Intratumoral T Cells, Recurrence, and Survival in Epithelial Ovarian Cancer
Lin Zhang, M.D., Jose R. Conejo-Garcia, M.D., Ph.D., Dionyssios Katsaros, M.D., Ph.D., Phyllis A. Gimotty, Ph.D., Marco Massobrio, M.D., Giorgia Regnani, M.D., Antonis Makrigiannakis, M.D., Ph.D., Heidi Gray, M.D., Katia Schlienger, M.D., Ph.D., Michael N. Liebman, Ph.D., Stephen C. Rubin, M.D., and George Coukos, M.D., Ph.D.
Background Although tumor-infiltrating T cells have been documentedin ovarian carcinoma, a clear association with clinical outcomehas not been established.
Methods We performed immunohistochemical analysis of 186 frozenspecimens from advanced-stage ovarian carcinomas to assess thedistribution of tumor-infiltrating T cells and conducted outcomeanalyses. Molecular analyses were performed in some tumors byreal-time polymerase chain reaction.
Results CD3+ tumor-infiltrating T cells were detected withintumor-cell islets (intratumoral T cells) in 102 of the 186 tumors(54.8 percent); they were undetectable in 72 tumors (38.7 percent);the remaining 12 tumors (6.5 percent) could not be evaluated.There were significant differences in the distributions of progression-freesurvival and overall survival according to the presence or absenceof intratumoral T cells (P<0.001 for both comparisons). Thefive-year overall survival rate was 38.0 percent among patientswhose tumors contained T cells and 4.5 percent among patientswhose tumors contained no T cells in islets. Significant differencesin the distributions of progression-free survival and overallsurvival according to the presence or absence of intratumoralT cells (P<0.001 for both comparisons) were also seen among74 patients with a complete clinical response after debulkingand platinum-based chemotherapy: the five-year overall survivalrate was 73.9 percent among patients whose tumors containedT cells and 11.9 percent among patients whose tumors containedno T cells in islets. The presence of intratumoral T cells independentlycorrelated with delayed recurrence or delayed death in multivariateanalysis and was associated with increased expression of interferon-,interleukin-2, and lymphocyte-attracting chemokines within thetumor. The absence of intratumoral T cells was associated withincreased levels of vascular endothelial growth factor.
Conclusions The presence of intratumoral T cells correlateswith improved clinical outcome in advanced ovarian carcinoma.
Source Information
From the Abramson Family Cancer Research Institute (L.Z., K.S., M.N.L., G.C.), the Center for Research on Reproduction and Women's Health (L.Z., J.R.C.-G., G.R., H.G., G.C.), the Division of Gynecologic Oncology, Department of Obstetrics and Gynecology (S.C.R., G.C.), and the Department of Biostatistics and Epidemiology (P.A.G.), University of Pennsylvania, Philadelphia; the Department of Obstetrics and Gynecology, University of Turin, Turin, Italy (D.K., M.M.); and the Department of Obstetrics and Gynecology, University of Heraklion, Heraklion, Greece (A.M.). Drs. Zhang, Conejo-Garcia, and Katsaros contributed equally to the article.
Address reprint requests to Dr. Coukos at the Center for Research on Reproduction and Women's Health, University of Pennsylvania, 1355 Biomedical Research Bldg. II/III, 421 Curie Blvd., Philadelphia, PA 19104, or at gcks{at}mail.med.upenn.edu.
T Cells in Ovarian Cancer
Fraggetta F., Scollo P., Pelosi G., Coukos G., Zhang L., Conejo-Garcia J. R.
Extract |
Full Text |
PDF
N Engl J Med 2003;
348:1814, May 1, 2003.
Correspondence
This article has been cited by other articles:
Scarlett, U. K., Cubillos-Ruiz, J. R., Nesbeth, Y. C., Martinez, D. G., Engle, X., Gewirtz, A. T., Ahonen, C. L., Conejo-Garcia, J. R.
(2009). In situ Stimulation of CD40 and Toll-like Receptor 3 Transforms Ovarian Cancer-Infiltrating Dendritic Cells from Immunosuppressive to Immunostimulatory Cells. Cancer Res.
69: 7329-7337
[Abstract][Full Text]
Hirschhaeuser, F., Leidig, T., Rodday, B., Lindemann, C., Mueller-Klieser, W.
(2009). Test System for Trifunctional Antibodies in 3D MCTS Culture. J Biomol Screen
14: 980-990
[Abstract]
Vella, L. A., Yu, M., Fuhrmann, S. R., El-Amine, M., Epperson, D. E., Finn, O. J.
(2009). Healthy individuals have T-cell and antibody responses to the tumor antigen cyclin B1 that when elicited in mice protect from cancer. Proc. Natl. Acad. Sci. USA
106: 14010-14015
[Abstract][Full Text]
Kryczek, I., Banerjee, M., Cheng, P., Vatan, L., Szeliga, W., Wei, S., Huang, E., Finlayson, E., Simeone, D., Welling, T. H., Chang, A., Coukos, G., Liu, R., Zou, W.
(2009). Phenotype, distribution, generation, and functional and clinical relevance of Th17 cells in the human tumor environments. Blood
114: 1141-1149
[Abstract][Full Text]
Alexe, G., Monaco, J., Doyle, S., Basavanhally, A., Reddy, A., Seiler, M., Ganesan, S., Bhanot, G., Madabhushi, A.
(2009). Towards Improved Cancer Diagnosis and Prognosis Using Analysis of Gene Expression Data and Computer Aided Imaging. Exp. Biol. Med.
234: 860-879
[Abstract][Full Text]
GIUNTOLI, R. L. II, WEBB, T. J., ZOSO, A., ROGERS, O., DIAZ-MONTES, T. P., BRISTOW, R. E., OELKE, M.
(2009). Ovarian Cancer-associated Ascites Demonstrates Altered Immune Environment: Implications for Antitumor Immunity. Anticancer Res
29: 2875-2884
[Abstract][Full Text]
Nesbeth, Y., Scarlett, U., Cubillos-Ruiz, J., Martinez, D., Engle, X., Turk, M.-J., Conejo-Garcia, J. R.
(2009). CCL5-Mediated Endogenous Antitumor Immunity Elicited by Adoptively Transferred Lymphocytes and Dendritic Cell Depletion. Cancer Res.
69: 6331-6338
[Abstract][Full Text]
Franciszkiewicz, K., Le Floc'h, A., Jalil, A., Vigant, F., Robert, T., Vergnon, I., Mackiewicz, A., Benihoud, K., Validire, P., Chouaib, S., Combadiere, C., Mami-Chouaib, F.
(2009). Intratumoral Induction of CD103 Triggers Tumor-Specific CTL Function and CCR5-Dependent T-Cell Retention. Cancer Res.
69: 6249-6255
[Abstract][Full Text]
Sun, T., Hu, Z., Shen, H., Lin, D.
(2009). Genetic Polymorphisms in Cytotoxic T-Lymphocyte Antigen 4 and Cancer: The Dialectical Nature of Subtle Human Immune Dysregulation. Cancer Res.
69: 6011-6014
[Abstract][Full Text]
Kandalaft, L. E., Facciabene, A., Buckanovich, R. J., Coukos, G.
(2009). Endothelin B Receptor, a New Target in Cancer Immune Therapy. Clin. Cancer Res.
15: 4521-4528
[Abstract][Full Text]
MATKOWSKI, R., GISTEREK, I., HALON, A., LACKO, A., SZEWCZYK, K., STASZEK, U., PUDELKO, M., SZYNGLAREWICZ, B., SZELACHOWSKA, J., ZOLNIEREK, A., KORNAFEL, J.
(2009). The Prognostic Role of Tumor-infiltrating CD4 and CD8 T Lymphocytes in Breast Cancer. Anticancer Res
29: 2445-2451
[Abstract][Full Text]
Oberlies, J., Watzl, C., Giese, T., Luckner, C., Kropf, P., Muller, I., Ho, A. D., Munder, M.
(2009). Regulation of NK Cell Function by Human Granulocyte Arginase. J. Immunol.
182: 5259-5267
[Abstract][Full Text]
Coveler, A. L., Disis, M. L.
(2009). Immunologic Biomarkers to Predict Vaccine Efficacy. aacredbook
2009: 125-128
[Full Text]
Chaput, N, Louafi, S, Bardier, A, Charlotte, F, Vaillant, J-C, Menegaux, F, Rosenzwajg, M, Lemoine, F, Klatzmann, D, Taieb, J
(2009). Identification of CD8+CD25+Foxp3+ suppressive T cells in colorectal cancer tissue. Gut
58: 520-529
[Abstract][Full Text]
Camus, M., Tosolini, M., Mlecnik, B., Pages, F., Kirilovsky, A., Berger, A., Costes, A., Bindea, G., Charoentong, P., Bruneval, P., Trajanoski, Z., Fridman, W.-H., Galon, J.
(2009). Coordination of Intratumoral Immune Reaction and Human Colorectal Cancer Recurrence. Cancer Res.
69: 2685-2693
[Abstract][Full Text]
Ruby, C. E., Weinberg, A. D.
(2009). OX40-Enhanced Tumor Rejection and Effector T Cell Differentiation Decreases with Age. J. Immunol.
182: 1481-1489
[Abstract][Full Text]
Brody, J. D., Goldstein, M. J., Czerwinski, D. K., Levy, R.
(2009). Immunotransplantation preferentially expands T-effector cells over T-regulatory cells and cures large lymphoma tumors. Blood
113: 85-94
[Abstract][Full Text]
Webb, T. J., Giuntoli, R. L. II, Rogers, O., Schneck, J., Oelke, M.
(2008). Ascites Specific Inhibition of CD1d-Mediated Activation of Natural Killer T Cells. Clin. Cancer Res.
14: 7652-7658
[Abstract][Full Text]
Callahan, M. J., Nagymanyoki, Z., Bonome, T., Johnson, M. E., Litkouhi, B., Sullivan, E. H., Hirsch, M. S., Matulonis, U. A., Liu, J., Birrer, M. J., Berkowitz, R. S., Mok, S. C.
(2008). Increased HLA-DMB Expression in the Tumor Epithelium Is Associated with Increased CTL Infiltration and Improved Prognosis in Advanced-Stage Serous Ovarian Cancer. Clin. Cancer Res.
14: 7667-7673
[Abstract][Full Text]
de la Cruz-Merino, L., Grande-Pulido, E., Albero-Tamarit, A., Codes-Manuel de Villena, M. E.
(2008). Cancer and Immune Response: Old and New Evidence for Future Challenges. The Oncologist
13: 1246-1254
[Abstract][Full Text]
Maccalli, C., Di Cristanziano, V., Fodale, V., Corsi, D., D'Agostino, G., Petrangeli, V., Laurenti, L., Guida, S., Mazzocchi, A., Arienti, F., Perrone, M. P., Castelli, C., Rivoltini, L., Zagonel, V., Tartaglia, M., Parmiani, G., Belardelli, F.
(2008). Induction of Both CD8+ and CD4+ T-Cell-Mediated Responses in Colorectal Cancer Patients by Colon Antigen-1. Clin. Cancer Res.
14: 7292-7303
[Abstract][Full Text]
Fang, L., Lee, V. C., Cha, E., Zhang, H., Hwang, S. T.
(2008). CCR7 regulates B16 murine melanoma cell tumorigenesis in skin. J. Leukoc. Biol.
84: 965-972
[Abstract][Full Text]
Dieu-Nosjean, M.-C., Antoine, M., Danel, C., Heudes, D., Wislez, M., Poulot, V., Rabbe, N., Laurans, L., Tartour, E., de Chaisemartin, L., Lebecque, S., Fridman, W.-H., Cadranel, J.
(2008). Long-Term Survival for Patients With Non-Small-Cell Lung Cancer With Intratumoral Lymphoid Structures. JCO
26: 4410-4417
[Abstract][Full Text]
Sun, T., Zhou, Y., Yang, M., Hu, Z., Tan, W., Han, X., Shi, Y., Yao, J., Guo, Y., Yu, D., Tian, T., Zhou, X., Shen, H., Lin, D.
(2008). Functional Genetic Variations in Cytotoxic T-Lymphocyte Antigen 4 and Susceptibility to Multiple Types of Cancer. Cancer Res.
68: 7025-7034
[Abstract][Full Text]
Haining, W. N., Davies, J., Kanzler, H., Drury, L., Brenn, T., Evans, J., Angelosanto, J., Rivoli, S., Russell, K., George, S., Sims, P., Neuberg, D., Li, X., Kutok, J., Morgan, J., Wen, P., Demetri, G., Coffman, R. L., Nadler, L. M.
(2008). CpG Oligodeoxynucleotides Alter Lymphocyte and Dendritic Cell Trafficking in Humans. Clin. Cancer Res.
14: 5626-5634
[Abstract][Full Text]
Tothill, R. W., Tinker, A. V., George, J., Brown, R., Fox, S. B., Lade, S., Johnson, D. S., Trivett, M. K., Etemadmoghadam, D., Locandro, B., Traficante, N., Fereday, S., Hung, J. A., Chiew, Y.-E., Haviv, I., Australian Ovarian Cancer Study Group, , Gertig, D., deFazio, A., Bowtell, D. D.L.
(2008). Novel Molecular Subtypes of Serous and Endometrioid Ovarian Cancer Linked to Clinical Outcome. Clin. Cancer Res.
14: 5198-5208
[Abstract][Full Text]
Chiang, C. L-L., Ledermann, J. A., Aitkens, E., Benjamin, E., Katz, D. R., Chain, B. M.
(2008). Oxidation of Ovarian Epithelial Cancer Cells by Hypochlorous Acid Enhances Immunogenicity and Stimulates T Cells that Recognize Autologous Primary Tumor. Clin. Cancer Res.
14: 4898-4907
[Abstract][Full Text]
Willimsky, G., Czeh, M., Loddenkemper, C., Gellermann, J., Schmidt, K., Wust, P., Stein, H., Blankenstein, T.
(2008). Immunogenicity of premalignant lesions is the primary cause of general cytotoxic T lymphocyte unresponsiveness. JEM
205: 1687-1700
[Abstract][Full Text]
Sawanobori, Y., Ueha, S., Kurachi, M., Shimaoka, T., Talmadge, J. E., Abe, J., Shono, Y., Kitabatake, M., Kakimi, K., Mukaida, N., Matsushima, K.
(2008). Chemokine-mediated rapid turnover of myeloid-derived suppressor cells in tumor-bearing mice. Blood
111: 5457-5466
[Abstract][Full Text]
Sfanos, K. S., Bruno, T. C., Maris, C. H., Xu, L., Thoburn, C. J., DeMarzo, A. M., Meeker, A. K., Isaacs, W. B., Drake, C. G.
(2008). Phenotypic Analysis of Prostate-Infiltrating Lymphocytes Reveals TH17 and Treg Skewing. Clin. Cancer Res.
14: 3254-3261
[Abstract][Full Text]
Han, L. Y., Fletcher, M. S., Urbauer, D. L., Mueller, P., Landen, C. N., Kamat, A. A., Lin, Y. G., Merritt, W. M., Spannuth, W. A., Deavers, M. T., De Geest, K., Gershenson, D. M., Lutgendorf, S. K., Ferrone, S., Sood, A. K.
(2008). HLA Class I Antigen Processing Machinery Component Expression and Intratumoral T-Cell Infiltrate as Independent Prognostic Markers in Ovarian Carcinoma. Clin. Cancer Res.
14: 3372-3379
[Abstract][Full Text]
Duncan, T. J., Al-Attar, A., Rolland, P., Scott, I. V., Deen, S., Liu, D. T.Y., Spendlove, I., Durrant, L. G.
(2008). Vascular Endothelial Growth Factor Expression in Ovarian Cancer: A Model for Targeted Use of Novel Therapies?. Clin. Cancer Res.
14: 3030-3035
[Abstract][Full Text]
Friedrichs, B., Siegel, S., Kloess, M., Barsoum, A., Coggin, J. Jr., Rohrer, J., Jakob, I., Tiemann, M., Heidorn, K., Schulte, C., Kabelitz, D., Steinmann, J., Schmitz, N., Zeis, M.
(2008). Humoral Immune Responses against the Immature Laminin Receptor Protein Show Prognostic Significance in Patients with Chronic Lymphocytic Leukemia. J. Immunol.
180: 6374-6384
[Abstract][Full Text]
Diefenbach, C. S.M., Gnjatic, S., Sabbatini, P., Aghajanian, C., Hensley, M. L., Spriggs, D. R., Iasonos, A., Lee, H., Dupont, B., Pezzulli, S., Jungbluth, A. A., Old, L. J., Dupont, J.
(2008). Safety and Immunogenicity Study of NY-ESO-1b Peptide and Montanide ISA-51 Vaccination of Patients with Epithelial Ovarian Cancer in High-Risk First Remission. Clin. Cancer Res.
14: 2740-2748
[Abstract][Full Text]
Raghuwanshi, S. K., Nasser, M. W., Chen, X., Strieter, R. M., Richardson, R. M.
(2008). Depletion of {beta}-Arrestin-2 Promotes Tumor Growth and Angiogenesis in a Murine Model of Lung Cancer. J. Immunol.
180: 5699-5706
[Abstract][Full Text]
Ino, K., Yamamoto, E., Shibata, K., Kajiyama, H., Yoshida, N., Terauchi, M., Nawa, A., Nagasaka, T., Takikawa, O., Kikkawa, F.
(2008). Inverse Correlation between Tumoral Indoleamine 2,3-Dioxygenase Expression and Tumor-Infiltrating Lymphocytes in Endometrial Cancer: Its Association with Disease Progression and Survival. Clin. Cancer Res.
14: 2310-2317
[Abstract][Full Text]
Ladoire, S., Arnould, L., Apetoh, L., Coudert, B., Martin, F., Chauffert, B., Fumoleau, P., Ghiringhelli, F.
(2008). Pathologic Complete Response to Neoadjuvant Chemotherapy of Breast Carcinoma Is Associated with the Disappearance of Tumor-Infiltrating Foxp3+ Regulatory T Cells. Clin. Cancer Res.
14: 2413-2420
[Abstract][Full Text]
Le Page, C., Ouellet, V., Quinn, M. C.J., Tonin, P. N., Provencher, D. M., Mes-Masson, A.-M.
(2008). BTF4/BTNA3.2 and GCS as Candidate mRNA Prognostic Markers in Epithelial Ovarian Cancer. Cancer Epidemiol. Biomarkers Prev.
17: 913-920
[Abstract][Full Text]
Worschech, A., Kmieciak, M., Knutson, K. L., Bear, H. D., Szalay, A. A., Wang, E., Marincola, F. M., Manjili, M. H.
(2008). Signatures Associated with Rejection or Recurrence in HER-2/neu-Positive Mammary Tumors. Cancer Res.
68: 2436-2446
[Abstract][Full Text]
Jordanova, E. S., Gorter, A., Ayachi, O., Prins, F., Durrant, L. G., Kenter, G. G., van der Burg, S. H., Fleuren, G. J.
(2008). Human Leukocyte Antigen Class I, MHC Class I Chain-Related Molecule A, and CD8+/Regulatory T-Cell Ratio: Which Variable Determines Survival of Cervical Cancer Patients?. Clin. Cancer Res.
14: 2028-2035
[Abstract][Full Text]
Fonseca, C., Dranoff, G.
(2008). Capitalizing on the Immunogenicity of Dying Tumor Cells. Clin. Cancer Res.
14: 1603-1608
[Abstract][Full Text]
Landen, C. N. Jr, Birrer, M. J., Sood, A. K.
(2008). Early Events in the Pathogenesis of Epithelial Ovarian Cancer. JCO
26: 995-1005
[Abstract][Full Text]
Amaravadi, R. K., Thompson, C. B.
(2007). The Roles of Therapy-Induced Autophagy and Necrosis in Cancer Treatment. Clin. Cancer Res.
13: 7271-7279
[Abstract][Full Text]
Katou, F., Ohtani, H., Watanabe, Y., Nakayama, T., Yoshie, O., Hashimoto, K.
(2007). Differing Phenotypes between Intraepithelial and Stromal Lymphocytes in Early-Stage Tongue Cancer. Cancer Res.
67: 11195-11201
[Abstract][Full Text]
Kiniwa, Y., Miyahara, Y., Wang, H. Y., Peng, W., Peng, G., Wheeler, T. M., Thompson, T. C., Old, L. J., Wang, R.-F.
(2007). CD8+ Foxp3+ Regulatory T Cells Mediate Immunosuppression in Prostate Cancer. Clin. Cancer Res.
13: 6947-6958
[Abstract][Full Text]
Yang, T., Wall, E. M., Milne, K., Theiss, P., Watson, P., Nelson, B. H.
(2007). CD8+ T Cells Induce Complete Regression of Advanced Ovarian Cancers by an Interleukin (IL)-2/IL-15 Dependent Mechanism. Clin. Cancer Res.
13: 7172-7180
[Abstract][Full Text]
Alexe, G., Dalgin, G. S., Scanfeld, D., Tamayo, P., Mesirov, J. P., DeLisi, C., Harris, L., Barnard, N., Martel, M., Levine, A. J., Ganesan, S., Bhanot, G.
(2007). High Expression of Lymphocyte-Associated Genes in Node-Negative HER2+ Breast Cancers Correlates with Lower Recurrence Rates. Cancer Res.
67: 10669-10676
[Abstract][Full Text]
Otahal, P., Knowles, B. B., Tevethia, S. S., Schell, T. D.
(2007). Anti-CD40 Conditioning Enhances the TCD8 Response to a Highly Tolerogenic Epitope and Subsequent Immunotherapy of Simian Virus 40 T Antigen-Induced Pancreatic Tumors. J. Immunol.
179: 6686-6695
[Abstract][Full Text]
Su, C.-C., Lin, Y.-P., Cheng, Y.-J., Huang, J.-Y., Chuang, W.-J., Shan, Y.-S., Yang, B.-C.
(2007). Phosphatidylinositol 3-Kinase/Akt Activation by Integrin-Tumor Matrix Interaction Suppresses Fas-Mediated Apoptosis in T Cells. J. Immunol.
179: 4589-4597
[Abstract][Full Text]
Odunsi, K., Qian, F., Matsuzaki, J., Mhawech-Fauceglia, P., Andrews, C., Hoffman, E. W., Pan, L., Ritter, G., Villella, J., Thomas, B., Rodabaugh, K., Lele, S., Shrikant, P., Old, L. J., Gnjatic, S.
(2007). Vaccination with an NY-ESO-1 peptide of HLA class I/II specificities induces integrated humoral and T cell responses in ovarian cancer. Proc. Natl. Acad. Sci. USA
104: 12837-12842
[Abstract][Full Text]
Sabbatini, P., Odunsi, K.
(2007). Immunologic Approaches to Ovarian Cancer Treatment. JCO
25: 2884-2893
[Abstract][Full Text]
Shaykhiev, R., Bals, R.
(2007). Interactions between epithelial cells and leukocytes in immunity and tissue homeostasis. J. Leukoc. Biol.
82: 1-15
[Abstract][Full Text]
Sharma, P., Shen, Y., Wen, S., Yamada, S., Jungbluth, A. A., Gnjatic, S., Bajorin, D. F., Reuter, V. E., Herr, H., Old, L. J., Sato, E.
(2007). CD8 tumor-infiltrating lymphocytes are predictive of survival in muscle-invasive urothelial carcinoma. Proc. Natl. Acad. Sci. USA
104: 3967-3972
[Abstract][Full Text]
Galon, J., Fridman, W.-H., Pages, F.
(2007). The Adaptive Immunologic Microenvironment in Colorectal Cancer: A Novel Perspective. Cancer Res.
67: 1883-1886
[Abstract][Full Text]
Liu, V. C., Wong, L. Y., Jang, T., Shah, A. H., Park, I., Yang, X., Zhang, Q., Lonning, S., Teicher, B. A., Lee, C.
(2007). Tumor Evasion of the Immune System by Converting CD4+CD25- T Cells into CD4+CD25+ T Regulatory Cells: Role of Tumor-Derived TGF-beta. J. Immunol.
178: 2883-2892
[Abstract][Full Text]
Nesslinger, N. J., Sahota, R. A., Stone, B., Johnson, K., Chima, N., King, C., Rasmussen, D., Bishop, D., Rennie, P. S., Gleave, M., Blood, P., Pai, H., Ludgate, C., Nelson, B. H.
(2007). Standard Treatments Induce Antigen-Specific Immune Responses in Prostate Cancer. Clin. Cancer Res.
13: 1493-1502
[Abstract][Full Text]
Hamanishi, J., Mandai, M., Iwasaki, M., Okazaki, T., Tanaka, Y., Yamaguchi, K., Higuchi, T., Yagi, H., Takakura, K., Minato, N., Honjo, T., Fujii, S.
(2007). Programmed cell death 1 ligand 1 and tumor-infiltrating CD8+ T lymphocytes are prognostic factors of human ovarian cancer. Proc. Natl. Acad. Sci. USA
104: 3360-3365
[Abstract][Full Text]
Kobayashi, N., Hiraoka, N., Yamagami, W., Ojima, H., Kanai, Y., Kosuge, T., Nakajima, A., Hirohashi, S.
(2007). FOXP3+ Regulatory T Cells Affect the Development and Progression of Hepatocarcinogenesis. Clin. Cancer Res.
13: 902-911
[Abstract][Full Text]
Piersma, S. J., Jordanova, E. S., van Poelgeest, M. I.E., Kwappenberg, K. M.C., van der Hulst, J. M., Drijfhout, J. W., Melief, C. J.M., Kenter, G. G., Fleuren, G. J., Offringa, R., van der Burg, S. H.
(2007). High Number of Intraepithelial CD8+ Tumor-Infiltrating Lymphocytes Is Associated with the Absence of Lymph Node Metastases in Patients with Large Early-Stage Cervical Cancer. Cancer Res.
67: 354-361
[Abstract][Full Text]
Coughlin, C. M., Fleming, M. D., Carroll, R. G., Pawel, B. R., Hogarty, M. D., Shan, X., Vance, B. A., Cohen, J. N., Jairaj, S., Lord, E. M., Wexler, M. H., Danet-Desnoyers, G.-a. H., Pinkus, J. L., Pinkus, G. S., Maris, J. M., Grupp, S. A., Vonderheide, R. H.
(2006). Immunosurveillance and Survivin-Specific T-Cell Immunity in Children With High-Risk Neuroblastoma. JCO
24: 5725-5734
[Abstract][Full Text]
Dirkx, A. E. M., oude Egbrink, M. G. A., Wagstaff, J., Griffioen, A. W.
(2006). Monocyte/macrophage infiltration in tumors: modulators of angiogenesis. J. Leukoc. Biol.
80: 1183-1196
[Abstract][Full Text]
Serafini, P., Meckel, K., Kelso, M., Noonan, K., Califano, J., Koch, W., Dolcetti, L., Bronte, V., Borrello, I.
(2006). Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function. JEM
203: 2691-2702
[Abstract][Full Text]
Galon, J., Costes, A., Sanchez-Cabo, F., Kirilovsky, A., Mlecnik, B., Lagorce-Pages, C., Tosolini, M., Camus, M., Berger, A., Wind, P., Zinzindohoue, F., Bruneval, P., Cugnenc, P.-H., Trajanoski, Z., Fridman, W.-H., Pages, F.
(2006). Type, density, and location of immune cells within human colorectal tumors predict clinical outcome.. Science
313: 1960-1964
[Abstract][Full Text]
Sabbatini, P., Dupont, J., Aghajanian, C., Derosa, F., Poynor, E., Anderson, S., Hensley, M., Livingston, P., Iasonos, A., Spriggs, D., McGuire, W., Reinartz, S., Schneider, S., Grande, C., Lele, S., Rodabaugh, K., Kepner, J., Ferrone, S., Odunsi, K.
(2006). Phase I study of abagovomab in patients with epithelial ovarian, fallopian tube, or primary peritoneal cancer.. Clin. Cancer Res.
12: 5503-5510
[Abstract][Full Text]
Chaput, N., Flament, C., Viaud, S., Taieb, J., Roux, S., Spatz, A., Andre, F., LePecq, J.-B., Boussac, M., Garin, J., Amigorena, S., Thery, C., Zitvogel, L.
(2006). Dendritic cell derived-exosomes: biology and clinical implementations. J. Leukoc. Biol.
80: 471-478
[Abstract][Full Text]
Taneichi, M., Ishida, H., Kajino, K., Ogasawara, K., Tanaka, Y., Kasai, M., Mori, M., Nishida, M., Yamamura, H., Mizuguchi, J., Uchida, T.
(2006). Antigen Chemically Coupled to the Surface of Liposomes Are Cross-Presented to CD8+ T Cells and Induce Potent Antitumor Immunity. J. Immunol.
177: 2324-2330
[Abstract][Full Text]
Bui, J. D., Uppaluri, R., Hsieh, C.-S., Schreiber, R. D.
(2006). Comparative Analysis of Regulatory and Effector T Cells in Progressively Growing versus Rejecting Tumors of Similar Origins.. Cancer Res.
66: 7301-7309
[Abstract][Full Text]
Norell, H., Carlsten, M., Ohlum, T., Malmberg, K.-J., Masucci, G., Schedvins, K., Altermann, W., Handke, D., Atkins, D., Seliger, B., Kiessling, R.
(2006). Frequent Loss of HLA-A2 Expression in Metastasizing Ovarian Carcinomas Associated with Genomic Haplotype Loss and HLA-A2-Restricted HER-2/neu-Specific Immunity.. Cancer Res.
66: 6387-6394
[Abstract][Full Text]
Grabenbauer, G. G., Lahmer, G., Distel, L., Niedobitek, G.
(2006). Tumor-Infiltrating Cytotoxic T Cells but not Regulatory T Cells Predict Outcome in Anal Squamous Cell Carcinoma.. Clin. Cancer Res.
12: 3355-3360
[Abstract][Full Text]
Hirano, N., Butler, M. O., Xia, Z., Berezovskaya, A., Murray, A. P., Ansen, S., Nadler, L. M.
(2006). Efficient Presentation of Naturally Processed HLA Class I Peptides by Artificial Antigen-Presenting Cells for the Generation of Effective Antitumor Responses.. Clin. Cancer Res.
12: 2967-2975
[Abstract][Full Text]
Dirkx, A. E. M., oude Egbrink, M. G. A., Castermans, K., van der Schaft, D. W. J., Thijssen, V. L. J. L., Dings, R. P. M., Kwee, L., Mayo, K. H., Wagstaff, J., ter Steege, J. C. A. B., Griffioen, A. W.
(2006). Anti-angiogenesis therapy can overcome endothelial cell anergy and promote leukocyte-endothelium interactions and infiltration in tumors. FASEB J.
20: 621-630
[Abstract][Full Text]
Vakkila, J., Jaffe, R., Michelow, M., Lotze, M. T.
(2006). Pediatric cancers are infiltrated predominantly by macrophages and contain a paucity of dendritic cells: a major nosologic difference with adult tumors.. Clin. Cancer Res.
12: 2049-2054
[Abstract][Full Text]
Lu, H., Ouyang, W., Huang, C.
(2006). Inflammation, a Key Event in Cancer Development. Mol Cancer Res
4: 221-233
[Abstract][Full Text]
Abramson, J. S.
(2006). T-cell/histiocyte-rich B-cell lymphoma: biology, diagnosis, and management.. The Oncologist
11: 384-392
[Abstract][Full Text]
Chan, J. K., Hamilton, C. A., Cheung, M. K., Karimi, M., Baker, J., Gall, J. M., Schulz, S., Thorne, S. H., Teng, N. N., Contag, C. H., Lum, L. G., Negrin, R. S.
(2006). Enhanced killing of primary ovarian cancer by retargeting autologous cytokine-induced killer cells with bispecific antibodies: a preclinical study.. Clin. Cancer Res.
12: 1859-1867
[Abstract][Full Text]
Brandacher, G., Perathoner, A., Ladurner, R., Schneeberger, S., Obrist, P., Winkler, C., Werner, E. R., Werner-Felmayer, G., Weiss, H. G., Gobel, G., Margreiter, R., Konigsrainer, A., Fuchs, D., Amberger, A.
(2006). Prognostic Value of Indoleamine 2,3-Dioxygenase Expression in Colorectal Cancer: Effect on Tumor-Infiltrating T Cells. Clin. Cancer Res.
12: 1144-1151
[Abstract][Full Text]
Kubuschok, B., Neumann, F., Breit, R., Sester, M., Schormann, C., Wagner, C., Sester, U., Hartmann, F., Wagner, M., Remberger, K., Schilling, M., Pfreundschuh, M.
(2006). Naturally Occurring T-Cell Response against Mutated p21 Ras Oncoprotein in Pancreatic Cancer. Clin. Cancer Res.
12: 1365-1372
[Abstract][Full Text]
Goodell, V., Salazar, L. G., Urban, N., Drescher, C. W., Gray, H., Swensen, R. E., McIntosh, M. W., Disis, M. L.
(2006). Antibody Immunity to the p53 Oncogenic Protein Is a Prognostic Indicator in Ovarian Cancer. JCO
24: 762-768
[Abstract][Full Text]
Sabbatini, P., Spriggs, D. R.
(2006). Consolidation for Ovarian Cancer in Remission. JCO
24: 537-539
[Full Text]
Valmori, D., Qian, F., Ayyoub, M., Renner, C., Merlo, A., Gjnatic, S., Stockert, E., Driscoll, D., Lele, S., Old, L. J., Odunsi, K.
(2006). Expression of Synovial Sarcoma X (SSX) Antigens in Epithelial Ovarian Cancer and Identification of SSX-4 Epitopes Recognized by CD4+ T Cells. Clin. Cancer Res.
12: 398-404
[Abstract][Full Text]
Badoual, C., Hans, S., Rodriguez, J., Peyrard, S., Klein, C., Agueznay, N. E. H., Mosseri, V., Laccourreye, O., Bruneval, P., Fridman, W. H., Brasnu, D. F., Tartour, E.
(2006). Prognostic Value of Tumor-Infiltrating CD4+ T-Cell Subpopulations in Head and Neck Cancers. Clin. Cancer Res.
12: 465-472
[Abstract][Full Text]
Roda, J. M., Parihar, R., Magro, C., Nuovo, G. J., Tridandapani, S., Carson, W. E. III
(2006). Natural Killer Cells Produce T Cell-Recruiting Chemokines in Response to Antibody-Coated Tumor Cells. Cancer Res.
66: 517-526
[Abstract][Full Text]
Pages, F., Berger, A., Camus, M., Sanchez-Cabo, F., Costes, A., Molidor, R., Mlecnik, B., Kirilovsky, A., Nilsson, M., Damotte, D., Meatchi, T., Bruneval, P., Cugnenc, P.-H., Trajanoski, Z., Fridman, W.-H., Galon, J.
(2005). Effector Memory T Cells, Early Metastasis, and Survival in Colorectal Cancer. NEJM
353: 2654-2666
[Abstract][Full Text]
Sato, E., Olson, S. H., Ahn, J., Bundy, B., Nishikawa, H., Qian, F., Jungbluth, A. A., Frosina, D., Gnjatic, S., Ambrosone, C., Kepner, J., Odunsi, T., Ritter, G., Lele, S., Chen, Y.-T., Ohtani, H., Old, L. J., Odunsi, K.
(2005). Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer. Proc. Natl. Acad. Sci. USA
102: 18538-18543
[Abstract][Full Text]
Disis, M. L., Lyerly, H. K.
(2005). Global Role of the Immune System in Identifying Cancer Initiation and Limiting Disease Progression. JCO
23: 8923-8925
[Full Text]
Dranoff, G.
(2005). The Therapeutic Implications of Intratumoral Regulatory T Cells. Clin. Cancer Res.
11: 8226-8229
[Full Text]
Coleman, S., Clayton, A., Mason, M. D., Jasani, B., Adams, M., Tabi, Z.
(2005). Recovery of CD8+ T-Cell Function During Systemic Chemotherapy in Advanced Ovarian Cancer. Cancer Res.
65: 7000-7006
[Abstract][Full Text]
Bronte, V., Kasic, T., Gri, G., Gallana, K., Borsellino, G., Marigo, I., Battistini, L., Iafrate, M., Prayer-Galetti, T., Pagano, F., Viola, A.
(2005). Boosting antitumor responses of T lymphocytes infiltrating human prostate cancers. JEM
201: 1257-1268
[Abstract][Full Text]
Fairey, A. S., Courneya, K. S., Field, C. J., Bell, G. J., Jones, L. W., Mackey, J. R.
(2005). Randomized controlled trial of exercise and blood immune function in postmenopausal breast cancer survivors. J. Appl. Physiol.
98: 1534-1540
[Abstract][Full Text]
Raspollini, M. R., Castiglione, F., Rossi Degl'Innocenti, D., Amunni, G., Villanucci, A., Garbini, F., Baroni, G., Taddei, G. L.
(2005). Tumour-infiltrating gamma/delta T-lymphocytes are correlated with a brief disease-free interval in advanced ovarian serous carcinoma. Ann Oncol
16: 590-596
[Abstract][Full Text]
Yu, P., Lee, Y., Liu, W., Krausz, T., Chong, A., Schreiber, H., Fu, Y.-X.
(2005). Intratumor depletion of CD4+ cells unmasks tumor immunogenicity leading to the rejection of late-stage tumors. JEM
201: 779-791
[Abstract][Full Text]
Noonan, K., Matsui, W., Serafini, P., Carbley, R., Tan, G., Khalili, J., Bonyhadi, M., Levitsky, H., Whartenby, K., Borrello, I.
(2005). Activated Marrow-Infiltrating Lymphocytes Effectively Target Plasma Cells and Their Clonogenic Precursors. Cancer Res.
65: 2026-2034
[Abstract][Full Text]
Zhang, L., Yang, N., Huang, J., Buckanovich, R. J., Liang, S., Barchetti, A., Vezzani, C., O'Brien-Jenkins, A., Wang, J., Ward, M. R., Courreges, M. C., Fracchioli, S., Medina, A., Katsaros, D., Weber, B. L., Coukos, G.
(2005). Transcriptional Coactivator Drosophila Eyes Absent Homologue 2 Is Up-Regulated in Epithelial Ovarian Cancer and Promotes Tumor Growth. Cancer Res.
65: 925-932
[Abstract][Full Text]
Bricard, G., Bouzourene, H., Martinet, O., Rimoldi, D., Halkic, N., Gillet, M., Chaubert, P., MacDonald, H. R., Romero, P., Cerottini, J.-C., Speiser, D. E.
(2005). Naturally Acquired MAGE-A10- and SSX-2-Specific CD8+ T Cell Responses in Patients with Hepatocellular Carcinoma. J. Immunol.
174: 1709-1716
[Abstract][Full Text]
Ryschich, E., Notzel, T., Hinz, U., Autschbach, F., Ferguson, J., Simon, I., Weitz, J., Frohlich, B., Klar, E., Buchler, M. W., Schmidt, J.
(2005). Control of T-Cell-Mediated Immune Response by HLA Class I in Human Pancreatic Carcinoma. Clin. Cancer Res.
11: 498-504
[Abstract][Full Text]
Vitale, M., Pelusi, G., Taroni, B., Gobbi, G., Micheloni, C., Rezzani, R., Donato, F., Wang, X., Ferrone, S.
(2005). HLA Class I Antigen Down-Regulation in Primary Ovary Carcinoma Lesions: Association with Disease Stage. Clin. Cancer Res.
11: 67-72
[Abstract][Full Text]
, interleukin-2, and lymphocyte-attracting chemokines within the tumor. The absence of intratumoral T cells was associated with increased levels of vascular endothelial growth factor. 
Previous
