Background Short-term studies have shown that inhaled corticosteroidsmay reduce the growth of children with asthma. However, theeffect of long-term treatment on adult height is uncertain.
Methods We conducted a prospective study in children with asthmato examine the effect of long-term treatment with inhaled budesonideon adult height. We report on 211 children who have attainedadult height: 142 budesonide-treated children with asthma, 18control patients with asthma who have never received inhaledcorticosteroids, and 51 healthy siblings of patients in thebudesonide group, who also served as controls.
Results The children in the budesonide group attained adultheight after a mean of 9.2 years of budesonide treatment (range,3 to 13) at a mean daily dose of 412 µg (range, 110 to877). The mean cumulative dose of budesonide was 1.35 g (range,0.41 to 3.99). The mean differences between the measured andtarget adult heights were +0.3 cm (95 percent confidence interval,–0.6 to +1.2) for the budesonide-treated children, –0.2cm (95 percent confidence interval, –2.4 to +2.1) forthe control children with asthma, and +0.9 cm (95 percent confidenceinterval, –0.4 to +2.2) for the healthy siblings. Theadult height depended significantly (P<0.001) on the child'sheight before budesonide treatment. Although growth rates weresignificantly reduced during the first years of budesonide treatment,these changes in growth rate were not significantly associatedwith adult height.
Conclusions Children with asthma who have received long-termtreatment with budesonide attain normal adult height.
Source Information
From the Department of Pediatrics, University of Southern Denmark and Kolding Hospital, Kolding, Denmark.
Address reprint requests to Dr. Agertoft at the Department of Pediatrics, Kolding Hospital, DK-6000 Kolding, Denmark, or at lone_agertoft{at}dadlnet.dk.
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