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Previous Volume 343:385-391 August 10, 2000 Number 6 Next

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ABSTRACT

Background Prevention of myocardial damage is the main goal of all reperfusion therapies in patients with acute myocardial infarction. The relative efficacy of various reperfusion strategies is under intensive investigation. We assessed whether coronary stenting combined with the blockade of platelet glycoprotein IIb/IIIa receptors produces a greater degree of myocardial salvage than fibrinolysis with an accelerated infusion of alteplase, a tissue plasminogen activator.

Methods A total of 140 patients were enrolled in the randomized trial; 71 were assigned to receive a stent plus abciximab, and 69 to receive intravenous alteplase. The primary end point was the degree of myocardial salvage, determined by means of serial scintigraphic studies with technetium Tc 99m sestamibi. The secondary end point was a composite of death, reinfarction, and stroke within six months after randomization.

Results In the group that received a stent plus abciximab, the median size of the final infarct was 14.3 percent of the left ventricle (25th and 75th percentiles, 6.8 and 24.5 percent), as compared with a median of 19.4 percent (25th and 75th percentiles, 7.9 and 34.2 percent) in the alteplase group (P=0.02). This difference was due to the larger salvage index (the percentage of the left ventricle that was salvaged, divided by the percentage that was compromised by the initial perfusion defect) in the stent group: 0.57 (25th and 75th percentiles, 0.35 and 0.69), as compared with 0.26 (25th and 75th percentiles, 0.09 and 0.61; P<0.001). The cumulative incidence of death, reinfarction, or stroke at six months was lower in the stent group than in the alteplase group (8.5 vs. 23.2 percent, P=0.02; relative risk, 0.34; 95 percent confidence interval, 0.13 to 0.88).

Conclusions In patients with acute myocardial infarction, coronary stenting plus abciximab leads to a greater degree of myocardial salvage and a better clinical outcome than does fibrinolysis with a tissue plasminogen activator.

Source Information

From the Deutsches Herzzentrum (A.S., A.K., J.D., J.M., S.M.), the 1. Medizinische Klinik rechts der Isar (A.S., J.P., F.-J.N.), and the Klinik und Poliklinik für Nuklearmedizin rechts der Isar (U.S., M.S.), Technische Universität, Munich, Germany.

Address reprint requests to Dr. Schömig at Deutsches Herzzentrum, Lazarettstr. 36, 80636 Munich, Germany, or at aschoemig{at}dhm.mhn.de.

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• Hurst, R. T., Lee, R. W. (2003). Increased Incidence of Coronary Atherosclerosis in Type 2 Diabetes Mellitus: Mechanisms and Management. ANN INTERN MED 139: 824-834 [Abstract] [Full Text]  
• Committee Members, , Blomstrom-Lundqvist, C., Scheinman, M. M., Aliot, E. M., Alpert, J. S., Calkins, H., Camm, A. J., Campbell, W. B., Haines, D. E., Kuck, K. H., Lerman, B. B., Miller, D. D., Shaeffer, C. W. Jr, Stevenson, W. G., Tomaselli, G. F., Task Force Members, , Antman, E. M., Smith, S. C. Jr, Alpert, J. S., Faxon, D. P., Fuster, V., Gibbons, R. J., Gregoratos, G., Hiratzka, L. F., Hunt, S. A., Jacobs, A. K., Russell, R. O. Jr, ESC Committee for Practice Guidelines Members, , Priori, S. G., Blanc, J.-J., Budaj, A., Burgos, E. F., Cowie, M., Deckers, J. W., Garcia, M. A. A., Klein, W. W., Lekakis, J., Lindahl, B., Mazzotta, G., Morais, J. C. A., Oto, A., Smiseth, O., Trappe, H.-J. (2003). ACC/AHA/ESC guidelines for the management of patients with supraventricular arrhythmias --executive summary: a report of the American college of cardiology/American heart association task force on practice guidelines and the European society of cardiology committee for practice guidelines (writing committee to develop guidelines for the management of patients with supraventricular arrhythmias) Developed in Collaboration with NASPE-Heart Rhythm Society. J Am Coll Cardiol 42: 1493-1531 [Full Text]  
• Blomstrom-Lundqvist, C., Scheinman, M. M., Aliot, E. M., Alpert, J. S., Calkins, H., Camm, A. J., Campbell, W. B., Haines, D. E., Kuck, K. H., Lerman, B. B., Miller, D. D., Shaeffer, C. W. Jr, Stevenson, W. G., Tomaselli, G. F., Antman, E. M., Smith, S. C. Jr, Alpert, J. S., Faxon, D. P., Fuster, V., Gibbons, R. J., Gregoratos, G., Hiratzka, L. F., Hunt, S. A., Jacobs, A. K., Russell, R. O. Jr, Priori, S. G., Blanc, J.-J., Budaj, A., Burgos, E. F., Cowie, M., Deckers, J. W., Garcia, M. A. A., Klein, W. W., Lekakis, J., Lindahl, B., Mazzotta, G., Morais, J. C. A., Oto, A., Smiseth, O., Trappe, H.-J., Committee Members, , Task Force Members, , ESC Committee for Practice Guidelines Members, (2003). ACC/AHA/ESC Guidelines for the Management of Patients With Supraventricular Arrhythmias*--Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Develop Guidelines for the Management of Patients With Supraventricular Arrhythmias). Circulation 108: 1871-1909 [Full Text]  
• Committee Members, , Blomstrom-Lundqvist, C., Scheinman, M. M, Aliot, E. M, Alpert, J. S, Calkins, H., Camm, A.J., Campbell, W.B., Haines, D. E, Kuck, K. H, Lerman, B. B, Miller, D.D., Shaeffer, C. W. Jr, Stevenson, W. G, Tomaselli, G. F, Task Force Members, , Antman, E. M, Smith, S. C Jr, Alpert, J. S, Faxon, D. P, Fuster, V., Gibbons, R. J, Gregoratos, G., Hiratzka, L. F, Hunt, S. A., Jacobs, A. K, Russell, R. O Jr, ESC Committee for Practice Guidelines Members, , Priori, S. G, Blanc, J.-J., Budaj, A., Burgos, E. F., Cowie, M., Deckers, J. W., Garcia, M. A. A., Klein, W. W, Lekakis, J., Lindahl, B., Mazzotta, G., Morais, J. C. A., Oto, A., Smiseth, O., Trappe, H.-J. (2003). ACC/AHA/ESC guidelines for the management of patients with supraventricular arrhythmias--executive summary: A Report of the American College of Cardiology/American HeartAssociation Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines(Writing Committee to Develop Guidelines for the Management of Patients With Supraventricular Arrhythmias)Developed in collaboration with NASPE-Heart Rhythm Society. Eur Heart J 24: 1857-1897 [Full Text]  
• Dobesh, P. P, Lanfear, S. L, Abu-Shanab, J. R, Lakamp, J. E, Gowda, S., Haikal, M. Y (2003). Outcomes with Changes in Prescribing of Glycoprotein IIb/IIIa Inhibitors in PCI. The Annals of Pharmacotherapy 37: 1375-1380 [Abstract] [Full Text]  
• Schomig, A., Ndrepepa, G., Mehilli, J., Schwaiger, M., Schuhlen, H., Nekolla, S., Pache, J., Martinoff, S., Bollwein, H., Kastrati, A. (2003). Therapy-Dependent Influence of Time-to-Treatment Interval on Myocardial Salvage in Patients With Acute Myocardial Infarction Treated With Coronary Artery Stenting or Thrombolysis. Circulation 108: 1084-1088 [Abstract] [Full Text]  
• Scheller, B., Hennen, B., Hammer, B., Walle, J., Hofer, C., Hilpert, V., Winter, H., Nickenig, G., Bohm, M., SIAM III Study Group, (2003). Beneficial effects of immediate stenting after thrombolysis in acute myocardial infarction. J Am Coll Cardiol 42: 634-641 [Abstract] [Full Text]  
• Dibra, A., Mehilli, J., Schwaiger, M., Schuhlen, H., Bollwein, H., Braun, S., Neverve, J., Schomig, A., Kastrati, A. (2003). Predictive value of basal C-reactive protein levels for myocardial salvage in patients with acute myocardial infarction is dependent on the type of reperfusion treatment. Eur Heart J 24: 1128-1133 [Abstract] [Full Text]  
• Crouch, M. A, Nappi, J. M, Cheang, K. I (2003). Glycoprotein IIb/IIIa Receptor Inhibitors in Percutaneous Coronary Intervention and Acute Coronary Syndrome. The Annals of Pharmacotherapy 37: 860-875 [Abstract] [Full Text]  
• Dibra, A., Mehilli, J., Dirschinger, J., Pache, J.u., Neverve, J., Schwaiger, M., Schomig, A., Kastrati, A. (2003). Thrombolysis in myocardial infarction myocardial perfusion grade in angiography correlates with myocardial salvage in patients with acute myocardial infarction treated with stenting or thrombolysis. J Am Coll Cardiol 41: 925-929 [Abstract] [Full Text]  
• Zijlstra, F (2003). Angioplasty vs thrombolysis for acute myocardial infarction: a quantitative overview of the effects of interhospital transportation. Eur Heart J 24: 21-23 [Full Text]  
• The Task Force on the Management of Acute Myocardi, , Van de Werf, F., Ardissino, D., Betriu, A., Cokkinos, D. V., Falk, E., Fox, K. A.A., Julian, D., Lengyel, M., Neumann, F.-J., Ruzyllo, W., Thygesen, C., Underwood, S. R., Vahanian, A., Verheugt, F. W.A., Wijns, W. (2003). Management of acute myocardial infarction in patients presenting with ST-segment elevation. Eur Heart J 24: 28-66 [Full Text]  
• Neumann, F.-J., Jander, N. (2002). How to best counteract the enemies? By ensuring adequate oxygen delivery. Eur Heart J Suppl 4: G35-G42 [Abstract]  
• Kupatt, C., Wichels, R., Horstkotte, J., Krombach, F., Habazettl, H., Boekstegers, P. (2002). Molecular mechanisms of platelet-mediated leukocyte recruitment during myocardial reperfusion. J. Leukoc. Biol. 72: 455-461 [Abstract] [Full Text]  
• Ribichini, F., Wijns, W. (2002). ACUTE MYOCARDIAL INFARCTION: REPERFUSION TREATMENT. Heart 88: 298-305 [Full Text]  
• Ryan, T. J. (2002). The Coronary Angiogram and Its Seminal Contributions to Cardiovascular Medicine Over Five Decades. Circulation 106: 752-756 [Full Text]  
• Dong, J., Ndrepepa, G., Schmitt, C., Mehilli, J., Schmieder, S., Schwaiger, M., Schomig, A., Kastrati, A. (2002). Early Resolution of ST-Segment Elevation Correlates With Myocardial Salvage Assessed by Tc-99m Sestamibi Scintigraphy in Patients With Acute Myocardial Infarction After Mechanical or Thrombolytic Reperfusion Therapy. Circulation 105: 2946-2949 [Abstract] [Full Text]  
• Singh, M., Ting, H. H., Berger, P. B., Garratt, K. N., Holmes, D. R. Jr, Gersh, B. J. (2002). Rationale for on-site cardiac surgery for primary angioplasty: a time for reappraisal. J Am Coll Cardiol 39: 1881-1889 [Abstract] [Full Text]  
• Cannon, C. P., Baim, D. S. (2002). Expanding the reach of primary percutaneous coronary intervention for the treatment of acute myocardial infarction. J Am Coll Cardiol 39: 1720-1722 [Full Text]  
• Cannon, C. P. (2002). Primary Percutaneous Coronary Intervention for All?. JAMA 287: 1987-1989 [Full Text]  
• Ott, I., Malcouvier, V., Schomig, A., Neumann, F.-J. (2002). Proteolysis of Tissue Factor Pathway Inhibitor-1 by Thrombolysis in Acute Myocardial Infarction. Circulation 105: 279-281 [Abstract] [Full Text]  
• Mehilli, J., Kastrati, A., Dirschinger, J., Pache, J., Seyfarth, M., Blasini, R., Hall, D., Neumann, F.-J., Schomig, A. (2002). Sex-Based Analysis of Outcome in Patients With Acute Myocardial Infarction Treated Predominantly With Percutaneous Coronary Intervention. JAMA 287: 210-215 [Abstract] [Full Text]  
• Buller, C. E., Carere, R. G. (2002). New advances in the management of acute coronary syndromes: 3. The role of catheter-based procedures. CMAJ 166: 51-61 [Full Text]  
• Frishman, W. H. (2001). Update in Cardiology. ANN INTERN MED 135: 439-446 [Full Text]  
• SCHULMAN, S. P., FESSLER, H. E. (2001). Management of Acute Coronary Syndromes. Am. J. Respir. Crit. Care Med. 164: 917-922 [Full Text]  
• Armstrong, P. W. (2001). New advances in the management of acute coronary syndromes: 2. Fibrinolytic therapy for acute ST-segment elevation myocardial infarction. CMAJ 165: 791-797 [Full Text]  
• Cannon, C. P. (2001). Importance of TIMI 3 Flow. Circulation 104: 624-626 [Full Text]  
• Priori, S.G., Aliot, E., Blomstrom-Lundqvist, C., Bossaert, L., Breithardt, G., Brugada, P., Camm, A.J., Cappato, R., Cobbe, S.M., Di Mario, C., Maron, B.J., McKenna, W.J., Pedersen, A.K., Ravens, U., Schwartz, P.J., Trusz-Gluza, M., Vardas, P., Wellens, H.J.J., Zipes, D.P. (2001). Task Force on Sudden Cardiac Death of the European Society of Cardiology. Eur Heart J 22: 1374-1450  
• Loubeyre, C, Lefevre, T, Louvard, Y, Dumas, P, Piechaud, J.-F, Lanore, J.-J, Angellier, J.-F, Le Tarnec, J.-Y, Karrillon, G, Margenet, A, Pouges, C, Morice, M.-C (2001). Outcome after combined reperfusion therapy for acute myocardial infarction, combining pre-hospital thrombolysis with immediate percutaneous coronary intervention and stent. Eur Heart J 22: 1128-1135 [Abstract]  
• Armstrong, P. W., Collen, D. (2001). Fibrinolysis for Acute Myocardial Infarction : Current Status and New Horizons for Pharmacological Reperfusion, Part 2. Circulation 103: 2987-2992 [Full Text]  
• Kastrati, A., Mehilli, J., Dirschinger, J., Dotzer, F., Schuhlen, H., Neumann, F.-J., Fleckenstein, M., Pfafferott, C., Seyfarth, M., Schomig, A. (2001). Intracoronary Stenting and Angiographic Results : Strut Thickness Effect on Restenosis Outcome (ISAR-STEREO) Trial. Circulation 103: 2816-2821 [Abstract] [Full Text]  
• Sechtem, U. (2001). Imaging myocardial area at risk and final infarct size. Eur Heart J Suppl 3: C36-C46  
• Widimsky, P. (2001). Pharmacological versus catheter-based reperfusion: What is present state of the art?. Eur Heart J Suppl 3: C47-C54 [Abstract]  
• Beller, G. A. (2001). Coronary Heart Disease in the First 30 Years of the 21st Century: Challenges and Opportunities : The 33rd Annual James B. Herrick Lecture of the Council on Clinical Cardiology of the American Heart Association. Circulation 103: 2428-2435 [Full Text]  
• Montalescot, G., Choussat, R., Collet, J.P. (2001). Glycoprotein IIb/IIIa receptors and primary stenting in acute myocardial infarction. Eur Heart J Suppl 3: A3-A7 [Abstract]