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Previous Volume 349:1803-1811 November 6, 2003 Number 19 Next

	Full Text PDF PDA Full Text PowerPoint Slide Set Perspective by Lerman, B. B. Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear PubMed Citation

ABSTRACT

Background Young age and inducibility of atrioventricular reciprocating tachycardia or atrial fibrillation during invasive electrophysiological testing identify asymptomatic patients with a Wolff–Parkinson–White pattern on the electrocardiogram as being at high risk for arrhythmic events. We tested the hypothesis that prophylactic catheter ablation of accessory pathways would provide meaningful and durable benefits as compared with no treatment in such patients.

Methods From 1997 to 2002, among 224 eligible asymptomatic patients with the Wolff–Parkinson–White syndrome, patients at high risk for arrhythmias were randomly assigned to radio-frequency catheter ablation of accessory pathways (37 patients) or no treatment (35 patients). The end point was the occurrence of arrhythmic events over a five-year follow-up period.

Results Patients assigned to ablation had base-line characteristics that were similar to those of the controls. Two patients in the ablation group (5 percent) and 21 in the control group (60 percent) had arrhythmic events. One control patient had ventricular fibrillation as the presenting arrhythmia. The five-year Kaplan–Meier estimates of the incidence of arrhythmic events were 7 percent among patients who underwent ablation and 77 percent among the controls (P<0.001 by the log-rank test); the risk reduction with ablation was 92 percent (relative risk, 0.08; 95 percent confidence interval, 0.02 to 0.33; P<0.001).

Conclusions Prophylactic accessory-pathway ablation markedly reduces the frequency of arrhythmic events in asymptomatic patients with the Wolff–Parkinson–White syndrome who are at high risk for such events.

Source Information

From the Department of Cardiology, Electrophysiology and Cardiac Pacing Unit, San Raffaele University Hospital, Milan (C.P., G.A., G.V., S.G., P.M., V.T., A.P., C.D.); the Department of Cardiology, University Hospital Federico II, Naples (V.S., F.M., O.S.) — both in Italy; and the Division of Cardiology, Department of Internal Medicine, University of Texas Medical Branch, Galveston (S.R.).

Address reprint requests to Dr. C. Pappone at the Department of Cardiology, San Raffaele University Hospital, Via Olgettina 60, 20132 Milan, Italy, or at carlo.pappone{at}hsr.it.

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