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Previous Volume 346:731-737 March 7, 2002 Number 10 Next

	Full Text PDF PDA Full Text PowerPoint Slide Set Editorial by Mitchell, A. A. Letters Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

ABSTRACT

Background The increased risk of low birth weight associated with the use of assisted reproductive technology has been attributed largely to the higher rate of multiple gestations associated with such technology. It is uncertain, however, whether singleton infants conceived with the use of assisted reproductive technology may also have a higher risk of low birth weight than those who are conceived spontaneously.

Methods We used population-based data to compare the rates of low birth weight (2500 g) and very low birth weight (<1500 g) among infants conceived with assisted reproductive technology with the rates in the general population.

Results We studied 42,463 infants who were born in 1996 and 1997 and conceived with assisted reproductive technology and used as a comparison group 3,389,098 infants born in the United States in 1997. Among singleton infants born at 37 weeks of gestation or later, those conceived with assisted reproductive technology had a risk of low birth weight that was 2.6 times that in the general population (95 percent confidence interval, 2.4 to 2.7). The use of assisted reproductive technology was associated with an increased rate of multiple gestations; however, its use was not associated with a further increase in the risk of low birth weight in multiple births. Among twins, the ratio of the rate of low birth weight after the use of assisted reproductive technology to the rate in the general population was 1.0 (95 percent confidence interval, 1.0 to 1.1). Infants conceived with assisted reproductive technology accounted for 0.6 percent of all infants born to mothers who were 20 years of age or older in 1997, but for 3.5 percent of low-birth-weight and 4.3 percent of very-low-birth-weight infants.

Conclusions The use of assisted reproductive technology accounts for a disproportionate number of low-birth-weight and very-low-birth-weight infants in the United States, in part because of absolute increases in multiple gestations and in part because of higher rates of low birth weight among singleton infants conceived with this technology.

Source Information

From the Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta.

Address reprint requests to Dr. Schieve at the Division of Reproductive Health, Centers for Disease Control and Prevention, Mailstop K-34, 4770 Buford Hwy., NE, Atlanta, GA 30341, or at LJS9{at}cdc.gov.

Full Text of this Article

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Low and Very Low Birth Weight after Use of Assisted Reproductive Technology
Kovalevsky G., Coutifaris C., Davies M. J., Schieve L. A., Meikle S. F., Ferre C.
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N Engl J Med 2002; 347:1451-1452, Oct 31, 2002. Correspondence

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