FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 348:1625-1638 April 24, 2003 Number 17 Next

	Full Text PDF PDA Full Text PowerPoint Slide Set Perspective by Adami, H.-O. Letters Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear PubMed Citation

ABSTRACT

Background The influence of excess body weight on the risk of death from cancer has not been fully characterized.

Methods In a prospectively studied population of more than 900,000 U.S. adults (404,576 men and 495,477 women) who were free of cancer at enrollment in 1982, there were 57,145 deaths from cancer during 16 years of follow-up. We examined the relation in men and women between the body-mass index in 1982 and the risk of death from all cancers and from cancers at individual sites, while controlling for other risk factors in multivariate proportional-hazards models. We calculated the proportion of all deaths from cancer that was attributable to overweight and obesity in the U.S. population on the basis of risk estimates from the current study and national estimates of the prevalence of overweight and obesity in the U.S. adult population.

Results The heaviest members of this cohort (those with a body-mass index [the weight in kilograms divided by the square of the height in meters] of at least 40) had death rates from all cancers combined that were 52 percent higher (for men) and 62 percent higher (for women) than the rates in men and women of normal weight. For men, the relative risk of death was 1.52 (95 percent confidence interval, 1.13 to 2.05); for women, the relative risk was 1.62 (95 percent confidence interval, 1.40 to 1.87). In both men and women, body-mass index was also significantly associated with higher rates of death due to cancer of the esophagus, colon and rectum, liver, gallbladder, pancreas, and kidney; the same was true for death due to non-Hodgkin's lymphoma and multiple myeloma. Significant trends of increasing risk with higher body-mass-index values were observed for death from cancers of the stomach and prostate in men and for death from cancers of the breast, uterus, cervix, and ovary in women. On the basis of associations observed in this study, we estimate that current patterns of overweight and obesity in the United States could account for 14 percent of all deaths from cancer in men and 20 percent of those in women.

Conclusions Increased body weight was associated with increased death rates for all cancers combined and for cancers at multiple specific sites.

Source Information

From the Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta.

Address reprint requests to Dr. Calle at the American Cancer Society, 1599 Clifton Rd., NE, Atlanta, GA 30329, or at jcalle{at}cancer.org.

Full Text of this Article

Related Letters:

Obesity and Cancer
Deutsch M. E., Flegal K. M., Williamson D. F., Graubard B. I., Frankel P. H., Gaesser G. A., Smith J. A., Calle E. E., Rodriguez C., Thun M. J.
Extract | Full Text | PDF  
N Engl J Med 2003; 349:502-504, Jul 31, 2003. Correspondence

This article has been cited by other articles:

• Novosyadlyy, R., Lann, D. E., Vijayakumar, A., Rowzee, A., Lazzarino, D. A., Fierz, Y., Carboni, J. M., Gottardis, M. M., Pennisi, P. A., Molinolo, A. A., Kurshan, N., Mejia, W., Santopietro, S., Yakar, S., Wood, T. L., LeRoith, D. (2010). Insulin-Mediated Acceleration of Breast Cancer Development and Progression in a Nonobese Model of Type 2 Diabetes. Cancer Res. 70: 741-751 [Abstract] [Full Text]  
• Komaru, A., Kamiya, N., Suzuki, H., Endo, T., Takano, M., Yano, M., Kawamura, K., Imamoto, T., Ichikawa, T. (2010). Implications of Body Mass Index in Japanese Patients with Prostate Cancer Who Had Undergone Radical Prostatectomy. Jpn J Clin Oncol 0: hyp164v1-hyp164 [Abstract] [Full Text]  
• Kettunen, J., Silander, K., Saarela, O., Amin, N., Muller, M., Timpson, N., Surakka, I., Ripatti, S., Laitinen, J., Hartikainen, A.-L., Pouta, A., Lahermo, P., Anttila, V., Mannisto, S., Jula, A., Virtamo, J., Salomaa, V., Lehtimaki, T., Raitakari, O., Gieger, C., Wichmann, E. H., Van Duijn, C. M., Smith, G. D., McCarthy, M. I., Jarvelin, M.-R., Perola, M., Peltonen, L. (2010). European lactase persistence genotype shows evidence of association with increase in body mass index. Hum Mol Genet 0: ddp561v2-ddp561 [Abstract] [Full Text]  
• Jayachandran, J., Aronson, W. J., Terris, M. K., Presti, J. C. Jr., Amling, C. L., Kane, C. J., Freedland, S. J. (2010). Diabetes and Outcomes After Radical Prostatectomy: Are Results Affected by Obesity and Race? Results from the Shared Equal-Access Regional Cancer Hospital Database. Cancer Epidemiol. Biomarkers Prev. 19: 9-17 [Abstract] [Full Text]  
• Hursting, S. D., Smith, S. M., Lashinger, L. M., Harvey, A. E., Perkins, S. N. (2010). Calories and carcinogenesis: lessons learned from 30 years of calorie restriction research. Carcinogenesis 31: 83-89 [Abstract] [Full Text]  
• Li, H., Stampfer, M. J., Mucci, L., Rifai, N., Qiu, W., Kurth, T., Ma, J. (2010). A 25-Year Prospective Study of Plasma Adiponectin and Leptin Concentrations and Prostate Cancer Risk and Survival. Clin. Chem. 56: 34-43 [Abstract] [Full Text]  
• Davey Smith, G., Sterne, J. A., Fraser, A., Tynelius, P., Lawlor, D. A, Rasmussen, F. (2009). The association between BMI and mortality using offspring BMI as an indicator of own BMI: large intergenerational mortality study. BMJ 339: b5043-b5043 [Abstract] [Full Text]  
• Vigneri, P., Frasca, F., Sciacca, L., Pandini, G., Vigneri, R. (2009). Diabetes and cancer. Endocr Relat Cancer 16: 1103-1123 [Abstract] [Full Text]  
• Rubenstein, J H, Kao, J Y, Madanick, R D, Zhang, M, Wang, M, Spacek, M B, Donovan, J L, Bright, S D, Shaheen, N J (2009). Association of adiponectin multimers with Barrett's oesophagus. Gut 58: 1583-1589 [Abstract] [Full Text]  
• DELORT, L., KWIATKOWSKI, F., CHALABI, N., SATIH, S., BIGNON, Y.-J., BERNARD-GALLON, D. J. (2009). Central Adiposity as a Major Risk Factor of Ovarian Cancer. Anticancer Res 29: 5229-5234 [Abstract] [Full Text]  
• Ehninger, G., Schmidt, A. H. (2009). Putting Insulin Glargine and Malignancies into Perspective. The Oncologist 14: 1169-1174 [Full Text]  
• Romero-Corral, A., Somers, V. K., Sierra-Johnson, J., Korenfeld, Y., Boarin, S., Korinek, J., Jensen, M. D., Parati, G., Lopez-Jimenez, F. (2009). Normal weight obesity: a risk factor for cardiometabolic dysregulation and cardiovascular mortality. Eur Heart J 0: ehp487v1-ehp487 [Abstract] [Full Text]  
• Zhao, M., Wan, Z.-l., Whittaker, L., Xu, B., Phillips, N. B., Katsoyannis, P. G., Ismail-Beigi, F., Whittaker, J., Weiss, M. A. (2009). Design of an Insulin Analog with Enhanced Receptor Binding Selectivity: RATIONALE, STRUCTURE, AND THERAPEUTIC IMPLICATIONS. J. Biol. Chem. 284: 32178-32187 [Abstract] [Full Text]  
• Oreopoulos, A., McAlister, F. A., Kalantar-Zadeh, K., Padwal, R., Ezekowitz, J. A., Sharma, A. M., Kovesdy, C. P., Fonarow, G. C., Norris, C. M. (2009). The relationship between body mass index, treatment, and mortality in patients with established coronary artery disease: a report from APPROACH. Eur Heart J 30: 2584-2592 [Abstract] [Full Text]  
• Galeone, C., Pelucchi, C., Maso, L. D., Negri, E., Talamini, R., Montella, M., Ramazzotti, V., Bellocco, R., Franceschi, S., La Vecchia, C. (2009). Glycemic index, glycemic load and renal cell carcinoma risk. Ann Oncol 20: 1881-1885 [Abstract] [Full Text]  
• Fontham, E. T. H., Thun, M. J., Ward, E., Balch, A. J., Delancey, J. O. L., Samet, J. M., ACS Cancer and the Environment Subcommittee, (2009). American Cancer Society Perspectives on Environmental Factors and Cancer. CA Cancer J Clin 59: 343-351 [Abstract] [Full Text]  
• XU, P., YE, W., JEN, R., LIN, S.-H., KUO, C.-T., LIN, Y. C. (2009). Mitogenic Activity of Zeranol in Human Breast Cancer Cells Is Enhanced by Leptin and Suppressed by Gossypol. Anticancer Res 29: 4621-4628 [Abstract] [Full Text]  
• Firestone, R T, Wong, K C, Ellison-Loschmann, L, Pearce, N, Jeffreys, M (2009). Characteristics of ovarian cancer in women residing in Aotearoa, New Zealand: 1993-2004. J. Epidemiol. Community Health 63: 814-819 [Abstract] [Full Text]  
• van Kruijsdijk, R. C.M., van der Wall, E., Visseren, F. L.J. (2009). Obesity and Cancer: The Role of Dysfunctional Adipose Tissue. Cancer Epidemiol. Biomarkers Prev. 18: 2569-2578 [Abstract] [Full Text]  
• Lagiou, P., Rossi, M., Tzonou, A., Georgila, C., Trichopoulos, D., La Vecchia, C. (2009). Glycemic load in relation to hepatocellular carcinoma among patients with chronic hepatitis infection. Ann Oncol 20: 1741-1745 [Abstract] [Full Text]  
• Behan, J. W., Yun, J. P., Proektor, M. P., Ehsanipour, E. A., Arutyunyan, A., Moses, A. S., Avramis, V. I., Louie, S. G., Butturini, A., Heisterkamp, N., Mittelman, S. D. (2009). Adipocytes Impair Leukemia Treatment in Mice. Cancer Res. 69: 7867-7874 [Abstract] [Full Text]  
• Lee, J. S., Cho, S.-I., Park, H. S. (2009). Metabolic syndrome and cancer-related mortality among Korean men and women. Ann Oncol 0: mdp344v1-mdp344 [Abstract] [Full Text]  
• Stephenson, A. J., Kattan, M. W., Eastham, J. A., Bianco, F. J. Jr, Yossepowitch, O., Vickers, A. J., Klein, E. A., Wood, D. P., Scardino, P. T. (2009). Prostate Cancer-Specific Mortality After Radical Prostatectomy for Patients Treated in the Prostate-Specific Antigen Era. JCO 27: 4300-4305 [Abstract] [Full Text]  
• Wee, C. C. (2009). A 52-Year-Old Woman With Obesity: Review of Bariatric Surgery. JAMA 302: 1097-1104 [Abstract] [Full Text]  
• Brown, C. H., Baidas, S. M., Hajdenberg, J. J., Kayaleh, O. R., Pennock, G. K., Shah, N. C., Tseng, J. E. (2009). Lifestyle Interventions in the Prevention and Treatment of Cancer. AMERICAN JOURNAL OF LIFESTYLE MEDICINE 3: 337-348 [Abstract]  
• Arnold, L. D., Patel, A. V., Yan, Y., Jacobs, E. J., Thun, M. J., Calle, E. E., Colditz, G. A. (2009). Are Racial Disparities in Pancreatic Cancer Explained by Smoking and Overweight/Obesity?. Cancer Epidemiol. Biomarkers Prev. 18: 2397-2405 [Abstract] [Full Text]  
• Demark-Wahnefried, W. (2009). A Weighty Matter -- Lifting after Breast Cancer. NEJM 361: 710-711 [Full Text]  
• Huhmann, M. B., August, D. A. (2009). Nutrition Support in Surgical Oncology. Nutr Clin Pract 24: 520-526 [Abstract] [Full Text]  
• Jackson, M. P., Sexton, S. A., Walter, W. L., Walter, W. K., Zicat, B. A. (2009). The impact of obesity on the mid-term outcome of cementless total knee replacement. J Bone Joint Surg Br 91-B: 1044-1048 [Abstract] [Full Text]  
• Jimenez-Garcia, R., Hernandez-Barrera, V., Carrasco-Garrido, P., Gil, A. (2009). Prevalence and Predictors of Breast and Cervical Cancer Screening Among Spanish Women With Diabetes. Diabetes Care 32: 1470-1472 [Abstract] [Full Text]  
• Pylypchuk, R. D., Schouten, L. J., Goldbohm, R. A., Schouten, H. C., van den Brandt, P. A. (2009). Body Mass Index, Height, and Risk of Lymphatic Malignancies: A Prospective Cohort Study. Am J Epidemiol 170: 297-307 [Abstract] [Full Text]  
• Pollak, M. (2009). Macronutrient Intake and Cancer: How Does Dietary Restriction Influence Tumor Growth and Why Should We Care?. Cancer Prevention Research 2: 698-701 [Abstract] [Full Text]  
• Jiralerspong, S., Palla, S. L., Giordano, S. H., Meric-Bernstam, F., Liedtke, C., Barnett, C. M., Hsu, L., Hung, M.-C., Hortobagyi, G. N., Gonzalez-Angulo, A. M. (2009). Metformin and Pathologic Complete Responses to Neoadjuvant Chemotherapy in Diabetic Patients With Breast Cancer. JCO 27: 3297-3302 [Abstract] [Full Text]  
• Terracciano, A., Sutin, A. R., McCrae, R. R., Deiana, B., Ferrucci, L., Schlessinger, D., Uda, M., Costa, P. T. Jr (2009). Facets of Personality Linked to Underweight and Overweight. Psychosom. Med. 71: 682-689 [Abstract] [Full Text]  
• Li, D., Morris, J. S., Liu, J., Hassan, M. M., Day, R. S., Bondy, M. L., Abbruzzese, J. L. (2009). Body Mass Index and Risk, Age of Onset, and Survival in Patients With Pancreatic Cancer. JAMA 301: 2553-2562 [Abstract] [Full Text]  
• McWilliams, R. R., Petersen, G. M. (2009). Overweight, Obesity, and Pancreatic Cancer: Beyond Risk Alone. JAMA 301: 2592-2593 [Full Text]  
• Zhang, Y., Daquinag, A., Traktuev, D. O., Amaya-Manzanares, F., Simmons, P. J., March, K. L., Pasqualini, R., Arap, W., Kolonin, M. G. (2009). White Adipose Tissue Cells Are Recruited by Experimental Tumors and Promote Cancer Progression in Mouse Models. Cancer Res. 69: 5259-5266 [Abstract] [Full Text]  
• Saquib, N., Rock, C. L., Natarajan, L., Flatt, S. W., Newman, V. A., Thomson, C. A., Caan, B. J., Pierce, J. P. (2009). Does a Healthy Diet Help Weight Management Among Overweight and Obese People?. Health Educ Behav 36: 518-531 [Abstract]  
• Cleary, M. P., Grossmann, M. E. (2009). Obesity and Breast Cancer: The Estrogen Connection. Endocrinology 150: 2537-2542 [Abstract] [Full Text]  
• Teng, A. C. T., Adamo, K., Tesson, F., Stewart, A. F. R. (2009). Functional characterization of a promoter polymorphism that drives ACSL5 gene expression in skeletal muscle and associates with diet-induced weight loss. FASEB J. 23: 1705-1709 [Abstract] [Full Text]  
• Yates, M. S., Tran, Q. T., Dolan, P. M., Osburn, W. O., Shin, S., McCulloch, C. C., Silkworth, J. B., Taguchi, K., Yamamoto, M., Williams, C. R., Liby, K. T., Sporn, M. B., Sutter, T. R., Kensler, T. W. (2009). Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice. Carcinogenesis 30: 1024-1031 [Abstract] [Full Text]  
• Ruiz, J. R., Sui, X., Lobelo, F., Lee, D.-c., Morrow, J. R. Jr., Jackson, A. W., Hebert, J. R., Matthews, C. E., Sjostrom, M., Blair, S. N. (2009). Muscular Strength and Adiposity as Predictors of Adulthood Cancer Mortality in Men. Cancer Epidemiol. Biomarkers Prev. 18: 1468-1476 [Abstract] [Full Text]  
• Staiger, J., Lueben, M. J., Berrigan, D., Malik, R., Perkins, S. N., Hursting, S. D., Johnson, P. F. (2009). C/EBP{beta} regulates body composition, energy balance-related hormones and tumor growth. Carcinogenesis 30: 832-840 [Abstract] [Full Text]  
• Kristinsson, S. Y., Derolf, A. R., Edgren, G., Dickman, P. W., Bjorkholm, M. (2009). Socioeconomic Differences in Patient Survival Are Increasing for Acute Myeloid Leukemia and Multiple Myeloma in Sweden. JCO 27: 2073-2080 [Abstract] [Full Text]  
• Cook, M. B., Dawsey, S. M., Freedman, N. D., Inskip, P. D., Wichner, S. M., Quraishi, S. M., Devesa, S. S., McGlynn, K. A. (2009). Sex Disparities in Cancer Incidence by Period and Age. Cancer Epidemiol. Biomarkers Prev. 18: 1174-1182 [Abstract] [Full Text]  
• Migita, T., Ruiz, S., Fornari, A., Fiorentino, M., Priolo, C., Zadra, G., Inazuka, F., Grisanzio, C., Palescandolo, E., Shin, E., Fiore, C., Xie, W., Kung, A. L., Febbo, P. G., Subramanian, A., Mucci, L., Ma, J., Signoretti, S., Stampfer, M., Hahn, W. C., Finn, S., Loda, M. (2009). Fatty Acid Synthase: A Metabolic Enzyme and Candidate Oncogene in Prostate Cancer. JNCI J Natl Cancer Inst 101: 519-532 [Abstract] [Full Text]  
• Lee, L. T.-H., Berger, D. H. (2009). Influence of Overweight on Patients With Gastric Cancer After Undergoing Curative Gastrectomy--Invited Critique. Arch Surg 144: 358-358 [Full Text]  
• Yang, S.-N., Chen, H.-T., Tsou, H.-K., Huang, C.-Y., Yang, W.-H., Su, C.-M., Fong, Y.-C., Tseng, W.-P., Tang, C.-H. (2009). Leptin enhances cell migration in human chondrosarcoma cells through OBRl leptin receptor. Carcinogenesis 30: 566-574 [Abstract] [Full Text]  
• Ambrosone, C. B. (2009). Eugenia Calle: In Memoriam (1952-2009). Cancer Res. 69: 3238-3239 [Full Text]  
• Hursting, S. D. (2009). Mechanistic Insights into Reducing the Weight of Breast Cancer. Cancer Prevention Research 2: 295-297 [Full Text]  
• Dellas, A., Jundt, G., Sartorius, G., Schneider, M., Moch, H. (2009). Combined PTEN and p27kip1 Protein Expression Patterns Are Associated with Obesity and Prognosis in Endometrial Carcinomas. Clin. Cancer Res. 15: 2456-2462 [Abstract] [Full Text]  
• Altekruse, S. F., McGlynn, K. A., Reichman, M. E. (2009). Hepatocellular Carcinoma Incidence, Mortality, and Survival Trends in the United States From 1975 to 2005. JCO 27: 1485-1491 [Abstract] [Full Text]  
• Khasawneh, J., Schulz, M. D., Walch, A., Rozman, J., de Angelis, M. H., Klingenspor, M., Buck, A., Schwaiger, M., Saur, D., Schmid, R. M., Kloppel, G., Sipos, B., Greten, F. R., Arkan, M. C. (2009). Inflammation and mitochondrial fatty acid {beta}-oxidation link obesity to early tumor promotion. Proc. Natl. Acad. Sci. USA 106: 3354-3359 [Abstract] [Full Text]  
• Anderegg, B. A., Worrall, C., Barbour, E., Simpson, K. N., DeLegge, M. (2009). Comparison of Resting Energy Expenditure Prediction Methods With Measured Resting Energy Expenditure in Obese, Hospitalized Adults. JPEN J Parenter Enteral Nutr 33: 168-175 [Abstract] [Full Text]  
• Grubb, R. L. III, Black, A., Izmirlian, G., Hickey, T. P., Pinsky, P. F., Mabie, J. E., Riley, T. L., Ragard, L. R., Prorok, P. C., Berg, C. D., Crawford, E. D., Church, T. R., Andriole, G. L. Jr., for the PLCO Project Team, (2009). Serum Prostate-Specific Antigen Hemodilution Among Obese Men Undergoing Screening in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Cancer Epidemiol. Biomarkers Prev. 18: 748-751 [Abstract] [Full Text]  
• Fleming, J. B., Gonzalez, R. J., Petzel, M. Q. B., Lin, E., Morris, J. S., Gomez, H., Lee, J. E., Crane, C. H., Pisters, P. W. T., Evans, D. B. (2009). Influence of Obesity on Cancer-Related Outcomes After Pancreatectomy to Treat Pancreatic Adenocarcinoma. Arch Surg 144: 216-221 [Abstract] [Full Text]  
• Andreopoulou, E., Hortobagyi, G. N. (2009). In Reply. JCO 27: 1147-1148 [Full Text]  
• Keenan, P. S. (2009). Smoking and Weight Change After New Health Diagnoses in Older Adults. Arch Intern Med 169: 237-242 [Abstract] [Full Text]  
• Aggarwal, B. B., Vijayalekshmi, R.V., Sung, B. (2009). Targeting Inflammatory Pathways for Prevention and Therapy of Cancer: Short-Term Friend, Long-Term Foe. Clin. Cancer Res. 15: 425-430 [Abstract] [Full Text]  
• Wolpin, B. M., Meyerhardt, J. A., Chan, A. T., Ng, K., Chan, J. A., Wu, K., Pollak, M. N., Giovannucci, E. L., Fuchs, C. S. (2009). Insulin, the Insulin-Like Growth Factor Axis, and Mortality in Patients With Nonmetastatic Colorectal Cancer. JCO 27: 176-185 [Abstract] [Full Text]  
• Birmann, B. M., Tamimi, R. M., Giovannucci, E., Rosner, B., Hunter, D. J., Kraft, P., Mitsiades, C., Anderson, K. C., Colditz, G. A. (2009). Insulin-like Growth Factor-1- and Interleukin-6-related Gene Variation and Risk of Multiple Myeloma. Cancer Epidemiol. Biomarkers Prev. 18: 282-288 [Abstract] [Full Text]  
• Randi, G., Malvezzi, M., Levi, F., Ferlay, J., Negri, E., Franceschi, S., La Vecchia, C. (2009). Epidemiology of biliary tract cancers: an update. Ann Oncol 20: 146-159 [Abstract] [Full Text]  
• Irwin, M L (2009). Physical activity interventions for cancer survivors. Br. J. Sports. Med. 43: 32-38 [Abstract] [Full Text]  
• Wang, P., Smit, E., Brouwers, M. C G J, Goossens, G. H, van der Kallen, C. J H, van Greevenbroek, M. M J, Mariman, E. C M (2008). Plasma pigment epithelium-derived factor is positively associated with obesity in Caucasian subjects, in particular with the visceral fat depot. Eur J Endocrinol 159: 713-718 [Abstract] [Full Text]  
• Saxena, N. K., Taliaferro-Smith, L., Knight, B. B., Merlin, D., Anania, F. A., O'Regan, R. M., Sharma, D. (2008). Bidirectional Crosstalk between Leptin and Insulin-like Growth Factor-I Signaling Promotes Invasion and Migration of Breast Cancer Cells via Transactivation of Epidermal Growth Factor Receptor. Cancer Res. 68: 9712-9722 [Abstract] [Full Text]  
• Yu, M.-W., Shih, W.-L., Lin, C.-L., Liu, C.-J., Jian, J.-W., Tsai, K.-S., Chen, C.-J. (2008). Body-Mass Index and Progression of Hepatitis B: A Population-Based Cohort Study in Men. JCO 26: 5576-5582 [Abstract] [Full Text]  
• Frieden, T. R., Myers, J. E., Krauskopf, M. S., Farley, T. A. (2008). A Public Health Approach to Winning the War Against Cancer. The Oncologist 13: 1306-1313 [Abstract] [Full Text]  
• Kendzor, D. E., Costello, T. J., Li, Y., Vidrine, J. I., Mazas, C. A., Reitzel, L. R., Cinciripini, P. M., Cofta-Woerpel, L. M., Businelle, M. S., Wetter, D. W. (2008). Race/Ethnicity and Multiple Cancer Risk Factors among Individuals Seeking Smoking Cessation Treatment. Cancer Epidemiol. Biomarkers Prev. 17: 2937-2945 [Abstract] [Full Text]  
• Peterson, N. B., Huang, Y., Newcomb, P. A., Titus-Ernstoff, L., Trentham-Dietz, A., Anic, G., Egan, K. M. (2008). Childbearing Recency and Modifiers of Premenopausal Breast Cancer Risk. Cancer Epidemiol. Biomarkers Prev. 17: 3284-3287 [Abstract] [Full Text]  
• Fujisawa, T, Endo, H, Tomimoto, A, Sugiyama, M, Takahashi, H, Saito, S, Inamori, M, Nakajima, N, Watanabe, M, Kubota, N, Yamauchi, T, Kadowaki, T, Wada, K, Nakagama, H, Nakajima, A (2008). Adiponectin suppresses colorectal carcinogenesis under the high-fat diet condition. Gut 57: 1531-1538 [Abstract] [Full Text]  
• Li, L., Hardy, R., Kuh, D., Lo Conte, R., Power, C. (2008). Child-to-Adult Body Mass Index and Height Trajectories: A Comparison of 2 British Birth Cohorts. Am J Epidemiol 168: 1008-1015 [Abstract] [Full Text]  
• Britton, J. A., Khan, A. E., Rohrmann, S., Becker, N., Linseisen, J., Nieters, A., Kaaks, R., Tjonneland, A., Halkjaer, J., Severinsen, M. T., Overvad, K., Pischon, T., Boeing, H., Trichopoulou, A., Kalapothaki, V., Trichopoulos, D., Mattiello, A., Tagliabue, G., Sacerdote, C., Peeters, P. H.M., Bueno-de-Mesquita, H. B., Ardanaz, E., Navarro, C., Jakszyn, P., Altzibar, J. M., Hallmans, G., Malmer, B., Berglund, G., Manjer, J., Allen, N., Key, T., Bingham, S., Besson, H., Ferrari, P., Jenab, M., Boffetta, P., Vineis, P., Riboli, E. (2008). Anthropometric characteristics and non-Hodgkin's lymphoma and multiple myeloma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). haematol 93: 1666-1677 [Abstract] [Full Text]  
• Marchesini, G., Moscatiello, S., Di Domizio, S., Forlani, G. (2008). Obesity-Associated Liver Disease. J. Clin. Endocrinol. Metab. 93: s74-s80 [Abstract] [Full Text]  
• Hursting, S. (2008). Abstract PL05-01: Mechanistic targets for preventing obesity-related cancers. Cancer Prevention Research 1: PL05-01-PL05-01  
• Garmey, E. G., Liu, Q., Sklar, C. A., Meacham, L. R., Mertens, A. C., Stovall, M. A., Yasui, Y., Robison, L. L., Oeffinger, K. C. (2008). Longitudinal Changes in Obesity and Body Mass Index Among Adult Survivors of Childhood Acute Lymphoblastic Leukemia: A Report From the Childhood Cancer Survivor Study. JCO 26: 4639-4645 [Abstract] [Full Text]  
• Kendzor, D. E., Cofta-Woerpel, L. M., Mazas, C. A., Li, Y., Vidrine, J. I., Reitzel, L. R., Costello, T. J., Businelle, M. S., Ahluwalia, J. S., Cinciripini, P. M., Wetter, D. W. (2008). Socioeconomic Status, Negative Affect, and Modifiable Cancer Risk Factors in African-American Smokers. Cancer Epidemiol. Biomarkers Prev. 17: 2546-2554 [Abstract] [Full Text]  
• Kaklamani, V. G., Wisinski, K. B., Sadim, M., Gulden, C., Do, A., Offit, K., Baron, J. A., Ahsan, H., Mantzoros, C., Pasche, B. (2008). Variants of the Adiponectin (ADIPOQ) and Adiponectin Receptor 1 (ADIPOR1) Genes and Colorectal Cancer Risk. JAMA 300: 1523-1531 [Abstract] [Full Text]  
• Zakikhani, M., Dowling, R. J.O., Sonenberg, N., Pollak, M. N. (2008). The Effects of Adiponectin and Metformin on Prostate and Colon Neoplasia Involve Activation of AMP-Activated Protein Kinase. Cancer Prevention Research 1: 369-375 [Abstract] [Full Text]  
• 45 and Up Study Collaborators, (2008). Cohort Profile: The 45 and Up Study. Int J Epidemiol 37: 941-947 [Full Text]  
• Griggs, J. J., Sabel, M. S. (2008). Obesity and Cancer Treatment: Weighing the Evidence. JCO 26: 4060-4062 [Full Text]  
• Algire, C., Zakikhani, M., Blouin, M.-J., Shuai, J. H., Pollak, M. (2008). Metformin attenuates the stimulatory effect of a high-energy diet on in vivo LLC1 carcinoma growth. Endocr Relat Cancer 15: 833-839 [Abstract] [Full Text]  
• Silver, L., Bassett, M. T. (2008). Food Safety for the 21st Century. JAMA 300: 957-959 [Full Text]  
• Fava, G., Alpini, G., Rychlicki, C., Saccomanno, S., DeMorrow, S., Trozzi, L., Candelaresi, C., Venter, J., Di Sario, A., Marzioni, M., Bearzi, I., Glaser, S., Alvaro, D., Marucci, L., Francis, H., Svegliati-Baroni, G., Benedetti, A. (2008). Leptin Enhances Cholangiocarcinoma Cell Growth. Cancer Res. 68: 6752-6761 [Abstract] [Full Text]  
• Eichinger, S., Hron, G., Bialonczyk, C., Hirschl, M., Minar, E., Wagner, O., Heinze, G., Kyrle, P. A. (2008). Overweight, Obesity, and the Risk of Recurrent Venous Thromboembolism. Arch Intern Med 168: 1678-1683 [Abstract] [Full Text]  
• Li, P. K.-T., Kwan, B. C.-H., Szeto, C. C., Ko, G. T.-C. (2008). Metabolic syndrome in peritoneal dialysis patients. NDT Plus 1: 206-214 [Abstract] [Full Text]  
• Tompkins, J., Bosch, P. R, Chenowith, R., Tiede, J. L, Swain, J. M (2008). Changes in Functional Walking Distance and Health-Related Quality of Life After Gastric Bypass Surgery. ptjournal 88: 928-935 [Abstract] [Full Text]  
• Kumanyika, S. K., Obarzanek, E., Stettler, N., Bell, R., Field, A. E., Fortmann, S. P., Franklin, B. A., Gillman, M. W., Lewis, C. E., Poston, W. C. II, Stevens, J., Hong, Y. (2008). Population-Based Prevention of Obesity: The Need for Comprehensive Promotion of Healthful Eating, Physical Activity, and Energy Balance: A Scientific Statement From American Heart Association Council on Epidemiology and Prevention, Interdisciplinary Committee for Prevention (Formerly the Expert Panel on Population and Prevention Science). Circulation 118: 428-464 [Abstract] [Full Text]  
• Song, Y.-M., Sung, J., Ha, M. (2008). Obesity and Risk of Cancer in Postmenopausal Korean Women. JCO 26: 3395-3402 [Abstract] [Full Text]  
• Weisberg, S. P., Leibel, R., Tortoriello, D. V. (2008). Dietary Curcumin Significantly Improves Obesity-Associated Inflammation and Diabetes in Mouse Models of Diabesity. Endocrinology 149: 3549-3558 [Abstract] [Full Text]  
• Bjorge, T., Engeland, A., Tverdal, A., Smith, G. D. (2008). Body Mass Index in Adolescence in Relation to Cause-specific Mortality: A Follow-up of 230,000 Norwegian Adolescents. Am J Epidemiol 168: 30-37 [Abstract] [Full Text]