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Previous Volume 344:1294-1303 April 26, 2001 Number 17 Next

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ABSTRACT

Background Data on global trends in resistance to antituberculosis drugs are lacking.

Methods We expanded the survey conducted by the World Health Organization and the International Union against Tuberculosis and Lung Disease to assess trends in resistance to antituberculosis drugs in countries on six continents. We obtained data using standard protocols from ongoing surveillance or from surveys of representative samples of all patients with tuberculosis. The standard sampling techniques distinguished between new and previously treated patients, and laboratory performance was checked by means of an international program of quality assurance.

Results Between 1996 and 1999, patients in 58 geographic sites were surveyed; 28 sites provided data for at least two years. For patients with newly diagnosed tuberculosis, the frequency of resistance to at least one antituberculosis drug ranged from 1.7 percent in Uruguay to 36.9 percent in Estonia (median, 10.7 percent). The prevalence increased in Estonia, from 28.2 percent in 1994 to 36.9 percent in 1998 (P=0.01), and in Denmark, from 9.9 percent in 1995 to 13.1 percent in 1998 (P=0.04). The median prevalence of multidrug resistance among new cases of tuberculosis was only 1.0 percent, but the prevalence was much higher in Estonia (14.1 percent), Henan Province in China (10.8 percent), Latvia (9.0 percent), the Russian oblasts of Ivanovo (9.0 percent) and Tomsk (6.5 percent), Iran (5.0 percent), and Zhejiang Province in China (4.5 percent). There were significant decreases in multidrug resistance in France and the United States. In Estonia, the prevalence in all cases increased from 11.7 percent in 1994 to 18.1 percent in 1998 (P<0.001).

Conclusions Multidrug-resistant tuberculosis continues to be a serious problem, particularly among some countries of eastern Europe. Our survey also identified areas with a high prevalence of multidrug-resistant tuberculosis in such countries as China and Iran.

Source Information

From the Communicable Diseases Cluster, World Health Organization, Geneva (M.A.E., L.S., C.D., R.W., M.C.R.); the International Union against Tuberculosis and Lung Disease, Paris (A.L., H.L.R.); the Laboratory Centre for Disease Control, Ottawa, Ont., Canada (A.L.); the Institut Pasteur, Algiers, Algeria (F.B.); the Korean Institute of Tuberculosis, Seoul, Republic of Korea (S.J.K.); the Instituto Panamericano de Protección de Alimentos y Zoonosis, Buenos Aires, Argentina (A.R.); the Swedish Institute for Infectious Disease Control, Stockholm (S.H.); and the Division of Tuberculosis Elimination, Centers for Disease Control and Prevention, Atlanta (N.B.).

Address reprint requests to Dr. Espinal at Communicable Diseases Control, Prevention, and Eradication, World Health Organization, 20 Ave. Appia, 1211 Geneva, Switzerland, or at espinalm{at}who.int.

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• Gali, N., Dominguez, J., Blanco, S., Prat, C., Quesada, M. D., Matas, L., Ausina, V. (2003). Utility of an In-House Mycobacteriophage-Based Assay for Rapid Detection of Rifampin Resistance in Mycobacterium tuberculosis Clinical Isolates. J. Clin. Microbiol. 41: 2647-2649 [Abstract] [Full Text]  
• Corbett, E. L., Watt, C. J., Walker, N., Maher, D., Williams, B. G., Raviglione, M. C., Dye, C. (2003). The Growing Burden of Tuberculosis: Global Trends and Interactions With the HIV Epidemic. Arch Intern Med 163: 1009-1021 [Abstract] [Full Text]  
• Yue, J., Shi, W., Xie, J., Li, Y., Zeng, E., Wang, H. (2003). Mutations in the rpoB Gene of Multidrug-Resistant Mycobacterium tuberculosis Isolates from China. J. Clin. Microbiol. 41: 2209-2212 [Abstract] [Full Text]  
• Werngren, J., Hoffner, S. E. (2003). Drug-Susceptible Mycobacterium tuberculosis Beijing Genotype Does Not Develop Mutation-Conferred Resistance to Rifampin at an Elevated Rate. J. Clin. Microbiol. 41: 1520-1524 [Abstract] [Full Text]  
• Sterling, T. R, Lehmann, H. P, Frieden, T. R (2003). Impact of DOTS compared with DOTS-plus on multidrug resistant tuberculosis and tuberculosis deaths: decision analysis. BMJ 326: 574-574 [Abstract] [Full Text]  
• Sola, C., Rastogi, N., Gutierrez, M. C., Vincent, V., Brosch, R., Parsons, L., Niemann, S., Rusch-Gerdes, S., Schwander, S. K. (2003). Is Mycobacterium africanum Subtype II (Uganda I and Uganda II) a Genetically Well-Defined Subspecies of the Mycobacterium tuberculosis Complex?. J. Clin. Microbiol. 41: 1345-1348 [Full Text]  
• (2003). American Thoracic Society/Centers for Disease Control and Prevention/Infectious Diseases Society of America: Treatment of Tuberculosis. Am. J. Respir. Crit. Care Med. 167: 603-662 [Full Text]  
• Mitnick, C., Bayona, J., Palacios, E., Shin, S., Furin, J., Alcantara, F., Sanchez, E., Sarria, M., Becerra, M., Fawzi, M. C. S., Kapiga, S., Neuberg, D., Maguire, J. H., Kim, J. Y., Farmer, P. (2003). Community-Based Therapy for Multidrug-Resistant Tuberculosis in Lima, Peru. NEJM 348: 119-128 [Abstract] [Full Text]  
• Khan, K., Muennig, P., Behta, M., Zivin, J. G. (2002). Global Drug-Resistance Patterns and the Management of Latent Tuberculosis Infection in Immigrants to the United States. NEJM 347: 1850-1859 [Abstract] [Full Text]  
• de Souza, A. O., Hemerly, F. P., Busollo, A. C., Melo, P. S., Machado, G. M. C., Miranda, C. C., Santa-Rita, R. M., Haun, M., Leon, L. L., Sato, D. N., de Castro, S. L., Duran, N. (2002). 3-[4'-Bromo-(1,1'-biphenyl)-4-yl]-N,N-dimethyl-3-(2-thienyl)-2-propen-1-amine: synthesis, cytotoxicity, and leishmanicidal, trypanocidal and antimycobacterial activities. J Antimicrob Chemother 50: 629-637 [Abstract] [Full Text]  
• Turner, D. J., Hoyle, S. L., Snewin, V. A., Gares, M.-P., Brown, I. N., Young, D. B. (2002). An ex vivo culture model for screening drug activity against in vivo phenotypes of Mycobacterium tuberculosis. Microbiology 148: 2929-2936 [Abstract] [Full Text]  
• Pym, A. S., Saint-Joanis, B., Cole, S. T. (2002). Effect of katG Mutations on the Virulence of Mycobacterium tuberculosis and the Implication for Transmission in Humans. Infect. Immun. 70: 4955-4960 [Abstract] [Full Text]  
• Drobniewski, F, Eltringham, I, Graham, C, Magee, J G, Smith, E G, Watt, B (2002). A national study of clinical and laboratory factors affecting the survival of patients with multiple drug resistant tuberculosis in the UK. Thorax 57: 810-816 [Abstract] [Full Text]  
• Palomino, J.-C., Martin, A., Camacho, M., Guerra, H., Swings, J., Portaels, F. (2002). Resazurin Microtiter Assay Plate: Simple and Inexpensive Method for Detection of Drug Resistance in Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 46: 2720-2722 [Abstract] [Full Text]  
• Mistry, N. F., Iyer, A. M., D'souza, D. T. B., Taylor, G. M., Young, D. B., Antia, N. H. (2002). Spoligotyping of Mycobacterium tuberculosis Isolates from Multiple-Drug-Resistant Tuberculosis Patients from Bombay, India. J. Clin. Microbiol. 40: 2677-2680 [Abstract] [Full Text]  
• Loddenkemper, R., Sagebiel, D., Brendel, A. (2002). Strategies against multidrug-resistant tuberculosis. Eur Respir J 20: 66S-77s [Abstract] [Full Text]  
• Cole, S.T. (2002). Comparative mycobacterial genomics as a tool for drug target and antigen discovery. Eur Respir J 20: 78S-86s [Abstract] [Full Text]  
• Iseman, M.D. (2002). Tuberculosis therapy: past, present and future. Eur Respir J 20: 87S-94s [Abstract] [Full Text]  
• Broekmans, J.F., Migliori, G.B., Rieder, H.L., Lees, J., Ruutu, P., Loddenkemper, R., Raviglione, M.C. (2002). European framework for tuberculosis control and elimination in countries with a low incidence: Recommendations of the World Health Organization (WHO), International Union Against Tuberculosis and Lung Disease (IUATLD) and Royal Netherlands Tuberculosis Association (KNCV) Working Group. Eur Respir J 19: 765-775 [Abstract] [Full Text]  
• Daley, C. L. (2002). Transmission of Multidrug-Resistant Tuberculosis . Limited by Man or Nature?. Am. J. Respir. Crit. Care Med. 165: 742-743 [Full Text]  
• Dye, C., Williams, B. G., Espinal, M. A., Raviglione, M. C. (2002). Erasing the World's Slow Stain: Strategies to Beat Multidrug-Resistant Tuberculosis. Science 295: 2042-2046 [Abstract] [Full Text]  
• Garcia de Viedma, D., del Sol Diaz Infantes, M., Lasala, F., Chaves, F., Alcala, L., Bouza, E. (2002). New Real-Time PCR Able To Detect in a Single Tube Multiple Rifampin Resistance Mutations and High-Level Isoniazid Resistance Mutations in Mycobacterium tuberculosis. J. Clin. Microbiol. 40: 988-995 [Abstract] [Full Text]  
• Qian, L., Abe, C., Lin, T.-P., Yu, M.-C., Cho, S.-N., Wang, S., Douglas, J. T. (2002). rpoB Genotypes of Mycobacterium tuberculosis Beijing Family Isolates from East Asian Countries. J. Clin. Microbiol. 40: 1091-1094 [Abstract] [Full Text]  
• DE MARIA, A, BERARDI, M, DIGNETTI, P, FERRERA, L, VIASSOLO, L, CANONICA, G W (2001). Side effects of antituberculous treatment. Thorax 56: 983-983 [Full Text]  
• Jenista, J. A. (2001). The Immigrant, Refugee, or Internationally Adopted Child. Pediatr. Rev. 22: 419-429 [Full Text]  
• Iseman, M. (2001). A 52-Year-Old Man With a Positive PPD. JAMA 286: 2015-2022 [Full Text]  
• Farmer, P. (2001). The Major Infectious Diseases in the World -- To Treat or Not to Treat?. NEJM 345: 208-210 [Full Text]