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Volume 344:1651-1658 May 31, 2001 Number 22 Next

	Full Text PDF Editorial by Braunwald, E. Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

ABSTRACT

Background Beta-blocking agents reduce the risk of hospitalization and death in patients with mild-to-moderate heart failure, but little is known about their effects in severe heart failure.

Methods We evaluated 2289 patients who had symptoms of heart failure at rest or on minimal exertion, who were clinically euvolemic, and who had an ejection fraction of less than 25 percent. In a double-blind fashion, we randomly assigned 1133 patients to placebo and 1156 patients to treatment with carvedilol for a mean period of 10.4 months, during which standard therapy for heart failure was continued. Patients who required intensive care, had marked fluid retention, or were receiving intravenous vasodilators or positive inotropic drugs were excluded.

Results There were 190 deaths in the placebo group and 130 deaths in the carvedilol group. This difference reflected a 35 percent decrease in the risk of death with carvedilol (95 percent confidence interval, 19 to 48 percent; P=0.0014, adjusted for interim analyses). A total of 507 patients died or were hospitalized in the placebo group, as compared with 425 in the carvedilol group. This difference reflected a 24 percent decrease in the combined risk of death or hospitalization with carvedilol. The favorable effects on both end points were seen consistently in all the subgroups we examined. Fewer patients in the carvedilol group than in the placebo group withdrew because of adverse effects or for other reasons (P=0.02).

Conclusions The previously reported benefits of carvedilol with regard to morbidity and mortality in patients with mild-to-moderate heart failure were also found in the patients with severe heart failure who were evaluated in this trial.

Source Information

From the College of Physicians and Surgeons, Columbia University, New York (M.P.); Royal Brompton Hospital, London (A.J.S.C.); Stanford University Medical Center, Stanford, Calif. (M.B.F.); Universitäts Klinikum Lübeck, Lübeck, Germany (H.A.K.); Monash University, Prahran, Victoria, Australia (H.K.); University Hospital, Bern, Switzerland (P.M.); University Health Network and Mount Sinai Hospital, Toronto (J.L.R.); Silesian School of Medicine, Katowice, Poland (M.T.); Hôpital Henri Mondor, Paris (A.C.); and the University of Wisconsin, Madison (E.B.R., M.K.S., D.L.D.).

Other authors were Christoph Staiger, M.D., of Roche Pharmaceuticals, Basel, Switzerland; and Ellen L. Curtin, M.D., of GlaxoSmithKline, Philadelphia.

Address reprint requests to Dr. Packer at the Division of Circulatory Physiology, Columbia University College of Physicians and Surgeons, 630 W. 168th St., New York, NY 10032, or at mp65{at}columbia.edu.

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• Vittorio, T. J., Zolty, R., Kasper, M. E., Khandwalla, R. M., Hirsh, D. S., Tseng, C.-H., Jorde, U. P., Ahuja, K. (2008). Differential Effects of Carvedilol and Metoprolol Succinate on Plasma Norepinephrine Release and Peak Exercise Heart Rate in Subjects With Chronic Heart Failure. J CARDIOVASC PHARMACOL THER 13: 51-57 [Abstract]  
• Zhao, J., Yang, Y., Pei, W., Sun, Y., Zhai, M, Liu, Y., Gao, R. (2008). Carvedilol reduces myocardial no-reflow by decreasing endothelin-1 via activation of the ATP-sensitive K+ channel. Perfusion 23: 111-115 [Abstract]  
• McMurray, J. J.V., Carson, P. E., Komajda, M., McKelvie, R., Zile, M. R., Ptaszynska, A., Staiger, C., Donovan, J. M., Massie, B. M. (2008). Heart failure with preserved ejection fraction: Clinical characteristics of 4133 patients enrolled in the I-PRESERVE trial. Eur J Heart Fail 10: 149-156 [Abstract] [Full Text]  
• Weir, R.A.P., McMurray, J. J.V., Puu, M., Solomon, S. D., Olofsson, B., Granger, C. B., Yusuf, S., Michelson, E. L., Swedberg, K., Pfeffer, M. A., CHARM Investigators, (2008). Efficacy and tolerability of adding an angiotensin receptor blocker in patients with heart failure already receiving an angiotensin-converting inhibitor plus aldosterone antagonist, with or without a beta blocker. Findings from the Candesartan in Heart failure: Assessment of Reduction in Mortality and morbidity (CHARM)-Added trial. Eur J Heart Fail 10: 157-163 [Abstract] [Full Text]  
• Ramasubbu, K., Estep, J., White, D. L., Deswal, A., Mann, D. L. (2008). Experimental and clinical basis for the use of statins in patients with ischemic and nonischemic cardiomyopathy.. J Am Coll Cardiol 51: 415-426 [Abstract] [Full Text]  
• Albert, N. M. (2007). Switching to Once-Daily Evidence-Based -Blockers in Patients With Systolic Heart Failure or Left Ventricular Dysfunction After Myocardial Infarction. Crit Care Nurse 27: 62-72 [Full Text]  
• Suma, H., Tanabe, H., Uejima, T., Suzuki, S., Horii, T., Isomura, T. (2007). Selected ventriculoplasty for idiopathic dilated cardiomyopathy with advanced congestive heart failure: midterm results and risk analysis. Eur. J. Cardiothorac. Surg. 32: 912-916 [Abstract] [Full Text]  
• Remme, W. J. (2007). Filling the gap between guidelines and clinical practice in heart failure treatment -- Still a far cry from reality. Eur J Heart Fail 9: 1143-1145 [Full Text]  
• de Groote, P., Isnard, R., Assyag, P., Clerson, P., Ducardonnet, A., Galinier, M., Jondeau, G., Leurs, I., Thebaut, J.-F., Komajda, M. (2007). Is the gap between guidelines and clinical practice in heart failure treatment being filled? Insights from the IMPACT RECO survey. Eur J Heart Fail 9: 1205-1211 [Abstract] [Full Text]  
• Jourdain, P., Jondeau, G., Juilliere, Y. (2007). Reply. J Am Coll Cardiol 50: 2098-2099 [Full Text]  
• Esmore, D., Spratt, P., Larbalestier, R., Tsui, S., Fiane, A., Ruygrok, P., Meyers, D., Woodard, J. (2007). VentrAssistTM left ventricular assist device: clinical trial results and Clinical Development Plan update. Eur. J. Cardiothorac. Surg. 32: 735-744 [Abstract] [Full Text]  
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• Hauptman, P. J., Goodlin, S. J., Lopatin, M., Costanzo, M. R., Fonarow, G. C., Yancy, C. W., for the ADHERE Scientific Advisory Committee and A, (2007). Characteristics of Patients Hospitalized With Acute Decompensated Heart Failure Who Are Referred for Hospice Care. Arch Intern Med 167: 1990-1997 [Abstract] [Full Text]  
• Granger, C. B (2007). Carvedilol was more effective than metoprolol for preventing cardiovascular events in heart failure. Evid. Based Med. 12: 141-141 [Full Text]  
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• Metra, M., Torp-Pedersen, C., Cleland, J. G.F., Di Lenarda, A., Komajda, M., Remme, W. J., Cas, L. D., Spark, P., Swedberg, K., Poole-Wilson, P. A., for the COMET investigators, (2007). Should beta-blocker therapy be reduced or withdrawn after an episode of decompensated heart failure? Results from COMET. Eur J Heart Fail 9: 901-909 [Abstract] [Full Text]  
• Gustafsson, F., Schou, M., Videbaek, L., Nielsen, T., Ulriksen, H., Markenvard, J., Svendsen, T. L., Ryde, H., Vigholt, E., Hildebrandt, P., on behalf of the Danish Heart Failure Clinics Netw, (2007). Treatment with beta-blockers in nurse-led heart failure clinics: Titration efficacy and predictors of failure. Eur J Heart Fail 9: 910-916 [Abstract] [Full Text]  
• Swedberg, K. (2007). Pure heart rate reduction: further perspectives in heart failure. Eur Heart J Suppl 9: F20-F24 [Abstract] [Full Text]  
• Telli, M. L., Hunt, S. A., Carlson, R. W., Guardino, A. E. (2007). Trastuzumab-Related Cardiotoxicity: Calling Into Question the Concept of Reversibility. JCO 25: 3525-3533 [Abstract] [Full Text]  
• Bruch, C., Bruch, C., Sindermann, J., Breithardt, G., Gradaus, R. (2007). Prevalence and prognostic impact of comorbidities in heart failure patients with implantable cardioverter defibrillator. Europace 9: 681-686 [Abstract] [Full Text]  
• Torp-Pedersen, C., Metra, M., Charlesworth, A., Spark, P., Lukas, M. A., Poole-Wilson, P. A, Swedberg, K., Cleland, J. G F, Di Lenarda, A., Remme, W. J, Scherhag, A., for the COMET investigators, (2007). Effects of metoprolol and carvedilol on pre-existing and new onset diabetes in patients with chronic heart failure: data from the Carvedilol Or Metoprolol European Trial (COMET). Heart 93: 968-973 [Abstract] [Full Text]  
• Rosendorff, C., Black, H. R., Cannon, C. P., Gersh, B. J., Gore, J., Izzo, J. L. Jr, Kaplan, N. M., O'Connor, C. M., O'Gara, P. T., Oparil, S. (2007). REPRINT Treatment of Hypertension in the Prevention and Management of Ischemic Heart Disease: A Scientific Statement From the American Heart Association Council for High Blood Pressure Research and the Councils on Clinical Cardiology and Epidemiology and Prevention. Hypertension 50: e28-e55 [Full Text]  
• Fonarow, G. C., Abraham, W. T., Albert, N. M., Gattis Stough, W., Gheorghiade, M., Greenberg, B. H., O'Connor, C. M., Pieper, K., Sun, J. L., Yancy, C. W., Young, J. B., for the OPTIMIZE-HF Investigators and Hospitals, (2007). Influence of a Performance-Improvement Initiative on Quality of Care for Patients Hospitalized With Heart Failure: Results of the Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients With Heart Failure (OPTIMIZE-HF). Arch Intern Med 167: 1493-1502 [Abstract] [Full Text]  
• Fruhwald, F. M., Fahrleitner-Pammer, A., Berger, R., Leyva, F., Freemantle, N., Erdmann, E., Gras, D., Kappenberger, L., Tavazzi, L., Daubert, J.-C., Cleland, J. G.F. (2007). Early and sustained effects of cardiac resynchronization therapy on N-terminal pro-B-type natriuretic peptide in patients with moderate to severe heart failure and cardiac dyssynchrony. Eur Heart J 28: 1592-1597 [Abstract] [Full Text]  
• Neglia, D., De Maria, R., Masi, S., Gallopin, M., Pisani, P., Pardini, S., Gavazzi, A., L'Abbate, A., Parodi, O. (2007). Effects of long-term treatment with carvedilol on myocardial blood flow in idiopathic dilated cardiomyopathy. Heart 93: 808-813 [Abstract] [Full Text]  
• Watson, A. M. D., Hood, S. G., Ramchandra, R., McAllen, R. M., May, C. N. (2007). Increased cardiac sympathetic nerve activity in heart failure is not due to desensitization of the arterial baroreflex. Am. J. Physiol. Heart Circ. Physiol. 293: H798-H804 [Abstract] [Full Text]  
• Pitt, B., Pitt, G. S. (2007). Added Benefit of Mineralocorticoid Receptor Blockade in the Primary Prevention of Sudden Cardiac Death. Circulation 115: 2976-2982 [Full Text]  
• Patel, J., Heywood, J. T. (2007). Mode of Death in Patients With Systolic Heart Failure. J CARDIOVASC PHARMACOL THER 12: 127-136 [Abstract]  
• Kristen, A. V., Perz, J. B., Schonland, S. O., Hegenbart, U., Schnabel, P. A., Kristen, J. H., Goldschmidt, H., Katus, H. A., Dengler, T. J. (2007). Non-invasive predictors of survival in cardiac amyloidosis. Eur J Heart Fail 9: 617-624 [Abstract] [Full Text]  
• Metra, M., Ponikowski, P., Dickstein, K., McMurray, J. J.V., Gavazzi, A., Bergh, C.-H., Fraser, A. G., Jaarsma, T., Pitsis, A., Mohacsi, P., Bohm, M., Anker, S., Dargie, H., Brutsaert, D., Komajda, M., on behalf of the Heart Failure Association of the, (2007). Advanced chronic heart failure: A position statement from the Study Group on Advanced Heart Failure of the Heart Failure Association of the European Society of Cardiology. Eur J Heart Fail 9: 684-694 [Abstract] [Full Text]  
• Authors/Task Force Members, , Ryden, L., Standl, E., Bartnik, M., Berghe, G. V. d., Betteridge, J., de Boer, M.-J., Cosentino, F., Jonsson, B., Laakso, M., Malmberg, K., Priori, S., Ostergren, J., Tuomilehto, J., Thrainsdottir, I., Other Contributors, , Vanhorebeek, I., Stramba-Badiale, M., Lindgren, P., Qiao, Q., ESC Committee for Practice Guidelines (CPG), , Priori, S. G., Blanc, J.-J., Budaj, A., Camm, J., Dean, V., Deckers, J., Dickstein, K., Lekakis, J., McGregor, K., Metra, M., Morais, J., Osterspey, A., Tamargo, J., Zamorano, J. L., Document Reviewers, , Deckers, J. W., Bertrand, M., Charbonnel, B., Erdmann, E., Ferrannini, E., Flyvbjerg, A., Gohlke, H., Juanatey, J. R. G., Graham, I., Monteiro, P. F., Parhofer, K., Pyorala, K., Raz, I., Schernthaner, G., Volpe, M., Wood, D. (2007). Guidelines on diabetes, pre-diabetes, and cardiovascular diseases: full text: The Task Force on Diabetes and Cardiovascular Diseases of the European Society of Cardiology (ESC) and of the European Association for the Study of Diabetes (EASD). Eur Heart J Suppl 9: C3-C74 [Full Text]  
• Imai, M., Rastogi, S., Gupta, R. C., Mishra, S., Sharov, V. G., Stanley, W. C., Mika, Y., Rousso, B., Burkhoff, D., Ben-Haim, S., Sabbah, H. N. (2007). Therapy With Cardiac Contractility Modulation Electrical Signals Improves Left Ventricular Function and Remodeling in Dogs With Chronic Heart Failure. J Am Coll Cardiol 49: 2120-2128 [Abstract] [Full Text]  
• Rosendorff, C., Black, H. R., Cannon, C. P., Gersh, B. J., Gore, J., Izzo, J. L. Jr, Kaplan, N. M., O'Connor, C. M., O'Gara, P. T., Oparil, S. (2007). Treatment of Hypertension in the Prevention and Management of Ischemic Heart Disease: A Scientific Statement From the American Heart Association Council for High Blood Pressure Research and the Councils on Clinical Cardiology and Epidemiology and Prevention. Circulation 115: 2761-2788 [Full Text]  
• Ong, H T (2007). beta blockers in hypertension and cardiovascular disease. BMJ 334: 946-949 [Full Text]  
• Jourdain, P., Jondeau, G., Funck, F., Gueffet, P., Le Helloco, A., Donal, E., Aupetit, J. F., Aumont, M. C., Galinier, M., Eicher, J. C., Cohen-Solal, A., Juilliere, Y. (2007). Plasma Brain Natriuretic Peptide-Guided Therapy to Improve Outcome in Heart Failure: The STARS-BNP Multicenter Study. J Am Coll Cardiol 49: 1733-1739 [Abstract] [Full Text]  
• Kasama, S., Toyama, T., Hatori, T., Sumino, H., Kumakura, H., Takayama, Y., Ichikawa, S., Suzuki, T., Kurabayashi, M. (2007). Evaluation of cardiac sympathetic nerve activity and left ventricular remodelling in patients with dilated cardiomyopathy on the treatment containing carvedilol. Eur Heart J 0: ehm048v1-7 [Abstract] [Full Text]  
• Taylor, A. L., Ziesche, S., Yancy, C. W., Carson, P., Ferdinand, K., Taylor, M., Adams, K., Olukotun, A. Y., Ofili, E., Tam, S. W., Sabolinski, M. L., Worcel, M., Cohn, J. N., on behalf of the African-American Heart Failure Tr, (2007). Early and Sustained Benefit on Event-Free Survival and Heart Failure Hospitalization From Fixed-Dose Combination of Isosorbide Dinitrate/Hydralazine: Consistency Across Subgroups in the African-American Heart Failure Trial. Circulation 115: 1747-1753 [Abstract] [Full Text]