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Volume 343:1666-1672 December 7, 2000 Number 23 Next

	Full Text PDF Editorial by Schafer, D. F. Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

ABSTRACT

Background Covalent attachment of a 40-kd branched-chain polyethylene glycol moiety to interferon alfa-2a results in a compound (peginterferon alfa-2a) that has sustained absorption, a slower rate of clearance, and a longer half-life than unmodified interferon alfa-2a. We compared the clinical effects of a regimen of peginterferon alfa-2a with those of a regimen of interferon alfa-2a in the initial treatment of patients with chronic hepatitis C.

Methods We randomly assigned 531 patients with chronic hepatitis C to receive either 180 µg of peginterferon alfa-2a subcutaneously once per week for 48 weeks (267 patients) or 6 million units of interferon alfa-2a subcutaneously three times per week for 12 weeks, followed by 3 million units three times per week for 36 weeks (264 patients). All the patients were assessed at week 72 for a sustained virologic response, defined as an undetectable level of hepatitis C virus RNA (<100 copies per milliliter).

Results In the peginterferon group, 223 of the 267 patients completed treatment and 206 completed follow-up. In the interferon group, 161 of the 264 patients completed treatment and 154 completed follow-up. In an intention-to-treat analysis in which patients who missed the examination at the end of treatment or follow-up were considered not to have had a response at that point, peginterferon alfa-2a was associated with a higher rate of virologic response than was interferon alfa-2a at week 48 (69 percent vs. 28 percent, P=0.001) and at week 72 (39 percent vs. 19 percent, P=0.001). Sustained normalization of serum alanine aminotransferase concentrations at week 72 was also more common in the peginterferon group than in the interferon group (45 percent vs. 25 percent, P=0.001). The two groups were similar with respect to the frequency and severity of adverse events, which were typical of those associated with interferon alfa.

Conclusions In patients with chronic hepatitis C, a regimen of peginterferon alfa-2a given once weekly is more effective than a regimen of interferon alfa-2a given three times weekly.

Source Information

From the Klinikum der Johann Wolfgang Goethe Universität, Frankfurt, Germany (S.Z.); Mount Sinai Hospital, Toronto (S.V.F.); Medizinische Universitätsklinik, Freiburg, Germany (J. Rasenack); Toronto Western Hospital, Toronto (E.J.H.); National Taiwan University Hospital, Taipei, Taiwan (M.-Y.L.); Middlemore Hospital, Auckland, New Zealand (E.G.); King's College Hospital, London (J.O.); Universitätsinstitut für Klinische Pharmakologie, Bern, Switzerland (J. Reichen); General Universitario, Valencia, Spain (M.D.); and Hoffmann–LaRoche, Nutley, N.J. (A.L., J.H., M.J.B.).

Address reprint requests to Dr. Zeuzem at Medizinische Klinik II, Zentrum der Inneren Medizin, Klinikum der Johann Wolfgang Goethe Universität, Theodor-Stern-Kai 7, D-60590 Frankfurt am Main, Germany, or at zeuzem{at}em.uni-frankfurt.de.

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