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Previous Volume 348:394-402 January 30, 2003 Number 5 Next

	Full Text PDF PDA Full Text PowerPoint Slide Set Perspective by Rose, E. A. Letters Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear PubMed Citation

ABSTRACT

Background The performance of coronary bypass surgery without cardiopulmonary bypass ("off pump") may reduce perioperative morbidity and costs, but it is uncertain whether the outcome is similar to that involving the use of cardiopulmonary bypass ("on pump").

Methods In a multicenter, randomized trial, we randomly assigned 139 patients with predominantly single- or double-vessel coronary disease to on-pump surgery and 142 to off-pump surgery. Cardiac outcome and cost effectiveness were determined one year after surgery. The uncertainty surrounding the cost-effectiveness ratio (cost differences per quality-adjusted year of life gained) was addressed by bootstrapping.

Results At one year, the rate of freedom from death, stroke, myocardial infarction, and coronary reintervention was 90.6 percent after on-pump surgery and 88.0 percent after off-pump surgery (absolute difference, 2.6 percent; 95 percent confidence interval, – 4.6 to 9.8). Graft patency in a randomized subgroup of patients was 93 percent after on-pump surgery and 91 percent after off-pump surgery (absolute difference, 2.0 percent; 95 percent confidence interval, – 6.5 to 10.4). On-pump surgery was associated with $1,839 in additional direct costs per patient ($14,908 vs. $13,069 — a difference of 14.1 percent) and an increase in quality-adjusted years of life of 0.83 as compared with 0.82 (difference, 0.01 year; 95 percent confidence interval, – 0.03 to 0.04). Off-pump surgery was more cost effective than on-pump surgery in 95 percent of bootstrap estimates.

Conclusions In low-risk patients, there was no difference in cardiac outcome at one year between those who underwent on-pump bypass surgery and those who underwent off-pump surgery. Off-pump surgery was more cost effective.

Source Information

From the Departments of Cardiology (H.M.N., C.B., P.P.T.J.), Anesthesiology (D.D., J.C.D., C.J.K.), Cardiothoracic Surgery (E.W.L.J., A.B.R.), and the Julius Center for Health Sciences and Primary Care (D.E.G., E.B.), University Medical Center Utrecht, Utrecht; the Department of Cardiothoracic Surgery, Isala Clinics, Weezenlanden Hospital, Zwolle (W.J.L.S.); and the Department of Cardiothoracic Surgery, Antonius Hospital, Nieuwegein (W.-J.B.) — all in the Netherlands.

Address reprint requests to Dr. de Jaegere at the University Medical Center Utrecht, Department of Cardiology (HPN: E 01.207), P.O. Box 85500, 3508 GA, Utrecht, the Netherlands, or at p.p.t.dejaegere{at}hli.azu.nl.

Full Text of this Article

Related Letters:

Off-Pump Coronary Bypass Surgery
Donias H. W., Pande R., Karamanoukian H. L., Gomberg-Maitland M., Halperin J. L., Healey J., Fenwick E., O'Brien B., Nathoe H. M., Buskens E., de Jaegere P. P.T., Rose E. A.
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N Engl J Med 2003; 348:1928-1931, May 8, 2003. Correspondence

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