Eplerenone, a Selective Aldosterone Blocker, in Patients with Left Ventricular Dysfunction after Myocardial Infarction
Bertram Pitt, M.D., Willem Remme, M.D., Faiez Zannad, M.D., James Neaton, Ph.D., Felipe Martinez, M.D., Barbara Roniker, M.D., Richard Bittman, Ph.D., Steve Hurley, B.S., Jay Kleiman, M.D., Marjorie Gatlin, M.D., for the Eplerenone PostAcute Myocardial Infarction Heart Failure Efficacy and Survival Study Investigators
Methods Patients were randomly assigned to eplerenone (25 mgper day initially, titrated to a maximum of 50 mg per day; 3313patients) or placebo (3319 patients) in addition to optimalmedical therapy. The study continued until 1012 deaths occurred.The primary end points were death from any cause and death fromcardiovascular causes or hospitalization for heart failure,acute myocardial infarction, stroke, or ventricular arrhythmia.
From the University of Michigan, Ann Arbor (B.P.); STICARES, Cardiovascular Research Foundation, Rotterdam, the Netherlands (W.R.); the Centre d'Investigation Clinique de Nancy, Nancy, France (F.Z.); the University of Minnesota, Minneapolis (J.N.); the Fundación Rusculleda, Cordoba, Argentina (F.M.); and Pharmacia, Skokie, Ill. (B.R., R.B., S.H., J.K., M.G.).
Address reprint requests to Dr. Pitt at the Department of Internal Medicine, Division of Cardiology, University of Michigan Medical Center, 3910 Taubman, 1500 E. Medical Center Dr., Ann Arbor, MI 48109-0366, or at bpitt{at}umich.edu.
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Authors/Task Force Members, , Dickstein, K., Cohen-Solal, A., Filippatos, G., McMurray, J. J.V., Ponikowski, P., Poole-Wilson, P. A., Stromberg, A., van Veldhuisen, D. J., Atar, D., Hoes, A. W., Keren, A., Mebazaa, A., Nieminen, M., Priori, S. G., Swedberg, K., ESC Committee for Practice Guidelines (CPG), , Vahanian, A., Camm, J., De Caterina, R., Dean, V., Dickstein, K., Filippatos, G., Funck-Brentano, C., Hellemans, I., Kristensen, S. D., McGregor, K., Sechtem, U., Silber, S., Tendera, M., Widimsky, P., Zamorano, J. L., Document Reviewers, , Tendera, M., Auricchio, A., Bax, J., Bohm, M., Corra, U., della Bella, P., Elliott, P. M., Follath, F., Gheorghiade, M., Hasin, Y., Hernborg, A., Jaarsma, T., Komajda, M., Kornowski, R., Piepoli, M., Prendergast, B., Tavazzi, L., Vachiery, J.-L., Verheugt, F. W. A., Zamorano, J. L., Zannad, F.
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Dickstein, K., Cohen-Solal, A., Filippatos, G., McMurray, J. J.V., Ponikowski, P., Poole-Wilson, P. A., Stromberg, A., van Veldhuisen, D. J., Atar, D., Hoes, A. W., Keren, A., Mebazaa, A., Nieminen, M., Priori, S. G., Swedberg, K.
(2008). ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2008 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association of the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM). Eur J Heart Fail
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