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	Full Text PDF PDA Full Text PowerPoint Slide Set Editorial by Redfield, M. M. Letters Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

ABSTRACT

Background Heart failure is a major public health problem. Long-term trends in the incidence of heart failure and survival after its onset in the community have not been characterized.

Methods We used statistical models to assess temporal trends in the incidence of heart failure and Cox proportional-hazards regression to evaluate survival after the onset of heart failure among subjects in the Framingham Heart Study. Cases of heart failure were classified according to the date of onset: 1950 through 1969 (223 cases), 1970 through 1979 (222), 1980 through 1989 (307), and 1990 through 1999 (323). We also calculated 30-day, 1-year, and 5-year age-adjusted mortality rates for each period.

Results Heart failure occurred in 1075 subjects (51 percent of whom were women). As compared with the rate for the period from 1950 through 1969, the incidence of heart failure remained virtually unchanged among men in the three subsequent periods but declined by 31 to 40 percent among women (rate ratio for the period from 1990 through 1999, 0.69; 95 percent confidence interval, 0.51 to 0.93). The 30-day, 1-year, and 5-year age-adjusted mortality rates among men declined from 12 percent, 30 percent, and 70 percent, respectively, in the period from 1950 through 1969 to 11 percent, 28 percent, and 59 percent, respectively, in the period from 1990 through 1999. The corresponding rates among women were 18 percent, 28 percent, and 57 percent for the period from 1950 through 1969 and 10 percent, 24 percent, and 45 percent for the period from 1990 through 1999. Overall, there was an improvement in the survival rate after the onset of heart failure of 12 percent per decade (P=0.01 for men and P=0.02 for women).

Conclusions Over the past 50 years, the incidence of heart failure has declined among women but not among men, whereas survival after the onset of heart failure has improved in both sexes. Factors contributing to these trends need further clarification.

Source Information

From the National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Mass. (D.L., S.K., M.G.L., E.J.B., M.J.K., J.M.M, R.S.V.); the Sections of Preventive Medicine (D.L., E.J.B., R.S.V.), General Internal Medicine (J.M.M.), and Cardiology (E.J.B., R.S.V.), Boston University School of Medicine, Boston; the Cardiology Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston (D.L., K.K.L.H.); the Harvard Clinical Research Institute, Boston (K.K.L.H.); and the National Heart, Lung, and Blood Institute, Bethesda, Md. (D.L.).

Full Text of this Article

Related Letters:

Heart Failure — Incidence and Survival
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Extract | Full Text | PDF  
N Engl J Med 2003; 348:660, Feb 13, 2003. Correspondence

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• Mehta, P A, Cowie, M R (2006). Gender and heart failure: a population perspective. Heart 92: iii14-iii18 [Full Text]  
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• Bhatia, G. S., Sosin, M. D., Patel, J. V., Grindulis, K. A., Khattak, F. H., Hughes, E. A., Lip, G. Y.H., Davis, R. C. (2006). Left Ventricular Systolic Dysfunction in Rheumatoid Disease: An Unrecognized Burden?. J Am Coll Cardiol 47: 1169-1174 [Abstract] [Full Text]  
• Rocca, H. P. B.-L., Capraro, J., Kiowski, W. (2006). Compliance by Referring Physicians With Recommendations on Heart Failure Therapy from a Tertiary Center. J CARDIOVASC PHARMACOL THER 11: 85-92 [Abstract]  
• Kamp, O. (2006). Advanced Systolic and Diastolic Function: Beyond the E-and A-wave. SEMIN CARDIOTHORAC VASC ANESTH 10: 63-65 [Abstract]  
• Gilbert, R. E., Connelly, K., Kelly, D. J., Pollock, C. A., Krum, H. (2006). Heart Failure and Nephropathy: Catastrophic and Interrelated Complications of Diabetes. CJASN 1: 193-208 [Abstract] [Full Text]  
• Barker, W. H., Mullooly, J. P., Getchell, W. (2006). Changing Incidence and Survival for Heart Failure in a Well-Defined Older Population, 1970-1974 and 1990-1994. Circulation 113: 799-805 [Abstract] [Full Text]  
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• Marcy, T. R., Ripley, T. L. (2006). Aldosterone antagonists in the treatment of heart failure. Am J Health Syst Pharm 63: 49-58 [Abstract] [Full Text]  
• Malkin, C. J., Pugh, P. J., West, J. N., van Beek, E. J.R., Jones, T. H., Channer, K. S. (2006). Testosterone therapy in men with moderate severity heart failure: a double-blind randomized placebo controlled trial. Eur Heart J 27: 57-64 [Abstract] [Full Text]  
• Jackson, B. M., Parish, L. M., Gorman, J. H. III, Enomoto, Y., Sakamoto, H., Plappert, T., St. John Sutton, M. G., Salgo, I., Gorman, R. C. (2005). Borderzone Geometry After Acute Myocardial Infarction: A Three-Dimensional Contrast Enhanced Echocardiographic Study. Ann. Thorac. Surg. 80: 2250-2255 [Abstract] [Full Text]  
• Ko, D. T., Tu, J. V., Masoudi, F. A., Wang, Y., Havranek, E. P., Rathore, S. S., Newman, A. M., Donovan, L. R., Lee, D. S., Foody, J. M., Krumholz, H. M. (2005). Quality of Care and Outcomes of Older Patients With Heart Failure Hospitalized in the United States and Canada. Arch Intern Med 165: 2486-2492 [Abstract] [Full Text]  
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• Bridges, C. R., Gopal, K., Holt, D. E., Yarnall, C., Cole, S., Anderson, R. B., Yin, X., Nelson, A., Kozyak, B. W., Wang, Z., Lesniewski, J., Su, L. T., Thesier, D. M., Sundar, H., Stedman, H. H. (2005). Efficient myocyte gene delivery with complete cardiac surgical isolation in situ. J. Thorac. Cardiovasc. Surg. 130: 1364-1364 [Abstract] [Full Text]  
• Grigorian Shamagian, L., Gonzalez-Juanatey, J. R., Roman, A. V., Acuna, J. M. G., Lamela, A. V. (2005). The death rate among hospitalized heart failure patients with normal and depressed left ventricular ejection fraction in the year following discharge: evolution over a 10-year period. Eur Heart J 26: 2251-2258 [Abstract] [Full Text]  
• Reiffel, J. A. (2005). Drug and Drug-Device Therapy in Heart Failure Patients in the Post-COMET and SCD-HeFT Era. J CARDIOVASC PHARMACOL THER 10: S45-S58 [Abstract]  
• Pignatelli, P., De Biase, L., Lenti, L., Tocci, G., Brunelli, A., Cangemi, R., Riondino, S., Grego, S., Volpe, M., Violi, F. (2005). Tumor necrosis factor-{alpha} as trigger of platelet activation in patients with heart failure. Blood 106: 1992-1994 [Abstract] [Full Text]  
• Murabito, J. M., Evans, J. C., D'Agostino, R. B. Sr., Wilson, P. W. F., Kannel, W. B. (2005). Temporal Trends in the Incidence of Intermittent Claudication from 1950 to 1999. Am J Epidemiol 162: 430-437 [Abstract] [Full Text]  
• Buckberg, G. D. (2005). Questions and answers about the STICH trial: A different perspective. J. Thorac. Cardiovasc. Surg. 130: 245-249 [Full Text]  
• Abraham, W. T., Adams, K. F., Fonarow, G. C., Costanzo, M. R., Berkowitz, R. L., LeJemtel, T. H., Cheng, M. L., Wynne, J., the ADHERE Scientific Advisory Committee Investiga, , and the ADHERE Study Group, (2005). In-Hospital Mortality in Patients With Acute Decompensated Heart Failure Requiring Intravenous Vasoactive Medications: An Analysis From the Acute Decompensated Heart Failure National Registry (ADHERE). J Am Coll Cardiol 46: 57-64 [Abstract] [Full Text]  
• George, J., Patal, S., Wexler, D., Abashidze, A., Shmilovich, H., Barak, T., Sheps, D., Keren, G. (2005). Circulating Erythropoietin Levels and Prognosis in Patients With Congestive Heart Failure: Comparison With Neurohormonal and Inflammatory Markers. Arch Intern Med 165: 1304-1309 [Abstract] [Full Text]  
• Perrino, C., Naga Prasad, S. V., Patel, M., Wolf, M. J., Rockman, H. A. (2005). Targeted Inhibition of {beta}-Adrenergic Receptor Kinase-1-Associated Phosphoinositide-3 Kinase Activity Preserves {beta}-Adrenergic Receptor Signaling and Prolongs Survival in Heart Failure Induced by Calsequestrin Overexpression. J Am Coll Cardiol 45: 1862-1870 [Abstract] [Full Text]  
• Wellenius, G. A., Bateson, T. F., Mittleman, M. A., Schwartz, J. (2005). Particulate Air Pollution and the Rate of Hospitalization for Congestive Heart Failure among Medicare Beneficiaries in Pittsburgh, Pennsylvania. Am J Epidemiol 161: 1030-1036 [Abstract] [Full Text]  
• Havranek, E. P. (2005). Improving the Outcomes of Heart Failure Care: Putting Technology Second. J Am Coll Cardiol 45: 1665-1666 [Full Text]  
• Petersson, M., Friberg, P., Eisenhofer, G., Lambert, G., Rundqvist, B. (2005). Long-term outcome in relation to renal sympathetic activity in patients with chronic heart failure. Eur Heart J 26: 906-913 [Abstract] [Full Text]  
• Patwala, A Y, Wright, D J (2005). Device based treatment of heart failure. Postgrad. Med. J. 81: 286-291 [Abstract] [Full Text]  
• Ishani, A., Weinhandl, E., Zhao, Z., Gilbertson, D. T., Collins, A. J., Yusuf, S., Herzog, C. A. (2005). Angiotensin-converting enzyme inhibitor as a risk factor for the development of anemia, and the impact of incident anemia on mortality in patients with left ventricular dysfunction. J Am Coll Cardiol 45: 391-399 [Abstract] [Full Text]  
• Yan, A. T., Yan, R. T., Liu, P. P. (2005). Narrative Review: Pharmacotherapy for Chronic Heart Failure: Evidence from Recent Clinical Trials. ANN INTERN MED 142: 132-145 [Abstract] [Full Text]  
• McMurray, J. J.V., Pfeffer, M. A. (2004). The year in heart failure. J Am Coll Cardiol 44: 2398-2405 [Full Text]  
• Formiga, F., Chivite, D., Ortega, C., Casas, S., Ramon, J.M., Pujol, R. (2004). End-of-life preferences in elderly patients admitted for heart failure. QJM 97: 803-808 [Abstract] [Full Text]  
• Lehman, R. (2004). Evidently.... Evid. Based Med. 9: 167-167 [Full Text]  
• Bihan, H., Espinosa, C., Valdes-Socin, H., Salenave, S., Young, J., Levasseur, S., Assayag, P., Beckers, A., Chanson, P. (2004). Long-Term Outcome of Patients with Acromegaly and Congestive Heart Failure. J. Clin. Endocrinol. Metab. 89: 5308-5313 [Abstract] [Full Text]  
• Young, J. B., Dunlap, M. E., Pfeffer, M. A., Probstfield, J. L., Cohen-Solal, A., Dietz, R., Granger, C. B., Hradec, J., Kuch, J., McKelvie, R. S., McMurray, J. J.V., Michelson, E. L., Olofsson, B., Ostergren, J., Held, P., Solomon, S. D., Yusuf, S., Swedberg, K., for the Candesartan in Heart failure Assessment of, (2004). Mortality and Morbidity Reduction With Candesartan in Patients With Chronic Heart Failure and Left Ventricular Systolic Dysfunction: Results of the CHARM Low-Left Ventricular Ejection Fraction Trials. Circulation 110: 2618-2626 [Abstract] [Full Text]  
• Bibbins-Domingo, K., Lin, F., Vittinghoff, E., Barrett-Connor, E., Grady, D., Shlipak, M. G. (2004). Renal insufficiency as an independent predictor of mortality among women with heart failure. J Am Coll Cardiol 44: 1593-1600 [Abstract] [Full Text]  
• Hernandez, A. F., Whellan, D. J., Stroud, S., Sun, J. L., O'Connor, C. M., Jollis, J. G. (2004). Outcomes in heart failure patients after major noncardiac surgery. J Am Coll Cardiol 44: 1446-1453 [Abstract] [Full Text]  
• Schellenbaum, G. D., Rea, T. D., Heckbert, S. R., Smith, N. L., Lumley, T., Roger, V. L., Kitzman, D. W., Taylor, H. A., Levy, D., Psaty, B. M. (2004). Survival Associated with Two Sets of Diagnostic Criteria for Congestive Heart Failure. Am J Epidemiol 160: 628-635 [Abstract] [Full Text]  
• Patten, R. D., Pourati, I., Aronovitz, M. J., Baur, J., Celestin, F., Chen, X., Michael, A., Haq, S., Nuedling, S., Grohe, C., Force, T., Mendelsohn, M. E., Karas, R. H. (2004). 17{beta}-Estradiol Reduces Cardiomyocyte Apoptosis In Vivo and In Vitro via Activation of Phospho-Inositide-3 Kinase/Akt Signaling. Circ. Res. 95: 692-699 [Abstract] [Full Text]  
• Bibbins-Domingo, K., Lin, F., Vittinghoff, E., Barrett-Connor, E., Hulley, S. B., Grady, D., Shlipak, M. G. (2004). Predictors of Heart Failure Among Women With Coronary Disease. Circulation 110: 1424-1430 [Abstract] [Full Text]  
• Hernandez, A. F., Newby, L. K., O'Connor, C. M. (2004). Preoperative Evaluation for Major Noncardiac Surgery: Focusing on Heart Failure. Arch Intern Med 164: 1729-1736 [Abstract] [Full Text]  
• Bleumink, G. S., Knetsch, A. M., Sturkenboom, M. C.J.M., Straus, S. M.J.M., Hofman, A., Deckers, J. W., Witteman, J. C.M., Stricker, B. H.Ch. (2004). Quantifying the heart failure epidemic: prevalence, incidence rate, lifetime risk and prognosis of heart failure: The Rotterdam Study. Eur Heart J 25: 1614-1619 [Abstract] [Full Text]  
• Lloyd-Jones, D. M., Wang, T. J., Leip, E. P., Larson, M. G., Levy, D., Vasan, R. S., D'Agostino, R. B., Massaro, J. M., Beiser, A., Wolf, P. A., Benjamin, E. J. (2004). Lifetime Risk for Development of Atrial Fibrillation: The Framingham Heart Study. Circulation 110: 1042-1046 [Abstract] [Full Text]