The Prognostic Value of B-Type Natriuretic Peptide in Patients with Acute Coronary Syndromes

doi:10.1056/NEJMoa011053

Volume 345:1014-1021		October 4, 2001		Number 14

The Prognostic Value of B-Type Natriuretic Peptide in Patients with Acute Coronary Syndromes

James A. de Lemos, M.D., David A. Morrow, M.D., M.P.H., Jane H. Bentley, B.Sc., Torbjorn Omland, M.D., Ph.D., M.P.H., Marc S. Sabatine, M.D., Carolyn H. McCabe, B.S., Christian Hall, M.D., Ph.D., Christopher P. Cannon, M.D., and Eugene Braunwald, M.D.

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by Rabbani, L. E.

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ABSTRACT

Background Brain (B-type) natriuretic peptide is a neurohormonesynthesized predominantly in ventricular myocardium. Althoughthe circulating level of this neurohormone has been shown toprovide independent prognostic information in patients withtransmural myocardial infarction, few data are available forpatients with acute coronary syndromes in the absence of ST-segmentelevation.

Methods We measured B-type natriuretic peptide in plasma specimensobtained a mean (±SD) of 40±20 hours after theonset of ischemic symptoms in 2525 patients from the Orbofibanin Patients with Unstable Coronary Syndromes–Thrombolysisin Myocardial Infarction 16 study.

Results The base-line level of B-type natriuretic peptide wascorrelated with the risk of death, heart failure, and myocardialinfarction at 30 days and 10 months. The unadjusted rate ofdeath increased in a stepwise fashion among patients in increasingquartiles of base-line B-type natriuretic peptide levels (P<0.001).This association remained significant in subgroups of patientswho had myocardial infarction with ST-segment elevation (P=0.02),patients who had myocardial infarction without ST-segment elevation(P<0.001), and patients who had unstable angina (P<0.001).After adjustment for independent predictors of the long-termrisk of death, the odds ratios for death at 10 months in thesecond, third, and fourth quartiles of B-type natriuretic peptidewere 3.8 (95 percent confidence interval, 1.1 to 13.3), 4.0(95 percent confidence interval, 1.2 to 13.7), and 5.8 (95 percentconfidence interval, 1.7 to 19.7). The level of B-type natriureticpeptide was also associated with the risk of new or recurrentmyocardial infarction (P=0.01) and new or worsening heart failure(P<0.001) at 10 months.

Conclusions A single measurement of B-type natriuretic peptide,obtained in the first few days after the onset of ischemic symptoms,provides predictive information for use in risk stratificationacross the spectrum of acute coronary syndromes. Cardiac neurohormonalactivation may be a unifying feature among patients at highrisk for death after acute coronary syndromes.

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From the Thrombolysis in Myocardial Infarction Study Group, Boston (J.A.D., D.A.M., M.S.S., C.H.M., C.P.C., E.B.); the Donald W. Reynolds Cardiovascular Clinical Research Center, University of Texas, Southwestern Medical School, Dallas (J.A.D.); the Cardiovascular Division and Department of Medicine, Brigham and Women's Hospital, Boston (D.A.M., M.S.S., C.H.M., C.P.C., E.B.); the Nottingham Clinical Research Group, Nottingham, United Kingdom (J.H.B.); and the Research Institute for Internal Medicine, National Hospital, University of Oslo, Oslo, Norway (T.O., C.H.).

Address reprint requests to Dr. de Lemos at UT Southwestern Medical Center, 5323 Harry Hines Blvd., Rm. CS7.142, Dallas, TX 75390-9047, or at james.delemos{at}utsouthwestern.edu.

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Desai, A. S., Bibbins-Domingo, K., Shlipak, M. G., Wu, A. H.B., Ali, S., Whooley, M. A. (2007). Association between anaemia and N-terminal pro-B-type natriuretic peptide (NT-proBNP): Findings from the Heart and Soul Study. Eur J Heart Fail 9: 886-891 [Abstract] [Full Text]
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Mueller, C. (2007). The Use of B-Type Natriuretic Peptides in Coronary Artery Disease: Utile or Futile?. J Am Coll Cardiol 50: 215-216 [Full Text]
Omland, T., Sabatine, M. S., Jablonski, K. A., Rice, M. M., Hsia, J., Wergeland, R., Landaas, S., Rouleau, J. L., Domanski, M. J., Hall, C., Pfeffer, M. A., Braunwald, E., for the PEACE Investigators, (2007). Prognostic Value of B-Type Natriuretic Peptides in Patients With Stable Coronary Artery Disease: The PEACE Trial. J Am Coll Cardiol 50: 205-214 [Abstract] [Full Text]
Struthers, A., Lang, C. (2007). The potential to improve primary prevention in the future by using BNP/N-BNP as an indicator of silent 'pancardiac' target organ damage: BNP/N-BNP could become for the heart what microalbuminuria is for the kidney. Eur Heart J 28: 1678-1682 [Abstract] [Full Text]
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McClure, S. J., Gall, S., Schechter, C. B., Kearney, M., Zaman, A. G. (2007). Percutaneous Coronary Revascularization Reduces Plasma N-Terminal Pro-B-Type Natriuretic Peptide Concentration in Stable Coronary Artery Disease. J Am Coll Cardiol 49: 2394-2397 [Abstract] [Full Text]
Shadman, R., Allison, M. A., Criqui, M. H. (2007). Glomerular Filtration Rate and N-Terminal Pro-Brain Natriuretic Peptide as Predictors of Cardiovascular Mortality in Vascular Patients. J Am Coll Cardiol 49: 2172-2181 [Abstract] [Full Text]
Ahmed, W., Zafar, S., Alam, A. Y., Ahktar, N., Shah, M. A., Alpert, M. A. (2007). Plasma Levels of B-Type Natriuretic Peptide in Patients With Unstable Angina Pectoris or Acute Myocardial Infarction: Prognostic Significance and Therapeutic Implications. ANGIOLOGY 58: 269-274 [Abstract]
Marz, W., Tiran, B., Seelhorst, U., Wellnitz, B., Bauersachs, J., Winkelmann, B. R., Boehm, B. O. (2007). N-Terminal Pro-B-Type Natriuretic Peptide Predicts Total and Cardiovascular Mortality in Individuals with or without Stable Coronary Artery Disease: The Ludwigshafen Risk and Cardiovascular Health Study. Clin. Chem. 53: 1075-1083 [Abstract] [Full Text]
Fonarow, G. C., Peacock, W. F., Phillips, C. O., Givertz, M. M., Lopatin, M., for the ADHERE Scientific Advisory Committee and I, (2007). Admission B-Type Natriuretic Peptide Levels and In-Hospital Mortality in Acute Decompensated Heart Failure. J Am Coll Cardiol 49: 1943-1950 [Abstract] [Full Text]
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Lorgis, L., Zeller, M., Dentan, G., Sicard, P., Jolak, M., L'Huillier, I., Vincent-Martin, M., Beer, J.C., Makki, H., Gambert, P., Cottin, Y., on behalf of the RICO survey working group, (2007). High levels of N-terminal pro B-type natriuretic peptide are associated with ST resolution failure after reperfusion for acute myocardial infarction. QJM 100: 211-216 [Abstract] [Full Text]
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Kwan, G., Isakson, S. R., Beede, J., Clopton, P., Maisel, A. S., Fitzgerald, R. L. (2007). Short-Term Serial Sampling of Natriuretic Peptides in Patients Presenting With Chest Pain. J Am Coll Cardiol 49: 1186-1192 [Abstract] [Full Text]
Liang, F., O'Rear, J., Schellenberger, U., Tai, L., Lasecki, M., Schreiner, G. F., Apple, F. S., Maisel, A. S., Pollitt, N. S., Protter, A. A. (2007). Evidence for Functional Heterogeneity of Circulating B-Type Natriuretic Peptide. J Am Coll Cardiol 49: 1071-1078 [Abstract] [Full Text]
Naegeli, B., Kurz, D. J., Koller, D., Straumann, E., Furrer, M., Maurer, D., Minder, E., Bertel, O. (2007). Single-chamber ventricular pacing increases markers of left ventricular dysfunction compared with dual-chamber pacing. Europace 9: 194-199 [Abstract] [Full Text]
Wollert, K. C., Kempf, T., Peter, T., Olofsson, S., James, S., Johnston, N., Lindahl, B., Horn-Wichmann, R., Brabant, G., Simoons, M. L., Armstrong, P. W., Califf, R. M., Drexler, H., Wallentin, L. (2007). Prognostic Value of Growth-Differentiation Factor-15 in Patients With Non-ST-Elevation Acute Coronary Syndrome. Circulation 115: 962-971 [Abstract] [Full Text]
Bibbins-Domingo, K., Gupta, R., Na, B., Wu, A. H. B., Schiller, N. B., Whooley, M. A. (2007). N-Terminal Fragment of the Prohormone Brain-Type Natriuretic Peptide (NT-proBNP), Cardiovascular Events, and Mortality in Patients With Stable Coronary Heart Disease. JAMA 297: 169-176 [Abstract] [Full Text]
Konstam, M. A. (2007). Natriuretic Peptides and Cardiovascular Events: More Than a Stretch. JAMA 297: 212-214 [Full Text]
Chang, A. Y., Abdullah, S. M., Jain, T., Stanek, H. G., Das, S. R., McGuire, D. K., Auchus, R. J., de Lemos, J. A. (2007). Associations Among Androgens, Estrogens, and Natriuretic Peptides in Young Women: Observations From the Dallas Heart Study. J Am Coll Cardiol 49: 109-116 [Abstract] [Full Text]
Ben-Dor, I., Haim, M., Rechavia, E., Murninkas, D., Harell, D., Porter, A., Iakobishvili, Z., Battler, A., Hasdai, D. (2007). Serum NT-proBNP Concentrations in the Early Phase Do Not Predict the Severity of Systolic or Diastolic Left Ventricular Dysfunction Among Patients With ST-Elevation Acute Myocardial Infarction. ANGIOLOGY 57: 686-693 [Abstract]
de Lemos, J. A. (2006). The Latest and Greatest New Biomarkers: Which Ones Should We Measure for Risk Prediction in Our Practice?. Arch Intern Med 166: 2428-2430 [Full Text]
Rothenbacher, D., Koenig, W., Brenner, H. (2006). Comparison of N-Terminal Pro-B-Natriuretic Peptide, C-Reactive Protein, and Creatinine Clearance for Prognosis in Patients With Known Coronary Heart Disease. Arch Intern Med 166: 2455-2460 [Abstract] [Full Text]
Whalley, G A, Gamble, G D, Doughty, R N (2006). Restrictive diastolic filling predicts death after acute myocardial infarction: systematic review and meta-analysis of prospective studies. Heart 92: 1588-1594 [Abstract] [Full Text]
James, S. K., Lindback, J., Tilly, J., Siegbahn, A., Venge, P., Armstrong, P., Califf, R., Simoons, M. L., Wallentin, L., Lindahl, B. (2006). Troponin-T and N-Terminal Pro-B-Type Natriuretic Peptide Predict Mortality Benefit From Coronary Revascularization in Acute Coronary Syndromes: A GUSTO-IV Substudy. J Am Coll Cardiol 48: 1146-1154 [Abstract] [Full Text]
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O'Donoghue, M., de Lemos, J. A., Morrow, D. A., Murphy, S. A., Buros, J. L., Cannon, C. P., Sabatine, M. S. (2006). Prognostic Utility of Heart-Type Fatty Acid Binding Protein in Patients With Acute Coronary Syndromes. Circulation 114: 550-557 [Abstract] [Full Text]
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Giugliano, R. P., Braunwald, E. (2006). The Year in Non-ST-Segment Elevation Acute Coronary Syndromes. J Am Coll Cardiol 48: 386-395 [Full Text]
Kistorp, C. (2006). Risk Stratification in Secondary Prevention: Advances in Multimarker Profiles, or Back to Basics?. Circulation 114: 184-186 [Full Text]
Blankenberg, S., McQueen, M. J., Smieja, M., Pogue, J., Balion, C., Lonn, E., Rupprecht, H. J., Bickel, C., Tiret, L., Cambien, F., Gerstein, H., Munzel, T., Yusuf, S., for the HOPE Study Investigators, (2006). Comparative Impact of Multiple Biomarkers and N-Terminal Pro-Brain Natriuretic Peptide in the Context of Conventional Risk Factors for the Prediction of Recurrent Cardiovascular Events in the Heart Outcomes Prevention Evaluation (HOPE) Study. Circulation 114: 201-208 [Abstract] [Full Text]
Rana, B S, Davies, J I, Band, M M, Pringle, S D, Morris, A, Struthers, A D (2006). B-type natriuretic peptide can detect silent myocardial ischaemia in asymptomatic type 2 diabetes. Heart 92: 916-920 [Abstract] [Full Text]
Koenig, W., Twardella, D., Brenner, H., Rothenbacher, D. (2006). Lipoprotein-Associated Phospholipase A2 Predicts Future Cardiovascular Events in Patients With Coronary Heart Disease Independently of Traditional Risk Factors, Markers of Inflammation, Renal Function, and Hemodynamic Stress. Arterioscler. Thromb. Vasc. Bio. 26: 1586-1593 [Abstract] [Full Text]
Hammerer-Lercher, A., Geiger, R., Mair, J., Url, C., Tulzer, G., Lechner, E., Puschendorf, B., Sommer, R. (2006). Utility of N-Terminal Pro-B-Type Natriuretic Peptide to Differentiate Cardiac Diseases from Noncardiac Diseases in Young Pediatric Patients. Clin. Chem. 52: 1415-1419 [Abstract] [Full Text]

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