Satish Kenchaiah, M.D., Jane C. Evans, D.Sc., Daniel Levy, M.D., Peter W.F. Wilson, M.D., Emelia J. Benjamin, M.D., Martin G. Larson, S.D., William B. Kannel, M.D., M.P.H., and Ramachandran S. Vasan, M.D.
Background Extreme obesity is recognized to be a risk factorfor heart failure. It is unclear whether overweight and lesserdegrees of obesity also pose a risk.
Methods We investigated the relation between the body-mass index(the weight in kilograms divided by the square of the heightin meters) and the incidence of heart failure among 5881 participantsin the Framingham Heart Study (mean age, 55 years; 54 percentwomen). With the use of Cox proportional-hazards models, thebody-mass index was evaluated both as a continuous variableand as a categorical variable (normal, 18.5 to 24.9; overweight,25.0 to 29.9; and obese, 30.0 or more).
Conclusions In our large, community-based sample, increasedbody-mass index was associated with an increased risk of heartfailure. Given the high prevalence of obesity in the UnitedStates, strategies to promote optimal body weight may reducethe population burden of heart failure.
Source Information
From the Framingham Heart Study, Framingham, Mass. (S.K., J.C.E., D.L., P.W.F.W., E.J.B., M.G.L., W.B.K., R.S.V.); the Section of Preventive Medicine (D.L., E.J.B., M.G.L., W.B.K., R.S.V.) and the Cardiology Section (E.J.B., R.S.V.), Boston University School of Medicine, Boston; the Cardiology Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston (D.L.); and the National Heart, Lung, and Blood Institute, Bethesda, Md. (D.L.).
Address reprint requests to Dr. Vasan at the Framingham Heart Study, 73 Mt. Wayte Ave., Suite 2, Framingham, MA 01702, or at vasan{at}fram.nhlbi.nih.gov.
Obesity and the Risk of Heart Failure
O'Brien G., Maurer M. S., Taegtmeyer H., Wilson C. R., Dart R. A., Jenny-Avital E. R., Kenchaiah S., Levy D., Vasan R. S., Massie B. M.
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N Engl J Med 2002;
347:1887-1889, Dec 5, 2002.
Correspondence
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