Circulating Endothelial Progenitor Cells, Vascular Function, and Cardiovascular Risk

doi:10.1056/NEJMoa022287

Volume 348:593-600		February 13, 2003		Number 7

Circulating Endothelial Progenitor Cells, Vascular Function, and Cardiovascular Risk

Jonathan M. Hill, M.R.C.P., Gloria Zalos, R.N., Julian P.J. Halcox, M.R.C.P., William H. Schenke, B.A., Myron A. Waclawiw, Ph.D., Arshed A. Quyyumi, M.D., and Toren Finkel, M.D., Ph.D.

Full Text

PDF

PDA Full Text

Perspective
by Rosenzweig, A.

Add to Personal Archive

Add to Citation Manager

Notify a Friend

E-mail When Cited

E-mail When Letters Appear

PubMed Citation

ABSTRACT

Background Cardiovascular risk factors contribute to atherogenesisby inducing endothelial-cell injury and dysfunction. We hypothesizedthat endothelial progenitor cells derived from bone marrow havea role in ongoing endothelial repair and that impaired mobilizationor depletion of these cells contributes to endothelial dysfunctionand cardiovascular disease progression.

Methods We measured the number of colony-forming units of endothelialprogenitor cells in peripheral-blood samples from 45 men (mean[±SE] age, 50±2 years). The subjects had variousdegrees of cardiovascular risk but no history of cardiovasculardisease. Endothelium-dependent and endothelium-independent functionwas assessed by high-resolution ultrasonography of the brachialartery.

Results We observed a strong correlation between the numberof circulating endothelial progenitor cells and the subjects'combined Framingham risk factor score (r=–0.47, P=0.001).Measurement of flow-mediated brachial-artery reactivity alsorevealed a significant relation between endothelial functionand the number of progenitor cells (r=0.59, P<0.001). Indeed,the levels of circulating endothelial progenitor cells werea better predictor of vascular reactivity than was the presenceor absence of conventional risk factors. In addition, endothelialprogenitor cells from subjects at high risk for cardiovascularevents had higher rates of in vitro senescence than cells fromsubjects at low risk.

Conclusions In healthy men, levels of endothelial progenitorcells may be a surrogate biologic marker for vascular functionand cumulative cardiovascular risk. These findings suggest thatendothelial injury in the absence of sufficient circulatingprogenitor cells may affect the progression of cardiovasculardisease.

Source Information

From the Cardiovascular Branch (J.M.H., G.Z., J.P.J.H., W.H.S., T.F.) and the Office of Biostatistics Research (M.A.W.), National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md.; and Emory University Hospital, Atlanta (A.A.Q.).

Address reprint requests to Dr. Finkel at the Cardiovascular Branch, NIH, Bldg. 10/6N-240, 10 Center Dr., Bethesda, MD 20892-1622, or at finkelt{at}nih.gov.

Full Text of this Article

This article has been cited by other articles:

Fujinaga, H., Baker, C. D., Ryan, S. L., Markham, N. E., Seedorf, G. J., Balasubramaniam, V., Abman, S. H. (2009). Hyperoxia disrupts vascular endothelial growth factor-nitric oxide signaling and decreases growth of endothelial colony-forming cells from preterm infants. Am. J. Physiol. Lung Cell. Mol. Physiol. 297: L1160-L1169 [Abstract] [Full Text]
Beijk, M. A.M., Klomp, M., Verouden, N. J.W., van Geloven, N., Koch, K. T., Henriques, J. P.S., Baan, J., Vis, M. M., Scheunhage, E., Piek, J. J., Tijssen, J. G.P., de Winter, R. J. (2009). GenousTM endothelial progenitor cell capturing stent vs. the Taxus Liberte stent in patients with de novo coronary lesions with a high-risk of coronary restenosis: a randomized, single-centre, pilot study. Eur Heart J 0: ehp476v1-ehp476 [Abstract] [Full Text]
Jenkins, N. T., Witkowski, S., Spangenburg, E. E., Hagberg, J. M. (2009). Effects of acute and chronic endurance exercise on intracellular nitric oxide in putative endothelial progenitor cells: role of NAPDH oxidase. Am. J. Physiol. Heart Circ. Physiol. 297: H1798-H1805 [Abstract] [Full Text]
Perry, T. E., Song, M., Despres, D. J., Kim, S. M., San, H., Yu, Z.-X., Raghavachari, N., Schnermann, J., Cannon, R. O. III, Orlic, D. (2009). Bone marrow-derived cells do not repair endothelium in a mouse model of chronic endothelial cell dysfunction. Cardiovasc Res 84: 317-325 [Abstract] [Full Text]
Gianella, A., Guerrini, U., Tilenni, M., Sironi, L., Milano, G., Nobili, E., Vaga, S., Capogrossi, M. C., Tremoli, E., Pesce, M. (2009). Magnetic resonance imaging of human endothelial progenitors reveals opposite effects on vascular and muscle regeneration into ischaemic tissues. Cardiovasc Res 0: cvp325v2-cvp325 [Abstract] [Full Text]
Linssen, G. C.M., Bakker, S. J.L., Voors, A. A., Gansevoort, R. T., Hillege, H. L., de Jong, P. E., van Veldhuisen, D. J., Gans, R. O.B., de Zeeuw, D. (2009). N-terminal pro-B-type natriuretic peptide is an independent predictor of cardiovascular morbidity and mortality in the general population. Eur Heart J 0: ehp420v1-ehp420 [Abstract] [Full Text]
John, R., Panch, S., Hrabe, J., Wei, P., Solovey, A., Joyce, L., Hebbel, R. (2009). Activation of endothelial and coagulation systems in left ventricular assist device recipients.. Ann. Thorac. Surg. 88: 1171-1179 [Abstract] [Full Text]
Boda, Z., Udvardy, M., Razso, K., Farkas, K., Toth, J., Jambor, L., Olah, Z., Ilonczai, P., Szarvas, M., Kappelmayer, J., Vereb, Z., Rajnavolgyi, E. (2009). Stem Cell Therapy: A Promising and Prospective Approach in the Treatment of Patients With Severe Buerger's Disease. CLIN APPL THROMB HEMOST 15: 552-560 [Abstract]
Lucchinetti, E., Zeisberger, S. M., Baruscotti, I., Wacker, J., Feng, J., Zaugg, K., Dubey, R., Zisch, A. H., Zaugg, M. (2009). Stem Cell-Like Human Endothelial Progenitors Show Enhanced Colony-Forming Capacity After Brief Sevoflurane Exposure: Preconditioning of Angiogenic Cells by Volatile Anesthetics. Anesth. Analg. 109: 1117-1126 [Abstract] [Full Text]
Jickling, G., Salam, A., Mohammad, A., Hussain, M. S., Scozzafava, J., Nasser, A. M., Jeerakathil, T., Shuaib, A., Camicioli, R. (2009). Circulating Endothelial Progenitor Cells and Age-Related White Matter Changes. Stroke 40: 3191-3196 [Abstract] [Full Text]
Thorin, E., Thorin-Trescases, N. (2009). Vascular endothelial ageing, heartbeat after heartbeat. Cardiovasc Res 84: 24-32 [Abstract] [Full Text]
Zavada, J., Kideryova, L., Pytlik, R., Hruskova, Z., Tesar, V. (2009). Reduced number of endothelial progenitor cells is predictive of early relapse in anti-neutrophil cytoplasmic antibody-associated vasculitis. Rheumatology (Oxford) 48: 1197-1201 [Abstract] [Full Text]
Piaggio, G., Rosti, V., Corselli, M., Bertolotti, F., Bergamaschi, G., Pozzi, S., Imperiale, D., Chiavarina, B., Bonetti, E., Novara, F., Sessarego, M., Villani, L., Garuti, A., Massa, M., Ghio, R., Campanelli, R., Bacigalupo, A., Pecci, A., Viarengo, G., Zuffardi, O., Frassoni, F., Barosi, G. (2009). Endothelial colony-forming cells from patients with chronic myeloproliferative disorders lack the disease-specific molecular clonality marker. Blood 114: 3127-3130 [Abstract] [Full Text]
Xu, J., Zou, M.-H. (2009). Molecular Insights and Therapeutic Targets for Diabetic Endothelial Dysfunction. Circulation 120: 1266-1286 [Full Text]
Balasubramaniam, V., Ingram, D. A. (2009). Endothelial Progenitors in the Risk of Developing Bronchopulmonary Dysplasia: Can We Include Endothelial Progenitor Cells in BPD Risk Assessment?. Am. J. Respir. Crit. Care Med. 180: 488-490 [Full Text]
Li, T.-S., Kubo, M., Ueda, K., Murakami, M., Ohshima, M., Kobayashi, T., Tanaka, T., Shirasawa, B., Mikamo, A., Hamano, K. (2009). Identification of Risk Factors Related to Poor Angiogenic Potency of Bone Marrow Cells From Different Patients. Circulation 120: S255-S261 [Abstract] [Full Text]
Foo, S. Y., Heller, E. R., Wykrzykowska, J., Sullivan, C. J., Manning-Tobin, J. J., Moore, K. J., Gerszten, R. E., Rosenzweig, A. (2009). Vascular effects of a low-carbohydrate high-protein diet. Proc. Natl. Acad. Sci. USA 106: 15418-15423 [Abstract] [Full Text]
Dotsenko, O., Jahangiri, M. (2009). Endogenous stem cells in patients undergoing coronary artery bypass graft surgery. Eur. J. Cardiothorac. Surg. 36: 563-571 [Abstract] [Full Text]
Baker, C. D., Ryan, S. L., Ingram, D. A., Seedorf, G. J., Abman, S. H., Balasubramaniam, V. (2009). Endothelial Colony-forming Cells from Preterm Infants Are Increased and More Susceptible to Hyperoxia. Am. J. Respir. Crit. Care Med. 180: 454-461 [Abstract] [Full Text]
Silvestre, J. S., Levy, B. I. (2009). Circulating progenitor cells and cardiovascular outcomes: latest evidence on angiotensin-converting enzyme inhibitors. Eur Heart J Suppl 11: E17-E21 [Abstract] [Full Text]
Ueno, H., Koyama, H., Fukumoto, S., Tanaka, S., Shoji, T., Shoji, T., Emoto, M., Tahara, H., Tsujimoto, Y., Tabata, T., Nishizawa, Y. (2009). Dialysis modality is independently associated with circulating endothelial progenitor cells in end-stage renal diseases patients. Nephrol Dial Transplant 0: gfp358v1-gfp358 [Abstract] [Full Text]
Prokopi, M., Pula, G., Mayr, U., Devue, C., Gallagher, J., Xiao, Q., Boulanger, C. M., Westwood, N., Urbich, C., Willeit, J., Steiner, M., Breuss, J., Xu, Q., Kiechl, S., Mayr, M. (2009). Proteomic analysis reveals presence of platelet microparticles in endothelial progenitor cell cultures. Blood 114: 723-732 [Abstract] [Full Text]
Pericleous, C, Giles, I, Rahman, A (2009). Are endothelial microparticles potential markers of vascular dysfunction in the antiphospholipid syndrome?. Lupus 18: 671-675 [Abstract]
Hibbert, B., Ma, X., Pourdjabbar, A., Holm, E., Rayner, K., Chen, Y.-X., Sun, J., Filion, L., O'Brien, E. R. (2009). Inhibition of endothelial progenitor cell glycogen synthase kinase-3{beta} results in attenuated neointima formation and enhanced re-endothelialization after arterial injury. Cardiovasc Res 83: 16-23 [Abstract] [Full Text]
Reinisch, A., Hofmann, N. A., Obenauf, A. C., Kashofer, K., Rohde, E., Schallmoser, K., Flicker, K., Lanzer, G., Linkesch, W., Speicher, M. R., Strunk, D. (2009). Humanized large-scale expanded endothelial colony-forming cells function in vitro and in vivo. Blood 113: 6716-6725 [Abstract] [Full Text]
Moreno, P. R., Sanz, J., Fuster, V. (2009). Promoting Mechanisms of Vascular Health: Circulating Progenitor Cells, Angiogenesis, and Reverse Cholesterol Transport. J Am Coll Cardiol 53: 2315-2323 [Abstract] [Full Text]
Moriya, J., Minamino, T., Tateno, K., Shimizu, N., Kuwabara, Y., Sato, Y., Saito, Y., Komuro, I. (2009). Long-Term Outcome of Therapeutic Neovascularization Using Peripheral Blood Mononuclear Cells for Limb Ischemia. Circ Cardiovasc Interv 2: 245-254 [Abstract] [Full Text]
Di Stefano, V., Cencioni, C., Zaccagnini, G., Magenta, A., Capogrossi, M. C., Martelli, F. (2009). p66ShcA modulates oxidative stress and survival of endothelial progenitor cells in response to high glucose. Cardiovasc Res 82: 421-429 [Abstract] [Full Text]
Lee, S-T, Chu, K., Jung, K-H, Park, H-K, Kim, D-H, Bahn, J-J, Kim, J-H, Oh, M-J, Lee, S. K., Kim, M., Roh, J-K (2009). Reduced circulating angiogenic cells in Alzheimer disease. Neurology 72: 1858-1863 [Abstract] [Full Text]
Cesselli, D., Beltrami, A. P., Rigo, S., Bergamin, N., D'Aurizio, F., Verardo, R., Piazza, S., Klaric, E., Fanin, R., Toffoletto, B., Marzinotto, S., Mariuzzi, L., Finato, N., Pandolfi, M., Leri, A., Schneider, C., Beltrami, C. A., Anversa, P. (2009). Multipotent Progenitor Cells Are Present in Human Peripheral Blood. Circ. Res. 104: 1225-1234 [Abstract] [Full Text]
Zhang, Y., Herbert, B.-S., Rajashekhar, G., Ingram, D. A., Yoder, M. C., Clauss, M., Rehman, J. (2009). Premature senescence of highly proliferative endothelial progenitor cells is induced by tumor necrosis factor-{alpha} via the p38 mitogen-activated protein kinase pathway. FASEB J. 23: 1358-1365 [Abstract] [Full Text]
Zhang, Y., Ingram, D. A., Murphy, M. P., Saadatzadeh, M. R., Mead, L. E., Prater, D. N., Rehman, J. (2009). Release of proinflammatory mediators and expression of proinflammatory adhesion molecules by endothelial progenitor cells. Am. J. Physiol. Heart Circ. Physiol. 296: H1675-H1682 [Abstract] [Full Text]
Leone, A. M., Valgimigli, M., Giannico, M. B., Zaccone, V., Perfetti, M., D'Amario, D., Rebuzzi, A. G., Crea, F. (2009). From bone marrow to the arterial wall: the ongoing tale of endothelial progenitor cells. Eur Heart J 30: 890-899 [Abstract] [Full Text]
Aghila Rani, K. G, Jayakumar, K., Sarma, P S., Kartha, C. C (2009). Clinical Determinants of ckit-Positive Cardiac Cell Yield in Coronary Disease. Asian Cardiovasc. Thorac. Ann. 17: 139-142 [Abstract] [Full Text]
Gyan, B., Goka, B. Q., Adjei, G. O., Tetteh, J. K. A., Kusi, K. A., Aikins, A., Dodoo, D., Lesser, M. L., Sison, C. P., Das, S., Howard, M. E., Milbank, E., Fischer, K., Rafii, S., Jin, D., Golightly, L. M. (2009). Cerebral Malaria Is Associated with Low Levels of Circulating Endothelial Progenitor Cells in African Children. Am J Trop Med Hyg 80: 541-546 [Abstract] [Full Text]
Sasahara, M., Otani, A., Yodoi, Y., Yoshimura, N. (2009). Circulating Hematopoietic Stem Cells in Patients with Idiopathic Choroidal Neovascularization. IOVS 50: 1575-1579 [Abstract] [Full Text]
Nakamura, S., Kimura, M., Goto, C., Noma, K., Yoshizumi, M., Chayama, K., Kihara, Y., Higashi, Y. (2009). Cigarette Smoking Abolishes Ischemic Preconditioning-Induced Augmentation of Endothelium-Dependent Vasodilation. Hypertension 53: 674-681 [Abstract] [Full Text]
Stellos, K., Bigalke, B., Langer, H., Geisler, T., Schad, A., Kogel, A., Pfaff, F., Stakos, D., Seizer, P., Muller, I., Htun, P., Lindemann, S., Gawaz, M. (2009). Expression of stromal-cell-derived factor-1 on circulating platelets is increased in patients with acute coronary syndrome and correlates with the number of CD34+ progenitor cells. Eur Heart J 30: 584-593 [Abstract] [Full Text]
Pirro, M., Schillaci, G., Romagno, P. F., Mannarino, M. R., Bagaglia, F., Razzi, R., Pasqualini, L., Vaudo, G., Mannarino, E. (2009). Influence of Short-term Rosuvastatin Therapy on Endothelial Progenitor Cells and Endothelial Function. J CARDIOVASC PHARMACOL THER 14: 14-21 [Abstract]
Robb, A.O., Mills, N.L., Smith, I.B.J., Short, A., Tura-Ceide, O., Barclay, G.R., Blomberg, A., Critchley, H.O.D., Newby, D.E., Denison, F.C. (2009). Influence of menstrual cycle on circulating endothelial progenitor cells. Hum Reprod 24: 619-625 [Abstract] [Full Text]
Chade, A. R., Zhu, X., Lavi, R., Krier, J. D., Pislaru, S., Simari, R. D., Napoli, C., Lerman, A., Lerman, L. O. (2009). Endothelial Progenitor Cells Restore Renal Function in Chronic Experimental Renovascular Disease. Circulation 119: 547-557 [Abstract] [Full Text]
Yamahara, K., Itoh, H. (2009). Potential use of endothelial progenitor cells for regeneration of the vasculature. Ther Adv Cardiovasc Dis 3: 17-27 [Abstract]
Matsumoto, Y., Adams, V., Walther, C., Kleinecke, C., Brugger, P., Linke, A., Walther, T., Mohr, F. W., Schuler, G. (2009). Reduced number and function of endothelial progenitor cells in patients with aortic valve stenosis: a novel concept for valvular endothelial cell repair. Eur Heart J 30: 346-355 [Abstract] [Full Text]
Devaraj, S., Singh, U., Jialal, I. (2009). The Evolving Role of C-Reactive Protein in Atherothrombosis. Clin. Chem. 55: 229-238 [Abstract] [Full Text]
Rafat, N., Beck, G. Ch., Pena-Tapia, P. G., Schmiedek, P., Vajkoczy, P. (2009). Increased Levels of Circulating Endothelial Progenitor Cells in Patients With Moyamoya Disease. Stroke 40: 432-438 [Abstract] [Full Text]
Chen, J., Li, H., Addabbo, F., Zhang, F., Pelger, E., Patschan, D., Park, H.-C., Kuo, M.-C., Ni, J., Gobe, G., Chander, P. N., Nasjletti, A., Goligorsky, M. S. (2009). Adoptive Transfer of Syngeneic Bone Marrow-Derived Cells in Mice with Obesity-Induced Diabetes: Selenoorganic Antioxidant Ebselen Restores Stem Cell Competence. Am. J. Pathol. 174: 701-711 [Abstract] [Full Text]
Distler, J H W, Allanore, Y, Avouac, J, Giacomelli, R, Guiducci, S, Moritz, F, Akhmetshina, A, Walker, U A, Gabrielli, A, Muller-Ladner, U, Tyndall, A, Matucci-Cerinic, M, Distler, O (2009). EULAR Scleroderma Trials and Research group statement and recommendations on endothelial precursor cells. Ann Rheum Dis 68: 163-168 [Abstract] [Full Text]
Pula, G., Mayr, U., Evans, C., Prokopi, M., Vara, D. S., Yin, X., Astroulakis, Z., Xiao, Q., Hill, J., Xu, Q., Mayr, M. (2009). Proteomics Identifies Thymidine Phosphorylase As a Key Regulator of the Angiogenic Potential of Colony-Forming Units and Endothelial Progenitor Cell Cultures. Circ. Res. 104: 32-40 [Abstract] [Full Text]
Desai, A., Glaser, A., Liu, D., Raghavachari, N., Blum, A., Zalos, G., Lippincott, M., McCoy, J. P., Munson, P. J., Solomon, M. A., Danner, R. L., Cannon, R. O. III (2009). Microarray-Based Characterization of a Colony Assay Used to Investigate Endothelial Progenitor Cells and Relevance to Endothelial Function in Humans. Arterioscler. Thromb. Vasc. Bio. 29: 121-127 [Abstract] [Full Text]
Obi, S., Yamamoto, K., Shimizu, N., Kumagaya, S., Masumura, T., Sokabe, T., Asahara, T., Ando, J. (2009). Fluid shear stress induces arterial differentiation of endothelial progenitor cells. J. Appl. Physiol. 106: 203-211 [Abstract] [Full Text]
Erusalimsky, J. D. (2009). Vascular endothelial senescence: from mechanisms to pathophysiology. J. Appl. Physiol. 106: 326-332 [Abstract] [Full Text]
Kondo, K., Shintani, S., Shibata, R., Murakami, H., Murakami, R., Imaizumi, M., Kitagawa, Y., Murohara, T. (2009). Implantation of Adipose-Derived Regenerative Cells Enhances Ischemia-Induced Angiogenesis. Arterioscler. Thromb. Vasc. Bio. 29: 61-66 [Abstract] [Full Text]
Dentelli, P., Trombetta, A., Togliatto, G., Zeoli, A., Rosso, A., Uberti, B., Orso, F., Taverna, D., Pegoraro, L., Brizzi, M. F. (2009). Formation of STAT5/PPAR{gamma} Transcriptional Complex Modulates Angiogenic Cell Bioavailability in Diabetes. Arterioscler. Thromb. Vasc. Bio. 29: 114-120 [Abstract] [Full Text]
Satoh, K., Fukumoto, Y., Nakano, M., Sugimura, K., Nawata, J., Demachi, J., Karibe, A., Kagaya, Y., Ishii, N., Sugamura, K., Shimokawa, H. (2009). Statin ameliorates hypoxia-induced pulmonary hypertension associated with down-regulated stromal cell-derived factor-1. Cardiovasc Res 81: 226-234 [Abstract] [Full Text]
Sanada, F., Taniyama, Y., Azuma, J., Iekushi, K., Dosaka, N., Yokoi, T., Koibuchi, N., Kusunoki, H., Aizawa, Y., Morishita, R. (2009). Hepatocyte Growth Factor, but not Vascular Endothelial Growth Factor, Attenuates Angiotensin II-Induced Endothelial Progenitor Cell Senescence. Hypertension 53: 77-82 [Abstract] [Full Text]
MacNee, W., Maclay, J., McAllister, D. (2008). Cardiovascular Injury and Repair in Chronic Obstructive Pulmonary Disease. Proc Am Thorac Soc 5: 824-833 [Abstract] [Full Text]
Smadja, D. M., Bieche, I., Silvestre, J.-S., Germain, S., Cornet, A., Laurendeau, I., Duong-Van-Huyen, J.-P., Emmerich, J., Vidaud, M., Aiach, M., Gaussem, P. (2008). Bone Morphogenetic Proteins 2 and 4 Are Selectively Expressed by Late Outgrowth Endothelial Progenitor Cells and Promote Neoangiogenesis. Arterioscler. Thromb. Vasc. Bio. 28: 2137-2143 [Abstract] [Full Text]
Ward, M. R., Lavoie, J., Stewart, D. J. (2008). "B2 or not B2?": Kinin Receptors and Endothelial Progenitor Cell Dysfunction. Circ. Res. 103: 1202-1203 [Full Text]
Zhu, S., Evans, S., Yan, B., Povsic, T. J., Tapson, V., Goldschmidt-Clermont, P. J., Dong, C. (2008). Transcriptional Regulation of Bim by FOXO3a and Akt Mediates Scleroderma Serum-Induced Apoptosis in Endothelial Progenitor Cells. Circulation 118: 2156-2165 [Abstract] [Full Text]
Westerweel, P. E., Visseren, F. L.J., Hajer, G. R., Olijhoek, J. K., Hoefer, I. E., de Bree, P., Rafii, S., Doevendans, P. A., Verhaar, M. C. (2008). Endothelial progenitor cell levels in obese men with the metabolic syndrome and the effect of simvastatin monotherapy vs. simvastatin/ezetimibe combination therapy. Eur Heart J 29: 2808-2817 [Abstract] [Full Text]
Gossl, M., Modder, U. I., Atkinson, E. J., Lerman, A., Khosla, S. (2008). Osteocalcin Expression by Circulating Endothelial Progenitor Cells in Patients With Coronary Atherosclerosis. J Am Coll Cardiol 52: 1314-1325 [Abstract] [Full Text]
Pirro, M., Bagaglia, F., Paoletti, L., Razzi, R., Mannarino, M. R. (2008). Review: Hypercholesterolemia-associated endothelial progenitor cell dysfunction. Ther Adv Cardiovasc Dis 2: 329-339 [Abstract]
Seals, D. R., DeSouza, C. A., Donato, A. J., Tanaka, H. (2008). Habitual exercise and arterial aging. J. Appl. Physiol. 105: 1323-1332 [Abstract] [Full Text]
Grisar, J., Steiner, C. W., Bonelli, M., Karonitsch, T., Schwarzinger, I., Weigel, G., Steiner, G., Smolen, J. S. (2008). Systemic lupus erythematosus patients exhibit functional deficiencies of endothelial progenitor cells. Rheumatology (Oxford) 47: 1476-1483 [Abstract] [Full Text]
Foubert, P., Matrone, G., Souttou, B., Lere-Dean, C., Barateau, V., Plouet, J., Le Ricousse-Roussanne, S., Levy, B. I., Silvestre, J.-S., Tobelem, G. (2008). Coadministration of Endothelial and Smooth Muscle Progenitor Cells Enhances the Efficiency of Proangiogenic Cell-Based Therapy. Circ. Res. 103: 751-760 [Abstract] [Full Text]
Hirschi, K. K., Ingram, D. A., Yoder, M. C. (2008). Assessing Identity, Phenotype, and Fate of Endothelial Progenitor Cells. Arterioscler. Thromb. Vasc. Bio. 28: 1584-1595 [Full Text]
Sugiura, T., Kondo, T., Kureishi-Bando, Y., Numaguchi, Y., Yoshida, O., Dohi, Y., Kimura, G., Ueda, R., Rabelink, T. J., Murohara, T. (2008). Nifedipine Improves Endothelial Function: Role of Endothelial Progenitor Cells. Hypertension 52: 491-498 [Abstract] [Full Text]
Schroeter, M. R., Leifheit, M., Sudholt, P., Heida, N.-M., Dellas, C., Rohm, I., Alves, F., Zientkowska, M., Rafail, S., Puls, M., Hasenfuss, G., Konstantinides, S., Schafer, K. (2008). Leptin Enhances the Recruitment of Endothelial Progenitor Cells Into Neointimal Lesions After Vascular Injury by Promoting Integrin-Mediated Adhesion. Circ. Res. 103: 536-544 [Abstract] [Full Text]
Fraccarollo, D., Widder, J. D., Galuppo, P., Thum, T., Tsikas, D., Hoffmann, M., Ruetten, H., Ertl, G., Bauersachs, J. (2008). Improvement in Left Ventricular Remodeling by the Endothelial Nitric Oxide Synthase Enhancer AVE9488 After Experimental Myocardial Infarction. Circulation 118: 818-827 [Abstract] [Full Text]
Santilli, F., Romano, M., Recchiuti, A., Dragani, A., Falco, A., Lessiani, G., Fioritoni, F., Lattanzio, S., Mattoscio, D., De Cristofaro, R., Rocca, B., Davi, G. (2008). Circulating endothelial progenitor cells and residual in vivo thromboxane biosynthesis in low-dose aspirin-treated polycythemia vera patients. Blood 112: 1085-1090 [Abstract] [Full Text]
Schlieper, G., Hristov, M., Brandenburg, V., Kruger, T., Westenfeld, R., Mahnken, A. H., Yagmur, E., Boecker, G., Heussen, N., Gladziwa, U., Ketteler, M., Weber, C., Floege, J. (2008). Predictors of low circulating endothelial progenitor cell numbers in haemodialysis patients. Nephrol Dial Transplant 23: 2611-2618 [Abstract] [Full Text]
van der Klaauw, A. A, Pereira, A. M, Rabelink, T. J, Corssmit, E. P M, Zonneveld, A.-J., Pijl, H., de Boer, H. C, Smit, J. W A, Romijn, J. A, de Koning, E. J P (2008). Recombinant human GH replacement increases CD34+ cells and improves endothelial function in adults with GH deficiency. Eur J Endocrinol 159: 105-111 [Abstract] [Full Text]
Campioni, D., Monaco, A. L., Lanza, F., Moretti, S., Ferrari, L., Fotinidi, M., La Corte, R., Cuneo, A., Trotta, F. (2008). CXCR4pos circulating progenitor cells coexpressing monocytic and endothelial markers correlating with fibrotic clinical features are present in the peripheral blood of patients affected by systemic sclerosis. haematol 93: 1233-1237 [Abstract] [Full Text]
Zeoli, A., Dentelli, P., Rosso, A., Togliatto, G., Trombetta, A., Damiano, L., di Celle, P. F., Pegoraro, L., Altruda, F., Brizzi, M. F. (2008). Interleukin-3 promotes expansion of hemopoietic-derived CD45+ angiogenic cells and their arterial commitment via STAT5 activation. Blood 112: 350-361 [Abstract] [Full Text]
Surdacki, A., Marewicz, E., Wieteska, E., Szastak, G., Rakowski, T., Wieczorek-Surdacka, E., Dudek, D., Pryjma, J., Dubiel, J. S. (2008). Association between endothelial progenitor cell depletion in blood and mild-to-moderate renal insufficiency in stable angina. Nephrol Dial Transplant 23: 2265-2273 [Abstract] [Full Text]
Rouhl, R. P.W., van Oostenbrugge, R. J., Damoiseaux, J., Tervaert, J.-W. C., Lodder, J. (2008). Endothelial Progenitor Cell Research in Stroke: A Potential Shift in Pathophysiological and Therapeutical Concepts. Stroke 39: 2158-2165 [Abstract] [Full Text]
Diller, G.-P., van Eijl, S., Okonko, D. O., Howard, L. S., Ali, O., Thum, T., Wort, S. J., Bedard, E., Gibbs, J. S. R., Bauersachs, J., Hobbs, A. J., Wilkins, M. R., Gatzoulis, M. A., Wharton, J. (2008). Circulating Endothelial Progenitor Cells in Patients With Eisenmenger Syndrome and Idiopathic Pulmonary Arterial Hypertension. Circulation 117: 3020-3030 [Abstract] [Full Text]
Muller-Ehmsen, J., Braun, D., Schneider, T., Pfister, R., Worm, N., Wielckens, K., Scheid, C., Frommolt, P., Flesch, M. (2008). Decreased number of circulating progenitor cells in obesity: beneficial effects of weight reduction. Eur Heart J 29: 1560-1568 [Abstract] [Full Text]
Povsic, T. J., Goldschmidt-Clermont, P. J. (2008). Review: Endothelial progenitor cells: markers of vascular reparative capacity. Ther Adv Cardiovasc Dis 2: 199-213 [Abstract]
Thill, M., Strunnikova, N. V., Berna, M. J., Gordiyenko, N., Schmid, K., Cousins, S. W., Thompson, D. J. S., Csaky, K. G. (2008). Late Outgrowth Endothelial Progenitor Cells in Patients with Age-Related Macular Degeneration. IOVS 49: 2696-2708 [Abstract] [Full Text]
Gurtner, G. C., Chang, E. (2008). "Priming" Endothelial Progenitor Cells: A New Strategy to Improve Cell Based Therapeutics. Arterioscler. Thromb. Vasc. Bio. 28: 1034-1035 [Full Text]
You, D., Cochain, C., Loinard, C., Vilar, J., Mees, B., Duriez, M., Levy, B. I., Silvestre, J.-S. (2008). Combination of the Angiotensin-Converting Enzyme Inhibitor Perindopril and the Diuretic Indapamide Activate Postnatal Vasculogenesis in Spontaneously Hypertensive Rats. J. Pharmacol. Exp. Ther. 325: 766-773 [Abstract] [Full Text]
Zampetaki, A., Kirton, J. P., Xu, Q. (2008). Vascular repair by endothelial progenitor cells. Cardiovasc Res 78: 413-421 [Abstract] [Full Text]
You, D., Cochain, C., Loinard, C., Vilar, J., Mees, B., Duriez, M., Levy, B. I., Silvestre, J.-S. (2008). Hypertension Impairs Postnatal Vasculogenesis: Role of Antihypertensive Agents. Hypertension 51: 1537-1544 [Abstract] [Full Text]
Heiss, C., Amabile, N., Lee, A. C., Real, W. M., Schick, S. F., Lao, D., Wong, M. L., Jahn, S., Angeli, F. S., Minasi, P., Springer, M. L., Hammond, S. K., Glantz, S. A., Grossman, W., Balmes, J. R., Yeghiazarians, Y. (2008). Brief Secondhand Smoke Exposure Depresses Endothelial Progenitor Cells Activity and Endothelial Function: Sustained Vascular Injury and Blunted Nitric Oxide Production. J Am Coll Cardiol 51: 1760-1771 [Abstract] [Full Text]

Comments and questions? Please contact us.