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ABSTRACT

Background Some epidemiologic studies suggest a link between hepatitis C virus (HCV) infection and some B-cell non-Hodgkin's lymphomas. We undertook this study after a patient with splenic lymphoma with villous lymphocytes had a hematologic response after antiviral treatment of HCV infection.

Methods Nine patients who had splenic lymphoma with villous lymphocytes and HCV infection were treated with interferon alfa-2b (3 million IU three times per week) alone or in combination with ribavirin (1000 to 1200 mg per day). The outcomes were compared with those of six similarly treated patients with splenic lymphoma with villous lymphocytes who tested negative for HCV infection.

Results Of the nine patients with HCV infection who received interferon alfa, seven had a complete remission after the loss of detectable HCV RNA. The other two patients had a partial and a complete remission after the addition of ribavirin and the loss of detectable HCV RNA. One patient had a relapse when the HCV RNA load again became detectable in blood. In contrast, none of the six HCV-negative patients had a response to interferon therapy.

Conclusions In patients with splenic lymphoma with villous lymphocytes who are infected with HCV, treatment with interferon can lead to regression of the lymphoma.

Source Information

From the Department of Hematology and Centre National de la Recherche Scientifique Unité Mixte de Recherche 8603, Hôpital Necker, Paris (O.H., F.L, F.V., B.V.); the Department of Hepatology, Centre Hospitalier Universitaire Nancy, Nancy (J.-P.B.); the Department of Rheumatology, Hôpital de Kremlin-Bicêtre, Le Kremlin-Bicêtre (X.M.); the Department of Hematology, Hôpital Cochin, Paris (K.J.); the Department of Hematology, Hôpital Jean Verdier, Bondy (V.E.-S.); the Department of Hematology, Hôpital Paul Brousse, Villejuif (B.D.); the Department of Internal Medicine, Hôpital Pitié–Salpétrière, Paris (P.C.); and the Department of Hematology, Centre Hospitalier Universitaire Côte de Nacre, Caen (X.T.) — all in France.

Address reprint requests to Dr. Hermine at the Service d'Hématologie, Hôpital Necker, 149-161 rue de Sèvres, 75743 Paris CEDEX 15, France, or at hermine{at}necker.fr.

Full Text of this Article

Related Letters:

Regression of Splenic Lymphoma after Treatment of Hepatitis C Virus Infection
Mazzaro C., Little D'A., Pozzato G., Emens L. A., Sulkowski M. S., Agnello V., Mecucci C., Casato M., Lefrère F., Troussard X., Hermine O.
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N Engl J Med 2002; 347:2168-2170, Dec 26, 2002. Correspondence

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