Background Although beta-adrenergicreceptor antagonistsreduce morbidity and mortality in patients with mild-to-moderatechronic heart failure, their effect on survival in patientswith more advanced heart failure is unknown.
Methods A total of 2708 patients with heart failure designatedas New York Heart Association (NYHA) functional class III (in92 percent of the patients) or IV (in 8 percent) and a leftventricular ejection fraction of 35 percent or lower were randomlyassigned to double-blind treatment with either bucindolol (1354patients) or placebo (1354 patients) and followed for the primaryend point of death from any cause.
Results The data and safety monitoring board recommended stoppingthe trial after the seventh interim analysis. At that time,there was no significant difference in mortality between thetwo groups (unadjusted P=0.16). The results presented here arebased on complete follow-up at the time of study termination(average, 2.0 years). There were a total of 449 deaths in theplacebo group (33 percent) and 411 deaths in the bucindololgroup (30 percent, adjusted P=0.13). The risk of the secondaryend point of death from cardiovascular causes was lower in thebucindolol group (hazard ratio, 0.86; 95 percent confidenceinterval, 0.74 to 0.99), as was the risk of heart transplantationor death. In a subgroup analysis, there was a survival benefitin nonblack patients.
Conclusions In a demographically diverse group of patients withNYHA class III and IV heart failure, bucindolol resulted inno significant overall survival benefit.
Source Information
The BEST Manuscript Writing Committee (Eric J. Eichhorn, M.D., Michael J. Domanski, M.D., Heidi Krause-Steinrauf, M.S., Michael R. Bristow, M.D., Ph.D., and Philip W. Lavori, Ph.D.) takes responsibility for the content of this article.
Address reprint requests to Dr. Eichhorn at the Cardiac Catheterization Laboratory (IIIA2), University of Texas Southwestern and Dallas Veterans Affairs Medical Center, 4500 S. Lancaster, Dallas, TX 75216, or at eric.eichhorn{at}utsouthwestern.edu.
Triposkiadis, F., Karayannis, G., Giamouzis, G., Skoularigis, J., Louridas, G., Butler, J.
(2009). The sympathetic nervous system in heart failure physiology, pathophysiology, and clinical implications.. J Am Coll Cardiol
54: 1747-1762
[Abstract][Full Text]
Foley, P. W.X., Leyva, F., Frenneaux, M. P.
(2009). What is treatment success in cardiac resynchronization therapy?. Europace
11: v58-v65
[Abstract][Full Text]
Dorn, G. W. II, Liggett, S. B.
(2009). Mechanisms of Pharmacogenomic Effects of Genetic Variation within the Cardiac Adrenergic Network in Heart Failure. Mol. Pharmacol.
76: 466-480
[Abstract][Full Text]
Ahmed, M. I., White, M., Ekundayo, O. J., Love, T. E., Aban, I., Liu, B., Aronow, W. S., Ahmed, A.
(2009). A history of atrial fibrillation and outcomes in chronic advanced systolic heart failure: a propensity-matched study. Eur Heart J
30: 2029-2037
[Abstract][Full Text]
Klapholz, M.
(2009). {beta}-Blocker Use for the Stages of Heart Failure. Mayo Clin Proc.
84: 718-729
[Abstract][Full Text]
Cresci, S., Kelly, R. J., Cappola, T. P., Diwan, A., Dries, D., Kardia, S. L.R., Dorn, G. W. II
(2009). Clinical and genetic modifiers of long-term survival in heart failure.. J Am Coll Cardiol
54: 432-444
[Abstract][Full Text]
McAlister, F. A., Wiebe, N., Ezekowitz, J. A., Leung, A. A., Armstrong, P. W.
(2009). Meta-analysis: {beta}-Blocker Dose, Heart Rate Reduction, and Death in Patients With Heart Failure. ANN INTERN MED
150: 784-794
[Abstract][Full Text]
Vilardaga, J.-P., Bunemann, M., Feinstein, T. N., Lambert, N., Nikolaev, V. O., Engelhardt, S., Lohse, M. J., Hoffmann, C.
(2009). Minireview: GPCR and G Proteins: Drug Efficacy and Activation in Live Cells. Mol. Endocrinol.
23: 590-599
[Abstract][Full Text]
Hunt, S. A., Abraham, W. T., Chin, M. H., Feldman, A. M., Francis, G. S., Ganiats, T. G., Jessup, M., Konstam, M. A., Mancini, D. M., Michl, K., Oates, J. A., Rahko, P. S., Silver, M. A., Stevenson, L. W., Yancy, C. W.
(2009). 2009 Focused Update Incorporated Into the ACC/AHA 2005 Guidelines for the Diagnosis and Management of Heart Failure in Adults: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines Developed in Collaboration With the International Society for Heart and Lung Transplantation. J Am Coll Cardiol
53: e1-e90
[Full Text]
Jessup, M., Abraham, W. T., Casey, D. E., Feldman, A. M., Francis, G. S., Ganiats, T. G., Konstam, M. A., Mancini, D. M., Rahko, P. S., Silver, M. A., Stevenson, L. W., Yancy, C. W.
(2009). 2009 Focused Update: ACCF/AHA Guidelines for the Diagnosis and Management of Heart Failure in Adults: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines Developed in Collaboration With the International Society for Heart and Lung Transplantation. J Am Coll Cardiol
53: 1343-1382
[Full Text]
2009 WRITING GROUP TO REVIEW NEW EVIDENCE AND UPDA, , Jessup, M., Abraham, W. T., Casey, D. E., Feldman, A. M., Francis, G. S., Ganiats, T. G., Konstam, M. A., Mancini, D. M., Rahko, P. S., Silver, M. A., Stevenson, L. W., Yancy, C. W.
(2009). 2009 Focused Update: ACCF/AHA Guidelines for the Diagnosis and Management of Heart Failure in Adults: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines: Developed in Collaboration With the International Society for Heart and Lung Transplantation. Circulation
119: 1977-2016
[Full Text]
2005 WRITING COMMITTEE MEMBERS, , Hunt, S. A., Abraham, W. T., Chin, M. H., Feldman, A. M., Francis, G. S., Ganiats, T. G., Jessup, M., Konstam, M. A., Mancini, D. M., Michl, K., Oates, J. A., Rahko, P. S., Silver, M. A., Stevenson, L. W., Yancy, C. W.
(2009). 2009 Focused Update Incorporated Into the ACC/AHA 2005 Guidelines for the Diagnosis and Management of Heart Failure in Adults: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines: Developed in Collaboration With the International Society for Heart and Lung Transplantation. Circulation
119: e391-e479
[Full Text]
Kim, E. S.H., Menon, V.
(2009). Status of Women in Cardiovascular Clinical Trials. Arterioscler. Thromb. Vasc. Bio.
29: 279-283
[Full Text]
Willenheimer, R.
(2009). The current role of beta-blockers in chronic heart failure: with special emphasis on the CIBIS III trial. Eur Heart J Suppl
11: A15-A20
[Abstract][Full Text]
Go, A. S., Yang, J., Gurwitz, J. H., Hsu, J., Lane, K., Platt, R.
(2008). Comparative Effectiveness of Different {beta}-Adrenergic Antagonists on Mortality Among Adults With Heart Failure in Clinical Practice. Arch Intern Med
168: 2415-2421
[Abstract][Full Text]
Rosskopf, D., Michel, M. C.
(2008). Pharmacogenomics of G Protein-Coupled Receptor Ligands in Cardiovascular Medicine. Pharmacol. Rev.
60: 513-535
[Abstract][Full Text]
Authors/Task Force Members, , Dickstein, K., Cohen-Solal, A., Filippatos, G., McMurray, J. J.V., Ponikowski, P., Poole-Wilson, P. A., Stromberg, A., van Veldhuisen, D. J., Atar, D., Hoes, A. W., Keren, A., Mebazaa, A., Nieminen, M., Priori, S. G., Swedberg, K., ESC Committee for Practice Guidelines (CPG), , Vahanian, A., Camm, J., De Caterina, R., Dean, V., Dickstein, K., Filippatos, G., Funck-Brentano, C., Hellemans, I., Kristensen, S. D., McGregor, K., Sechtem, U., Silber, S., Tendera, M., Widimsky, P., Zamorano, J. L., Document Reviewers, , Tendera, M., Auricchio, A., Bax, J., Bohm, M., Corra, U., della Bella, P., Elliott, P. M., Follath, F., Gheorghiade, M., Hasin, Y., Hernborg, A., Jaarsma, T., Komajda, M., Kornowski, R., Piepoli, M., Prendergast, B., Tavazzi, L., Vachiery, J.-L., Verheugt, F. W. A., Zamorano, J. L., Zannad, F.
(2008). ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2008 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association of the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM). Eur Heart J
29: 2388-2442
[Full Text]
Dickstein, K., Cohen-Solal, A., Filippatos, G., McMurray, J. J.V., Ponikowski, P., Poole-Wilson, P. A., Stromberg, A., van Veldhuisen, D. J., Atar, D., Hoes, A. W., Keren, A., Mebazaa, A., Nieminen, M., Priori, S. G., Swedberg, K.
(2008). ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2008 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association of the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM). Eur J Heart Fail
10: 933-989
[Full Text]
Gohler, A., Conrads-Frank, A., Worrell, S. S., Geisler, B. P., Halpern, E. F., Dietz, R., Anker, S. D., Gazelle, G. S., Siebert, U.
(2008). Decision-analytic evaluation of the clinical effectiveness and cost-effectiveness of management programmes in chronic heart failure. Eur J Heart Fail
10: 1026-1032
[Abstract][Full Text]
Johnson, J. A.
(2008). Ethnic Differences in Cardiovascular Drug Response: Potential Contribution of Pharmacogenetics. Circulation
118: 1383-1393
[Full Text]
Conen, D., Torres, J., Ridker, P. M
(2008). Differential Citation Rates of Major Cardiovascular Clinical Trials According to Source of Funding: A Survey From 2000 to 2005. Circulation
118: 1321-1327
[Abstract][Full Text]
Fonarow, G. C., Yancy, C. W., Albert, N. M., Curtis, A. B., Stough, W. G., Gheorghiade, M., Heywood, J. T., McBride, M. L., Mehra, M. R., O'Connor, C. M., Reynolds, D., Walsh, M. N.
(2008). Heart Failure Care in the Outpatient Cardiology Practice Setting: Findings From IMPROVE HF. Circ Heart Fail
1: 98-106
[Abstract][Full Text]
Prisant, L. M., Thomas, K. L., Lewis, E. F., Huang, Z., Francis, G. S., Weaver, W. D., Pfeffer, M. A., McMurray, J. J.V., Califf, R. M., Velazquez, E. J.
(2008). Racial Analysis of Patients With Myocardial Infarction Complicated by Heart Failure and/or Left Ventricular Dysfunction Treated With Valsartan, Captopril, or Both. J Am Coll Cardiol
51: 1865-1871
[Abstract][Full Text]
Vittorio, T. J., Zolty, R., Kasper, M. E., Khandwalla, R. M., Hirsh, D. S., Tseng, C.-H., Jorde, U. P., Ahuja, K.
(2008). Differential Effects of Carvedilol and Metoprolol Succinate on Plasma Norepinephrine Release and Peak Exercise Heart Rate in Subjects With Chronic Heart Failure. J CARDIOVASC PHARMACOL THER
13: 51-57
[Abstract]
Fantoni, C., Regoli, F., Ghanem, A., Raffa, S., Klersy, C., Sorgente, A., Faletra, F., Baravelli, M., Inglese, L., Salerno-Uriarte, J. A., Klein, H. U., Moccetti, T., Auricchio, A.
(2008). Long-term outcome in diabetic heart failure patients treated with cardiac resynchronization therapy. Eur J Heart Fail
10: 298-307
[Abstract][Full Text]
Granger, C. B
(2007). Carvedilol was more effective than metoprolol for preventing cardiovascular events in heart failure. Evid. Based Med.
12: 141-141
[Full Text]
Lunkenheimer, P. P., Redmann, K., Cryer, C. W., Batista, R. V., Stanton, J. J., Niederer, P., Anderson, R. H.
(2007). Beta-blockade at low doses restoring the physiological balance in myocytic antagonism. Eur. J. Cardiothorac. Surg.
32: 225-230
[Abstract][Full Text]
Patel, J., Heywood, J. T.
(2007). Mode of Death in Patients With Systolic Heart Failure. J CARDIOVASC PHARMACOL THER
12: 127-136
[Abstract]
Momary, K. M.
(2007). Cardiovascular Pharmacogenomics. Journal of Pharmacy Practice
20: 265-276
[Abstract]
Ong, H T
(2007). beta blockers in hypertension and cardiovascular disease. BMJ
334: 946-949
[Full Text]
Taylor, M. R.G., Slavov, D., Ku, L., Di Lenarda, A., Sinagra, G., Carniel, E., Haubold, K., Boucek, M. M., Ferguson, D., Graw, S. L., Zhu, X., Cavanaugh, J., Sucharov, C. C., Long, C. S., Bristow, M. R., Lavori, P., Mestroni, L., for the Familial Cardiomyopathy Registry and the B,
(2007). Prevalence of Desmin Mutations in Dilated Cardiomyopathy. Circulation
115: 1244-1251
[Abstract][Full Text]
Nasr, I. A., Bouzamondo, A., Hulot, J.-S., Dubourg, O., Le Heuzey, J.-Y., Lechat, P.
(2007). Prevention of atrial fibrillation onset by beta-blocker treatment in heart failure: a meta-analysis. Eur Heart J
0: ehl484v1-6
[Abstract][Full Text]
Bibbins-Domingo, K., Fernandez, A.
(2007). BiDil for Heart Failure in Black Patients: Implications of the U.S. Food and Drug Administration Approval. ANN INTERN MED
146: 52-56
[Abstract][Full Text]
Dzau, V. J., Antman, E. M., Black, H. R., Hayes, D. L., Manson, J. E., Plutzky, J., Popma, J. J., Stevenson, W.
(2006). The Cardiovascular Disease Continuum Validated: Clinical Evidence of Improved Patient Outcomes: Part II: Clinical Trial Evidence (Acute Coronary Syndromes Through Renal Disease) and Future Directions. Circulation
114: 2871-2891
[Full Text]
Gheorghiade, M., Sopko, G., De Luca, L., Velazquez, E. J., Parker, J. D., Binkley, P. F., Sadowski, Z., Golba, K. S., Prior, D. L., Rouleau, J. L., Bonow, R. O.
(2006). Navigating the Crossroads of Coronary Artery Disease and Heart Failure. Circulation
114: 1202-1213
[Full Text]
Groban, L., Butterworth, J.
(2006). Perioperative management of chronic heart failure.. Anesth. Analg.
103: 557-575
[Abstract][Full Text]
Liggett, S. B., Mialet-Perez, J., Thaneemit-Chen, S., Weber, S. A., Greene, S. M., Hodne, D., Nelson, B., Morrison, J., Domanski, M. J., Wagoner, L. E., Abraham, W. T., Anderson, J. L., Carlquist, J. F., Krause-Steinrauf, H. J., Lazzeroni, L. C., Port, J. D., Lavori, P. W., Bristow, M. R.
(2006). A polymorphism within a conserved beta1-adrenergic receptor motif alters cardiac function and beta-blocker response in human heart failure. Proc. Natl. Acad. Sci. USA
103: 11288-11293
[Abstract][Full Text]
Ahmed, A., Aban, I. B., Weaver, M. T., Aronow, W. S., Fleg, J. L.
(2006). Serum digoxin concentration and outcomes in women with heart failure: A bi-directional effect and a possible effect modification by ejection fraction. Eur J Heart Fail
8: 409-419
[Abstract][Full Text]
Lechat, P.
(2006). The evolution of heart failure management over recent decades: from CONSENSUS to CIBIS. Eur Heart J Suppl
8: C5-C12
[Abstract][Full Text]
Funck-Brentano, C.
(2006). Beta-blockade in CHF: from contraindication to indication. Eur Heart J Suppl
8: C19-C27
[Abstract][Full Text]
Vanoli, E., Adamson, P. B.
(2006). What does the future hold for the management of chronic heart failure?. Eur Heart J Suppl
8: C51-C57
[Abstract][Full Text]
Brady, A J B, Poole-Wilson, P A
(2006). ESC-CHF: guidelines for the aspirational and the practical.. Heart
92: 437-440
[Abstract][Full Text]
Pleger, S. T., Koch, W. J.
(2006). The yin and yang of increased beta-adrenergic signaling: beta1-adrenergic genetic polymorphism and protection against acute myocardial ischemic injury. Am. J. Physiol. Heart Circ. Physiol.
290: H1408-H1409
[Full Text]
Gillespie, N. D
(2006). The diagnosis and management of chronic heart failure in the older patient. Br Med Bull
75-76: 49-62
[Abstract][Full Text]
Taylor, A. L., Wright, J. T. Jr, Cooper, R. S., Psaty, B. M., Taylor, A. L., Wright, J. T. Jr, Cooper, R. S., Psaty, B. M.
(2005). Importance of Race/Ethnicity in Clinical Trials: Lessons From the African-American Heart Failure Trial (A-HeFT), the African-American Study of Kidney Disease and Hypertension (AASK), and the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). Circulation
112: 3654-3666
[Full Text]
Jost, A., Rauch, B., Hochadel, M., Winkler, R., Schneider, S., Jacobs, M., Kilkowski, C., Kilkowski, A., Lorenz, H., Muth, K., Zugck, C., Remppis, A., Haass, M., Senges, J., for the HELUMA study group,
(2005). Beta-blocker treatment of chronic systolic heart failure improves prognosis even in patients meeting one or more exclusion criteria of the MERIT-HF study. Eur Heart J
26: 2689-2697
[Abstract][Full Text]
Cohen-Solal, A., Rouzet, F., Berdeaux, A., Le Guludec, D., Abergel, E., Syrota, A., Merlet, P.
(2005). Effects of Carvedilol on Myocardial Sympathetic Innervation in Patients with Chronic Heart Failure. JNM
46: 1796-1803
[Abstract][Full Text]
Krum, H., Haas, S. J., Eichhorn, E., Ghali, J., Gilbert, E., Lechat, P., Packer, M., Roecker, E., Verkenne, P., Wedel, H., Wikstrand, J.
(2005). Prognostic benefit of beta-blockers in patients not receiving ACE-Inhibitors. Eur Heart J
26: 2154-2158
[Abstract][Full Text]
Singh, B. N.
(2005). {beta}-Adrenergic Blockers as Antiarrhythmic and Antifibrillatory Compounds: An Overview. J CARDIOVASC PHARMACOL THER
10: S3-S14
[Abstract]
Reiffel, J. A.
(2005). Drug and Drug-Device Therapy in Heart Failure Patients in the Post-COMET and SCD-HeFT Era. J CARDIOVASC PHARMACOL THER
10: S45-S58
[Abstract]
Developed in Collaboration With the American Colle, , Endorsed by the Heart Rhythm Society, , Hunt, S. A., Abraham, W. T., Chin, M. H., Feldman, A. M., Francis, G. S., Ganiats, T. G., Jessup, M., Konstam, M. A., Mancini, D. M., Michl, K., Oates, J. A., Rahko, P. S., Silver, M. A., Stevenson, L. W., Yancy, C. W., Antman, E. M., Smith, S. C. Jr, Adams, C. D., Anderson, J. L., Faxon, D. P., Fuster, V., Halperin, J. L., Hiratzka, L. F., Hunt, S. A., Jacobs, A. K., Nishimura, R., Ornato, J. P., Page, R. L., Riegel, B.
(2005). ACC/AHA 2005 Guideline Update for the Diagnosis and Management of Chronic Heart Failure in the Adult--Summary Article: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Update the 2001 Guidelines for the Evaluation and Management of Heart Failure). J Am Coll Cardiol
46: 1116-1143
[Full Text]
Hunt, S. A., Abraham, W. T., Chin, M. H., Feldman, A. M., Francis, G. S., Ganiats, T. G., Jessup, M., Konstam, M. A., Mancini, D. M., Michl, K., Oates, J. A., Rahko, P. S., Silver, M. A., Stevenson, L. W., Yancy, C. W., Antman, E. M., Smith, S. C. Jr, Adams, C. D., Anderson, J. L., Faxon, D. P., Fuster, V., Halperin, J. L., Hiratzka, L. F., Hunt, S. A., Jacobs, A. K., Nishimura, R., Ornato, J. P., Page, R. L., Riegel, B.
(2005). ACC/AHA 2005 Guideline Update for the Diagnosis and Management of Chronic Heart Failure in the Adult--Summary Article: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Update the 2001 Guidelines for the Evaluation and Management of Heart Failure): Developed in Collaboration With the American College of Chest Physicians and the International Society for Heart and Lung Transplantation: Endorsed by the Heart Rhythm Society. Circulation
112: 1825-1852
[Full Text]
Paterson, D. J.
(2005). Targeting Arterial Chemoreceptor Over-Activity in Heart Failure With a Gas. Circ. Res.
97: 201-203
[Full Text]
The National Heart, Lung, and Blood Institute Work,
(2005). Major Clinical Trials of Hypertension: What Should Be Done Next?. Hypertension
46: 1-6
[Abstract][Full Text]
Authors/Task Force Members, , Swedberg, K., Writing Committee:, , Cleland, J., Dargie, H., Drexler, H., Follath, F., Komajda, M., Tavazzi, L., Smiseth, O. A., Other Contributors, , Gavazzi, A., Haverich, A., Hoes, A., Jaarsma, T., Korewicki, J., Levy, S., Linde, C., Lopez-Sendon, J.-L., Nieminen, M. S., Pierard, L., Remme, W. J.
(2005). Guidelines for the diagnosis and treatment of chronic heart failure: executive summary (update 2005): The Task Force for the Diagnosis and Treatment of Chronic Heart Failure of the European Society of Cardiology. Eur Heart J
26: 1115-1140
[Full Text]
Al-Hesayen, A., Azevedo, E. R., Floras, J. S., Hollingshead, S., Lopaschuk, G. D., Parker, J. D.
(2005). Selective versus nonselective {beta}-adrenergic receptor blockade in chronic heart failure: differential effects on myocardial energy substrate utilization. Eur J Heart Fail
7: 618-623
[Abstract][Full Text]
Mann, D. L., Bristow, M. R.
(2005). Mechanisms and Models in Heart Failure: The Biomechanical Model and Beyond. Circulation
111: 2837-2849
[Full Text]
Grayburn, P. A., Appleton, C. P., DeMaria, A. N., Greenberg, B., Lowes, B., Oh, J., Plehn, J. F., Rahko, P., St. John Sutton, M., Eichhorn, E. J., the BEST Trial Echocardiographic Substudy Investig,
(2005). Echocardiographic predictors of morbidity and mortality in patients with advanced heart failure: The Beta-blocker Evaluation of Survival Trial (BEST). J Am Coll Cardiol
45: 1064-1071
[Abstract][Full Text]
Yancy, C. W., Benjamin, E. J., Fabunmi, R. P., Bonow, R. O.
(2005). Discovering the Full Spectrum of Cardiovascular Disease: Minority Health Summit 2003: Executive Summary. Circulation
111: 1339-1349
[Full Text]
Flather, M. D., Shibata, M. C., Coats, A. J.S., Van Veldhuisen, D. J., Parkhomenko, A., Borbola, J., Cohen-Solal, A., Dumitrascu, D., Ferrari, R., Lechat, P., Soler-Soler, J., Tavazzi, L., Spinarova, L., Toman, J., Bohm, M., Anker, S. D., Thompson, S. G., Poole-Wilson, P. A., on behalf of the SENIORS Investigators,
(2005). Randomized trial to determine the effect of nebivolol on mortality and cardiovascular hospital admission in elderly patients with heart failure (SENIORS). Eur Heart J
26: 215-225
[Abstract][Full Text]
McMurray, J.
(2005). Making sense of SENIORS. Eur Heart J
26: 203-206
[Full Text]
Yan, A. T., Yan, R. T., Liu, P. P.
(2005). Narrative Review: Pharmacotherapy for Chronic Heart Failure: Evidence from Recent Clinical Trials. ANN INTERN MED
142: 132-145
[Abstract][Full Text]
McMurray, J. J.V., Pfeffer, M. A.
(2004). The year in heart failure. J Am Coll Cardiol
44: 2398-2405
[Full Text]
Lalukota, K., Cleland, J. G.F., Ingle, L., Clark, A. L., Coletta, A. P.
(2004). Clinical trials update from the Heart Failure Society of America: EMOTE, HERB-CHF, BEST genetic sub-study and RHYTHM-ICD. Eur J Heart Fail
6: 953-955
[Abstract][Full Text]
Ghali, J. K.
(2004). Cerebroprotection mediated by angiotensin II. J Am Coll Cardiol
44: 2097-2097
[Full Text]
Taylor, A. L., Ziesche, S., Yancy, C., Carson, P., D'Agostino, R. Jr., Ferdinand, K., Taylor, M., Adams, K., Sabolinski, M., Worcel, M., Cohn, J. N., the African-American Heart Failure Trial Investiga,
(2004). Combination of Isosorbide Dinitrate and Hydralazine in Blacks with Heart Failure. NEJM
351: 2049-2057
[Abstract][Full Text]
Tomaselli, G. F., Zipes, D. P.
(2004). What Causes Sudden Death in Heart Failure?. Circ. Res.
95: 754-763
[Abstract][Full Text]
Satwani, S., Dec, G. W., Narula, J.
(2004). {beta}-Adrenergic Blockers in Heart Failure: Review of Mechanisms of Action and Clinical Outcomes. J CARDIOVASC PHARMACOL THER
9: 243-255
[Abstract]
Cleland, J. G.F., Loh, P. H., Freemantle, N., Clark, A. L., Coletta, A. P.
(2004). Clinical trials update from the European Society of Cardiology: SENIORS, ACES, PROVE-IT, ACTION, and the HF-ACTION trial. Eur J Heart Fail
6: 787-791
[Abstract][Full Text]
Bristow, M.R., Krause-Steinrauf, H., Nuzzo, R., Liang, C.-S., Lindenfeld, J., Lowes, B.D., Hattler, B., Abraham, W.T., Olson, L., Krueger, S., Thaneemit-Chen, S., Hare, J.M., Loeb, H.S., Domanski, M.J., Eichhorn, E.J., Zelis, R., Lavori, P.
(2004). Effect of Baseline or Changes in Adrenergic Activity on Clinical Outcomes in the {beta}-Blocker Evaluation of Survival Trial. Circulation
110: 1437-1442
[Abstract][Full Text]
Nichol, G., Kaul, P., Huszti, E., Bridges, J. F.P.
(2004). Cost-Effectiveness of Cardiac Resynchronization Therapy in Patients with Symptomatic Heart Failure. ANN INTERN MED
141: 343-351
[Abstract][Full Text]
Task Force Members, , Lopez-Sendo, J., Swedberg, K., McMurray, J., Tamargo, J., Maggioni, A. P., Dargie, H., Tendera, M., Waagstein, F., Kjekshus, J., Lechat, P., Pedersen, C. T., ESC Committee for Practice Guidelines, , Priori, S. G., Alonso Garcia, M. A., Blanc, J.-J., Budaj, A., Cowie, M., Dean, V., Deckers, J., Fernandez Burgos, E., Lekakis, J., Lindahl, B., Mazzotta, G., McGregor, K., Morais, J., Oto, A., Smiseth, O. A., Document Reviewers, , Alonso Garcia, M. A., Ardissino, D., Avendano, C., Lundqvist, C. B., ment, D. C., Drexler, H., Ferrari, R., Fox, K. A., Julian, D., Kearney, P., Klein, W., ber, L. K., Mancia, G., Nieminen, M., Ruzyllo, W., Simoons, M., Thygesen, K., Tognoni, G., Tritto, I., Wallentin, L.
(2004). Expert consensus document on {beta}-adrenergic receptor blockers: The Task Force on Beta-Blockers of the European Society of Cardiology. Eur Heart J
25: 1341-1362
[Full Text]
Gluckman, T. J., Baranowski, B., Ashen, M. D., Henrikson, C. A., McAllister, M., Braunstein, J. B., Blumenthal, R. S.
(2004). A Practical and Evidence-Based Approach to Cardiovascular Disease Risk Reduction. Arch Intern Med
164: 1490-1500
[Abstract][Full Text]
Ko, D. T., Hebert, P. R., Coffey, C. S., Curtis, J. P., Foody, J. M., Sedrakyan, A., Krumholz, H. M.
(2004). Adverse Effects of {beta}-Blocker Therapy for Patients With Heart Failure: A Quantitative Overview of Randomized Trials. Arch Intern Med
164: 1389-1394
[Abstract][Full Text]
Zaugg, M., Schulz, C., Wacker, J., Schaub, M. C.
(2004). Sympatho-modulatory therapies in perioperative medicine. Br J Anaesth
93: 53-62
[Abstract][Full Text]
Jessup, M., Pina, I. L.
(2004). Is it important to examine gender differences in the epidemiology and outcome of severe heart failure?. J. Thorac. Cardiovasc. Surg.
127: 1247-1252
[Full Text]
Julius, S., Alderman, M. H., Beevers, G., Dahlof, B., Devereux, R. B., Douglas, J. G., Edelman, J. M., Harris, K. E., Kjeldsen, S. E., Nesbitt, S., Randall, O. S., Wright, J. T. Jr
(2004). Cardiovascular risk reduction in hypertensive black patients with left ventricular hypertrophy: The life study. J Am Coll Cardiol
43: 1047-1055
[Abstract][Full Text]
Sackner-Bernstein, J. D., Skopicki, H. A.
(2004). Racing away from bias. J Am Coll Cardiol
43: 785-786
[Full Text]
Metra, M., Nodari, S., Dei Cas, L.
(2004). Current guidelines in the pharmacological management of chronic heart failure. Journal of Renin-Angiotensin-Aldosterone System
5: S11-S16
[Abstract]
Ghali, J. K., Krause-Steinrauf, H. J., Adams, K. F. Jr, Khan, S. S., Rosenberg, Y. D., Yancy, C. W. Jr, Young, J. B., Goldman, S., Peberdy, M. A., Lindenfeld, J.
(2003). Gender differences in advanced heart failure: insights from the BEST study. J Am Coll Cardiol
42: 2128-2134
[Abstract][Full Text]
Baker, J. G., Hall, I. P., Hill, S. J.
(2003). Agonist and Inverse Agonist Actions of {beta}-Blockers at the Human {beta}2-Adrenoceptor Provide Evidence for Agonist-Directed Signaling. Mol. Pharmacol.
64: 1357-1369
[Abstract][Full Text]
Lohse, M. J., Engelhardt, S., Eschenhagen, T.
(2003). What Is the Role of {beta}-Adrenergic Signaling in Heart Failure?. Circ. Res.
93: 896-906
[Abstract][Full Text]
Eichhorn, E. J., Grayburn, P. A., Mayer, S. A., St John Sutton, M., Appleton, C., Plehn, J., Oh, J., Greenberg, B., DeMaria, A., Frantz, R., Krause-Steinrauf, H., for the BEST Investigators,
(2003). Myocardial Contractile Reserve by Dobutamine Stress Echocardiography Predicts Improvement in Ejection Fraction With {beta}-Blockade in Patients With Heart Failure: The {beta}-Blocker Evaluation of Survival Trial (BEST). Circulation
108: 2336-2341
[Abstract][Full Text]
Bello, D., Shah, D. J., Farah, G. M., Di Luzio, S., Parker, M., Johnson, M. R., Cotts, W. G., Klocke, F. J., Bonow, R. O., Judd, R. M., Gheorghiade, M., Kim, R. J.
(2003). Gadolinium Cardiovascular Magnetic Resonance Predicts Reversible Myocardial Dysfunction and Remodeling in Patients With Heart Failure Undergoing {beta}-Blocker Therapy. Circulation
108: 1945-1953
[Abstract][Full Text]
Lindenfeld, J., Ghali, J. K., Krause-Steinrauf, H. J., Khan, S., Adams, K. Jr, Goldman, S., Peberdy, M. A., Yancy, C., Thaneemit-Chen, S., Larsen, R. L., Young, J., Lowes, B., Rosenberg, Y. D., BEST Investigators,
(2003). Hormone replacement therapy is associated with improved survival in women with advanced heart failure. J Am Coll Cardiol
42: 1238-1245
[Abstract][Full Text]
Petitti, D. B.
(2003). New hope for hormone replacement and the heart?. J Am Coll Cardiol
42: 1246-1248
[Full Text]
Toyama, T., Hoshizaki, H., Seki, R., Isobe, N., Adachi, H., Naito, S., Oshima, S., Taniguchi, K.
(2003). Efficacy of Carvedilol Treatment on Cardiac Function and Cardiac Sympathetic Nerve Activity in Patients with Dilated Cardiomyopathy: Comparison with Metoprolol Therapy. JNM
44: 1604-1611
[Abstract][Full Text]
Domanski, M., Krause-Steinrauf, H., Deedwania, P., Follmann, D., Ghali, J. K., Gilbert, E., Haffner, S., Katz, R., Lindenfeld, J., Lowes, B. D., Martin, W., McGrew, F., Bristow, M. R., BEST Investigators,
(2003). The effect of diabetes on outcomes of patients with advanced heart failure in the BEST trial. J Am Coll Cardiol
42: 914-922
[Abstract][Full Text]
Liang, C.-s.
(2003). Sympatholysis and cardiac sympathetic nerve function in the treatment of congestive heart failure. J Am Coll Cardiol
42: 549-551
[Full Text]
Maack, C., Bohm, M., Vlaskin, L., Dabew, E., Lorenz, K., Schafers, H.-J., Lohse, M. J., Engelhardt, S.
(2003). Partial Agonist Activity of Bucindolol Is Dependent on the Activation State of the Human {beta}1-Adrenergic Receptor. Circulation
108: 348-353
[Abstract][Full Text]
Bouzamondo, A., Hulot, J.-S., Sanchez, P., Lechat, P.
(2003). Beta-blocker benefit according to severity of heart failure. Eur J Heart Fail
5: 281-289
[Abstract][Full Text]
Baker, J. G., Hall, I. P., Hill, S. J.
(2003). Agonist Actions of "{beta}-Blockers" Provide Evidence for Two Agonist Activation Sites or Conformations of the Human {beta}1-Adrenoceptor. Mol. Pharmacol.
63: 1312-1321
[Abstract][Full Text]
Nohria, A., Tsang, S. W., Fang, J. C., Lewis, E. F., Jarcho, J. A., Mudge, G. H., Stevenson, L. W.
(2003). Clinical assessment identifies hemodynamic profiles that predict outcomes in patients admitted with heart failure. J Am Coll Cardiol
41: 1797-1804
[Abstract][Full Text]
Shekelle, P. G., Rich, M. W., Morton, S. C., Atkinson, Col. S. W., Tu, W., Maglione, M., Rhodes, S., Barrett, M., Fonarow, G. C., Greenberg, B., Heidenreich, P. A., Knabel, T., Konstam, M. A., Steimle, A., Warner Stevenson, L.
(2003). Efficacy of angiotensin-converting enzyme inhibitors and beta-blockers in the management of left ventricular systolic dysfunction according to race, gender, and diabetic status: A meta-analysis of major clinical trials. J Am Coll Cardiol
41: 1529-1538
[Abstract][Full Text]