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Previous Volume 344:1117-1124 April 12, 2001 Number 15 Next

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ABSTRACT

Background The recent recognition that coronary-artery stenting has improved the short- and long-term outcomes of patients treated with angioplasty has made it necessary to reevaluate the relative benefits of bypass surgery and percutaneous interventions in patients with multivessel disease.

Methods A total of 1205 patients were randomly assigned to undergo stent implantation or bypass surgery when a cardiac surgeon and an interventional cardiologist agreed that the same extent of revascularization could be achieved by either technique. The primary clinical end point was freedom from major adverse cardiac and cerebrovascular events at one year. The costs of hospital resources used were also determined.

Results At one year, there was no significant difference between the two groups in terms of the rates of death, stroke, or myocardial infarction. Among patients who survived without a stroke or a myocardial infarction, 16.8 percent of those in the stenting group underwent a second revascularization, as compared with 3.5 percent of those in the surgery group. The rate of event-free survival at one year was 73.8 percent among the patients who received stents and 87.8 percent among those who underwent bypass surgery (P<0.001 by the log-rank test). The costs for the initial procedure were $4,212 less for patients assigned to stenting than for those assigned to bypass surgery, but this difference was reduced during follow-up because of the increased need for repeated revascularization; after one year, the net difference in favor of stenting was estimated to be $2,973 per patient.

Conclusions As measured one year after the procedure, coronary stenting for multivessel disease is less expensive than bypass surgery and offers the same degree of protection against death, stroke, and myocardial infarction. However, stenting is associated with a greater need for repeated revascularization.

Source Information

From the Academisch Ziekenhuis Rotterdam Dijkzigt, Rotterdam, the Netherlands (P.W.S., M.J.B.B., L.A.H.); Klinik fuer Herzchirurgie, Salzburg, Austria (F.U.), Instituto Dante Pazzanese de Cardiologia, São Paulo, Brazil (J.E.S., A.J.); Catharina Ziekenhuis, Eindhoven, the Netherlands (H.J.R.M.B., J.P.A.M.S.); Queen Elizabeth Hospital, Birmingham, United Kingdom (N.B., R.B.); Cardialysis, Rotterdam, the Netherlands (M.-A.M.M.); and the Institute for Medical Technology Assessment, Rotterdam, the Netherlands (B.A.H.).

Address reprint requests to Dr. Serruys at the Department of Interventional Cardiology Heart Center, Erasmus University Rotterdam, Dr. Molewaterplein 40, 3015 GD Rotterdam, the Netherlands, or at serruys{at}card.azr.nl.

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• Gao, G., Wu, Y., Grunkemeier, G. L., Furnary, A. P., Starr, A. (2006). Long-term survival of patients after coronary artery bypass graft surgery: comparison of the pre-stent and post-stent eras.. Ann. Thorac. Surg. 82: 806-810 [Abstract] [Full Text]  
• Stone, P. H., Gratsiansky, N. A., Blokhin, A., Huang, I-Z., Meng, L., for the ERICA Investigators, (2006). Antianginal Efficacy of Ranolazine When Added to Treatment With Amlodipine: The ERICA (Efficacy of Ranolazine in Chronic Angina) Trial. J Am Coll Cardiol 48: 566-575 [Abstract] [Full Text]  
• Ong, A. T.L., Serruys, P. W. (2006). Complete Revascularization: Coronary Artery Bypass Graft Surgery Versus Percutaneous Coronary Intervention. Circulation 114: 249-255 [Full Text]  
• Guyton, R. A. (2006). Coronary Artery Bypass is Superior to Drug-Eluting Stents in Multivessel Coronary Artery Disease. Ann. Thorac. Surg. 81: 1949-1957 [Abstract] [Full Text]  
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• Serruys, P. W. (2006). Fourth Annual American College of Cardiology International Lecture: A Journey in the Interventional Field. J Am Coll Cardiol 47: 1754-1768 [Full Text]  
• Roiron, C, Sanchez, P, Bouzamondo, A, Lechat, P, Montalescot, G (2006). Drug eluting stents: an updated meta-analysis of randomised controlled trials. Heart 92: 641-649 [Abstract] [Full Text]  
• Urban, P., Gershlick, A. H., Guagliumi, G., Guyon, P., Lotan, C., Schofer, J., Seth, A., Sousa, J. E., Wijns, W., Berge, C., Deme, M., Stoll, H.-P., on behalf of the e-Cypher Investigators, (2006). Safety of Coronary Sirolimus-Eluting Stents in Daily Clinical Practice: One-Year Follow-Up of the e-Cypher Registry. Circulation 113: 1434-1441 [Abstract] [Full Text]  
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• Raja, S. G. (2006). Drug-Eluting Stents and the Future of Coronary Artery Bypass Surgery: Facts and Fiction.. Ann. Thorac. Surg. 81: 1162-1171 [Abstract] [Full Text]  
• Lee, M. S., Kapoor, N., Jamal, F., Czer, L., Aragon, J., Forrester, J., Kar, S., Dohad, S., Kass, R., Eigler, N., Trento, A., Shah, P. K., Makkar, R. R. (2006). Comparison of Coronary Artery Bypass Surgery With Percutaneous Coronary Intervention With Drug-Eluting Stents for Unprotected Left Main Coronary Artery Disease. J Am Coll Cardiol 47: 864-870 [Abstract] [Full Text]  
• Bassand, J.-P. (2006). Clinical implications of inhibition of the late sodium current: ranolazine. Eur Heart J Suppl 8: A14-A19 [Abstract] [Full Text]  
• Klein, L. W. (2006). Are Drug-Eluting Stents the Preferred Treatment for Multivessel Coronary Artery Disease?. J Am Coll Cardiol 47: 22-26 [Abstract] [Full Text]  
• Bagust, A, Grayson, A D, Palmer, N D, Perry, R A, Walley, T (2006). Cost effectiveness of drug eluting coronary artery stenting in a UK setting: cost-utility study. Heart 92: 68-74 [Abstract] [Full Text]  
• King, S. B. III (2005). Angioplasty Is Better Than Medical Therapy for Alleviating Chronic Angina Pectoris. Arch Intern Med 165: 2589-2592 [Full Text]  
• Herz, I., Moshkovitz, Y., Loberman, D., Uretzky, G., Braunstein, R., Hendler, A., Zivi, E., Ben-Gal, Y., Mohr, R. (2005). Drug-Eluting Stents Versus Bilateral Internal Thoracic Grafting for Multivessel Coronary Disease. Ann. Thorac. Surg. 80: 2086-2090 [Abstract] [Full Text]  
• Thiele, H., Oettel, S., Jacobs, S., Hambrecht, R., Sick, P., Gummert, J. F., Mohr, F. W., Schuler, G., Falk, V. (2005). Comparison of Bare-Metal Stenting With Minimally Invasive Bypass Surgery for Stenosis of the Left Anterior Descending Coronary Artery: A 5-Year Follow-Up. Circulation 112: 3445-3450 [Abstract] [Full Text]  
• Gershlick, A H (2005). Is there any place for oral anti-restenotic treatment in the era of drug eluting stents?. Heart 91: 1377-1379 [Abstract] [Full Text]  
• Lauruschkat, A. H., Arnrich, B., Albert, A. A., Walter, J. A., Amann, B., Rosendahl, U. P., Alexander, T., Ennker, J. (2005). Prevalence and Risks of Undiagnosed Diabetes Mellitus in Patients Undergoing Coronary Artery Bypass Grafting. Circulation 112: 2397-2402 [Abstract] [Full Text]  
• Ramanathan, K. B., Weiman, D. S., Sacks, J., Morrison, D. A., Sedlis, S., Sethi, G., Henderson, W. G. (2005). Percutaneous Intervention Versus Coronary Bypass Surgery for Patients Older Than 70 Years of Age With High-Risk Unstable Angina. Ann. Thorac. Surg. 80: 1340-1346 [Abstract] [Full Text]  
• Valgimigli, M., Percoco, G., Cicchitelli, G., Campo, G., Gardini, E., Pellegrino, L., Malagutti, P., Giretti, C., Ferrari, R. (2005). New and old strategies to afford the liberal use of drug-eluting stents in real-life scenarios. Eur Heart J Suppl 7: K31-K35 [Abstract] [Full Text]  
• Colombo, A., Cosgrave, J. (2005). Paclitaxel-Eluting Stents in Complex Lesions. JAMA 294: 1268-1270 [Full Text]  
• King, S. B. III, Dangas, G., Moses, J. W., King, S. B. III, Dangas, G., Moses, J. W. (2005). Surgery Is Preferred for the Diabetic With Multivessel Disease. Circulation 112: 1500-1515 [Full Text]  
• Zimarino, M., Calafiore, A. M., De Caterina, R. (2005). Complete myocardial revascularization: between myth and reality. Eur Heart J 26: 1824-1830 [Abstract] [Full Text]  
• Davidavicius, G., Van Praet, F., Mansour, S., Casselman, F., Bartunek, J., Degrieck, I., Wellens, F., De Geest, R., Vanermen, H., Wijns, W., De Bruyne, B. (2005). Hybrid Revascularization Strategy: A Pilot Study on the Association of Robotically Enhanced Minimally Invasive Direct Coronary Artery Bypass Surgery and Fractional Flow Reserve-Guided Percutaneous Coronary Intervention. Circulation 112: I-317-I-322 [Abstract] [Full Text]  
• Malenka, D. J., Leavitt, B. J., Hearne, M. J., Robb, J. F., Baribeau, Y. R., Ryan, T. J., Helm, R. E., Kellett, M. A., Dauerman, H. L., Dacey, L. J., Silver, M. T., VerLee, P. N., Weldner, P. W., Hettleman, B. D., Olmstead, E. M., Piper, W. D., O'Connor, G. T., for the Northern New England Cardiovascular Diseas, (2005). Comparing Long-Term Survival of Patients With Multivessel Coronary Disease After CABG or PCI: Analysis of BARI-Like Patients in Northern New England. Circulation 112: I-371-I-376 [Abstract] [Full Text]  
• Serruys, P. W., Ong, A. T.L., van Herwerden, L. A., Sousa, J. E., Jatene, A., Bonnier, J. J.R.M., Schonberger, J. P.M.A., Buller, N., Bonser, R., Disco, C., Backx, B., Hugenholtz, P. G., Firth, B. G., Unger, F. (2005). Five-Year Outcomes After Coronary Stenting Versus Bypass Surgery for the Treatment of Multivessel Disease: The Final Analysis of the Arterial Revascularization Therapies Study (ARTS) Randomized Trial. J Am Coll Cardiol 46: 575-581 [Abstract] [Full Text]  
• Rodriguez, A. E., Baldi, J., Pereira, C. F., Navia, J., Alemparte, M. R., Delacasa, A., Vigo, F., Vogel, D., O'Neill, W., Palacios, I. F., on behalf of the ERACI II Investigators, (2005). Five-Year Follow-Up of the Argentine Randomized Trial of Coronary Angioplasty With Stenting Versus Coronary Bypass Surgery in Patients With Multiple Vessel Disease (ERACI II). J Am Coll Cardiol 46: 582-588 [Abstract] [Full Text]  
• Berger, A., Botman, K.-J., MacCarthy, P. A., Wijns, W., Bartunek, J., Heyndrickx, G. R., Pijls, N. H.J., De Bruyne, B. (2005). Long-Term Clinical Outcome After Fractional Flow Reserve-Guided Percutaneous Coronary Intervention in Patients With Multivessel Disease. J Am Coll Cardiol 46: 438-442 [Abstract] [Full Text]  
• Mercado, N., Wijns, W., Serruys, P. W., Sigwart, U., Flather, M. D., Stables, R. H., O'Neill, W. W., Rodriguez, A., Lemos, P. A., Hueb, W. A., Gersh, B. J., Booth, J., Boersma, E. (2005). One-year outcomes of coronary artery bypass graft surgery versus percutaneous coronary intervention with multiple stenting for multisystem disease: A meta-analysis of individual patient data from randomized clinical trials. J. Thorac. Cardiovasc. Surg. 130: 512-519 [Abstract] [Full Text]  
• Moshkovitz, Y., Mohr, R., Braunstein, R., Zivi, E., Uretzky, G., Ben-Gal, Y., Herz, I. (2005). Revascularization of Left Anterior Descending Coronary Artery in Patients With Single and Multivessel Disease: Comparison Between Off-Pump Internal Thoracic Artery and Drug-Eluting Stent. Chest 128: 804-809 [Abstract] [Full Text]  
• Aoki, J., Ong, A. T.L., Hoye, A., van Herwerden, L. A., Sousa, J. E., Jatene, A., Bonnier, J. J.R.M., Schonberger, J. P.M.A., Buller, N., Bonser, R., Lindeboom, W., Unger, F., Serruys, P. W. (2005). Five year clinical effect of coronary stenting and coronary artery bypass grafting in renal insufficient patients with multivessel coronary artery disease: insights from ARTS trial. Eur Heart J 26: 1488-1493 [Abstract] [Full Text]  
• Weinrich, M., Stuart, M., Hoyer, T. (2005). Rules for Rehabilitation: An Agenda for Research. Neurorehabil Neural Repair 19: 72-83 [Abstract]