Regression of Metastatic Renal-Cell Carcinoma after Nonmyeloablative Allogeneic Peripheral-Blood Stem-Cell Transplantation

doi:10.1056/NEJM200009143431101

Volume 343:750-758		September 14, 2000		Number 11

Regression of Metastatic Renal-Cell Carcinoma after Nonmyeloablative Allogeneic Peripheral-Blood Stem-Cell Transplantation

Richard Childs, M.D., Allen Chernoff, M.D., Nathalie Contentin, M.D., Erkut Bahceci, M.D., David Schrump, M.D., Susan Leitman, M.D., Elizabeth J. Read, M.D., John Tisdale, M.D., Cynthia Dunbar, M.D., W. Marston Linehan, M.D., Neal S. Young, M.D., and A. John Barrett, M.D.

Full Text

PDF

Editorial
by Slavin, S.

Add to Personal Archive

Add to Citation Manager

Notify a Friend

E-mail When Cited

PubMed Citation

ABSTRACT

Background Since allogeneic stem-cell transplantation can inducecurative graft-versus-leukemia reactions in patients with hematologiccancers, we sought to induce analogous graft-versus-tumor effectsin patients with metastatic renal-cell carcinoma by means ofnonmyeloablative allogeneic peripheral-blood stem-cell transplantation.

Methods Nineteen consecutive patients with refractory metastaticrenal-cell carcinoma who had suitable donors received a preparativeregimen of cyclophosphamide and fludarabine, followed by aninfusion of a peripheral-blood stem-cell allograft from an HLA-identicalsibling or a sibling with a mismatch of a single HLA antigen.Cyclosporine, used to prevent graft-versus-host disease, waswithdrawn early in patients with mixed T-cell chimerism or diseaseprogression. Patients with no response received up to threeinfusions of donor lymphocytes.

Results At the time of the last follow-up, 9 of the 19 patientswere alive 287 to 831 days after transplantation (median follow-up,402 days). Two had died of transplantation-related causes, andeight from progressive disease. In 10 patients (53 percent)metastatic disease regressed; 3 had a complete response, and7 had a partial response. The patients who had a complete responseremained in remission 27, 25, and 16 months after transplantation.Regression of metastases was delayed, occurring a median of129 days after transplantation, and often followed the withdrawalof cyclosporine and the establishment of complete donor–T-cellchimerism. These results are consistent with a graft-versus-tumoreffect.

Conclusions Nonmyeloablative allogeneic stem-cell transplantationcan induce sustained regression of metastatic renal-cell carcinomain patients who have had no response to conventional immunotherapy.

Source Information

From the Hematology Branch, National Heart, Lung, and Blood Institute (R.C., N.C., E.B., C.D., N.S.Y., A.J.B.); the Urologic Oncology Branch (A.C., W.M.L.) and the Surgery Branch (D.S.), Division of Clinical Sciences, National Cancer Institute; the Department of Transfusion Medicine, Warren Grant Magnuson Clinical Center (S.L., E.J.R.), and the Molecular and Clinical Hematology Branch (J.T.), National Institute of Diabetes and Digestive and Kidney Diseases — all at the National Institutes of Health, Bethesda, Md. Other authors were Emmanuel Clave, Ph.D., Diane Epperson, Ph.D., and Virginia Mayo, R.N., Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md.

Address reprint requests to Dr. Childs at the Hematology Branch, NHLBI/NIH, 10/7C103, 10 Center Dr., M.S.C. 1652, Bethesda, MD 20892-1652, or at childsr{at}nih.gov.

Full Text of this Article

This article has been cited by other articles:

Sangiolo, D., Martinuzzi, E., Todorovic, M., Vitaggio, K., Vallario, A., Jordaney, N., Carnevale-Schianca, F., Capaldi, A., Geuna, M., Casorzo, L., Nash, R. A., Aglietta, M., Cignetti, A. (2008). Alloreactivity and anti-tumor activity segregate within two distinct subsets of cytokine-induced killer (CIK) cells: implications for their infusion across major HLA barriers. Int Immunol 0: dxn042v1-dxn042 [Abstract] [Full Text]
Eto, M., Kamiryo, Y., Takeuchi, A., Harano, M., Tatsugami, K., Harada, M., Kiyoshima, K., Hamaguchi, M., Teshima, T., Tsuneyoshi, M., Yoshikai, Y., Naito, S. (2008). Posttransplant Administration of Cyclophosphamide and Donor Lymphocyte Infusion Induces Potent Antitumor Immunity to Solid Tumor. Clin. Cancer Res. 14: 2833-2840 [Abstract] [Full Text]
Stelljes, M., Hermann, S., Albring, J., Kohler, G., Loffler, M., Franzius, C., Poremba, C., Schlosser, V., Volkmann, S., Opitz, C., Bremer, C., Kucharzik, T., Silling, G., Schober, O., Berdel, W. E., Schafers, M., Kienast, J. (2008). Clinical molecular imaging in intestinal graft-versus-host disease: mapping of disease activity, prediction, and monitoring of treatment efficiency by positron emission tomography. Blood 111: 2909-2918 [Abstract] [Full Text]
Conrad, R., Remberger, M., Cederlund, K., Ringden, O., Barkholt, L. (2008). A comparison between low intensity and reduced intensity conditioning in allogeneic hematopoietic stem cell transplantation for solid tumors. haematol 93: 265-272 [Abstract] [Full Text]
Yoshida, Y., Hirano, T., Son, G., Iimuro, Y., Imado, T., Iwasaki, T., Fujimoto, J. (2007). Allogeneic bone marrow transplantation for hepatocellular carcinoma: hepatocyte growth factor suppresses graft-vs.-host disease. Am. J. Physiol. Gastrointest. Liver Physiol. 293: G1114-G1123 [Abstract] [Full Text]
Costa, L. J., Drabkin, H. A. (2007). Renal Cell Carcinoma: New Developments in Molecular Biology and Potential for Targeted Therapies. The Oncologist 12: 1404-1415 [Abstract] [Full Text]
Carella, A. M., Bregni, M. (2007). Current role of allogeneic stem cell transplantation in breast cancer. Ann Oncol 18: 1591-1593 [Full Text]
Yao, Y.-G., Childs, R. W., Kajigaya, S., McCoy, J. P. Jr., Young, N. S. (2007). Mitochondrial DNA Sequence Heterogeneity of Single CD34+ Cells After Nonmyeloablative Allogeneic Stem Cell Transplantation. Stem Cells 25: 2670-2676 [Abstract] [Full Text]
Ramirez-Montagut, T., Chow, A., Kochman, A. A., Smith, O. M., Suh, D., Sindhi, H., Lu, S., Borsotti, C., Grubin, J., Patel, N., Terwey, T. H., Kim, T. D., Heller, G., Murphy, G. F., Liu, C., Alpdogan, O., van den Brink, M. R. M. (2007). IFN-{gamma} and Fas Ligand Are Required for Graft-versus-Tumor Activity against Renal Cell Carcinoma in the Absence of Lethal Graft-versus-Host Disease. J. Immunol. 179: 1669-1680 [Abstract] [Full Text]
Weng, L., Dyson, J., Dazzi, F. (2007). Low-intensity transplant regimens facilitate recruitment of donor-specific regulatory T cells that promote hematopoietic engraftment. Proc. Natl. Acad. Sci. USA 104: 8415-8420 [Abstract] [Full Text]
Siddiqui, S. A., Frigola, X., Bonne-Annee, S., Mercader, M., Kuntz, S. M., Krambeck, A. E., Sengupta, S., Dong, H., Cheville, J. C., Lohse, C. M., Krco, C. J., Webster, W. S., Leibovich, B. C., Blute, M. L., Knutson, K. L., Kwon, E. D. (2007). Tumor-Infiltrating Foxp3-CD4+CD25+ T Cells Predict Poor Survival in Renal Cell Carcinoma. Clin. Cancer Res. 13: 2075-2081 [Abstract] [Full Text]
Krambeck, A. E., Dong, H., Thompson, R. H., Kuntz, S. M., Lohse, C. M., Leibovich, B. C., Blute, M. L., Sebo, T. J., Cheville, J. C., Parker, A. S., Kwon, E. D. (2007). Survivin and B7-H1 Are Collaborative Predictors of Survival and Represent Potential Therapeutic Targets for Patients with Renal Cell Carcinoma. Clin. Cancer Res. 13: 1749-1756 [Abstract] [Full Text]
Rizzieri, D. A., Koh, L. P., Long, G. D., Gasparetto, C., Sullivan, K. M., Horwitz, M., Chute, J., Smith, C., Gong, J. Z., Lagoo, A., Niedzwiecki, D., Dowell, J. M., Waters-Pick, B., Liu, C., Marshall, D., Vredenburgh, J. J., Gockerman, J., Decastro, C., Moore, J., Chao, N. J. (2007). Partially Matched, Nonmyeloablative Allogeneic Transplantation: Clinical Outcomes and Immune Reconstitution. JCO 25: 690-697 [Abstract] [Full Text]
Koike, Y., Adachi, Y., Suzuki, Y., Iwasaki, M., Koike-Kiriyama, N., Minamino, K., Nakano, K., Mukaide, H., Shigematsu, A., Kiyozuka, Y., Tubura, A., Kamiyama, Y., Ikehara, S. (2007). Allogeneic Intrabone Marrow-Bone Marrow Transplantation plus Donor Lymphocyte Infusion Suppresses Growth of Colon Cancer Cells Implanted in Skin and Liver of Rats. Stem Cells 25: 385-391 [Abstract] [Full Text]
Eto, M., Harano, M., Tatsugami, K., Harada, M., Kamiryo, Y., Kiyoshima, K., Hamaguchi, M., Tsuneyoshi, M., Yoshikai, Y., Naito, S. (2007). Cyclophosphamide-Using Nonmyeloablative Allogeneic Cell Therapy against Renal Cancer with a Reduced Risk of Graft-versus-Host Disease. Clin. Cancer Res. 13: 1029-1035 [Abstract] [Full Text]
Thompson, R. H., Dong, H., Kwon, E. D. (2007). Implications of B7-H1 Expression in Clear Cell Carcinoma of the Kidney for Prognostication and Therapy. Clin. Cancer Res. 13: 709s-715s [Abstract] [Full Text]
Antin, J. H. (2007). Reduced-Intensity Stem Cell Transplantation: "...whereof a little More than a little is by much too much." King Henry IV, part 1, I, 2. ASH Education Book 2007: 47-54 [Abstract] [Full Text]
Yao, M., Huang, Y., Shioi, K., Hattori, K., Murakami, T., Nakaigawa, N., Kishida, T., Nagashima, Y., Kubota, Y. (2007). Expression of Adipose Differentiation-Related Protein: A Predictor of Cancer-Specific Survival in Clear Cell Renal Carcinoma. Clin. Cancer Res. 13: 152-160 [Abstract] [Full Text]
May, K. F. Jr, Lute, K., Kocak, E., Abdessalam, S., Yin, L., Li, O., Guan, Z., Philips, G., Zheng, P., Liu, Y. (2007). Immune competence of cancer-reactive T cells generated de novo in adult tumor-bearing mice. Blood 109: 253-258 [Abstract] [Full Text]
Shioi, K.-i., Komiya, A., Hattori, K., Huang, Y., Sano, F., Murakami, T., Nakaigawa, N., Kishida, T., Kubota, Y., Nagashima, Y., Yao, M. (2006). Vascular Cell Adhesion Molecule 1 Predicts Cancer-Free Survival in Clear Cell Renal Carcinoma Patients. Clin. Cancer Res. 12: 7339-7346 [Abstract] [Full Text]
Yang, J. C., Childs, R. (2006). Immunotherapy for Renal Cell Cancer. JCO 24: 5576-5583 [Abstract] [Full Text]
Kausche, S., Wehler, T., Schnurer, E., Lennerz, V., Brenner, W., Melchior, S., Grone, M., Nonn, M., Strand, S., Meyer, R., Ranieri, E., Huber, C., Falk, C. S., Herr, W. (2006). Superior Antitumor In vitro Responses of Allogeneic Matched Sibling Compared with Autologous Patient CD8+ T Cells. Cancer Res. 66: 11447-11454 [Abstract] [Full Text]
Aschan, J. (2006). Allogeneic haematopoietic stem cell transplantation: current status and future outlook. Br Med Bull 0: ldl005v2-14 [Abstract] [Full Text]
Perales, M.-A., Diab, A., Cohen, A. D., Huggins, D. W., Guevara-Patino, J. A., Hubbard, V. M., Engelhorn, M. E., Kochman, A. A., Eng, J. M., Mortazavi, F., Alpdogan, O., Terwey, T. H., Heller, G., Wolchok, J. D., Houghton, A. N., van den Brink, M. R. M. (2006). DNA Immunization against Tissue-Restricted Antigens Enhances Tumor Immunity after Allogeneic Hemopoietic Stem Cell Transplantation. J. Immunol. 177: 4159-4167 [Abstract] [Full Text]
Shaughnessy, P. J., Bachier, C., LeMaistre, C. F., Akay, C., Pollock, B. H., Gazitt, Y. (2006). Granulocyte Colony-Stimulating Factor Mobilizes More Dendritic Cell Subsets Than Granulocyte-Macrophage Colony-Stimulating Factor with No Polarization of Dendritic Cell Subsets in Normal Donors. Stem Cells 24: 1789-1797 [Abstract] [Full Text]
Barkholt, L., Bregni, M., Remberger, M., Blaise, D., Peccatori, J., Massenkeil, G., Pedrazzoli, P., Zambelli, A., Bay, J.-O., Francois, S., Martino, R., Bengala, C., Brune, M., Lenhoff, S., Porcellini, A., Falda, M., Siena, S., Demirer, T., Niederwieser, D., Ringden, O., On behalf of the French ITAC group and the EBMT So, (2006). Allogeneic haematopoietic stem cell transplantation for metastatic renal carcinoma in Europe. Ann Oncol 17: 1134-1140 [Abstract] [Full Text]
Linker, C., Hurd, D. (2006). The cancer and leukemia group B transplant committee.. Clin. Cancer Res. 12: 3635s-3637s [Abstract] [Full Text]
Beck, K. E., Blansfield, J. A., Tran, K. Q., Feldman, A. L., Hughes, M. S., Royal, R. E., Kammula, U. S., Topalian, S. L., Sherry, R. M., Kleiner, D., Quezado, M., Lowy, I., Yellin, M., Rosenberg, S. A., Yang, J. C. (2006). Enterocolitis in Patients With Cancer After Antibody Blockade of Cytotoxic T-Lymphocyte-Associated Antigen 4. JCO 24: 2283-2289 [Abstract] [Full Text]
Carnevale-Schianca, F., Cignetti, A., Capaldi, A., Vitaggio, K., Vallario, A., Ricchiardi, A., Sperti, E., Ferraris, R., Gatti, M., Grignani, G., Rota-Scalabrini, D., Geuna, M., Fizzotti, M., Sangiolo, D., Sottile, A., De Rosa, G., Bucci, A. R., Lambertenghi-Deliliers, G., Benedetti, E., Nash, R., Aglietta, M. (2006). Allogeneic nonmyeloablative hematopoietic cell transplantation in metastatic colon cancer: tumor-specific T cells directed to a tumor-associated antigen are generated in vivo during GVHD. Blood 107: 3795-3803 [Abstract] [Full Text]
Nakaigawa, N., Yao, M., Baba, M., Kato, S., Kishida, T., Hattori, K., Nagashima, Y., Kubota, Y. (2006). Inactivation of von Hippel-Lindau Gene Induces Constitutive Phosphorylation of MET Protein in Clear Cell Renal Carcinoma.. Cancer Res. 66: 3699-3705 [Abstract] [Full Text]
Ohashi, M., Kobayashi, A., Hara, H., Miura, Y., Yoshida, K., Kushida, M., Ikarashi, Y., Mandai, M., Kitajima, M., Yoshida, T., Aoki, K. (2006). Allogeneic MHC gene transfer enhances antitumor activity of allogeneic hematopoietic stem cell transplantation without exacerbating graft-versus-host disease.. Clin. Cancer Res. 12: 2208-2215 [Abstract] [Full Text]
Duval, L., Schmidt, H., Kaltoft, K., Fode, K., Jensen, J. J., Sorensen, S. M., Nishimura, M. I., von der Maase, H. (2006). Adoptive Transfer of Allogeneic Cytotoxic T Lymphocytes Equipped with a HLA-A2 Restricted MART-1 T-Cell Receptor: A Phase I Trial in Metastatic Melanoma. Clin. Cancer Res. 12: 1229-1236 [Abstract] [Full Text]
Morecki, S., Lindhofer, H., Yacovlev, E., Gelfand, Y., Slavin, S. (2006). Use of trifunctional bispecific antibodies to prevent graft versus host disease induced by allogeneic lymphocytes. Blood 107: 1564-1569 [Abstract] [Full Text]
Lin, F., Zhang, P. L., Yang, X. J., Prichard, J. W., Lun, M., Brown, R. E. (2006). Morphoproteomic and Molecular Concomitants of an Overexpressed and Activated mTOR Pathway in Renal Cell Carcinomas. Annals of Clinical & Laboratory Science 36: 283-293 [Abstract] [Full Text]
Cohen, H. T., McGovern, F. J. (2005). Renal-Cell Carcinoma. NEJM 353: 2477-2490 [Full Text]
Harano, M., Eto, M., Iwai, T., Tatsugami, K., Kiyoshima, K., Kamiryo, Y., Tsuneyoshi, M., Yoshikai, Y., Naito, S. (2005). Renal Cancer Treatment with Low Levels of Mixed Chimerism Induced by Nonmyeloablative Regimen Using Cyclophosphamide in Mice. Cancer Res. 65: 10032-10040 [Abstract] [Full Text]
Xue, S.-A., Gao, L., Hart, D., Gillmore, R., Qasim, W., Thrasher, A., Apperley, J., Engels, B., Uckert, W., Morris, E., Stauss, H. (2005). Elimination of human leukemia cells in NOD/SCID mice by WT1-TCR gene-transduced human T cells. Blood 106: 3062-3067 [Abstract] [Full Text]
Beyer, M., Kochanek, M., Darabi, K., Popov, A., Jensen, M., Endl, E., Knolle, P. A., Thomas, R. K., von Bergwelt-Baildon, M., Debey, S., Hallek, M., Schultze, J. L. (2005). Reduced frequencies and suppressive function of CD4+CD25hi regulatory T cells in patients with chronic lymphocytic leukemia after therapy with fludarabine. Blood 106: 2018-2025 [Abstract] [Full Text]
Whitelegg, A. M. E., Oosten, L. E. M., Jordan, S., Kester, M., van Halteren, A. G. S., Madrigal, J. A., Goulmy, E., Barber, L. D. (2005). Investigation of Peptide Involvement in T Cell Allorecognition Using Recombinant HLA Class I Multimers. J. Immunol. 175: 1706-1714 [Abstract] [Full Text]
Okamura, J., Utsunomiya, A., Tanosaki, R., Uike, N., Sonoda, S., Kannagi, M., Tomonaga, M., Harada, M., Kimura, N., Masuda, M., Kawano, F., Yufu, Y., Hattori, H., Kikuchi, H., Saburi, Y. (2005). Allogeneic stem-cell transplantation with reduced conditioning intensity as a novel immunotherapy and antiviral therapy for adult T-cell leukemia/lymphoma. Blood 105: 4143-4145 [Abstract] [Full Text]
Dudley, M. E., Wunderlich, J. R., Yang, J. C., Sherry, R. M., Topalian, S. L., Restifo, N. P., Royal, R. E., Kammula, U., White, D. E., Mavroukakis, S. A., Rogers, L. J., Gracia, G. J., Jones, S. A., Mangiameli, D. P., Pelletier, M. M., Gea-Banacloche, J., Robinson, M. R., Berman, D. M., Filie, A. C., Abati, A., Rosenberg, S. A. (2005). Adoptive Cell Transfer Therapy Following Non-Myeloablative but Lymphodepleting Chemotherapy for the Treatment of Patients With Refractory Metastatic Melanoma. JCO 23: 2346-2357 [Abstract] [Full Text]
Baron, F., Maris, M. B., Sandmaier, B. M., Storer, B. E., Sorror, M., Diaconescu, R., Woolfrey, A. E., Chauncey, T. R., Flowers, M. E.D., Mielcarek, M., Maloney, D. G., Storb, R. (2005). Graft-Versus-Tumor Effects After Allogeneic Hematopoietic Cell Transplantation With Nonmyeloablative Conditioning. JCO 23: 1993-2003 [Abstract] [Full Text]
Suzuki, Y., Adachi, Y., Minamino, K., Zhang, Y., Iwasaki, M., Nakano, K., Koike, Y., Ikehara, S. (2005). A New Strategy for Treatment of Malignant Tumor: Intra-Bone Marrow-Bone Marrow Transplantation Plus CD4- Donor Lymphocyte Infusion. Stem Cells 23: 365-370 [Abstract] [Full Text]
Frankenberger, B., Pohla, H., Noessner, E., Willimsky, G., Papier, B., Pezzutto, A., Kopp, J., Oberneder, R., Blankenstein, T., Schendel, D. J. (2005). Influence of CD80, Interleukin-2, and Interleukin-7 Expression in Human Renal Cell Carcinoma on the Expansion, Function, and Survival of Tumor-Specific CTLs. Clin. Cancer Res. 11: 1733-1742 [Abstract] [Full Text]
Yada, S., Takamura, N., Inagaki-Ohara, K., O'Leary, M. K., Wasem, C., Brunner, T., Green, D. R., Lin, T., Pinkoski, M. J. (2005). The Role of p53 and Fas in a Model of Acute Murine Graft-versus-Host Disease. J. Immunol. 174: 1291-1297 [Abstract] [Full Text]
Koscielniak, E., Gross-Wieltsch, U., Treuner, J., Winkler, P., Klingebiel, T., Lang, P., Bader, P., Niethammer, D., Handgretinger, R. (2005). Graft-Versus-Ewing Sarcoma Effect and Long-Term Remission Induced by Haploidentical Stem-Cell Transplantation in a Patient With Relapse of Metastatic Disease. JCO 23: 242-244 [Full Text]
Foria, V, Surendra, T, Poller, D N (2005). Prognostic relevance of extensive necrosis in renal cell carcinoma. J. Clin. Pathol. 58: 39-43 [Abstract] [Full Text]
Hashimoto, D., Asakura, S., Miyake, S., Yamamura, T., Van Kaer, L., Liu, C., Tanimoto, M., Teshima, T. (2005). Stimulation of Host NKT Cells by Synthetic Glycolipid Regulates Acute Graft-versus-Host Disease by Inducing Th2 Polarization of Donor T Cells. J. Immunol. 174: 551-556 [Abstract] [Full Text]
Giralt, S. (2005). Reduced-Intensity Conditioning Regimens for Hematologic Malignancies: What Have We Learned over the Last 10 Years?. ASH Education Book 2005: 384-389 [Abstract] [Full Text]
Kami, M., Makimoto, A., Heike, Y., Takaue, Y. (2004). Reduced-intensity Hematopoietic Stem Cell Transplantation (RIST) for Solid Malignancies. Jpn J Clin Oncol 34: 707-716 [Abstract] [Full Text]
Tykodi, S. S., Warren, E. H., Thompson, J. A., Riddell, S. R., Childs, R. W., Otterud, B. E., Leppert, M. F., Storb, R., Sandmaier, B. M. (2004). Allogeneic Hematopoietic Cell Transplantation for Metastatic Renal Cell Carcinoma after Nonmyeloablative Conditioning: Toxicity, Clinical Response, and Immunological Response to Minor Histocompatibility Antigens. Clin. Cancer Res. 10: 7799-7811 [Abstract] [Full Text]
Dorrschuck, A., Schmidt, A., Schnurer, E., Gluckmann, M., Albrecht, C., Wolfel, C., Lennerz, V., Lifke, A., Di Natale, C., Ranieri, E., Gesualdo, L., Huber, C., Karas, M., Wolfel, T., Herr, W. (2004). CD8+ cytotoxic T lymphocytes isolated from allogeneic healthy donors recognize HLA class Ia/Ib-associated renal carcinoma antigens with ubiquitous or restricted tissue expression. Blood 104: 2591-2599 [Abstract] [Full Text]
Bishop, M. R., Fowler, D. H., Marchigiani, D., Castro, K., Kasten-Sportes, C., Steinberg, S. M., Gea-Banacloche, J. C., Dean, R., Chow, C. K., Carter, C., Read, E. J., Leitman, S., Gress, R. (2004). Allogeneic Lymphocytes Induce Tumor Regression of Advanced Metastatic Breast Cancer. JCO 22: 3886-3892 [Abstract] [Full Text]
Ueno, N. T., Shpall, E. J., Champlin, R. E., Jones, R. B. (2004). Graft--Versus--Breast Cancer Effect by Allogeneic Hematopoietic Stem-Cell Transplantation: A Possible New Frontier. JCO 22: 3846-3847 [Full Text]
Avigan, D. (2004). Dendritic Cell-Tumor Fusion Vaccines for Renal Cell Carcinoma. Clin. Cancer Res. 10: 6347S-6352S [Abstract] [Full Text]
Takahashi, Y., Childs, R. W. (2004). Nonmyeloablative Transplantation: An Allogeneic-Based Immunotherapy for Renal Cell Carcinoma. Clin. Cancer Res. 10: 6353S-6359S [Abstract] [Full Text]
Diaconescu, R., Flowers, C. R., Storer, B., Sorror, M. L., Maris, M. B., Maloney, D. G., Sandmaier, B. M., Storb, R. (2004). Morbidity and mortality with nonmyeloablative compared with myeloablative conditioning before hematopoietic cell transplantation from HLA-matched related donors. Blood 104: 1550-1558 [Abstract] [Full Text]
Stelljes, M., Strothotte, R., Pauels, H.-G., Poremba, C., Milse, M., Specht, C., Albring, J., Bisping, G., Scheffold, C., Kammertoens, T., Oelmann, E., Silling, G., Berdel, W. E., Kienast, J. (2004). Graft-versus-host disease after allogeneic hematopoietic stem cell transplantation induces a CD8+ T cell-mediated graft-versus-tumor effect that is independent of the recognition of alloantigenic tumor targets. Blood 104: 1210-1216 [Abstract] [Full Text]
Blattman, J. N., Greenberg, P. D. (2004). Cancer Immunotherapy: A Treatment for the Masses. Science 305: 200-205 [Abstract] [Full Text]
Curti, B. D. (2004). Renal Cell Carcinoma. JAMA 292: 97-100 [Full Text]
Nencioni, A., Brossart, P. (2004). Cellular Immunotherapy with Dendritic Cells in Cancer: Current Status. Stem Cells 22: 501-513 [Abstract] [Full Text]
Igarashi, T., Wynberg, J., Srinivasan, R., Becknell, B., McCoy, J. P. Jr, Takahashi, Y., Suffredini, D. A., Linehan, W. M., Caligiuri, M. A., Childs, R. W. (2004). Enhanced cytotoxicity of allogeneic NK cells with killer immunoglobulin-like receptor ligand incompatibility against melanoma and renal cell carcinoma cells. Blood 104: 170-177 [Abstract] [Full Text]
Negrier, S., Perol, D., Menetrier-Caux, C., Escudier, B., Pallardy, M., Ravaud, A., Douillard, J.-Y., Chevreau, C., Lasset, C., Blay, J.-Y. (2004). Interleukin-6, Interleukin-10, and Vascular Endothelial Growth Factor in Metastatic Renal Cell Carcinoma: Prognostic Value of Interleukin-6--From the Groupe Francais d'Immunotherapie. JCO 22: 2371-2378 [Abstract] [Full Text]
Miyakoshi, S., Yuji, K., Kami, M., Kusumi, E., Kishi, Y., Kobayashi, K., Murashige, N., Hamaki, T., Kim, S.-W., Ueyama, J.-i., Mori, S.-i., Morinaga, S.-i., Muto, Y., Masuo, S., Kanemaru, M., Hayashi, T., Takaue, Y., Taniguchi, S. (2004). Successful Engraftment After Reduced-Intensity Umbilical Cord Blood Transplantation for Adult Patients with Advanced Hematological Diseases. Clin. Cancer Res. 10: 3586-3592 [Abstract] [Full Text]
Griffiths, T R L, Mellon, J K (2004). Evolving immunotherapeutic strategies in bladder and renal cancer. Postgrad. Med. J. 80: 320-327 [Abstract] [Full Text]
Matte, C. C., Cormier, J., Anderson, B. E., Athanasiadis, I., Liu, J., Emerson, S. G., Pear, W., Shlomchik, W. D. (2004). Graft-versus-leukemia in a retrovirally induced murine CML model: mechanisms of T-cell killing. Blood 103: 4353-4361 [Abstract] [Full Text]
Childs, R. W. (2004). Evolving trends in hematopoietic cell transplantation for solid tumors: tempering enthusiasm with clinical reality. Ann Oncol 15: 543-544 [Full Text]
Mapara, M. Y., Sykes, M. (2004). Tolerance and Cancer: Mechanisms of Tumor Evasion and Strategies for Breaking Tolerance. JCO 22: 1136-1151 [Abstract] [Full Text]
Atkins, M. B., Hidalgo, M., Stadler, W. M., Logan, T. F., Dutcher, J. P., Hudes, G. R., Park, Y., Liou, S.-H., Marshall, B., Boni, J. P., Dukart, G., Sherman, M. L. (2004). Randomized Phase II Study of Multiple Dose Levels of CCI-779, a Novel Mammalian Target of Rapamycin Kinase Inhibitor, in Patients With Advanced Refractory Renal Cell Carcinoma. JCO 22: 909-918 [Abstract] [Full Text]
Nakamura, K., Inaba, M., Sugiura, K., Yoshimura, T., Kwon, A-H., Kamiyama, Y., Ikehara, S. (2004). Enhancement of Allogeneic Hematopoietic Stem Cell Engraftment and Prevention of GvHD by Intra-Bone Marrow Bone Marrow Transplantation Plus Donor Lymphocyte Infusion. Stem Cells 22: 125-134 [Abstract] [Full Text]
Takahashi, Y., McCoy, J. P. Jr, Carvallo, C., Rivera, C., Igarashi, T., Srinivasan, R., Young, N. S., Childs, R. W. (2004). In vitro and in vivo evidence of PNH cell sensitivity to immune attack after nonmyeloablative allogeneic hematopoietic cell transplantation. Blood 103: 1383-1390 [Abstract] [Full Text]
Carvallo, C., Geller, N., Kurlander, R., Srinivasan, R., Mena, O., Igarashi, T., Griffith, L. M., Linehan, W. M., Childs, R. W. (2004). Prior chemotherapy and allograft CD34+ dose impact donor engraftment following nonmyeloablative allogeneic stem cell transplantation in patients with solid tumors. Blood 103: 1560-1563 [Abstract] [Full Text]
Kolb, H.-J., Schmid, C., Barrett, A. J., Schendel, D. J. (2004). Graft-versus-leukemia reactions in allogeneic chimeras. Blood 103: 767-776 [Abstract] [Full Text]
Blaise, D., Bay, J. O., Faucher, C., Michallet, M., Boiron, J.-M., Choufi, B., Cahn, J.-Y., Gratecos, N., Sotto, J.-J., Francois, S., Fleury, J., Mohty, M., Chabannon, C., Bilger, K., Gravis, G., Viret, F., Braud, A. C., Bardou, V. J., Maraninchi, D., Viens, P. (2004). Reduced-intensity preparative regimen and allogeneic stem cell transplantation for advanced solid tumors. Blood 103: 435-441 [Abstract] [Full Text]
Butterfield, L. H., Ribas, A., Meng, W. S., Dissette, V. B., Amarnani, S., Vu, H. T., Seja, E., Todd, K., Glaspy, J. A., McBride, W. H., Economou, J. S. (2003). T-Cell Responses to HLA-A*0201 Immunodominant Peptides Derived from {alpha}-Fetoprotein in Patients with Hepatocellular Cancer. Clin. Cancer Res. 9: 5902-5908 [Abstract] [Full Text]
Young, K. J., Kay, L. S., Phillips, M. J., Zhang, L. (2003). Antitumor Activity Mediated by Double-Negative T Cells. Cancer Res. 63: 8014-8021 [Abstract] [Full Text]
Ueno, N. T., Cheng, Y. C., Rondon, G., Tannir, N. M., Gajewski, J. L., Couriel, D. R., Hosing, C., de Lima, M. J., Anderlini, P., Khouri, I. F., Booser, D. J., Hortobagyi, G. N., Pagliaro, L. C., Jonasch, E., Giralt, S. A., Champlin, R. E. (2003). Rapid induction of complete donor chimerism by the use of a reduced-intensity conditioning regimen composed of fludarabine and melphalan in allogeneic stem cell transplantation for metastatic solid tumors. Blood 102: 3829-3836 [Abstract] [Full Text]
Sosman, J. A. (2003). Targeting of the VHL-Hypoxia-Inducible Factor-Hypoxia-Induced Gene Pathway for Renal Cell Carcinoma Therapy. J. Am. Soc. Nephrol. 14: 2695-2702 [Abstract] [Full Text]
Strair, R. K., Schaar, D., Medina, D., Todd, M. B., Aisner, J., DiPaola, R. S., Manago, J., Knox, B., Jenkinson, A., Senzon, R., Baker, C., Dudek, L., Ciardella, M., Kuriyan, M., Rubin, A., Lattime, E. C. (2003). Antineoplastic Effects of Partially HLA-Matched Irradiated Blood Mononuclear Cells in Patients With Renal Cell Carcinoma. JCO 21: 3785-3791 [Abstract] [Full Text]
Pantuck, A. J., Zeng, G., Belldegrun, A. S., Figlin, R. A. (2003). Pathobiology, Prognosis, and Targeted Therapy for Renal Cell Carcinoma: Exploiting the Hypoxia-Induced Pathway. Clin. Cancer Res. 9: 4641-4652 [Abstract] [Full Text]
Fukuda, T., Hackman, R. C., Guthrie, K. A., Sandmaier, B. M., Boeckh, M., Maris, M. B., Maloney, D. G., Deeg, H. J., Martin, P. J., Storb, R. F., Madtes, D. K. (2003). Risks and outcomes of idiopathic pneumonia syndrome after nonmyeloablative and conventional conditioning regimens for allogeneic hematopoietic stem cell transplantation. Blood 102: 2777-2785 [Abstract] [Full Text]
Barker, J. N., Weisdorf, D. J., DeFor, T. E., Blazar, B. R., Miller, J. S., Wagner, J. E. (2003). Rapid and complete donor chimerism in adult recipients of unrelated donor umbilical cord blood transplantation after reduced-intensity conditioning. Blood 102: 1915-1919 [Abstract] [Full Text]
Renga, M., Pedrazzoli, P., Siena, S. (2003). Present results and perspectives of allogeneic non-myeloablative hematopoietic stem cell transplantation for treatment of human solid tumors. Ann Oncol 14: 1177-1184 [Abstract] [Full Text]
Fukuda, T., Boeckh, M., Carter, R. A., Sandmaier, B. M., Maris, M. B., Maloney, D. G., Martin, P. J., Storb, R. F., Marr, K. A. (2003). Risks and outcomes of invasive fungal infections in recipients of allogeneic hematopoietic stem cell transplants after nonmyeloablative conditioning. Blood 102: 827-833 [Abstract] [Full Text]
Mohty, M., Bay, J.-O., Faucher, C., Choufi, B., Bilger, K., Tournilhac, O., Vey, N., Stoppa, A.-M., Coso, D., Chabannon, C., Viens, P., Maraninchi, D., Blaise, D. (2003). Graft-versus-host disease following allogeneic transplantation from HLA-identical sibling with antithymocyte globulin-based reduced-intensity preparative regimen. Blood 102: 470-476 [Abstract] [Full Text]
Ribas, A., Butterfield, L. H., Glaspy, J. A., Economou, J. S. (2003). Current Developments in Cancer Vaccines and Cellular Immunotherapy. JCO 21: 2415-2432 [Abstract] [Full Text]
Andersson, G., Illigens, B. M. W., Johnson, K. W., Calderhead, D., LeGuern, C., Benichou, G., White-Scharf, M. E., Down, J. D. (2003). Nonmyeloablative conditioning is sufficient to allow engraftment of EGFP-expressing bone marrow and subsequent acceptance of EGFP-transgenic skin grafts in mice. Blood 101: 4305-4312 [Abstract] [Full Text]
Messing, E. M., Manola, J., Wilding, G., Propert, K., Fleischmann, J., Crawford, E. D., Pontes, J. E., Hahn, R., Trump, D. (2003). Phase III Study of Interferon Alfa-NL as Adjuvant Treatment for Resectable Renal Cell Carcinoma: An Eastern Cooperative Oncology Group/Intergroup Trial. JCO 21: 1214-1222 [Abstract] [Full Text]
Indolfi, P., Terenziani, M., Casale, F., Carli, M., Bisogno, G., Schiavetti, A., Mancini, A., Rondelli, R., Pession, A., Jenkner, A., Pierani, P., Tamaro, P., De Bernardi, B., Ferrari, A., Santoro, N., Giuliano, M., Cecchetto, G., Piva, L., Surico, G., Di Tullio, M. T. (2003). Renal Cell Carcinoma in Children: A Clinicopathologic Study. JCO 21: 530-535 [Abstract] [Full Text]
Molrine, D. C., Antin, J. H., Guinan, E. C., Soiffer, R. J., MacDonald, K., Malley, R., Malinoski, F., Trocciola, S., Wilson, M., Ambrosino, D. M. (2003). Donor immunization with pneumococcal conjugate vaccine and early protective antibody responses following allogeneic hematopoietic cell transplantation. Blood 101: 831-836 [Abstract] [Full Text]
Or, R., Shapira, M. Y., Resnick, I., Amar, A., Ackerstein, A., Samuel, S., Aker, M., Naparstek, E., Nagler, A., Slavin, S. (2003). Nonmyeloablative allogeneic stem cell transplantation for the treatment of chronic myeloid leukemia in first chronic phase. Blood 101: 441-445 [Abstract] [Full Text]
Meunier, M.-C., Roy-Proulx, G., Labrecque, N., Perreault, C. (2003). Tissue distribution of target antigen has a decisive influence on the outcome of adoptive cancer immunotherapy. Blood 101: 766-770 [Abstract] [Full Text]
Down, J. D., White-Scharf, M. E. (2003). Reprogramming Immune Responses: Enabling Cellular Therapies and Regenerative Medicine. Stem Cells 21: 21-32 [Abstract] [Full Text]
Storb, R. F., Lucarelli, G., McSweeney, P. A., Childs, R. W. (2003). Hematopoietic Cell Transplantation for Benign Hematological Disorders and Solid Tumors. ASH Education Book 2003: 372-397 [Abstract] [Full Text]
Hochberg, E. P., Miklos, D. B., Neuberg, D., Eichner, D. A., McLaughlin, S. F., Mattes-Ritz, A., Alyea, E. P., Antin, J. H., Soiffer, R. J., Ritz, J. (2003). A novel rapid single nucleotide polymorphism (SNP)-based method for assessment of hematopoietic chimerism after allogeneic stem cell transplantation. Blood 101: 363-369 [Abstract] [Full Text]
Dudley, M. E., Wunderlich, J. R., Robbins, P. F., Yang, J. C., Hwu, P., Schwartzentruber, D. J., Topalian, S. L., Sherry, R., Restifo, N. P., Hubicki, A. M., Robinson, M. R., Raffeld, M., Duray, P., Seipp, C. A., Rogers-Freezer, L., Morton, K. E., Mavroukakis, S. A., White, D. E., Rosenberg, S. A. (2002). Cancer Regression and Autoimmunity in Patients After Clonal Repopulation with Antitumor Lymphocytes. Science 298: 850-854 [Abstract] [Full Text]

Comments and questions? Please contact us.