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Previous Volume 346:1616-1622 May 23, 2002 Number 21 Next

	Full Text PDF PDA Full Text PowerPoint Slide Set Editorial by Haber, D. Letters Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

ABSTRACT

Background Data concerning the efficacy of bilateral prophylactic oophorectomy for reducing the risk of gynecologic cancer in women with BRCA1 or BRCA2 mutations are limited. We investigated whether this procedure reduces the risk of cancers of the coelomic epithelium and breast in women who carry such mutations.

Methods A total of 551 women with disease-associated germ-line BRCA1 or BRCA2 mutations were identified from registries and studied for the occurrence of ovarian and breast cancer. We determined the incidence of ovarian cancer in 259 women who had undergone bilateral prophylactic oophorectomy and in 292 matched controls who had not undergone the procedure. In a subgroup of 241 women with no history of breast cancer or prophylactic mastectomy, the incidence of breast cancer was determined in 99 women who had undergone bilateral prophylactic oophorectomy and in 142 matched controls. The length of postoperative follow-up for both groups was at least eight years.

Results Six women who underwent prophylactic oophorectomy (2.3 percent) received a diagnosis of stage I ovarian cancer at the time of the procedure; two women (0.8 percent) received a diagnosis of papillary serous peritoneal carcinoma 3.8 and 8.6 years after bilateral prophylactic oophorectomy. Among the controls, 58 women (19.9 percent) received a diagnosis of ovarian cancer, after a mean follow-up of 8.8 years. With the exclusion of the six women whose cancer was diagnosed at surgery, prophylactic oophorectomy significantly reduced the risk of coelomic epithelial cancer (hazard ratio, 0.04; 95 percent confidence interval, 0.01 to 0.16). Of 99 women who underwent bilateral prophylactic oophorectomy and who were studied to determine the risk of breast cancer, breast cancer developed in 21 (21.2 percent), as compared with 60 (42.3 percent) in the control group (hazard ratio, 0.47; 95 percent confidence interval, 0.29 to 0.77).

Conclusions Bilateral prophylactic oophorectomy reduces the risk of coelomic epithelial cancer and breast cancer in women with BRCA1 or BRCA2 mutations.

Source Information

From the Center for Clinical Epidemiology and Biostatistics (T.R.R.), Cancer Center (T.R.R., B.L.W.), and Abramson Family Cancer Institute (B.L.W.), University of Pennsylvania School of Medicine, Philadelphia; Creighton University, Omaha, Nebr. (H.T.L.); the Division of Genetic Epidemiology, University of Utah, Salt Lake City (S.L.N.); Women's College Hospital, Toronto (S.A.N.); the Netherlands Cancer Institute, Amsterdam (L.V.); Dana–Farber Cancer Institute, Boston (J.E.G.); St. Mary's Hospital, Manchester, United Kingdom (G.E.); Lombardi Cancer Center, Georgetown University, Washington, D.C. (C.I.); Fox Chase Cancer Center, Philadelphia (M.B.D.); Yale University, New Haven, Conn. (E.M.); and University of Chicago, Chicago (O.I.O.).

Address reprint requests to Dr. Rebbeck at the University of Pennsylvania School of Medicine, 904 Blockley Hall, 423 Guardian Dr., Philadelphia, PA 19104-6021, or at trebbeck{at}cceb.med.upenn.edu.

Full Text of this Article

Related Letters:

Oophorectomy in Carriers of BRCA Mutations
Zhuang S. H., Leonard G. D., Swain S. M., Peshkin B. N., DeMarco T. A., Schwartz M. D., Anderson W. F., Brawley O. W., Chang S., Whitfield G. A., Kauff N. D., Robson M. E., Offit K., Rebbeck T. R., Weber B. L.
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N Engl J Med 2002; 347:1037-1040, Sep 26, 2002. Correspondence

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