk Factors. Circ Heart Fail
2: 11-17
[Abstract][Full Text]
Qi, L., Kang, K., Zhang, C., van Dam, R. M., Kraft, P., Hunter, D., Lee, C.-H., Hu, F. B.
(2008). Fat Mass-and Obesity-Associated (FTO) Gene Variant Is Associated With Obesity: Longitudinal Analyses in Two Cohort Studies and Functional Test. Diabetes
57: 3145-3151
[Abstract][Full Text]
Djousse, L., Rudich, T., Gaziano, J M.
(2008). Nut consumption and risk of heart failure in the Physicians' Health Study I. Am. J. Clin. Nutr.
88: 930-933
[Abstract][Full Text]
Dam, R. M v., Li, T., Spiegelman, D., Franco, O. H, Hu, F. B
(2008). Combined impact of lifestyle factors on mortality: prospective cohort study in US women. BMJ
337: a1440-a1440
[Abstract][Full Text]
Chiuve, S. E., Rexrode, K. M., Spiegelman, D., Logroscino, G., Manson, J. E., Rimm, E. B.
(2008). Primary Prevention of Stroke by Healthy Lifestyle. Circulation
118: 947-954
[Abstract][Full Text]
Kahn, R., Robertson, R. M., Smith, R., Eddy, D.
(2008). The Impact of Prevention on Reducing the Burden of Cardiovascular Disease. Diabetes Care
31: 1686-1696
[Abstract][Full Text]
Carbillon, L.
(2008). Pregnancy Is an Essential Spontaneous Screening Stress Test for the Risk of Early Stroke in Women. Stroke
39: e138-e138
[Full Text]
Kahn, R., Robertson, R. M., Smith, R., Eddy, D.
(2008). The Impact of Prevention on Reducing the Burden of Cardiovascular Disease. Circulation
118: 576-585
[Abstract][Full Text]
Appel, L. J.
(2008). Dietary Patterns and Longevity: Expanding the Blue Zones. Circulation
118: 214-215
[Full Text]
Colditz, G. A., Winn, D. M.
(2008). Criteria for the Evaluation of Large Cohort Studies: An Application to the Nurses' Health Study. JNCI J Natl Cancer Inst
100: 918-925
[Abstract][Full Text]
Mozaffarian, D., Wilson, P. W.F., Kannel, W. B.
(2008). Beyond Established and Novel Risk Factors: Lifestyle Risk Factors for Cardiovascular Disease. Circulation
117: 3031-3038
[Full Text]
Bassuk, S. S., Manson, J. E.
(2008). Lifestyle and Risk of Cardiovascular Disease and Type 2 Diabetes in Women: A Review of the Epidemiologic Evidence. AMERICAN JOURNAL OF LIFESTYLE MEDICINE
2: 191-213
[Abstract]
Genovesi, S., Pieruzzi, F., Giussani, M., Tono, V., Stella, A., Porta, A., Pagani, M., Lucini, D.
(2008). Analysis of Heart Period and Arterial Pressure Variability in Childhood Hypertension: Key Role of Baroreflex Impairment. Hypertension
51: 1289-1294
[Abstract][Full Text]
Meka, N., Katragadda, S., Cherian, B., Arora, R. R.
(2008). Review: Endurance exercise and resistance training in cardiovascular disease. Ther Adv Cardiovasc Dis
2: 115-121
[Abstract]
Anand, S. S., Islam, S., Rosengren, A., Franzosi, M. G., Steyn, K., Yusufali, A. H., Keltai, M., Diaz, R., Rangarajan, S., Yusuf, S., on behalf of the INTERHEART Investigators,
(2008). Risk factors for myocardial infarction in women and men: insights from the INTERHEART study. Eur Heart J
29: 932-940
[Abstract][Full Text]
Rees, M., Stevenson, J., on behalf of the British Menopause Society Council,
(2008). Primary prevention of coronary heart disease in women. Menopause Int
14: 40-45
[Abstract][Full Text]
King, D. E., Mainous, A. G. III, Egan, B. M., Woolson, R. F., Geesey, M. E.
(2008). Effect of Psyllium Fiber Supplementation on C-Reactive Protein: The Trial to Reduce Inflammatory Markers (TRIM). Ann Fam Med
6: 100-106
[Abstract][Full Text]
Skilton, M. R.
(2008). Intrauterine Risk Factors for Precocious Atherosclerosis. Pediatrics
121: 570-574
[Abstract][Full Text]
Nesto, R. W., Mackie, K.
(2008). Endocannabinoid system and its implications for obesity and cardiometabolic risk. Eur Heart J Suppl
10: B34-B41
[Abstract][Full Text]
Lutsey, P. L., Steffen, L. M., Stevens, J.
(2008). Dietary Intake and the Development of the Metabolic Syndrome: The Atherosclerosis Risk in Communities Study. Circulation
117: 754-761
[Abstract][Full Text]
Writing Group Members, , Rosamond, W., Flegal, K., Furie, K., Go, A., Greenlund, K., Haase, N., Hailpern, S. M., Ho, M., Howard, V., Kissela, B., Kittner, S., Lloyd-Jones, D., McDermott, M., Meigs, J., Moy, C., Nichol, G., O'Donnell, C., Roger, V., Sorlie, P., Steinberger, J., Thom, T., Wilson, M., Hong, Y., for the American Heart Association Statistics Comm,
(2008). Heart Disease and Stroke Statistics--2008 Update: A Report From the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation
117: e25-e146
[Full Text]
Akesson, A., Weismayer, C., Newby, P. K., Wolk, A.
(2007). Combined Effect of Low-Risk Dietary and Lifestyle Behaviors in Primary Prevention of Myocardial Infarction in Women. Arch Intern Med
167: 2122-2127
[Abstract][Full Text]
Wister, A. PhD, Loewen, N. MD, Kennedy-Symonds, H. MHSc, McGowan, B. MD, McCoy, B. MA, Singer, J. PhD
(2007). One-year follow-up of a therapeutic lifestyle intervention targeting cardiovascular disease risk. CMAJ
177: 859-865
[Abstract][Full Text]
Bengmark, S.
(2007). Advanced Glycation and Lipoxidation End Products-Amplifiers of Inflammation: The Role of Food. JPEN J Parenter Enteral Nutr
31: 430-440
[Abstract][Full Text]
Drogan, D., Hoffmann, K., Schulz, M., Bergmann, M. M., Boeing, H., Weikert, C.
(2007). A Food Pattern Predicting Prospective Weight Change Is Associated with Risk of Fatal but Not with Nonfatal Cardiovascular Disease. J. Nutr.
137: 1961-1967
[Abstract][Full Text]
Gao, X., Qi, L., Qiao, N., Choi, H. K., Curhan, G., Tucker, K. L., Ascherio, A.
(2007). Intake of Added Sugar and Sugar-Sweetened Drink and Serum Uric Acid Concentration in US Men and Women. Hypertension
50: 306-312
[Abstract][Full Text]
Li, C., Ford, E. S., Mokdad, A. H., Jiles, R., Giles, W. H.
(2007). Clustering of Multiple Healthy Lifestyle Habits and Health-Related Quality of Life Among U.S. Adults With Diabetes. Diabetes Care
30: 1770-1776
[Abstract][Full Text]
Ballard-Barbash, R., McTiernan, A.
(2007). Is the Whole Larger Than the Sum of the Parts? The Promise of Combining Physical Activity and Diet to Improve Cancer Outcomes. JCO
25: 2335-2337
[Full Text]
Pierce, J. P., Stefanick, M. L., Flatt, S. W., Natarajan, L., Sternfeld, B., Madlensky, L., Al-Delaimy, W. K., Thomson, C. A., Kealey, S., Hajek, R., Parker, B. A., Newman, V. A., Caan, B., Rock, C. L.
(2007). Greater Survival After Breast Cancer in Physically Active Women With High Vegetable-Fruit Intake Regardless of Obesity. JCO
25: 2345-2351
[Abstract][Full Text]
Reiter, M., Wirth, S., Pourazim, A., Puchner, S., Baghestanian, M., Minar, E., Bucek, R. A.
(2007). Skin tissue cholesterol is not related to vascular occlusive disease. Vasc Med
12: 129-134
[Abstract]
Vigorito, C., Giallauria, F., Palomba, S., Cascella, T., Manguso, F., Lucci, R., De Lorenzo, A., Tafuri, D., Lombardi, G., Colao, A., Orio, F.
(2007). Beneficial Effects of a Three-Month Structured Exercise Training Program on Cardiopulmonary Functional Capacity in Young Women with Polycystic Ovary Syndrome. J. Clin. Endocrinol. Metab.
92: 1379-1384
[Abstract][Full Text]
Stamler, J.
(2007). Low Risk--and the "No More Than 50%" Myth/Dogma. Arch Intern Med
167: 537-539
[Full Text]
Hozawa, A., Folsom, A. R., Sharrett, A. R., Chambless, L. E.
(2007). Absolute and Attributable Risks of Cardiovascular Disease Incidence in Relation to Optimal and Borderline Risk Factors: Comparison of African American With White Subjects--Atherosclerosis Risk in Communities Study. Arch Intern Med
167: 573-579
[Abstract][Full Text]
Kabagambe, E. K., Baylin, A., Campos, H.
(2007). Nonfatal Acute Myocardial Infarction in Costa Rica: Modifiable Risk Factors, Population-Attributable Risks, and Adherence to Dietary Guidelines. Circulation
115: 1075-1081
[Abstract][Full Text]
Lloyd-Jones, D. M., Liu, K., Colangelo, L. A., Yan, L. L., Klein, L., Loria, C. M., Lewis, C. E., Savage, P.
(2007). Consistently Stable or Decreased Body Mass Index in Young Adulthood and Longitudinal Changes in Metabolic Syndrome Components: The Coronary Artery Risk Development in Young Adults Study. Circulation
115: 1004-1011
[Abstract][Full Text]
Rosamond, W., Flegal, K., Friday, G., Furie, K., Go, A., Greenlund, K., Haase, N., Ho, M., Howard, V., Kissela, B., Kittner, S., Lloyd-Jones, D., McDermott, M., Meigs, J., Moy, C., Nichol, G., O'Donnell, C. J., Roger, V., Rumsfeld, J., Sorlie, P., Steinberger, J., Thom, T., Wasserthiel-Smoller, S., Hong, Y., for the American Heart Association Statistics Comm,
(2007). Heart Disease and Stroke Statistics--2007 Update: A Report From the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation
115: e69-e171
[Full Text]
Bloomgarden, Z. T.
(2007). Prevention of Cardiovascular Disease. Diabetes Care
30: 423-431
[Abstract][Full Text]
Ignarro, L. J., Balestrieri, M. L., Napoli, C.
(2007). Nutrition, physical activity, and cardiovascular disease: An update. Cardiovasc Res
73: 326-340
[Abstract][Full Text]
Pearson, T. A.
(2007). The Prevention Of Cardiovascular Disease: Have We Really Made Progress?. Health Aff (Millwood)
26: 49-60
[Abstract][Full Text]
Lynch, E. B., Liu, K., Kiefe, C. I., Greenland, P.
(2006). Cardiovascular Disease Risk Factor Knowledge in Young Adults and 10-year Change in Risk Factors: The Coronary Artery Risk Development in Young Adults (CARDIA) Study. Am J Epidemiol
164: 1171-1179
[Abstract][Full Text]
Napoli, C., Lerman, L. O., de Nigris, F., Gossl, M., Balestrieri, M. L., Lerman, A.
(2006). Rethinking Primary Prevention of Atherosclerosis-Related Diseases. Circulation
114: 2517-2527
[Full Text]
Lampe, J. W.
(2006). For Debate: Investment in Nutrigenomics Will Advance the Role of Nutrition in Public Health. Cancer Epidemiol. Biomarkers Prev.
15: 2329-2330
[Full Text]
Rosenfeld, A. G.
(2006). State of the Heart: Building Science to Improve Women's Cardiovascular Health. Am J Crit Care
15: 556-566
[Abstract][Full Text]
Mukamal, K. J., Chiuve, S. E., Rimm, E. B.
(2006). Alcohol consumption and risk for coronary heart disease in men with healthy lifestyles.. Arch Intern Med
166: 2145-2150
[Abstract][Full Text]
Blankenberg, S., Yusuf, S.
(2006). The Inflammatory Hypothesis: Any Progress in Risk Stratification and Therapeutic Targets?. Circulation
114: 1557-1560
[Full Text]
Gemmell, I, Heller, R F, Payne, K, Edwards, R, Roland, M, Durrington, P
(2006). Potential population impact of the UK government strategy for reducing the burden of coronary heart disease in England: comparing primary and secondary prevention strategies.. Qual Saf Health Care
15: 339-343
[Abstract][Full Text]
The ESHRE Capri Workshop Group,
(2006). Hormones and cardiovascular health in women. Hum Reprod Update
12: 483-497
[Abstract][Full Text]
Michels, K. B
(2006). The women's health initiative--curse or blessing?. Int J Epidemiol
35: 814-816
[Full Text]
Mittleman, M. A.
(2006). A 39-year-old woman with hypercholesterolemia.. JAMA
296: 319-326
[Abstract][Full Text]
Chiuve, S. E., McCullough, M. L., Sacks, F. M., Rimm, E. B.
(2006). Healthy Lifestyle Factors in the Primary Prevention of Coronary Heart Disease Among Men: Benefits Among Users and Nonusers of Lipid-Lowering and Antihypertensive Medications. Circulation
114: 160-167
[Abstract][Full Text]
Kurth, T., Moore, S. C., Gaziano, J. M., Kase, C. S., Stampfer, M. J., Berger, K., Buring, J. E.
(2006). Healthy lifestyle and the risk of stroke in women.. Arch Intern Med
166: 1403-1409
[Abstract][Full Text]
Eckel, R. H.
(2006). Preventive Cardiology by Lifestyle Intervention: Opportunity and/or Challenge?: Presidential Address at the 2005 American Heart Association Scientific Sessions. Circulation
113: 2657-2661
[Full Text]
Gelfand, E. V., Cannon, C. P.
(2006). Rimonabant: A Cannabinoid Receptor Type 1 Blocker for Management of Multiple Cardiometabolic Risk Factors. J Am Coll Cardiol
47: 1919-1926
[Abstract][Full Text]
Giampaoli, S., Palmieri, L., Panico, S., Vanuzzo, D., Ferrario, M., Chiodini, P., Pilotto, L., Donfrancesco, C., Cesana, G., Sega, R., Stamler, J.
(2006). Favorable Cardiovascular Risk Profile (Low Risk) and 10-Year Stroke Incidence in Women and Men: Findings from 12 Italian Population Samples. Am J Epidemiol
163: 893-902
[Abstract][Full Text]
Lloyd-Jones, D. M., Leip, E. P., Larson, M. G., D'Agostino, R. B., Beiser, A., Wilson, P. W.F., Wolf, P. A., Levy, D.
(2006). Prediction of Lifetime Risk for Cardiovascular Disease by Risk Factor Burden at 50 Years of Age. Circulation
113: 791-798
[Abstract][Full Text]
Li, T. Y., Rana, J. S., Manson, J. E., Willett, W. C., Stampfer, M. J., Colditz, G. A., Rexrode, K. M., Hu, F. B.
(2006). Obesity as Compared With Physical Activity in Predicting Risk of Coronary Heart Disease in Women. Circulation
113: 499-506
[Abstract][Full Text]
Gronniger, J. T.
(2006). A Semiparametric Analysis of the Relationship of Body Mass Index to Mortality. Am. J. Public Health
96: 173-178
[Abstract][Full Text]
Ellison, R. C.
(2005). Importance of Pattern of Alcohol Consumption. Circulation
112: 3818-3819
[Full Text]
Franco, O. H., de Laet, C., Peeters, A., Jonker, J., Mackenbach, J., Nusselder, W.
(2005). Effects of Physical Activity on Life Expectancy With Cardiovascular Disease. Arch Intern Med
165: 2355-2360
[Abstract][Full Text]
Sorensen, G., Barbeau, E., Stoddard, A. M., Hunt, M. K., Kaphingst, K., Wallace, L.
(2005). Promoting Behavior Change Among Working-Class, Multiethnic Workers: Results of the Healthy Directions--Small Business Study. Am. J. Public Health
95: 1389-1395
[Abstract][Full Text]
Weikert, C., Hoffmann, K., Dierkes, J., Zyriax, B.-C., Klipstein-Grobusch, K., Schulze, M. B., Jung, R., Windler, E., Boeing, H.
(2005). A Homocysteine Metabolism-Related Dietary Pattern and the Risk of Coronary Heart Disease in Two Independent German Study Populations. J. Nutr.
135: 1981-1988
[Abstract][Full Text]
Millen, B. E, Quatromoni, P. A, Nam, B.-H., Pencina, M. J, Polak, J. F, Kimokoti, R. W, Ordovas, J. M, D'Agostino, R. B
(2005). Compliance with expert population-based dietary guidelines and lower odds of carotid atherosclerosis in women: the Framingham Nutrition Studies. Am. J. Clin. Nutr.
82: 174-180
[Abstract][Full Text]
Reeves, M. J., Rafferty, A. P.
(2005). Healthy Lifestyle Characteristics Among Adults in the United States, 2000. Arch Intern Med
165: 854-857
[Abstract][Full Text]
Mai, V., Kant, A. K, Flood, A., Lacey, J. V Jr, Schairer, C., Schatzkin, A.
(2005). Diet quality and subsequent cancer incidence and mortality in a prospective cohort of women. Int J Epidemiol
34: 54-60
[Abstract][Full Text]
Gluckman, T. J., Sachdev, M., Schulman, S. P., Blumenthal, R. S.
(2005). A Simplified Approach to the Management of Non-ST-Segment Elevation Acute Coronary Syndromes. JAMA
293: 349-357
[Abstract][Full Text]
Roberts, C. K., Barnard, R. J.
(2005). Effects of exercise and diet on chronic disease. J. Appl. Physiol.
98: 3-30
[Abstract][Full Text]
Anderson, J. W
(2004). Whole grains and coronary heart disease: the whole kernel of truth. Am. J. Clin. Nutr.
80: 1459-1460
[Full Text]
Califf, R. M., Ryan, T., Douglas, P., Goldschmidt-Clermont, P. J.
(2004). A time of accelerated change in academic cardiovascular medicine: Implications for academic divisions of cardiology and their training programs. J Am Coll Cardiol
44: 1957-1965
[Abstract][Full Text]
Daviglus, M. L., Stamler, J., Pirzada, A., Yan, L. L., Garside, D. B., Liu, K., Wang, R., Dyer, A. R., Lloyd-Jones, D. M., Greenland, P.
(2004). Favorable Cardiovascular Risk Profile in Young Women and Long-term Risk of Cardiovascular and All-Cause Mortality. JAMA
292: 1588-1592
[Abstract][Full Text]
Knoops, K. T. B., de Groot, L. C. P. G. M., Kromhout, D., Perrin, A.-E., Moreiras-Varela, O., Menotti, A., van Staveren, W. A.
(2004). Mediterranean Diet, Lifestyle Factors, and 10-Year Mortality in Elderly European Men and Women: The HALE Project. JAMA
292: 1433-1439
[Abstract][Full Text]
Rimm, E. B., Stampfer, M. J.
(2004). Diet, Lifestyle, and Longevity--The Next Steps?. JAMA
292: 1490-1492
[Full Text]
Hoffmann, K., Zyriax, B.-C., Boeing, H., Windler, E.
(2004). A dietary pattern derived to explain biomarker variation is strongly associated with the risk of coronary artery disease. Am. J. Clin. Nutr.
80: 633-640
[Abstract][Full Text]
Rajpathak, S., Rimm, E. B., Li, T., Morris, J. S., Stampfer, M. J., Willett, W. C., Hu, F. B.
(2004). Lower Toenail Chromium in Men With Diabetes and Cardiovascular Disease Compared With Healthy Men. Diabetes Care
27: 2211-2216
[Abstract][Full Text]
Tucker, R. M., May, C., Bennett, R., Hymer, J., McHaney, B.
(2004). A Gym-Based Wellness Challenge for People With Type 2 Diabetes: Effect on Weight Loss, Body Composition, and Glycemic Control. Diabetes Spectr.
17: 176-180
[Abstract][Full Text]
He, K., Song, Y., Daviglus, M. L., Liu, K., Van Horn, L., Dyer, A. R., Greenland, P.
(2004). Accumulated Evidence on Fish Consumption and Coronary Heart Disease Mortality: A Meta-Analysis of Cohort Studies. Circulation
109: 2705-2711
[Abstract][Full Text]
Emberson, J. R, Whincup, P. H, Morris, R. W, Walker, M.
(2004). Social class differences in coronary heart disease in middle-aged British men: implications for prevention. Int J Epidemiol
33: 289-296
[Abstract][Full Text]
Sacks, F. M.
(2004). High-Intensity Statin Treatment for Coronary Heart Disease. JAMA
291: 1132-1134
[Full Text]
Mosca, L., Ferris, A., Fabunmi, R., Robertson, R. M.
(2004). Tracking Women's Awareness of Heart Disease: An American Heart Association National Study. Circulation
109: 573-579
[Abstract][Full Text]
Greenland, P.
(2004). Traditional Risk Factors for Coronary Heart Disease--Reply. JAMA
291: 300-301
[Full Text]
Shapo, L., Pomerleau, J., McKee, M.
(2004). Physical Inactivity in a country in transition: a population-based survey in Tirana City, Albania. Scand J Public Health
32: 60-67
[Abstract]
Walker, A R P, Walker, B F, Segal, I
(2004). Some puzzling situations in the onset, occurrence and future of coronary heart disease in developed and developing populations, particularly such in sub-Saharan Africa. The Journal of the Royal Society for the Promotion of Health
124: 40-46
[Abstract]
Liu, J.-M., Hankinson, S. E, Stampfer, M. J, Rifai, N., Willett, W. C, Ma, J.
(2003). Body iron stores and their determinants in healthy postmenopausal US women. Am. J. Clin. Nutr.
78: 1160-1167
[Abstract][Full Text]
Anderson, J. W.
(2003). Ethical Aspects of Recommending Lifestyle Interventions to Patients--Reply. JAMA
290: 2660-2661
[Full Text]
Daviglus, M. L., Liu, K., Pirzada, A., Yan, L. L., Garside, D. B., Feinglass, J., Guralnik, J. M., Greenland, P., Stamler, J.
(2003). Favorable Cardiovascular Risk Profile in Middle Age and Health-Related Quality of Life in Older Age. Arch Intern Med
163: 2460-2468
[Abstract][Full Text]
Emberson, J. R, Whincup, P. H, Morris, R. W, Walker, M.
(2003). Re-assessing the contribution of serum total cholesterol, blood pressure and cigarette smoking to the aetiology of coronary heart disease: impact of regression dilution bias. Eur Heart J
24: 1719-1726
[Abstract][Full Text]
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