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Previous Volume 347:1999-2009 December 19, 2002 Number 25 Next

	Full Text PDF PDA Full Text PowerPoint Slide Set Perspective by Sauter, G. Editorial by Kallioniemi, A. Letters Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

ABSTRACT

Background A more accurate means of prognostication in breast cancer will improve the selection of patients for adjuvant systemic therapy.

Methods Using microarray analysis to evaluate our previously established 70-gene prognosis profile, we classified a series of 295 consecutive patients with primary breast carcinomas as having a gene-expression signature associated with either a poor prognosis or a good prognosis. All patients had stage I or II breast cancer and were younger than 53 years old; 151 had lymph-node–negative disease, and 144 had lymph-node–positive disease. We evaluated the predictive power of the prognosis profile using univariable and multivariable statistical analyses.

Results Among the 295 patients, 180 had a poor-prognosis signature and 115 had a good-prognosis signature, and the mean (±SE) overall 10-year survival rates were 54.6±4.4 percent and 94.5±2.6 percent, respectively. At 10 years, the probability of remaining free of distant metastases was 50.6±4.5 percent in the group with a poor-prognosis signature and 85.2±4.3 percent in the group with a good-prognosis signature. The estimated hazard ratio for distant metastases in the group with a poor-prognosis signature, as compared with the group with the good-prognosis signature, was 5.1 (95 percent confidence interval, 2.9 to 9.0; P<0.001). This ratio remained significant when the groups were analyzed according to lymph-node status. Multivariable Cox regression analysis showed that the prognosis profile was a strong independent factor in predicting disease outcome.

Conclusions The gene-expression profile we studied is a more powerful predictor of the outcome of disease in young patients with breast cancer than standard systems based on clinical and histologic criteria.

Source Information

From the Divisions of Diagnostic Oncology (M.J.V., L.J.V., D.W.V., J.L.P., D.A., A.W., A.G., L.D.), Radiotherapy (A.A.M.H., H.B.), Medical Oncology (S.R.), Biometrics (T.V.), Surgical Oncology (E.T.R.), and Molecular Carcinogenesis (R.B.), Netherlands Cancer Institute, Amsterdam; the Center for Biomedical Genetics, Amsterdam (R.B.); and Rosetta Inpharmatics, Kirkland, Wash. (Y.D.H., H.D., G.J.S., C.R., M.J.M., M.P., S.H.F.).

Drs. van de Vijver, He, and van 't Veer contributed equally to this article.

Address reprint requests to Dr. Bernards at the Division of Molecular Carcinogenesis, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands, or at r.bernards{at}nki.nl.

Full Text of this Article

Related Letters:

Gene-Expression Signatures in Breast Cancer
Helmbold P., Haerting J., Kölbl H., Kopans D. B., Kunkler I. H., Ransohoff D. F., van de Vijver M. J., He Y. D., van 't Veer L. J., Bernards R.
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N Engl J Med 2003; 348:1715-1717, Apr 24, 2003. Correspondence

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• Desmedt, C., Haibe-Kains, B., Wirapati, P., Buyse, M., Larsimont, D., Bontempi, G., Delorenzi, M., Piccart, M., Sotiriou, C. (2008). Biological Processes Associated with Breast Cancer Clinical Outcome Depend on the Molecular Subtypes. Clin. Cancer Res. 14: 5158-5165 [Abstract] [Full Text]  
• John, T., Black, M. A., Toro, T. T., Leader, D., Gedye, C. A., Davis, I. D., Guilford, P. J., Cebon, J. S. (2008). Predicting Clinical Outcome through Molecular Profiling in Stage III Melanoma. Clin. Cancer Res. 14: 5173-5180 [Abstract] [Full Text]  
• Landemaine, T., Jackson, A., Bellahcene, A., Rucci, N., Sin, S., Abad, B. M., Sierra, A., Boudinet, A., Guinebretiere, J.-M., Ricevuto, E., Nogues, C., Briffod, M., Bieche, I., Cherel, P., Garcia, T., Castronovo, V., Teti, A., Lidereau, R., Driouch, K. (2008). A Six-Gene Signature Predicting Breast Cancer Lung Metastasis. Cancer Res. 68: 6092-6099 [Abstract] [Full Text]  
• Han, Y., Yang, L., Suarez-Saiz, F., San-Marina, S., Cui, J., Minden, M. D. (2008). Wilms' Tumor 1 Suppressor Gene Mediates Antiestrogen Resistance via Down-Regulation of Estrogen Receptor-{alpha} Expression in Breast Cancer Cells. Mol Cancer Res 6: 1347-1355 [Abstract] [Full Text]  
• Sturgeon, C. M., Hoffman, B. R., Chan, D. W., Ch'ng, S.-L., Hammond, E., Hayes, D. F., Liotta, L. A., Petricoin, E. F., Schmitt, M., Semmes, O. J., Soletormos, G., van der Merwe, E., Diamandis, E. P. (2008). National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines for Use of Tumor Markers in Clinical Practice: Quality Requirements. Clin. Chem. 54: e1-e10 [Abstract] [Full Text]  
• Turner, N. C, Jones, A. L (2008). Management of breast cancer--Part II. BMJ 337: a540-a540 [Full Text]  
• Anders, C. K., Hsu, D. S., Broadwater, G., Acharya, C. R., Foekens, J. A., Zhang, Y., Wang, Y., Marcom, P. K., Marks, J. R., Febbo, P. G., Nevins, J. R., Potti, A., Blackwell, K. L. (2008). Young Age at Diagnosis Correlates With Worse Prognosis and Defines a Subset of Breast Cancers With Shared Patterns of Gene Expression. JCO 26: 3324-3330 [Abstract] [Full Text]  
• Ellsworth, R. E., Ellsworth, D. L., Patney, H. L., Deyarmin, B., Hooke, J. A., Love, B., Shriver, C. D. (2008). Genomic Alterations Associated with Early Stages of Breast Tumor Metastasis. Ann. Surg. Oncol. 15: 1989-1995 [Abstract] [Full Text]  
• Colman, H., Aldape, K. (2008). Molecular Predictors in Glioblastoma: Toward Personalized Therapy. Arch Neurol 65: 877-883 [Abstract] [Full Text]  
• Schmidt, M., Bohm, D., von Torne, C., Steiner, E., Puhl, A., Pilch, H., Lehr, H.-A., Hengstler, J. G., Kolbl, H., Gehrmann, M. (2008). The Humoral Immune System Has a Key Prognostic Impact in Node-Negative Breast Cancer. Cancer Res. 68: 5405-5413 [Abstract] [Full Text]  
• Nowak, G., Tibshirani, R. (2008). Complementary hierarchical clustering. Biostatistics 9: 467-483 [Abstract] [Full Text]  
• Singh, B., Pfister, D. G. (2008). Individualized Treatment Selection in Patients With Head and Neck Cancer: Do Molecular Markers Meet the Challenge?. JCO 26: 3114-3116 [Full Text]  
• Grube, B. J., Christy, C. J., Black, D., Martel, M., Harris, L., Weidhaas, J., DiGiovanna, M. P., Chung, G., Abu-Khalaf, M. M., Miller, K. D., Higgins, S. A., Philpotts, L., Tavassoli, F. A., Lannin, D. R. (2008). Breast Sentinel Lymph Node Dissection Before Preoperative Chemotherapy. Arch Surg 143: 692-700 [Abstract] [Full Text]  
• Jiang, Y., Casey, G., Lavery, I. C., Zhang, Y., Talantov, D., Martin-McGreevy, M., Skacel, M., Manilich, E., Mazumder, A., Atkins, D., Delaney, C. P., Wang, Y. (2008). Development of a Clinically Feasible Molecular Assay to Predict Recurrence of Stage II Colon Cancer. J. Mol. Diagn. 10: 346-354 [Abstract] [Full Text]  
• Nam, D.-H., Jeon, H.-M., Kim, S., Kim, M. H., Lee, Y.-J., Lee, M. S., Kim, H., Joo, K. M., Lee, D.-S., Price, J. E., Bang, S. I., Park, W.-Y. (2008). Activation of Notch Signaling in a Xenograft Model of Brain Metastasis. Clin. Cancer Res. 14: 4059-4066 [Abstract] [Full Text]  
• Diomedi-Camassei, F., McDowell, H. P., De Ioris, M. A., Uccini, S., Altavista, P., Raschella, G., Vitali, R., Mannarino, O., De Sio, L., Cozzi, D. A., Donfrancesco, A., Inserra, A., Callea, F., Dominici, C. (2008). Clinical Significance of CXC Chemokine Receptor-4 and c-Met in Childhood Rhabdomyosarcoma. Clin. Cancer Res. 14: 4119-4127 [Abstract] [Full Text]  
• Glinsky, G. V. (2008). "Stemness" Genomics Law Governs Clinical Behavior of Human Cancer: Implications for Decision Making in Disease Management. JCO 26: 2846-2853 [Abstract] [Full Text]  
• Weinberg, R. A. (2008). Mechanisms of malignant progression. Carcinogenesis 29: 1092-1095 [Full Text]  
• Sauer, G., Schneiderhan-Marra, N., Kazmaier, C., Hutzel, K., Koretz, K., Muche, R., Kreienberg, R., Joos, T., Deissler, H. (2008). Prediction of Nodal Involvement in Breast Cancer Based on Multiparametric Protein Analyses from Preoperative Core Needle Biopsies of the Primary Lesion. Clin. Cancer Res. 14: 3345-3353 [Abstract] [Full Text]  
• Winnard, P. T. Jr., Pathak, A. P., Dhara, S., Cho, S. Y., Raman, V., Pomper, M. G. (2008). Molecular Imaging of Metastatic Potential. JNM 49: 96S-112S [Abstract] [Full Text]  
• Wittner, B. S., Sgroi, D. C., Ryan, P. D., Bruinsma, T. J., Glas, A. M., Male, A., Dahiya, S., Habin, K., Bernards, R., Haber, D. A., Van't Veer, L. J., Ramaswamy, S. (2008). Analysis of the MammaPrint Breast Cancer Assay in a Predominantly Postmenopausal Cohort. Clin. Cancer Res. 14: 2988-2993 [Abstract] [Full Text]  
• Dieterich, C., Iglehart, D., Riccio, E., Mirsalis, J. C., Ng, H. H. (2008). Microarray Evaluation of the Listeria monocytogenes Infection and Amoxicillin Treatment in Mice. International Journal of Toxicology 27: 265-272 [Abstract] [Full Text]  
• Barnett, D. H., Sheng, S., Howe Charn, T., Waheed, A., Sly, W. S., Lin, C.-Y., Liu, E. T., Katzenellenbogen, B. S. (2008). Estrogen Receptor Regulation of Carbonic Anhydrase XII through a Distal Enhancer in Breast Cancer. Cancer Res. 68: 3505-3515 [Abstract] [Full Text]