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Previous Volume 346:738-746 March 7, 2002 Number 10 Next

	Full Text PDF PDA Full Text PowerPoint Slide Set Editorial by Abkowitz, J. L. Letters Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

ABSTRACT

Background Bone marrow contains stem cells with the potential to differentiate into mature cells of various organs. We determined whether circulating stem cells have a similar potential.

Methods Biopsy specimens from the liver, gastrointestinal tract, and skin were obtained from 12 patients who had undergone transplantation of hematopoietic stem cells from peripheral blood (11 patients) or bone marrow (1 patient). Six female patients had received transplants from a male donor. Five had received a sex-matched transplant, and one had received an autologous transplant. Hematopoietic stem-cell engraftment was verified by cytogenetic analysis or restriction-fragment–length polymorphism analysis. The biopsies were studied for the presence of donor-derived epithelial cells or hepatocytes with the use of fluorescence in situ hybridization of interphase nuclei and immunohistochemical staining for cytokeratin, CD45 (leukocyte common antigen), and a hepatocyte-specific antigen.

Results All six recipients of sex-mismatched transplants showed evidence of complete hematopoietic donor chimerism. XY-positive epithelial cells or hepatocytes accounted for 0 to 7 percent of the cells in histologic sections of the biopsy specimens. These cells were detected in liver tissue as early as day 13 and in skin tissue as late as day 354 after the transplantation of peripheral-blood stem cells. The presence of donor cells in the biopsy specimens did not seem to depend on the intensity of tissue damage induced by graft-versus-host disease.

Conclusions Circulating stem cells can differentiate into mature hepatocytes and epithelial cells of the skin and gastrointestinal tract.

Source Information

From the Departments of Blood and Marrow Transplantation (M.K., G.R., R.E.C.), Pathology (R.L.K., A.K., A.C.R.), Hematopathology (M.A.), and Bioimmunotherapy (Z.E.), University of Texas M.D. Anderson Cancer Center, Houston.

Address reprint requests to Dr. Körbling at the University of Texas M.D. Anderson Cancer Center, Department of Blood and Marrow Transplantation, Box 423, 1515 Holcombe Blvd., Houston, TX 77030, or at mkorblin{at}mdanderson.org.

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Related Letters:

Male Cells in Female Recipients of Hematopoietic-Cell Transplants
Brouard M., Barrandon Y., Stevens A.M., McDonnell W.M., Nelson J.L., Taussig D. C., Pearce D. J., Bonnet D. A., Kaygusuz A., Akarsu A. N., Tuncer A. M., Körbling M., Estrov Z.
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N Engl J Med 2002; 347:218-220, Jul 18, 2002. Correspondence

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