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Previous Volume 346:793-801 March 14, 2002 Number 11 Next

	Full Text PDF PDA Full Text PowerPoint Slide Set Editorial by Balady, G. J. Letters Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

ABSTRACT

Background Exercise capacity is known to be an important prognostic factor in patients with cardiovascular disease, but it is uncertain whether it predicts mortality equally well among healthy persons. There is also uncertainty regarding the predictive power of exercise capacity relative to other clinical and exercise-test variables.

Methods We studied a total of 6213 consecutive men referred for treadmill exercise testing for clinical reasons during a mean (±SD) of 6.2±3.7 years of follow-up. Subjects were classified into two groups: 3679 had an abnormal exercise-test result or a history of cardiovascular disease, or both, and 2534 had a normal exercise-test result and no history of cardiovascular disease. Overall mortality was the end point.

Results There were a total of 1256 deaths during the follow-up period, resulting in an average annual mortality of 2.6 percent. Men who died were older than those who survived and had a lower maximal heart rate, lower maximal systolic and diastolic blood pressure, and lower exercise capacity. After adjustment for age, the peak exercise capacity measured in metabolic equivalents (MET) was the strongest predictor of the risk of death among both normal subjects and those with cardiovascular disease. Absolute peak exercise capacity was a stronger predictor of the risk of death than the percentage of the age-predicted value achieved, and there was no interaction between the use or nonuse of beta-blockade and the predictive power of exercise capacity. Each 1-MET increase in exercise capacity conferred a 12 percent improvement in survival.

Conclusions Exercise capacity is a more powerful predictor of mortality among men than other established risk factors for cardiovascular disease.

Source Information

From the Division of Cardiovascular Medicine, Stanford University Medical Center and the Veterans Affairs Palo Alto Health Care System — both in Palo Alto, Calif.

Address reprint requests to Dr. Myers at the Cardiology Division (111C), Veterans Affairs Palo Alto Health Care System, 3081 Miranda Ave., Palo Alto, CA 94304, or at drj993{at}aol.com.

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Exercise Capacity and Mortality
Palatini P., Ko D. T., Hebert P. R., Krumholz H. M., Perlo D. H., Myers J., Froelicher V., Balady G. J.
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N Engl J Med 2002; 347:288-290, Jul 25, 2002. Correspondence

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• Bogaty, P., Noel, M., Poirier, P., Dagenais, G. R. (2008). Can prolonged exercise-induced myocardial ischaemia be innocuous? reply. Eur Heart J 29: 139-140 [Full Text]  
• Koch, L. G., Britton, S. L. (2008). Aerobic metabolism underlies complexity and capacity. J. Physiol. 586: 83-95 [Abstract] [Full Text]  
• Javaheri, S. (2007). Treatment of obstructive and central sleep apnoea in heart failure: practical options. ERR 16: 183-188 [Abstract] [Full Text]  
• Mota, J., Valente, M., Aires, L., Silva, P., Paula Santos, M., Ribeiro, J. C. (2007). Accelerometer cut-points and youth physical activity prevalence. European Physical Education Review 13: 287-299 [Abstract]  
• Nieminen, T., Lehtimaki, T., Viik, J., Lehtinen, R., Nikus, K., Koobi, T., Niemela, K., Turjanmaa, V., Kaiser, W., Huhtala, H., Verrier, R. L., Huikuri, H., Kahonen, M. (2007). T-wave alternans predicts mortality in a population undergoing a clinically indicated exercise test. Eur Heart J 28: 2332-2337 [Abstract] [Full Text]  
• Courneya, K. S., Segal, R. J., Mackey, J. R., Gelmon, K., Reid, R. D., Friedenreich, C. M., Ladha, A. B., Proulx, C., Vallance, J. K.H., Lane, K., Yasui, Y., McKenzie, D. C. (2007). Effects of Aerobic and Resistance Exercise in Breast Cancer Patients Receiving Adjuvant Chemotherapy: A Multicenter Randomized Controlled Trial. JCO 25: 4396-4404 [Abstract] [Full Text]  
• Ribisl, P. M., Lang, W., Jaramillo, S. A., Jakicic, J. M., Stewart, K. J., Bahnson, J., Bright, R., Curtis, J. F., Crow, R. S., Soberman, J. E., on behalf of the Look AHEAD Research Group, (2007). Exercise Capacity and Cardiovascular/Metabolic Characteristics of Overweight and Obese Individuals With Type 2 Diabetes: The Look AHEAD clinical trial. Diabetes Care 30: 2679-2684 [Abstract] [Full Text]  
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• Koch, L. G., Britton, S. L. (2007). Evolution, atmospheric oxygen, and complex disease. Physiol. Genomics 30: 205-208 [Abstract] [Full Text]  
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• Arena, R., Myers, J., Williams, M. A., Gulati, M., Kligfield, P., Balady, G. J., Collins, E., Fletcher, G. (2007). Assessment of Functional Capacity in Clinical and Research Settings: A Scientific Statement From the American Heart Association Committee on Exercise, Rehabilitation, and Prevention of the Council on Clinical Cardiology and the Council on Cardiovascular Nursing. Circulation 116: 329-343 [Full Text]  
• Perez, M., Mate-Munoz, J. L., Foster, C., Rubio, J. C., Andreu, A. L., Martin, M. A., Arenas, J., Lucia, A. (2007). Exercise Capacity in a Child With McArdle Disease. J Child Neurol 22: 880-882 [Abstract]  
• Lightfoot, J. T., Turner, M. J., Knab, A. K., Jedlicka, A. E., Oshimura, T., Marzec, J., Gladwell, W., Leamy, L. J., Kleeberger, S. R. (2007). Quantitative trait loci associated with maximal exercise endurance in mice. J. Appl. Physiol. 103: 105-110 [Abstract] [Full Text]  
• Wisloff, U., Stoylen, A., Loennechen, J. P., Bruvold, M., Rognmo, O., Haram, P. M., Tjonna, A. E., Helgerud, J., Slordahl, S. A., Lee, S. J., Videm, V., Bye, A., Smith, G. L., Najjar, S. M., Ellingsen, O., Skjaerpe, T. (2007). Superior Cardiovascular Effect of Aerobic Interval Training Versus Moderate Continuous Training in Heart Failure Patients: A Randomized Study. Circulation 115: 3086-3094 [Abstract] [Full Text]  
• Sui, X., LaMonte, M. J., Blair, S. N. (2007). Cardiorespiratory Fitness as a Predictor of Nonfatal Cardiovascular Events in Asymptomatic Women and Men. Am J Epidemiol 165: 1413-1423 [Abstract] [Full Text]  
• McAuley, P. A., Myers, J. N., Abella, J. P., Tan, S. Y., Froelicher, V. F. (2007). Exercise Capacity and Body Mass as Predictors of Mortality Among Male Veterans With Type 2 Diabetes. Diabetes Care 30: 1539-1543 [Abstract] [Full Text]  
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• Kullo, I. J., Khaleghi, M., Hensrud, D. D. (2007). Markers of inflammation are inversely associated with VO2 max in asymptomatic men. J. Appl. Physiol. 102: 1374-1379 [Abstract] [Full Text]  
• Ways, J. A., Smith, B. M., Barbato, J. C., Ramdath, R. S., Pettee, K. M., DeRaedt, S. J., Allison, D. C., Koch, L. G., Lee, S. J., Cicila, G. T. (2007). Congenic strains confirm aerobic running capacity quantitative trait loci on rat chromosome 16 and identify possible intermediate phenotypes. Physiol. Genomics 29: 91-97 [Abstract] [Full Text]  
• Ingul, C. B., Rozis, E., Slordahl, S. A., Marwick, T. H. (2007). Incremental Value of Strain Rate Imaging to Wall Motion Analysis for Prediction of Outcome in Patients Undergoing Dobutamine Stress Echocardiography. Circulation 115: 1252-1259 [Abstract] [Full Text]  
• Madamanchi, N. R., Runge, M. S. (2007). Mitochondrial Dysfunction in Atherosclerosis. Circ. Res. 100: 460-473 [Abstract] [Full Text]  
• Greenstone, C. L. (2007). A Commentary on Lifestyle Medicine Strategies for Risk Factor Reduction, Prevention, and Treatment of Coronary Artery Disease. AMERICAN JOURNAL OF LIFESTYLE MEDICINE 1: 91-94 [Abstract]  
• Redman, L. M., Heilbronn, L. K., Martin, C. K., Alfonso, A., Smith, S. R., Ravussin, E., for the Pennington CALERIE Team, (2007). Effect of Calorie Restriction with or without Exercise on Body Composition and Fat Distribution. J. Clin. Endocrinol. Metab. 92: 865-872 [Abstract] [Full Text]  
• Ruiz, J. R., Sola, R., Gonzalez-Gross, M., Ortega, F. B., Vicente-Rodriguez, G., Garcia-Fuentes, M., Gutierrez, A., Sjostrom, M., Pietrzik, K., Castillo, M. J. (2007). Cardiovascular Fitness Is Negatively Associated With Homocysteine Levels in Female Adolescents. Arch Pediatr Adolesc Med 161: 166-171 [Abstract] [Full Text]  
• Ignarro, L. J., Balestrieri, M. L., Napoli, C. (2007). Nutrition, physical activity, and cardiovascular disease: An update. Cardiovasc Res 73: 326-340 [Abstract] [Full Text]  
• Cohen, O., Basu, R., Bock, G., Dalla Man, C., Campioni, M., Basu, A., Toffolo, G., Cobelli, C., Rizza, R. A. (2006). Prediction of Postprandial Glycemic Exposure: Utility of fasting and 2-h glucose measurements alone and in combination with assessment of body composition, fitness, and strength. Diabetes Care 29: 2708-2713 [Abstract] [Full Text]  
• De Filippis, E., Cusi, K., Ocampo, G., Berria, R., Buck, S., Consoli, A., Mandarino, L. J. (2006). Exercise-Induced Improvement in Vasodilatory Function Accompanies Increased Insulin Sensitivity in Obesity and Type 2 Diabetes Mellitus. J. Clin. Endocrinol. Metab. 91: 4903-4910 [Abstract] [Full Text]  
• Rubio, J. C., Lucia, A., Fernandez-Cadenas, I., Cabello, A., Blazquez, A., Gamez, J., Andreu, A. L., Martin, M. A., Arenas, J. (2006). Novel Mutation in the PYGM Gene Resulting in McArdle Disease. Arch Neurol 63: 1782-1784 [Abstract] [Full Text]  
• Lujan, H. L., Britton, S. L., Koch, L. G., DiCarlo, S. E. (2006). Reduced susceptibility to ventricular tachyarrhythmias in rats selectively bred for high aerobic capacity. Am. J. Physiol. Heart Circ. Physiol. 291: H2933-H2941 [Abstract] [Full Text]  
• Kligfield, P., Lauer, M. S. (2006). Exercise Electrocardiogram Testing: Beyond the ST Segment. Circulation 114: 2070-2082 [Full Text]  
• Gonzalez, N. C., Kirkton, S. D., Howlett, R. A., Britton, S. L., Koch, L. G., Wagner, H. E., Wagner, P. D. (2006). Continued divergence in VO2 max of rats artificially selected for running endurance is mediated by greater convective blood O2 delivery. J. Appl. Physiol. 101: 1288-1296 [Abstract] [Full Text]  
• Armstrong, K., Rakhit, D., Jeffriess, L., Johnson, D., Leano, R., Prins, J., Garske, L., Marwick, T., Isbel, N. (2006). Cardiorespiratory Fitness Is Related to Physical Inactivity, Metabolic Risk Factors, and Atherosclerotic Burden in Glucose-Intolerant Renal Transplant Recipients. CJASN 1: 1275-1283 [Abstract] [Full Text]  
• Christensen, U., Schmidt, L., Budtz-Jorgensen, E., Avlund, K. (2006). Group Cohesion and Social Support in Exercise Classes: Results From a Danish Intervention Study. Health Educ Behav 33: 677-689 [Abstract]