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Previous Volume 346:1699-1705 May 30, 2002 Number 22 Next

	Full Text PDF PDA Full Text PowerPoint Slide Set Editorial by Black, J. Letters Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

ABSTRACT

Background Asthma and eosinophilic bronchitis are characterized by similar inflammatory infiltrates in the submucosa of the lower airway. However, eosinophilic bronchitis differs from asthma in that there is no variable airflow obstruction or airway hyperresponsiveness in the former condition. We tested the hypothesis that there were differences between the two conditions in the microlocalization of mast cells within the airway smooth muscle.

Methods Immunohistochemical analysis of bronchial-biopsy specimens was completed in 17 subjects with asthma, 13 subjects with eosinophilic bronchitis, and 11 normal controls recruited from two centers.

Results Both groups with disease had a similar degree of submucosal eosinophilia and thickening of the basement membrane and lamina reticularis. By contrast, the number of tryptase-positive mast cells in the bundles of airway smooth muscle from subjects with asthma (median, 5.1 mast cells per square millimeter of smooth muscle [range, 0 to 33.3]) was substantially higher than that in subjects with eosinophilic bronchitis (median, 0 mast cells per square millimeter; range, 0 to 4.8) and that in normal controls (median, 0 mast cells per square millimeter [range, 0 to 6.4]; P<0.001 for the comparison among the three groups). T cells and eosinophils were not usually seen in the airway smooth muscle in any of the groups.

Conclusions The infiltration of airway smooth muscle by mast cells is associated with the disordered airway function found in asthma.

Source Information

From the Division of Respiratory Medicine, Institute for Lung Health, Leicester–Warwick Medical School and University Hospitals of Leicester, Leicester (C.E.B., P.B., F.A.S., A.J.W., I.D.P.); and the University of Southampton and Southampton General Hospital, Southampton (S.T.H.) — both in the United Kingdom.

Address reprint requests to Dr. Pavord at the Department of Respiratory Medicine, University Hospitals of Leicester, Groby Rd., Leicester LE3 9QP, United Kingdom.

Full Text of this Article

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Mast Cells in Airway Smooth Muscle
Tunon-de-Lara J.-M., Berger P., Bégueret H., Brightling C. E., Bradding P., Pavord I. D.
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N Engl J Med 2002; 347:1040-1041, Sep 26, 2002. Correspondence

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