FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 346:1773-1780 June 6, 2002 Number 23 Next

	Full Text PDF PDA Full Text PowerPoint Slide Set Perspective by Curfman, G. D. Letters Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited Related Article by Sharma, S. PubMed Citation

ABSTRACT

Background The need for repeated treatment of restenosis of a treated vessel remains the main limitation of percutaneous coronary revascularization. Because sirolimus (rapamycin) inhibits the proliferation of lymphocytes and smooth-muscle cells, we compared a sirolimus-eluting stent with a standard uncoated stent in patients with angina pectoris.

Methods We performed a randomized, double-blind trial to compare the two types of stents for revascularization of single, primary lesions in native coronary arteries. The trial included 238 patients at 19 medical centers. The primary end point was in-stent late luminal loss (the difference between the minimal luminal diameter immediately after the procedure and the diameter at six months). Secondary end points included the percentage of in-stent stenosis of the luminal diameter and the rate of restenosis (luminal narrowing of 50 percent or more). We also analyzed a composite clinical end point consisting of death, myocardial infarction, and percutaneous or surgical revascularization at 1, 6, and 12 months.

Results At six months, the degree of neointimal proliferation, manifested as the mean (±SD) late luminal loss, was significantly lower in the sirolimus-stent group (–0.01±0.33 mm) than in the standard-stent group (0.80±0.53 mm, P<0.001). None of the patients in the sirolimus-stent group, as compared with 26.6 percent of those in the standard-stent group, had restenosis of 50 percent or more of the luminal diameter (P<0.001). There were no episodes of stent thrombosis. During a follow-up period of up to one year, the overall rate of major cardiac events was 5.8 percent in the sirolimus-stent group and 28.8 percent in the standard-stent group (P<0.001). The difference was due entirely to a higher rate of revascularization of the target vessel in the standard-stent group.

Conclusions As compared with a standard coronary stent, a sirolimus-eluting stent shows considerable promise for the prevention of neointimal proliferation, restenosis, and associated clinical events.

Source Information

From Institut Cardiovasculaire Paris Sud, Massy, France (M.-C.M.); Thoraxcentrum, Rotterdam, the Netherlands (P.W.S.); Institute Dante Pazzanese de Cardiologia, São Paulo, Brazil (J.E.S.); Clinique Pasteur, Toulouse, France (J.F.); Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico (E.B.H.); the Heart Institute of the University of São Paulo, São Paulo, Brazil (M.P.); Centro Cuore Columbus, Milan, Italy (A.C.); Herzzentrum, Leipzig, Germany (G.S.); Centre Hospitalier Privé Beauregard, Marseilles, France (P.B.); Azienda Ospedaliera Ospedali Riuniti di Bergamo, Bergamo, Italy (G.G.); Semmelweis Egyetem Egészégtudomanyi Kar, Budapest, Hungary (F.M.); and Cordis, Johnson & Johnson, Warren, N.J. (R.F.).

Address reprint requests to Dr. Morice at the Institut Hospitalier Jacques Cartier, Ave. du Noyer Lambert, 91300 Massy, France.

Full Text of this Article

Related Letters:

Sirolimus-Eluting Coronary Stents
Sharma S., Bhambi B., Nyitray W., Morice M.-C.
Extract | Full Text | PDF  
N Engl J Med 2002; 347:1285, Oct 17, 2002. Correspondence

This article has been cited by other articles:

• Mehilli, J., Byrne, R. A., Wieczorek, A., Iijima, R., Schulz, S., Bruskina, O., Pache, J., Wessely, R., Schomig, A., Kastrati, A., for the Intracoronary Stenting and Angiographic Re, (2008). Randomized trial of three rapamycin-eluting stents with different coating strategies for the reduction of coronary restenosis. Eur Heart J 29: 1975-1982 [Abstract] [Full Text]  
• Takano, M., Yamamoto, M., Murakami, D., Inami, S., Okamatsu, K., Seimiya, K., Ohba, T., Seino, Y., Mizuno, K. (2008). Lack of Association Between Large Angiographic Late Loss and Low Risk of In-Stent Thrombus: Angioscopic Comparison Between Paclitaxel- and Sirolimus-Eluting Stents. Circ Cardiovasc Intervent 1: 20-27 [Abstract] [Full Text]  
• Austin, D., Oldroyd, K. G., McConnachie, A., Slack, R., Eteiba, H., Flapan, A. D., Jennings, K. P., Northcote, R. J., Pell, A. C.H., Starkey, I. R., Pell, J. P. (2008). Drug-Eluting Stents Versus Bare-Metal Stents for Off-Label Indications: A Propensity Score-Matched Outcome Study. Circ Cardiovasc Intervent 1: 45-52 [Abstract] [Full Text]  
• Shaoliang Chen, , Junjie Zhang, , Fei Ye, , Zhongsheng Zhu, , Song Lin, , Nailiang Tian, , Zhizhong Liu, , Weiyi Fang, , Yundai Chen, , Xuewen Sun, , Kwan, T. W. (2008). Crush Stenting With Paclitaxel-Eluting or Sirolimus-Eluting Stents for the Treatment of Coronary Bifurcation Lesions. ANGIOLOGY 59: 475-483 [Abstract]  
• Newsome, L. T., Kutcher, M. A., Royster, R. L. (2008). Coronary Artery Stents: Part I. Evolution of Percutaneous Coronary Intervention. Anesth. Analg. 107: 552-569 [Abstract] [Full Text]  
• Booth, J., Clayton, T., Pepper, J., Nugara, F., Flather, M., Sigwart, U., Stables, R. H., on Behalf of the SoS Investigators, (2008). Randomized, Controlled Trial of Coronary Artery Bypass Surgery Versus Percutaneous Coronary Intervention in Patients With Multivessel Coronary Artery Disease: Six-Year Follow-Up From the Stent or Surgery Trial (SoS). Circulation 118: 381-388 [Abstract] [Full Text]  
• Ishii, H., Kumada, Y., Toriyama, T., Aoyama, T., Takahashi, H., Yamada, S., Yasuda, Y., Yuzawa, Y., Maruyama, S., Matsuo, S., Matsubara, T., Murohara, T. (2008). Cilostazol Improves Long-Term Patency after Percutaneous Transluminal Angioplasty in Hemodialysis Patients with Peripheral Artery Disease. CJASN 3: 1034-1040 [Abstract] [Full Text]  
• Meliga, E., Garcia-Garcia, H. M., Valgimigli, M., Chieffo, A., Biondi-Zoccai, G., Maree, A. O., Cook, S., Reardon, L., Moretti, C., De Servi, S., Palacios, I. F., Windecker, S., Colombo, A., van Domburg, R., Sheiban, I., Serruys, P. W. (2008). Longest available clinical outcomes after drug-eluting stent implantation for unprotected left main coronary artery disease: the DELFT (Drug Eluting stent for LeFT main) Registry.. J Am Coll Cardiol 51: 2212-2219 [Abstract] [Full Text]  
• Ishii, Y., Sakamoto, S.-i., Kronengold, R. T., Virmani, R., Rivera, E. A., Goldman, S. M., Prechtel, E. J., Hill, J. G., Damiano, R. J. Jr. (2008). A novel bioengineered small-caliber vascular graft incorporating heparin and sirolimus: Excellent 6-month patency.. J. Thorac. Cardiovasc. Surg. 135: 1237-1246 [Abstract] [Full Text]  
• Sobel, M., Verhaeghe, R. (2008). Antithrombotic Therapy for Peripheral Artery Occlusive Disease: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest 133: 815S-843S [Abstract] [Full Text]  
• Barilli, A., Visigalli, R., Sala, R., Gazzola, G. C., Parolari, A., Tremoli, E., Bonomini, S., Simon, A., Closs, E. I., Dall'Asta, V., Bussolati, O. (2008). In human endothelial cells rapamycin causes mTORC2 inhibition and impairs cell viability and function. Cardiovasc Res 78: 563-571 [Abstract] [Full Text]  
• Groeneveld, P. W., Matta, M. A., Greenhut, A. P., Yang, F. (2008). Drug-Eluting Compared With Bare-Metal Coronary Stents Among Elderly Patients. J Am Coll Cardiol 51: 2017-2024 [Abstract] [Full Text]  
• Bhatt, S. H, Hauser, T. H (2008). Very Late Stent Thrombosis After Dual Antiplatelet Therapy Discontinuation in a Patient with a History of Acute Stent Thrombosis. The Annals of Pharmacotherapy 42: 708-712 [Abstract] [Full Text]  
• Hannan, E. L., Racz, M., Holmes, D. R., Walford, G., Sharma, S., Katz, S., Jones, R. H., King, S. B. III (2008). Comparison of Coronary Artery Stenting Outcomes in the Eras Before and After the Introduction of Drug-Eluting Stents. Circulation 117: 2071-2078 [Abstract] [Full Text]  
• Raja, S. G, Dreyfus, G. D (2008). Current Status of Off-pump Coronary Artery Bypass Surgery. Asian Cardiovasc. Thorac. Ann. 16: 164-178 [Abstract] [Full Text]  
• Ricciardi, R., Virnig, B. A., Ogilvie, J. W. Jr, Dahlberg, P. S., Selker, H. P., Baxter, N. N. (2008). Volume-Outcome Relationship for Coronary Artery Bypass Grafting in an Era of Decreasing Volume. Arch Surg 143: 338-344 [Abstract] [Full Text]  
• Hannan, E. L., Racz, M., Walford, G., Holmes, D. R., Jones, R. H., Sharma, S., Katz, S., King, S. B. III (2008). Drug-Eluting Versus Bare-Metal Stents in the Treatment of Patients With ST-Segment Elevation Myocardial Infarction. J Am Coll Cardiol Intv 1: 129-135 [Abstract] [Full Text]  
• van der Hoeven, B. L., Liem, S.-S., Dijkstra, J., Bergheanu, S. C., Putter, H., Antoni, M. L., Atsma, D. E., Bootsma, M., Zeppenfeld, K., Jukema, J. W., Schalij, M. J. (2008). Stent Malapposition After Sirolimus-Eluting and Bare-Metal Stent Implantation in Patients with ST-Segment Elevation Myocardial Infarction: Acute and 9-Month Intravascular Ultrasound Results of the MISSION! Intervention Study. J Am Coll Cardiol Intv 1: 192-201 [Abstract] [Full Text]  
• Cheng, C., Tempel, D., Oostlander, A., Helderman, F., Gijsen, F., Wentzel, J., van Haperen, R., Haitsma, D. B., Serruys, P. W., van der Steen, A. F.W., de Crom, R., Krams, R. (2008). Rapamycin modulates the eNOS vs. shear stress relationship. Cardiovasc Res 78: 123-129 [Abstract] [Full Text]  
• Pinto Slottow, T. L., Waksman, R. (2008). Overview of the 2007 Food and Drug Administration Circulatory System Devices Panel Meeting on the Endeavor Zotarolimus-Eluting Coronary Stent. Circulation 117: 1603-1608 [Full Text]  
• Billinger, M., Beutler, J., Taghetchian, K. R., Remondino, A., Wenaweser, P., Cook, S., Togni, M., Seiler, C., Stettler, C., Eberli, F. R., Luscher, T. F., Wandel, S., Juni, P., Meier, B., Windecker, S. (2008). Two-year clinical outcome after implantation of sirolimus-eluting and paclitaxel-eluting stents in diabetic patients. Eur Heart J 29: 718-725 [Abstract] [Full Text]  
• Abraham, N. G., Kappas, A. (2008). Pharmacological and Clinical Aspects of Heme Oxygenase. Pharmacol. Rev. 60: 79-127 [Abstract] [Full Text]  
• Hoffmann, R, Morice, M-C, Moses, J W, Fitzgerald, P J, Mauri, L, Breithardt, G, Schofer, J, Serruys, P W, Stoll, H-P, Leon, M B (2008). Impact of late incomplete stent apposition after sirolimus-eluting stent implantation on 4-year clinical events: intravascular ultrasound analysis from the multicentre, randomised, RAVEL, E-SIRIUS and SIRIUS trials. Heart 94: 322-328 [Abstract] [Full Text]  
• Kip, K. E., Hollabaugh, K., Marroquin, O. C., Williams, D. O. (2008). The Problem With Composite End Points in Cardiovascular Studies The Story of Major Adverse Cardiac Events and Percutaneous Coronary Intervention.. J Am Coll Cardiol 51: 701-707 [Abstract] [Full Text]  
• van der Hoeven, B. L., Liem, S.-S., Jukema, J. W., Suraphakdee, N., Putter, H., Dijkstra, J., Atsma, D. E., Bootsma, M., Zeppenfeld, K., Oemrawsingh, P. V., van der Wall, E. E., Schalij, M. J. (2008). Sirolimus-eluting stents versus bare-metal stents in patients with ST-segment elevation myocardial infarction: 9-month angiographic and intravascular ultrasound results and 12-month clinical outcome results from the MISSION! Intervention Study.. J Am Coll Cardiol 51: 618-626 [Abstract] [Full Text]  
• Jeremias, A., Kirtane, A. (2008). Balancing Efficacy and Safety of Drug-Eluting Stents in Patients Undergoing Percutaneous Coronary Intervention. ANN INTERN MED 148: 234-238 [Abstract] [Full Text]  
• Teirstein, P. S. (2008). Unprotected Left Main Intervention: Patient Selection, Operator Technique, and Clinical Outcomes. J Am Coll Cardiol Intv 1: 5-13 [Abstract] [Full Text]  
• Melikian, N, Wijns, W (2008). Drug-eluting stents: a critique. Heart 94: 145-152 [Abstract] [Full Text]  
• Romagnoli, E., Sangiorgi, G. M., Cosgrave, J., Guillet, E., Colombo, A. (2008). Drug-Eluting Stenting: The Case for Post-Dilation. J Am Coll Cardiol Intv 1: 22-31 [Abstract] [Full Text]  
• Rogacka, R., Chieffo, A., Michev, I., Airoldi, F., Latib, A., Cosgrave, J., Montorfano, M., Carlino, M., Sangiorgi, G. M., Castelli, A., Godino, C., Magni, V., Aranzulla, T. C., Romagnoli, E., Colombo, A. (2008). Dual Antiplatelet Therapy After Percutaneous Coronary Intervention With Stent Implantation in Patients Taking Chronic Oral Anticoagulation. J Am Coll Cardiol Intv 1: 56-61 [Abstract] [Full Text]  
• Hannan, E. L., Wu, C., Walford, G., Culliford, A. T., Gold, J. P., Smith, C. R., Higgins, R. S.D., Carlson, R. E., Jones, R. H. (2008). Drug-Eluting Stents vs. Coronary-Artery Bypass Grafting in Multivessel Coronary Disease. NEJM 358: 331-341 [Abstract] [Full Text]  
• Marroquin, O. C., Selzer, F., Mulukutla, S. R., Williams, D. O., Vlachos, H. A., Wilensky, R. L., Tanguay, J.-F., Holper, E. M., Abbott, J. D., Lee, J. S., Smith, C., Anderson, W. D., Kelsey, S. F., Kip, K. E. (2008). A Comparison of Bare-Metal and Drug-Eluting Stents for Off-Label Indications. NEJM 358: 342-352 [Abstract] [Full Text]  
• American College of Cardiology/American Heart Asso, , 2007 Writing Group to Review New Evidence and Upda, , King, S. B. III, Smith, S. C. Jr, Hirshfeld, J. W. Jr, Jacobs, A. K., Morrison, D. A., Williams, D. O. (2008). 2007 Focused Update of the ACC/AHA/SCAI 2005 Guideline Update for Percutaneous Coronary Intervention. J Am Coll Cardiol 51: 172-209 [Full Text]  
• King, S. B. III, Smith, S. C. Jr, Hirshfeld, J. W. Jr, Jacobs, A. K., Morrison, D. A., Williams, D. O., 2005 WRITING COMMITTEE MEMBERS, , Smith, S. C. Jr, Feldman, T. E., Hirshfeld, J. W. Jr, Jacobs, A. K., Kern, M. J., King, S. B. III, Morrison, D. A., O'Neill, W. W., Schaff, H. V., Whitlow, P. L., Williams, D. O., Smith, S. C. Jr, Jacobs, A. K., Adams, C. D., Anderson, J. L., Buller, C. E., Creager, M. A., Ettinger, S. M., Halperin, J. L., Hunt, S. A., Krumholz, H. M., Kushner, F. G., Lytle, B. W., Nishimura, R., Page, R. L., Riegel, B., Tarkington, L. G., Yancy, C. W. (2008). 2007 Focused Update of the ACC/AHA/SCAI 2005 Guideline Update for Percutaneous Coronary Intervention: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines: 2007 Writing Group to Review New Evidence and Update the ACC/AHA/SCAI 2005 Guideline Update for Percutaneous Coronary Intervention, Writing on Behalf of the 2005 Writing Committee. Circulation 117: 261-295 [Full Text]  
• Pocock, S. J., Lansky, A. J., Mehran, R., Popma, J. J., Fahy, M. P., Na, Y., Dangas, G., Moses, J. W., Pucelikova, T., Kandzari, D. E., Ellis, S. G., Leon, M. B., Stone, G. W. (2008). Angiographic surrogate end points in drug-eluting stent trials: a systematic evaluation based on individual patient data from 11 randomized, controlled trials.. J Am Coll Cardiol 51: 23-32 [Abstract] [Full Text]  
• Sutphin, D., Stevens, S., Kirzeder, D., Gash, J. (2008). Acute Thrombosis of a Mesenteric Artery Drug-Eluting Stent Following Clopidogrel Cessation. VASC ENDOVASCULAR SURG 41: 564-567 [Abstract]  
• Wilson, J. M., Willerson, J. T. (2008). Myocardial Revascularization with Percutaneous Devices. Card Surg Adult 3: 573-598 [Full Text]  
• Griffith, B. P., Haddad, M., Poston, R. S. (2008). Immunobiology of Heart and Heart-Lung Transplantation. Card Surg Adult 3: 1513-1538 [Full Text]  
• Jensen, L. O., Thayssen, P., Thuesen, L., Hansen, H. S., Lassen, J. F., Kelbaek, H., Junker, A., Hansen, K. N., Boetker, H. E., Krusell, L. R., Pedersen, K. E. (2007). Influence of a Pressure Gradient Distal to Implanted Bare-Metal Stent on In-Stent Restenosis After Percutaneous Coronary Intervention. Circulation 116: 2802-2808 [Abstract] [Full Text]  
• Russo, R. J, Silva, P. D, Yeager, M. (2007). Coronary artery overexpansion increases neointimal hyperplasia after stent placement in a porcine model. Heart 93: 1609-1615 [Abstract] [Full Text]  
• Solinas, E., Nikolsky, E., Lansky, A. J., Kirtane, A. J., Morice, M.-C., Popma, J. J., Schofer, J., Schampaert, E., Pucelikova, T., Aoki, J., Fahy, M., Dangas, G. D., Moses, J. W., Cutlip, D. E., Leon, M. B., Mehran, R. (2007). Gender-Specific Outcomes After Sirolimus-Eluting Stent Implantation. J Am Coll Cardiol 50: 2111-2116 [Abstract] [Full Text]  
• Williams, D. O., Abbott, J. D. (2007). Et Tu, Bare Metal Stent?. Circulation 116: 2363-2365 [Full Text]  
• Colombo, A. (2007). Directional Coronary Atherectomy and Implantation of Drug-Eluting Stents in Selected Bifurcation Lesions: A Logical Combination Waiting Evidence. J Am Coll Cardiol 50: 1946-1947 [Full Text]  
• Palmerini, T., Barlocco, F., Santarelli, A., Bacchi-Reggiani, L., Savini, C., Baldini, E., Alessi, L., Ruffini, M., Di Credico, G., Piovaccari, G., Di Bartolomeo, R., Marzocchi, A., Branzi, A., De Servi, S. (2007). A comparison between coronary artery bypass grafting surgery and drug eluting stent for the treatment of unprotected left main coronary artery disease in elderly patients (aged >=75 years). Eur Heart J 28: 2714-2719 [Abstract] [Full Text]  
• Grube, E., Dawkins, K. D., Guagliumi, G., Banning, A. P., Zmudka, K., Colombo, A., Thuesen, L., Hauptman, K., Marco, J., Wijns, W., Popma, J. J., Buellesfeld, L., Koglin, J., Russell, M. E. (2007). TAXUS VI 2-year follow-up: randomized comparison of polymer-based paclitaxel-eluting with bare metal stents for treatment of long, complex lesions. Eur Heart J 28: 2578-2582 [Abstract] [Full Text]  
• Mullenix, P. S., Steele, S. R., Martin, M. J., Starnes, B. W., Andersen, C. A. (2007). C-reactive Protein Level and Traditional Vascular Risk Factors in the Prediction of Carotid Stenosis. Arch Surg 142: 1066-1071 [Abstract] [Full Text]  
• Das, K. M., El-Menyar, A. A., Salam, A. M., Singh, R., Dabdoob, W. A. K., Albinali, H. A., Al Suwaidi, J. (2007). Contrast-enhanced 64-Section Coronary Multidetector CT Angiography versus Conventional Coronary Angiography for Stent Assessment. Radiology 245: 424-432 [Abstract] [Full Text]  
• Baumgart, D., Klauss, V., Baer, F., Hartmann, F., Drexler, H., Motz, W., Klues, H., Hofmann, S., Volker, W., Pfannebecker, T., Stoll, H.-P., Nickenig, G., for the SCORPIUS Study Investigators, (2007). One-Year Results of the SCORPIUS Study: A German Multicenter Investigation on the Effectiveness of Sirolimus-Eluting Stents in Diabetic Patients. J Am Coll Cardiol 50: 1627-1634 [Abstract] [Full Text]  
• Morice, M.-C., Serruys, P. W., Barragan, P., Bode, C., Van Es, G.-A., Stoll, H.-P., Snead, D., Mauri, L., Cutlip, D. E., Sousa, E. (2007). Long-Term Clinical Outcomes With Sirolimus-Eluting Coronary Stents: Five-Year Results of the RAVEL Trial. J Am Coll Cardiol 50: 1299-1304 [Abstract] [Full Text]  
• Kanemitsu, S., Tanaka, K., Tanaka, J., Suzuki, H., Kinoshita, T. (2007). Initial clinical impact of drug eluting stents on coronary artery bypass graft surgery. ICVTS 6: 632-635 [Abstract] [Full Text]  
• McMurtry, M. S., Bonnet, S., Michelakis, E. D., Bonnet, S., Haromy, A., Archer, S. L. (2007). Statin therapy, alone or with rapamycin, does not reverse monocrotaline pulmonary arterial hypertension: the rapamcyin-atorvastatin-simvastatin study. Am. J. Physiol. Lung Cell. Mol. Physiol. 293: L933-L940 [Abstract] [Full Text]  
• Okura, H., Taguchi, H., Kubo, T., Toda, I., Yoshiyama, M., Yoshikawa, J., Yoshida, K. (2007). Impact of arterial remodelling and plaque rupture on target and non-target lesion revascularisation after stent implantation in patients with acute coronary syndrome: an intravascular ultrasound study. Heart 93: 1219-1225 [Abstract] [Full Text]  
• Togni, M., Eber, S., Widmer, J., Billinger, M., Wenaweser, P., Cook, S., Vogel, R., Seiler, C., Eberli, F. R., Maier, W., Corti, R., Roffi, M., Luscher, T. F., Garachemani, A., Hess, O. M., Wandel, S., Meier, B., Juni, P., Windecker, S. (2007). Impact of Vessel Size on Outcome After Implantation of Sirolimus-Eluting and Paclitaxel-Eluting Stents: A Subgroup Analysis of the SIRTAX Trial. J Am Coll Cardiol 50: 1123-1131 [Abstract] [Full Text]  
• Colombo, A., Chieffo, A. (2007). Drug-Eluting Stent Update 2007: Part III: Technique and Unapproved/Unsettled Indications (Left Main, Bifurcations, Chronic Total Occlusions, Small Vessels and Long Lesions, Saphenous Vein Grafts, Acute Myocardial Infarctions, and Multivessel Disease). Circulation 116: 1424-1432 [Full Text]  
• Rodriguez, A. E., Maree, A. O., Mieres, J., Berrocal, D., Grinfeld, L., Fernandez-Pereira, C., Curotto, V., Rodriguez-Granillo, A., O'Neill, W., Palacios, I. F. (2007). Late loss of early benefit from drug-eluting stents when compared with bare-metal stents and coronary artery bypass surgery: 3 years follow-up of the ERACI III registry. Eur Heart J 28: 2118-2125 [Abstract] [Full Text]  
• Park, D.-W., Lee, C. W., Yun, S.-C., Kim, Y.-H., Hong, M.-K., Kim, J.-J., Park, S.-W., Park, S.-J. (2007). Prognostic impact of preprocedural C reactive protein levels on 6-month angiographic and 1-year clinical outcomes after drug-eluting stent implantation. Heart 93: 1087-1092 [Abstract] [Full Text]  
• Awata, M., Kotani, J.-i., Uematsu, M., Morozumi, T., Watanabe, T., Onishi, T., Iida, O., Sera, F., Nanto, S., Hori, M., Nagata, S. (2007). Serial Angioscopic Evidence of Incomplete Neointimal Coverage After Sirolimus-Eluting Stent Implantation: Comparison With Bare-Metal Stents. Circulation 116: 910-916 [Abstract] [Full Text]  
• Jimenez-Quevedo, P., Sabate, M., Angiolillo, D. J., Alfonso, F., Hernandez-Antolin, R., SanMartin, M., Gomez-Hospital, J. A., Banuelos, C., Escaned, J., Moreno, R., Fernandez, C., Fernandez-Aviles, F., Macaya, C., for the DIABETES Investigators, (2007). Long-term clinical benefit of sirolimus-eluting stent implantation in diabetic patients with de novo coronary stenoses: long-term results of the DIABETES trial. Eur Heart J 28: 1946-1952 [Abstract] [Full Text]  
• Kawatsu, S., Oda, K., Saiki, Y., Tabata, Y., Tabayashi, K. (2007). External Application of Rapamycin-Eluting Film at Anastomotic Sites Inhibits Neointimal Hyperplasia in a Canine Model. Ann. Thorac. Surg. 84: 560-567 [Abstract] [Full Text]  
• Jensen, L. O., Thayssen, P., Lassen, J. F., Hansen, H. S., Kelbaek, H., Junker, A., Pedersen, K. E., Hansen, K. N., Krusell, L. R., Botker, H. E., Thuesen, L. (2007). Recruitable collateral blood flow index predicts coronary instent restenosis after percutaneous coronary intervention. Eur Heart J 28: 1820-1826 [Abstract] [Full Text]  
• Bode, C., Zehender, M. (2007). The use of antiplatelet agents following percutaneous coronary intervention: focus on late stent thrombosis. Eur Heart J Suppl 9: D10-D19 [Abstract] [Full Text]  
• Jensen, L. O., Maeng, M., Kaltoft, A., Thayssen, P., Hansen, H. H. T., Bottcher, M., Lassen, J. F., Krussel, L. R., Rasmussen, K., Hansen, K. N., Pedersen, L., Johnsen, S. P., Soerensen, H. T., Thuesen, L. (2007). Stent Thrombosis, Myocardial Infarction, and Death After Drug-Eluting and Bare-Metal Stent Coronary Interventions. J Am Coll Cardiol 50: 463-470 [Abstract] [Full Text]  
• Vermeersch, P., Agostoni, P., Verheye, S., Van den Heuvel, P., Convens, C., Van den Branden, F., Van Langenhove, G., DELAYED RRISC (Death and Events at Long-term follo, (2007). Increased Late Mortality After Sirolimus-Eluting Stents Versus Bare-Metal Stents in Diseased Saphenous Vein Grafts: Results From the Randomized DELAYED RRISC Trial. J Am Coll Cardiol 50: 261-267 [Abstract] [Full Text]  
• Valgimigli, M., Campo, G., Arcozzi, C., Malagutti, P., Carletti, R., Ferrari, F., Barbieri, D., Parrinello, G., Percoco, G., Ferrari, R. (2007). Two-Year Clinical Follow-Up After Sirolimus-Eluting Versus Bare-Metal Stent Implantation Assisted by Systematic Glycoprotein IIb/IIIa Inhibitor Infusion in Patients With Myocardial Infarction: Results From the STRATEGY Study. J Am Coll Cardiol 50: 138-145 [Abstract] [Full Text]  
• Holmes, D. R. Jr, Kereiakes, D. J., Laskey, W. K., Colombo, A., Ellis, S. G., Henry, T. D., Popma, J. J., Serruys, P. W.J.C., Kimura, T., Williams, D. O., Windecker, S., Krucoff, M. W. (2007). Thrombosis and Drug-Eluting Stents: An Objective Appraisal. J Am Coll Cardiol 50: 109-118 [Abstract] [Full Text]  
• Moreno, R., Fernandez, C., Sanchez-Recalde, A., Galeote, G., Calvo, L., Alfonso, F., Hernandez, R., Sanchez-Aquino, R., Angiolillo, D. J., Villarreal, S., Macaya, C., Lopez-Sendon, J. L. (2007). Clinical impact of in-stent late loss after drug-eluting coronary stent implantation. Eur Heart J 28: 1583-1591 [Abstract] [Full Text]  
• Weissman, N. J., Ellis, S. G., Grube, E., Dawkins, K. D., Greenberg, J. D., Mann, T., Cannon, L. A., Cambier, P. A., Fernandez, S., Mintz, G. S., Mandinov, L., Koglin, J., Stone, G. W. (2007). Effect of the polymer-based, paclitaxel-eluting TAXUS Express stent on vascular tissue responses: a volumetric intravascular ultrasound integrated analysis from the TAXUS IV, V, and VI trials. Eur Heart J 28: 1574-1582 [Abstract] [Full Text]  
• Marzocchi, A., Saia, F., Piovaccari, G., Manari, A., Aurier, E., Benassi, A., Cremonesi, A., Percoco, G., Varani, E., Magnavacchi, P., Guastaroba, P., Grilli, R., Maresta, A. (2007). Long-Term Safety and Efficacy of Drug-Eluting Stents: Two-Year Results of the REAL (REgistro AngiopLastiche dell'Emilia Romagna) Multicenter Registry. Circulation 115: 3181-3188 [Abstract] [Full Text]  
• Cademartiri, F., Schuijf, J. D., Pugliese, F., Mollet, N. R., Jukema, J. W., Maffei, E., Kroft, L. J., Palumbo, A., Ardissino, D., Serruys, P. W., Krestin, G. P., Van der Wall, E. E., de Feyter, P. J., Bax, J. J. (2007). Usefulness of 64-Slice Multislice Computed Tomography Coronary Angiography to Assess In-Stent Restenosis. J Am Coll Cardiol 49: 2204-2210 [Abstract] [Full Text]  
• Brilakis, E. S., Banerjee, S., Berger, P. B. (2007). Perioperative Management of Patients With Coronary Stents. J Am Coll Cardiol 49: 2145-2150 [Abstract] [Full Text]  
• Stone, G. W., Ellis, S. G., Colombo, A., Dawkins, K. D., Grube, E., Cutlip, D. E., Friedman, M., Baim, D. S., Koglin, J. (2007). Offsetting Impact of Thrombosis and Restenosis on the Occurrence of Death and Myocardial Infarction After Paclitaxel-Eluting and Bare Metal Stent Implantation. Circulation 115: 2842-2847 [Abstract] [Full Text]  
• Wong, S. H, Wan, S., Underwood, M. J (2007). Myocardial Revascularization: Surgery or Stenting?. Asian Cardiovasc. Thorac. Ann. 15: 264-269 [Abstract] [Full Text]  
• Siqueira, D. A., Abizaid, A. A., Costa, J. d. R., Feres, F., Mattos, L. A., Staico, R., Abizaid, A. A., Tanajura, L. F., Chaves, A., Centemero, M., Sousa, A. G.M.R., Sousa, J. E. M.R. (2007). Late incomplete apposition after drug-eluting stent implantation: incidence and potential for adverse clinical outcomes. Eur Heart J 28: 1304-1309 [Abstract] [Full Text]  
• Maeng, M., Okkels Jensen, L., Rasmussen, K., Flensted Lassen, J., Romer Krusell, L., Thayssen, P., Thuesen, L. (2007). Target lesion revascularisation in patients treated with a sirolimus-eluting or paclitaxel-eluting stent. Heart 93: 694-697 [Abstract] [Full Text]  
• Falcone, E. L., Tangri, N. (2007). Drug-eluting stents. CMAJ 176: 1611-1611 [Full Text]