Tejal K. Gandhi, M.D., M.P.H., Saul N. Weingart, M.D., Ph.D., Joshua Borus, B.A., Andrew C. Seger, R.Ph., Josh Peterson, M.D., Elisabeth Burdick, M.S., Diane L. Seger, R.Ph., Kirstin Shu, B.A., Frank Federico, R.Ph., Lucian L. Leape, M.D., and David W. Bates, M.D.
Background Adverse events related to drugs occur frequentlyamong inpatients, and many of these events are preventable.However, few data are available on adverse drug events amongoutpatients. We conducted a study to determine the rates, types,severity, and preventability of such events among outpatientsand to identify preventive strategies.
Methods We performed a prospective cohort study, including asurvey of patients and a chart review, at four adult primarycare practices in Boston (two hospital-based and two community-based),involving a total of 1202 outpatients who received at leastone prescription during a four-week period. Prescriptions werecomputerized at two of the practices and handwritten at theother two.
Conclusions Adverse events related to drugs are common in primarycare, and many are preventable or ameliorable. Monitoring forand acting on symptoms are important. Improving communicationbetween outpatients and providers may help prevent adverse eventsrelated to drugs.
Source Information
From the Division of General Internal Medicine, Brigham and Women's Hospital (T.K.G., J.B., A.C.S., J.P., E.B., D.L.S., K.S., D.W.B.); the Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center (S.N.W.); the Harvard Risk Management Foundation (F.F.); and the Harvard School of Public Health (L.L.L.) — all in Boston.
Address reprint requests to Dr. Gandhi at the Division of General Medicine, Brigham and Women's Hospital, 75 Francis St., Boston, MA 02115, or at tgandhi{at}partners.org.
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